Результаты поиска

The impact of knowledge on attitudes of emergency department staff towards patients with substance related presentations: a quantitative systematic review protocol.

CENTER CONDUCTING THE REVIEW: University of Manitoba and Queens Joanna Briggs Collaboration for Patient Safety: a Collaborating Center of the Joanna Briggs Institute REVIEW QUESTION/OBJECTIVE: The overall objective of this systematic review is to synthesize the available evidence on the relationship between new knowledge (gained through educational interventions about substance use/abuse) and health care providers' attitudes (measured by well validated instruments such as the Drug and Drug Problems Perceptions Questionnaire [DDPPQ], the Short Alcohol and Alcohol Problems Perception Questionna…

2018 Ежегодное совещание СНГ: Североамериканская конференция по вопросам неадекватности и регулирования.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… of Wisconsin 4 Full Professor, Department of Pediatrics, Faculty of Medicine, Université de Montréal, Professor, CHU Sainte-Justine, Department of Pediatrics, Department of microbiology, infectiology and immunology, University of Montreal, Montreal, QC, Canada 5 Associate Professor, University of Manitoba … , Manitoba Blood and Marrow Program 6 Biostatistician I, Medical College of Wisconsin 7 Associate Professor, Memorial Sloan-Kettering Cancer Center 8 Allergy & Immunology Specialist, Division of Allergy and Immunology, Duke University Medical Center 9 Medical Officer, National Institute of Allergy …

Staff perspectives on the feasibility of a clinical pathway for anxiety and depression in cancer care, and mid-implementation adaptations.

BackgroundClinical pathways (CPs) are intended to standardise and improve care but do not always produce positive outcomes, possibly because they were not adapted to suit the specific context in which they were enacted. This qualitative study aimed to explore staff perspectives of implementation of a CP for routine screening, assessment, referral and management of anxiety and depression (the ADAPT CP) for patients with cancer, focussing on perceived feasibility of the CP and negotiated adaptations made during the implementation phase.MethodsThe ADAPT CP was implemented in 12 urban and regional

Совпадение в полном тексте источника
… Campsie, NSW, Australia. 6 HammondCare Palliative Care Services, Sydney, Australia. 7 The University of Sydney, School of Psychology, Centre for Medical Psychology and Evidence-Based Decisions-Making (CeMPED), Sydney, NSW, Australia. 8 College of Nursing, Rady Faculty of Health Services, University of Manitoba … , Winnipeg, Canada. 9 CancerCare Manitoba Research Institute, Winnipeg, Canada. 10 School of Medicine & Public Health, University of Newcastle, Callaghan NSW, Australia. 11 School of Public Health, The University of Sydney, Sydney, NSW, Australia. 12 Nepean Cancer Centre, NSW, Australia. 13 Northern …

Факторы риска для перинатальных психических заболеваний при многочисленных склерозах.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Матери с РС сталкиваются с возросшей распространенностью и распространенностью перинатальных психических заболеваний по сравнению с матерями, не имеющими НР. ЦЕЛЬ: Определение факторов, связанных с риском перинатальных психических заболеваний у матерей с НР. МЕТОДЫ: В период с 2002 по 2019 год мы выявили матерей с НР с живыми родами с использованием увязанных с демографическими данными административных данных из Онтарио, Канада. Используя подтвержденные определения, мы оценивали распространенность психических заболеваний (депрессия, беспокойство, биполярное расстройство)

Совпадение в полном тексте источника
… The University of Manitoba Health Research Ethics Board approved the study. …

The Diagnosis and Therapy of Osteoporosis in Gaucher Disease.

Gaucher disease is a rare lysosomal storage disorder characterized by the accumulation of glucocerebroside lipids within multiple organs due to a deficiency of the lysosomal enzyme (acid β-glucosidase). It is an inherited autosomal recessive disease. The onset of symptoms can vary depending on disease type and severity, with milder forms presenting in adulthood. The main clinical manifestations include cytopenia, splenomegaly, hepatomegaly, and bone lesions. GD is characterized by several bone manifestations, such as osteopenia/osteoporosis, focal lytic or sclerotic lesions, osteonecrosis acut

Совпадение в полном тексте источника
… Hans D Goertzen AL Krieg MA Leslie WD Bone micro-architecture assessed by TBS predicts osteoporotic fractures independent of bone density: the Manitoba study J Bone Miner Res 2011 26 2762 2769 21887701 10.1002/jbmr.499 Hans D, Goertzen AL, Krieg MA, Leslie WD (2011) Bone micro-architecture assessed by … TBS predicts osteoporotic fractures independent of bone density: the Manitoba study. …

Hypophosphatasia.

