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Evidence for Conservation of the Calcitonin Superfamily and Activity-regulating Mechanisms in the Basal Chordate Branchiostoma floridae: INSIGHTS INTO THE MOLECULAR AND FUNCTIONAL EVOLUTION IN CHORDATES.

The calcitonin (CT)/CT gene-related peptide (CGRP) family is conserved in vertebrates. The activities of this peptide family are regulated by a combination of two receptors, namely the calcitonin receptor (CTR) and the CTR-like receptor (CLR), and three receptor activity-modifying proteins (RAMPs). Furthermore, RAMPs act as escort proteins by translocating CLR to the cell membrane. Recently, CT/CGRP family peptides have been identified or inferred in several invertebrates. However, the molecular characteristics and relevant functions of the CTR/CLR and RAMPs in invertebrates remain unclear. In

Promising Activities of Marine Natural Products against Hematopoietic Malignancies.

According to the WHO classification of tumors, more than 150 typologies of hematopoietic and lymphoid tumors exist, and most of them remain incurable diseases that require innovative approaches to improve therapeutic outcome and avoid side effects. Marine organisms represent a reservoir of novel bioactive metabolites, but they are still less studied compared to their terrestrial counterparts. This review is focused on marine natural products with anticancer activity against hematological tumors, highlighting recent advances and possible perspectives. Until now, there are five commercially avai

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… Among the marine organism phyla tested, there were Annelida, Bryozoa, Chlorophyta, Chordata, Cnidaria, Cyanophyta, Echinodermata, Mollusca, Phaeophyta, Porifera, Rhodophyta, and Tracheophyta (Mangrove), and 620 of 9945 organisms were found to have anti-leukemia properties (an extract was considered “ … Compound | Activity on Cells/Tissues | Organism | Mechanism of Action | Concentration | Reference NA | K562 and HL-60 leukemia cell lines | Annelida, Bryozoa, Chlorophyta, Chordata, Cnidaria, Cyanophyta, Echinodermata, Mollusca, Phaeophyta, Porifera, Rhodophyta and Tracheophyta | NA | 100 µg/mL | [ 73 …

Potential Approaches Versus Approved or Developing Chronic Myeloid Leukemia Therapy.

Tyrosine kinase inhibitors (TKIs) have revolutionized the treatment of patients with chronic myeloid leukemia (CML). However, continued use of these inhibitors has contributed to the increase in clinical resistance and the persistence of resistant leukemic stem cells (LSCs). So, there is an urgent need to introduce additional targeted and selective therapies to eradicate quiescent LSCs, and to avoid the relapse and disease progression. Here, we focused on emerging BCR-ABL targeted and non-BCR-ABL targeted drugs employed in clinical trials and on alternative CML treatments, including antioxidan

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… Data showed that different phyla, including Annelida, Bryozoa, Chlorophyta, Chordata, Cnidaria, Cyanophyta, Echinodermata, Mollusca, Phaeophyta, Porifera, Rhodophyta and Tracheophyta (Mangrove) and 620/9945 extracts had antileukemia properties. …

Perspective Applications and Associated Challenges of Using Nanocellulose in Treating Bone-Related Diseases.

Bone serves to maintain the shape of the human body due to its hard and solid nature. A loss or weakening of bone tissues, such as in case of traumatic injury, diseases (e.g., osteosarcoma), or old age, adversely affects the individuals quality of life. Although bone has the innate ability to remodel and regenerate in case of small damage or a crack, a loss of a large volume of bone in case of a traumatic injury requires the restoration of bone function by adopting different biophysical approaches and chemotherapies as well as a surgical reconstruction. Compared to the biophysical and chemothe

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… Animals Nanocellulose has also been obtained from some animals such as Styela clava and Halocynthia roretzi Drasche (tunicates from phylum Chordata) ( Bacakova et al., 2019 ). …

An Updated Review on Marine Anticancer Compounds: The Use of Virtual Screening for the Discovery of Small-Molecule Cancer Drugs.

Marine secondary metabolites are a promising source of unexploited drugs that have a wide structural diversity and have shown a variety of biological activities. These compounds are produced in response to the harsh and competitive conditions that occur in the marine environment. Invertebrates are considered to be among the groups with the richest biodiversity. To date, a significant number of marine natural products (MNPs) have been established as antineoplastic drugs. This review gives an overview of MNPs, both in research or clinical stages, from diverse organisms that were reported as bein

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… The rest of them were in the phyla Echinodermata (7.4%), Chordata (6.0%), and Mollusca (5.0%). They also compared the MNPs by chemical group and demonstrated that in the Porifera or Cnidaria phyla, a particular chemical group was not always prevalent through the same phylum [ 47 ]. …

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