Результаты поиска

Particulate matter exposure induces maternal scalp hair loss after birth in C57/B6 mouse via alteration of inflammatory and apoptotic pathways.

PM 2.5 exposure is associated with a variety of health effects, including effects on the reproductive and skin. However, the relationship between PM2.5 exposure and postpartum hair loss has not been investigated. In this study, we evaluated the effect of PM2.5 exposure on hair loss after birth in mouse model and analyzed possible associated molecular changes. Female mice were exposed to PM2.5 using nasal inhalation method. After 4 weeks, mating tests were conducted and postpartum scalp tissues from PM2.5-exposed mice and those without exposure were harvested and analyzed. Then, human immortali

Exploring the causal relationship between long-term exposure to particulate matter 2.5 and risk of thyroid disorders: a Mendelian randomization analysis.

Particulate matter 2.5 (PM2.5) has been increasingly linked to thyroid dysfunction, yet causal evidence remains limited. This study employs a two-sample Mendelian Randomization (MR) approach to assess the causal relationship between long-term PM2.5 exposure and thyroid disorders. Genetic instruments for PM2.5 exposure were sourced from the UK Biobank, while outcome data on thyroid dysfunction and its subtypes were obtained from the FinnGen consortium. The primary method was inverse-variance weighted (IVW), supplemented by MR-Egger, weighted median, simple mode and weighted mode analyses. Pleio…

Cities as hotspots of compound heat and fine particulate matter pollution: A 23-year urban-rural comparison across the United States.

Heat stress and fine particulate matter (PM2.5) pollution are major stressors that threaten public health and environmental quality. When heat waves and PM2.5 pollution episodes co-occur as compound events, their impacts intensify, often leading to increased mortality and morbidity. This study provides a 23-year (2000-2022) analysis of heat waves, PM2.5 pollution episodes, and their compound occurrences during the warm season across urban and surrounding rural areas of the contiguous U.S. using reconstructed daily minimum air temperature and PM2.5 datasets. Results show that urban areas genera…

Association of greenness exposure with serum vitamin D status and effects of ambient particulate matter among pregnant women in early pregnancy.

Adequate vitamin D is essential for the health of both the mother and fetus, and it can be influenced by environmental factors. However, res … ciency (VDD). Subgroup and mediation analyses were conducted to estimate the association of ambient particulate matter (PM) on the association between NDVI and VDD. A total of 64,663 pregnant women with a mean maternal age of 30.6 (standard deviation: 3.86) years were included. 250-m NDVI was negatively associated with the risk of VDD (per 0.1-unit increase, relativ …

Pirfenidone Alleviates Against Fine Particulate Matter-Induced Pulmonary Fibrosis Modulating via TGF-β1/TAK1/MKK3/p38 MAPK Signaling Pathway in Rats.

Increased exposure to particulate matter (PM) from air pollution causes lung inflammation and increases morbidity and mortality due to respiratory diseases. Pirfenidone is an anti-fibrotic agent used to treat idiopathic pulmonary fibrosis. Background/Objectives: In this experiment, we studied the therapeutic effects of pirfenidone on PM-induced pulmonary fibrosis. Methods: Pulmonary fibrosis was induced by the intratracheal application of 100 μg/kg PM10 mixed with 200 μL saline. After 42 days of PM10 infusion, 0.2 mL of distilled water with pirfenidone was orally administered to the pirfenidon…

Disability in mitochondrial aerobic metabolism and Mg2+ transport: linking biomarkers and mechanisms of ischemic heart disease to diesel particulate matter exposure.

BACKGROUND: Ischemic heart disease (IHD) is a major cardiovascular health concern. In addition to metabolic and behavioral risks, diesel particulate matter (DPM), with a widely exposed population, is an important external environmental risk factor for IHD. However, the effect biomarkers used to diagnose DPM-caused IHD and underlying mechanisms remain unknown. We investigated the biomarkers and underlying mechanisms of DPM in relation to myocardial hypoxia injury. METHODS: This study applied a unique population of diesel engine testers with stable DPM exposure. Electrocardiogram examination, e…

Острые твердые частицы (ТЧ10)