Hypophosphatasia (HPP) is an inherited metabolic disease caused by loss-of-function mutations in the tissue non-specific alkaline phosphatase (TNAP) gene. Reduced activity of TNAP leads to the accumulation of its substrates, mainly inorganic pyrophosphate and pyridoxal-5'-phosphate, metabolic aberrations that largely explain the musculoskeletal and systemic features of the disease. More than 400 ALPL mutations, mostly missense, are reported to date, transmitted by either autosomal dominant or recessive mode. Severe disease is rare, with incidence ranging from 1:100,000 to 1:300,000 live births

Совпадение в полном тексте источника
… Perinatal HPP (OMIM 241500) This is the most life-threatening type of HPP, inherited with the autosomal recessive trait and is rare (Canada 1/100,000, Europe 1/300,000, Japan 1/182,000) [ 18 ], with the exception of Mennonite families in Manitoba (Canada), in whom the prevalence is high (1/2500). … Outcome of perinatal hypophosphatasia in manitoba mennonites: A retrospective cohort analysis JIMD Rep. 2013 11 73 78 10.1007/8904_2013_224 23580367 PMC3755555 22. Castells L. Cassanello P. Muñiz F. de Castro M.J. Couce M.L. …

Abstracts of the Cell Therapy Transplant Canada 2022 Annual Conference.

On behalf of Cell Therapy Transplant Canada (CTTC), we are pleased to present the Abstracts of the CTTC 2022 Annual Conference. The conference was held in-person 15-18 June 2022, in Niagara Falls, Ontario. Poster authors presented their work during a lively and engaging welcome reception on Thursday, 16 June, and oral abstract authors were featured during the oral abstract session in the afternoon on Friday, 17 June 2022. Thirty-three (33) abstracts were selected for presentation as posters and six (6) as oral presentations. The top abstracts in each of four (4) categories, (1) Basic/Translati

Совпадение в полном тексте источника
… Schultz 1 1 Michael Cuccione Childhood Cancer Research Program, British Columbia Children’s Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada 2 CancerCare Manitoba, University of Manitoba, Winnipeg, MB, Canada 3 British Columbia Children’s Hospital Research Institute … Seftel 5 , David Szwajcer 1 and Andrew Daly 6 1 Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada 2 CancerCare Manitoba, Winnipeg, MB, Canada 3 Stem Cell Transplant Program, McGill University Health Center, Montreal, QC, Canada 4 Department of Immunology, University of …

Изучение того, что имеет наибольшее значение для пациентов при повторном рефрактальном лечении нескольких миелом: канадский эксперимент по дискретному выбору пациентов, лиц, обеспечивающих уход, и врачей.

КОЛИЧЕСТВО: Возвращение/изъятие нескольких миелом (RRMM) оказывает значительное воздействие на качество жизни пациентов. В рамках этого исследования были изучены особенности лечения, характерные для RRMM в Канаде, при этом были сопоставлены параметры традиционных методов лечения с характеристиками химической антигенной рецепторной (CAR) T-клетокой терапии. Она была направлена на понимание предпочтений пациентов и того, каким образом те, кто ухаживает за больными, и специалисты в области здравоохранения (ХЦП) воспринимают эти предпочтения. МЕТОДЫ: Был проведен эксперимент по дискретному выбору

