Результаты поиска

Comparative effectiveness of teriflunomide and ocrelizumab on smoldering activity in multiple sclerosis: an observational study in the Swiss Multiple Sclerosis Cohort.

BACKGROUND: This study aimed to compare the effects of teriflunomide and ocrelizumab on clinical and MRI endpoints related to smoldering activity in relapsing-remitting multiple sclerosis (RRMS). METHODS: In this observational, longitudinal, multicenter study, we included 128 people with RRMS (pwRRMS) treated with teriflunomide and 495 treated with ocrelizumab. Outcomes included time to progression independent of relapse activity (PIRA). In a subset, we also assessed brain volume loss (BVL), longitudinal changes in diffusion tensor imaging (DTI) metrics, and the burden of paramagnetic rim les…

Untackling the economics of multiple sclerosis: A systematic review of economic evaluations of disease-modifying therapies indicated for multiple sclerosis

OBJECTIVES: Multiple sclerosis (MS) comprises a chronic, neurodegenerative, and inflammatory illness of the central nervous system that affects 2.8 million people worldwide. MS is only treatable, and to this direction, the disease armamentarium has been significantly enriched with new agents, albeit with burgeoning costs and engulfed by uncertainty. The scope of this review is to assess the efficiency of MS agents. METHODS: We performed a systematic literature review, spanning from 2000 to 2023 on adult patients with any form of MS, receiving any MS indicated modality and whose outcome was IC…

The Broad Concept of "Spasticity-Plus Syndrome" in Multiple Sclerosis: A Possible New Concept in the Management of Multiple Sclerosis Symptoms.

Multiple sclerosis (MS) pathology progressively affects multiple central nervous system (CNS) areas. Due to this fact, MS produces a wide array of symptoms. Symptomatic therapy of one MS symptom can cause or worsen other unwanted symptoms (anticholinergics used for bladder dysfunction produce impairment of cognition, many MS drugs produce erectile dysfunction, etc.). Appropriate symptomatic therapy is an unmet need. Several important functions/symptoms (muscle tone, sleep, bladder, pain) are mediated, in great part, in the brainstem. Cannabinoid receptors are distributed throughout the CNS irr…

Frequency of chronic headaches in Japanese patients with multiple sclerosis: with special reference to opticospinal and common forms of multiple sclerosis.

BACKGROUND: Headache is common in Western patients with multiple sclerosis (MS), but its frequency has not been reported in Asian patients. In Asians, the opticospinal form of MS, showing similar characteristics to relapsing neuromyelitis optica in Westerners, is regarded as a different subtype from conventional MS. OBJECTIVES: The aim of this study was to clarify the frequency of primary and chronic secondary headaches in Japanese patients with MS and the factors associated with the emergence of such headaches. METHODS: We investigated 127 consecutive patients with clinically definite MS. F…

Apo E in multiple sclerosis and optic neuritis: the apo E-epsilon4 allele is associated with progression of multiple sclerosis.

OBJECTIVE: To investigate the association between apolipoprotein E (Apo E) genotype in multiple sclerosis (MS) and acute monosymptomatic optic neuritis (ON) in a genetically homogeneous population with a high frequency of the Apo epsilon4 allele. BACKGROUND: The association between heterozygosity of Apo epsilon4 and the development of MS is thoroughly investigated, while the association between homozygosity of Apo epsilon4 and the development of MS is insufficiently studied. The association between Apo E genotype and disease progression remains controversial. METHODS: 475 patients were inclu…

Progressive multiple sclerosis: Six trials to watch.

Emerging therapies for progressive multiple sclerosis (PMS) increasingly target CNS-compartmentalized inflammation driving progression independent of relapse activity. Six pivotal trials are evaluating Bruton's tyrosine kinase inhibitors, CD40-CD40L blockade, and CD19-directed CAR-T cells. Together, these studies may establish mechanism-based strategies to modulate microglia and B cell pathology, redefining treatment of progression and addressing a major unmet clinical need.

Двойная автономность: синдром Эванса и множественный склероз.

Синдром Эванса (ES) — редкое аутоиммунное расстройство, связанное с аутоиммунной гемолитической анемией и иммунной тромбоцитопенией (ИТП). Пациенты, как правило, страдают от петехии, пурпуры, паллора и усталости. Диагностические критерии включают в себя положительное прямое антиглобулиновое испытание, ретикулокитоз, снижение уровня гаптоглобина, а также повышенный косвенный уровень билюродина и лактата дегидрогеназы. ЭУ может быть связано с другими аутоиммунными заболеваниями, включая системный волчанки эритематос, ревматоидный артрит и аутоиммунный гепатит. Вместе с тем в научной литературе в

Совпадение в аннотации оригинала
Evans syndrome (ES) is an uncommon autoimmune disorder associated with autoimmune hemolytic anemia and immune thrombocytopenia (ITP). Patien … erythematosus, rheumatoid arthritis, and autoimmune hepatitis. However, the co-occurrence of ES and multiple sclerosis (MS) is exceedingly rare in the scientific literature. We report the case of a 46-year-old female patient with MS and a previous diagnosis of ITP. Further diagnostic workup confirmed ES. This report highlights the need to consider ES in patients wit …

Первичный прогрессивный множественный склероз: новые терапевтические подходы.