Множественный склероз (MS) является хроническим заболеванием центральной нервной системы, где нейроинфламмация и аутоиммунная реакция на миелин приводят к функциональным расстройствам, когнитивным и психическим симптомам. Воздействие загрязнения воздуха, в частности на пики твердых частиц (ТЧ), связано с увеличением числа госпитализаций в случае возникновения и рецидивов MS, а также с усилением нейроинфламации у пациентов с MS. Здесь, в модели мыши MOG35-55, спровоцированной аутоиммунной энцефаломиелитом (EAE) MS, мы проверили гипотезу о том, что воздействие ТЧ10 может повлиять на курс и остро

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is a chronic disease of the central nervous system, where neuroinflammation and autoimmune response against myelin lead to functional impairments, cognitive and psychiatric symptoms. Exposure to air pollution-in particular to peaks of particulate matter (PM)-has been associated with an increase in hospital admissions for MS onset and …

Impact of fine particulate matter on latent tuberculosis infection and active tuberculosis in older adults: a population-based multicentre cohort study.

Evidence showed that air pollution was associated with an increased risk of tuberculosis (TB). This study aimed to study the impact of long-term exposure to ambient particulate matter with an aerodynamic diameter less than 2.5 μm (PM2.5) on the acquisition of LTBI and on the risk of subsequent active disease development among rural older adults from a multicentre cohort, which have not yet been investigated to date. A total of 4790 older adults were included in a population-based, multicentre, prospective cohort study (LATENTTB-NSTM) from 2013 to 2018. The level of long-term exposure to PM2.5 …

KCNQ1 rs2237892 polymorphism modify the association between short-term ambient particulate matter exposure and fasting blood glucose: A family-based study.

BACKGROUND: The association between particulate matter and fasting blood glucose (FBG) has shown conflicting results. Genome-wide association studies have shown that KCNQ1 rs2237892 polymorphism is associated with the risk of diabetes. Whether KCNQ1 rs2237892 polymorphism might modify the association between particulate matter and FBG is still uncertain. METHODS: Data collected from a family-based cohort study in Northern China, were used to perform the analysis. A generalized additive Gaussian model was used to examine the short-term effects of air pollutants on FBG. We further conducted int…

Personal airborne particulate matter exposure and intake dose, indoor air quality, biometric, and activity dataset from the city of Ljubljana, Slovenia.

To gain a comprehensive understanding of the effects of air pollution on human health, it is imperative to assess exposure at an individual … on, i.e., age, height, weight. (b) Time Activity Diaries maintained by participants. (a) A personal particulate matter sensing unit that recorded data on PM1, PM2.5, PM10, ambient temperature, relative humidity, and geographical location coordinates. (b) A wrist-worn Smart Activity Tracker that captures heart rate and movement data. (c) An Indoor Air Quality sensing …

Characterizing nighttime vertical profiles of atmospheric particulate matter and ozone in a megacity of south China using unmanned aerial vehicle measurements.

Daytime atmospheric pollution has received wide attention, while the vertical structures of atmospheric pollutants at night play a crucial r … n and convection significantly influenced the vertical distribution of all pollutants, particularly particulate matter. External air masses carrying high concentrations of pollutants increased PM1.0 and PM2.5 levels by 145% and 455%, respectively, compared to unaffected periods. The ratio of BC to PM2.5 indicated that local emissions had a minor role in nighttime pa …

Long-term exposure to fine particulate matter and site-specific cancer mortality: A difference-in-differences analysis in Jiangsu province, China.

BACKGROUND: Accumulating studies have reported that chronic exposure to ambient fine particulate matter (PM2.5) can lead to adverse effects on lung cancer mortality; however, such chronic effects are less clear for mortality from other site-specific cancers. OBJECTIVE: To explore the causal effect of long-term PM2.5 exposure on mortality from all-site and a variety of site-specific cancers in Jiangsu province, China during 2015-2020 using a difference-in-differences analysis. METHODS: For each of 53 county-based spatial units in Jiangsu province, we calculated annual death counts for all-sit…

Di-(2-ethylhexyl) phthalate aggravates fine particulate matter-induced asthma in weanling mice due to T follicular helper cell-dependent response.

Environmental pollutants fine particulate matter and di-(2-ethylhexyl) phthalate (DEHP) are believed to be the risk factors for childhood asthma. Allergic asthma is basically an immediate hypersensitivity mediated by IgE, the product of humoral immune response. T follicular helper cells (Tfh) have been newly identified as the crucial T helper cells for supporting B cells to produce immunoglobulins in humoral immunity. Tfh cells are therefore potentially to serve as the diagnostic marker and therapeutic target of immune diseases. In this study, we examined the joint effects of fine particulate …

Size-specific particulate matter and outpatient visits for allergic conjunctivitis in children: a time-stratified case-crossover study in Guangzhou, China.