Совпадение в полном тексте источника
… 3 (3%) 1 (2%) White 90 (92%) 41 (91%) South Asian 1 (1%) 2 (4%) Chinese 2 (2%) 0 (0%) Black 1 (1%) 0 (0%) Arab 1 (1%) 0 (0%) Japanese 1 (1%) 0 (0%) Prefer not to answer 2 (2%) 2 (4%) Province/territory living in British Columbia 18 (18%) 12 (26%) Alberta 17 (17%) 7 (15%) Saskatchewan 1 (1%) 0 (0%) Manitoba … 91%) South Asian | 1 (1%) | 2 (4%) Chinese | 2 (2%) | 0 (0%) Black | 1 (1%) | 0 (0%) Arab | 1 (1%) | 0 (0%) Japanese | 1 (1%) | 0 (0%) Prefer not to answer | 2 (2%) | 2 (4%) Province/territory living in British Columbia | 18 (18%) | 12 (26%) Alberta | 17 (17%) | 7 (15%) Saskatchewan | 1 (1%) | 0 (0%) Manitoba …

Частота и распространенность множественных склерозов в Венгрии на основе рекордной увязки общенациональных многочисленных административных данных в области здравоохранения.

ЦЕЛИ: Поскольку в Венгрии проводились лишь региональные исследования по вопросу о распространенности множественного склероза (МС), мы стремились оценить его эпидемиологические особенности с использованием данных венгерской системы медицинского страхования с одним плательщиком. МЕТОДЫ: Псевудонимная база данных о жалобах, представленных больницами и амбулаторными службами в период между 2004-2016 был проанализирован и увязан с независимой базой данных о заправке амбулаторными аптеками 2010-2016. Мы установили административное определение MS и подтвердили его на медицинских записях 309 Последова

Совпадение в полном тексте источника
… Regarding MS, among the first works aiming to determine an administrative MS case definition was carried out by Culpepper et al. investigating the Veterans Health Administration databases in the USA [ 45 ] and Marrie et al. in Canada [ 20 ] using health insurance claims data in the province of Manitoba … The rising prevalence and changing age distribution of multiple sclerosis in Manitoba. Neurology. 2010;74(6):465–471. 10.1212/WNL.0b013e3181cf6ec0 21. Polman CH, Reingold SC, Edan G, Filippi M, Hartung HP, Kappos L, et al. …

Health management program: factors influencing completion of therapy with high-dose interferon alfa-2b for high-risk melanoma.

The goal of the 1-year observational, multicentre, open-label study reported here was to identify factors influencing adherence to high-dose interferon alfa-2b adjuvant therapy in patients at high risk of recurrence following surgical excision of malignant melanoma. The study was carried out in 23 tertiary-care centres across Canada.The 225 patients enrolled in the study all had malignant melanoma that was surgically excised and that required adjuvant treatment with interferon alfa-2b. Of these patients, 64% were men. Mean age was 51.7 years. All patients received interferon alfa-2b treatment

Совпадение в полном тексте источника
… Wong, Cancer Care Manitoba–St. Boniface General Hospital, Winnipeg, MB; Dr. John Yun, Richmond Health Science Centre, Richmond, BC; Dr. Scott Ernst, London Regional Cancer Center, London, ON. 6. …

Increase in major osteoporotic fractures after therapy with immune checkpoint inhibitors.

BackgroundImmune checkpoint inhibitors (ICIs) can cause severe and sometimes long-standing immune-related adverse events (irAEs). Enhanced immune activation from ICI can theoretically result in osteoclast activation, bone loss and fracture. The objective of this study was to evaluate the incidence rates of major osteoporotic fractures (MOFs) in patients with melanoma treated with ICI.MethodsWe conducted a before-after cohort study using a commercial healthcare claims dataset of adult patients with melanoma from the USA who received ICI therapy between 2011 and 2022. Incidence rates of MOF befo

Совпадение в полном тексте источника
… Radiological validation of fracture definitions from administrative data: the Manitoba bone mineral density database. J BONE Miner Res. 2018:275. 17. Center for Drug Evaluation, Research . U.S. Food and Drug Administration; 2019. [12-Jul-2024]. …

Screening, assessment, and treatment of osteoporosis for the nurse practitioner: key questions and answers for clinical practice--a Canadian perspective.