ЦЕЛЬ И ЗАДАЧА: Первичный прогрессивный множественный склероз (ППМС) представляет собой клинически иную форму MS, которая вызывает постепенное и необратимое неврологическое расстройство вследствие возникновения симптомов без рецидивов или ремиссий. С учетом того, что средний возраст наступает в 37-43 года, СУПЗ затрагивает 10-15% пациентов, страдающих НР, и вызывает особые проблемы с диагностикой и лечением. Проблемы с мобильностью, постоянная боль, сенсорные расстройства, когнитивные недостатки, а также проблемы с кишечником и мочевым пузырем с течением времени обостряются. Нейроимация показыв

Совпадение в аннотации оригинала
BACKGROUND AND PURPOSE: Primary progressive multiple sclerosis (PPMS) is a clinically different form of MS that causes gradual and irreversible neurological impairment from symptom onset without relapses or remissions. With a mean onset age of 37-43 years, PPMS affects 10%-15% of MS patients and presents distinct diagnostic and treatment issues. Mobility iss…

Подписываю аппарат с множественным склерозом.

Несмотря на то, что усталость является распространенным и изнуряющим симптомом множественного склероза (MS), ее плохо понимают. В этой связи мы представляем информацию о проведенных практикумах и обследованиях с целью определения потребностей и предпочтений людей, имеющих НР, в целях информирования о дальнейшей работе по подготовке обследований усталости.

Совпадение в аннотации оригинала
Despite fatigue being a common and debilitating symptom of Multiple Sclerosis (MS), it is poorly understood. Here we report on facilitated workshops and surveys to capture the needs and preferences of people with MS to inform further work towards fatigue survey Apps.

Заболевание дымом при педиатрическом склерозе.

Заболевание дымом при множественном склерозе (MS) относится к хроническим процессам центральной нервной системы, которые происходят после острого воспаления, приводящего к длительной инвалидности. Несмотря на то, что нынешняя терапия эффективно сокращает частоту рецидивов и поражения МРТ, многие люди находятся в процессе развития независимо от активности рецидивов. Хотя клиническая прогрессия необычная в детстве или подростковом возрасте, все больше фактов указывает на то, что субклиническое прогрессивное заболевание биология уже действует даже в этой молодой возрастной группе, что требует ран

Совпадение в аннотации оригинала
Smouldering disease in multiple sclerosis (MS) refers to chronic central nervous system processes that occur beyond acute inflammation, driving long-term disability. Although current therapies effectively reduce relapse rates and MRI lesions, many individuals experience progression independent of relapse activity. While clinical progression is uncommon durin…

Menopause Impact on Multiple Sclerosis Disability Progression.

IMPORTANCE: Most women with multiple sclerosis (MS) will experience menopause while living with MS. Despite this, the impact of menopause on MS disease trajectory remains unclear. OBJECTIVE: To assess whether menopause modifies the risk of disability progression for women with relapse-onset MS. DESIGN, SETTING, AND PARTICIPANTS: This retrospective cohort study used prospective clinical data that were collected within the MSBase Registry. Data were extracted from MSBase on July 1, 2023. These data were analyzed from January 2023 through February 2025. Female participants were recruited from 8…

Aging-dependent immunological changes in multiple sclerosis.

Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease in which immune dysregulation plays a central role. As the life expectancy of people with MS (pwMS) increases, understanding how aging affects their immune system-collectively referred to as immunosenescence-has become crucial. In this study, we characterized immunosenescence in pwMS by analyzing age-related changes in the immune system. To fulfill this, blood samples were collected from pwMS and healthy controls (HCs) of independent cohorts: i) immune cell populations were assessed in PBMCs (n= 110), ii) thymic in…

Фрейлти испытает инвалидность при прогрессивном множественном склерозе.

ОКРУЖАЮЩАЯ СРЕДА: Оценка хрупкости при сильном прогрессивном множественном склерозе (ПМС) и изучение основополагающих механизмов. МЕТОДЫ: Это перспективное, сквозное, многоцентральное исследование охватывало позднюю серьёзную группу ПМС, нуждающуюся в квалифицированном уходе (n = 53), и группу ПМС, сравнивающую возраст, пол и продолжительность болезни (n = 53). Участники получили неврологические и МРТ-анализы и представили образцы крови. Площадь была измерена по шкале Эдмонтона. Инвалидность измерялась по расширенной шкале статуса инвалидов (EDSS), а усталость оценивалась по шкале усталости. И

Совпадение в аннотации оригинала
BACKGROUND: To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. METHODS: This prospective, cross-sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration-matched control PMS group (n = 53). Participants received neurolog…

Ofatumumab-exposed breastfeeding in multiple sclerosis patients.

BACKGROUND: In Europe, ofatumumab is approved for breastfeeding, but data on its transfer into breast milk and clinical experience are lacking. OBJECTIVE: To analyze (1) health, development, and adverse events after live vaccination of ofatumumab-exposed breastfed infants and (2) detectability of ofatumumab in breast milk, and to calculate the relative infant dose (RID) using two methods, the traditional method and a second method considering maternal exposure to multiple ofatumumab doses and extended collection period. METHODS: In this observational study, clinical data were collected by st