This time-stratified case-crossover study aims to quantify the risk of allergic conjunctivitis (AC) associated with short-term exposure to PMs (i.e., PM1, PM2.5, PMc, and PM10) among children in Guangzhou, China. We collected data on children's daily AC outpatient visits from the Guangzhou Women and Children Medical Center during February 20, 2016 to December 31, 2018, and also extracted air pollution and meteorological data in the same time frame. We used conditional logistic regression model to estimate the associations between PMs and AC outpatient visits, and conducted subgroup analyses st

The impact of fine particulate matter (PM) on various beneficial functions of human endometrial stem cells through its key regulator SERPINB2.

Fine particulate matter (PM) has a small diameter but a large surface area; thus, it may have broad toxic effects that subsequently damage many tissues of the human body. Interestingly, many studies have suggested that the recent decline in female fertility could be associated with increased PM exposure. However, the precise mechanisms underlying the negative effects of PM exposure on female fertility are still a matter of debate. A previous study demonstrated that resident stem cell deficiency limits the cyclic regenerative capacity of the endometrium and subsequently increases the pregnancy …

Association between Exposure to Particulate Matter during Pregnancy and Multidimensional Development in School-Age Children: A Cross-Sectional Study in Italy.

Air pollutants can potentially affect the development of children. However, data on the effect of exposure to air pollution during pregnancy and developmental outcomes in school children are rare. We investigated the link between prenatal exposure to particulate matters smaller than 10 microns (PM10) and the development of school-age children in multiple domains. Cross-sectional data were collected in Italy between 2013 and 2014. Children aged between 5 and 8 years (n = 1187) were assessed on cognitive, communication, socio-emotional, adaptive, and motor developmental domains using the Develop…

Impacts of Short-Term Fine Particulate Matter Exposure on Blood Pressure Were Modified by Control Status and Treatment in Hypertensive Patients.

[Figure: see text].

PP2A-mTOR-p70S6K/4E-BP1 axis regulates M1 polarization of pulmonary macrophages and promotes ambient particulate matter induced mouse lung injury.

To identify key signaling pathways involved in ambient particulate matter (PM)-induced pulmonary injury, we generated a mouse model with myeloid-specific deletion of Ppp2r1a gene (encoding protein phosphatase 2 A (PP2A) A subunit), and conducted experiments in a real-ambient PM exposure system. PP2A Aα-/- homozygote (Aα HO) mice and matched wild-type (WT) littermates were exposed to PM over 3-week and 6-week. The effects of PM exposure on pulmonary inflammation, oxidative stress, and apoptosis were significantly enhanced in Aα HO compared to WT mice. The number of pulmonary macrophages increas…

Characterizing Nitrogen Oxides and Fine Particulate Matter near Major Highways in the United States Using the National Near-Road Monitoring Network.

As part of the United States Environmental Protection Agency's 2010 Nitrogen Dioxide (NO2) National Ambient Air Quality Standards (NAAQS) review, a national network of near-road sites was established to characterize pollutant behavior, interaction, and dispersion in the ambient near-road environment. Using spatial interpolation to estimate the near-road concentration increments of NO2 and particulate matter with an aerodynamic diameter of 2.5 μm and less (PM2.5) relative to nearby non-near-road monitors, we found that the 2013-2018 national average increment is 6.9 ppb and 1.0 μg m-3 for NO2 a…

Dimethyl Ether as the Next Generation Fuel to Control Nitrogen Oxides and Particulate Matter Emissions from Internal Combustion Engines: A Review.

Dimethyl ether (DME) is a new generation fuel produced from natural gas and coal. This fuel can be used directly to a conventional internal combustion (IC) engine without any significant modifications. The main advantage of DME combustion in IC engines is the low NO x and particulate emissions compared with the fossil liquid fuel. Thus, the usage of DME in IC engines is potentially to improve engine efficiency and reduce emissions in the future with minimum attempts. This paper offers a comprehensive review of some topics related to DME as an alternative fuel for IC engines and efforts to incr