PurposeUsing a case-based approach, we review key clinical questions relevant to nurse practitioners (NPs) regarding the screening, assessment, and treatment of patients at risk for osteoporosis and fractures in a Canadian general practice setting.Data sourcesA case presentation with relevant questions and answers to guide management of a patient.ConclusionsOsteoporosis is a common condition in both the aging male and female populations. Screening, diagnosis, and treatment of osteoporosis is lagging behind relative to other chronic disease states. NPs have a unique opportunity to help reduce t

Совпадение в полном тексте источника
… Construction and validation of a simplified fracture risk assessment tool for Canadian women and men: Results from the CaMos and Manitoba cohorts. Osteoporosis International. 2011;22(6):1873–1883. doi: 10.1007/s00198-010-1445-5. …

Albuminuria as a diagnostic criterion and a therapeutic target in heart failure and other cardiovascular disease.

The high disease burden and bidirectional relationship of chronic kidney disease (CKD), heart failure (HF) and other cardiovascular disease (CVD) necessitate the need for early diagnosis of these diseases. While current screening and detection methods are recommended by CKD and CVD guidelines, their adoption in practice is low. Urine albumin-to-creatinine ratio (uACR) is recognized as a diagnostic marker for CKD and a prognostic marker for CKD progression, HF and CVD outcomes, therefore albuminuria changes have been accepted as a surrogate outcome for kidney and cardiovascular endpoints. Furth

Совпадение в полном тексте источника
… Country/Region | Number/Population | Methods/Results Clinical studies Manitoba, Canada 113 | 1353 people screened vs. matched controls Rural and remote indigenous communities | 44% of participants were at risk of kidney failure at screening. … Impact of point‐of‐care screening for hypertension, diabetes and progression of chronic kidney disease in rural Manitoba indigenous communities . CMAJ 2021 ; 193 : E1076 – E1084 . 10.1503/cmaj.201731 34281964 PMC8315205 114 Wong LL , Kalantar‐Zadeh K , Page V , Hayashida G , You AS , Rhee CM . …

European guidance for the diagnosis and management of osteoporosis in postmenopausal women.

Guidance is provided in a European setting on the assessment and treatment of postmenopausal women at risk from fractures due to osteoporosis.IntroductionThe International Osteoporosis Foundation and European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis published guidance for the diagnosis and management of osteoporosis in 2013. This manuscript updates these in a European setting.MethodsSystematic reviews were updated.ResultsThe following areas are reviewed: the role of bone mineral density measurement for the diagnosis of osteoporosis and assessment of fracture

Совпадение в полном тексте источника
… The impact of spine/femoral neck T-score discordance has been explored in a large BMD-referral population from Manitoba, Canada. There was approximately a 10% change in fracture risk for each unit of T-score discordance [ 101 ]. …

The efficacy and safety of thalidomide in the treatment of refractory Crohn's disease in adults: a double-center, double-blind, randomized-controlled trial.

BACKGROUND: Thalidomide is applied in therapy for refractory Crohn's disease (CD) in adults, but systematic and rigorous clinical evidence is scant. The aim was to provide theoretical references for the efficacy of thalidomide in the therapy for refractory CD in adults. METHODS: A double-center, double-blind, placebo-controlled, randomized clinical trial of refractory CD in adults in two inflammatory bowel disease centers in China. In the double-blind trial, patients were randomly assigned to 100 mg of thalidomide or placebo daily for 8 weeks. The primary outcome was considered as the clinica

Совпадение в полном тексте источника
… Inflammatory bowel disease in children of Manitoba: 30 years' experience of a tertiary center . …

Interventions to improve cancer survivorship among Indigenous Peoples and communities: a systematic review with a narrative synthesis.

PurposeThe purpose of this systematic review is to synthesize the evidence on the types of interventions that have been utilized by Indigenous Peoples living with cancer, and report on their relevance to Indigenous communities and how they align with holistic wellness.MethodsA systematic review with narrative synthesis was conducted.ResultsThe search yielded 7995 unique records; 27 studies evaluating 20 interventions were included. The majority of studies were conducted in USA, with five in Australia and one in Peru. Study designs were cross-sectional (n=13); qualitative (n=5); mixed methods (

Совпадение в полном тексте источника
… In the province of Manitoba, First Nations people diagnosed with cancer were significantly younger with significantly higher mortality rates, despite similar incidence rates after adjusting for age, sex, income, and area of residence [ 8 ]. … Cancer incidence, mortality, and stage at diagnosis in First Nations living in Manitoba. Curr Oncol. 2016;23(4):225–232. doi: 10.3747/co.23.2906. 8. Horrill TC, Dahl L, Sanderson E, Munro G, Garson C, Taylor C, Fransoo R, Thompson G, Cook C, Linton J, Schultz ASH. …

Utility of REMS-Derived Fragility Score and Trabecular Bone Score in Evaluating Bone Health in Type 2 Diabetes Mellitus.

Background/Objectives: A significantly higher fracture risk characterizes Type 2 diabetes mellitus (T2DM) patients when compared to the non-diabetic population, even though their average bone mineral density (BMD) tends to be normal or high. This elevated risk is primarily driven by defective bone quality. The trabecular bone score (TBS) and radiofrequency echographic multispectrometry (REMS) have recently been proposed to improve the assessment of bone quality in T2DM individuals. This study aimed to evaluate whether TBS and REMS can improve the identification of osteoporosis and fracture ris

Совпадение в полном тексте источника
… Manitoba Bone Density Program TBS (trabecular bone score) and diabetes-related fracture risk J. Clin. Endocrinol. Metab. 2013 98 602 609 10.1210/jc.2012-3118 23341489 16. Trandafir A.I. Sima O.C. Gheorghe A.M. Ciuche A. Cucu A.P. Nistor C. Carsote M. …

Prevalence, characteristics, and mortality of patients with transthyretin amyloid cardiomyopathy in the Nordic countries.

AimsTransthyretin amyloid cardiomyopathy (ATTR-CM) is a progressive condition caused by deposition of transthyretin amyloid fibrils in the heart and is associated with poor quality of life and a shortened lifespan. This study aimed to describe the prevalence, clinical characteristics, and mortality of patients with ATTR-CM, using multiple national health registers in Denmark, Finland, Norway, and Sweden.Methods and resultsTransthyretin amyloid cardiomyopathy patients were identified during 2008-2018 using a combination of diagnosis codes for amyloidosis and heart disease and were matched to pa

Совпадение в полном тексте источника
… The Epidemiology and Outcomes of Critical Illness in Manitoba . 2012 04/01. 18 Maurer MS , Bokhari S , Damy T , Dorbala S , Drachman BM , Fontana M , Grogan M , Kristen AV , Lousada I , Nativi‐Nicolau J . …

Clinical practice guideline for management of osteoporosis and fracture prevention in Canada: 2023 update.

BACKGROUND: In Canada, more than 2 million people live with osteoporosis, a disease that increases the risk for fractures, which result in excess mortality and morbidity, decreased quality of life and loss of autonomy. This guideline update is intended to assist Canadian health care professionals in the delivery of care to optimize skeletal health and prevent fractures in postmenopausal females and in males aged 50 years and older. METHODS: This guideline is an update of the 2010 Osteoporosis Canada clinical practice guideline on the diagnosis and management of osteoporosis in Canada. We foll

Совпадение в полном тексте источника
… The development of certain recommendations was supported by the results of analyses from a large observational Canadian cohort registry (the Manitoba Bone Mineral Density registry). 32 , 38 We searched for systematic reviews for patient values and preferences. … Construction and validation of a simplified fracture risk assessment tool for Canadian women and men: results from the CaMos and Manitoba cohorts . …

Burden of cancer in the Eastern Mediterranean Region, 2005-2015: findings from the Global Burden of Disease 2015 Study.

ObjectivesTo estimate incidence, mortality, and disability-adjusted life years (DALYs) caused by cancer in the Eastern Mediterranean Region (EMR) between 2005 and 2015.MethodsVital registration system and cancer registry data from the EMR region were analyzed for 29 cancer groups in 22 EMR countries using the Global Burden of Disease Study 2015 methodology.ResultsIn 2015, cancer was responsible for 9.4% of all deaths and 5.1% of all DALYs. It accounted for 722,646 new cases, 379,093 deaths, and 11.7 million DALYs. Between 2005 and 2015, incident cases increased by 46%, deaths by 33%, and DALYs

Совпадение в полном тексте источника
… Al Artaman, PhD, University of Manitoba, Winnipeg, Manitoba, Canada. Solomon Weldegebreal Asgedom, PhD, Mekelle University, Mekelle, Ethiopia. Tesfay Mehari Atey, MS, Mekelle University, Mekelle, Ethiopia. …