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Therapeutic potential of phenolic acids in bone tissue healing and regeneration: a scoping review.

This scoping review evaluated the effects of dietary phenolic acids on bone healing and regeneration, focusing on their osteogenic and antiresorptive properties. The review followed the PRISMA-ScR guidelines. A comprehensive search was conducted in PubMed, Scopus, Web of Science, Embase, and Cochrane Library. Eligible studies included in vitro and in vivo investigations assessing the effects of phenolic acids on bone tissue. Two reviewers independently screened studies, extracted data, and synthesized the findings. Of 1053 records identified, 49 studies were included. Phenolic acids, naturally…

Facile Fabrication of Multifunctional Metal-Phenolic Network Nanoparticles for Bacterial Keratitis Treatment.

The management of methicillin-resistant Staphylococcus aureus (MRSA) keratitis remains highly challenging due to escalating antibiotic resistance and the severe, vision-threatening damage driven by uncontrolled inflammation. In this work, EGCG-Zn-VAN nanoparticles (NPs) were engineered as a multifunctional metal-phenolic network (MPN)-based platform to overcome these limitations through three integrated mechanisms: enhanced ocular retention, infection microenvironment-responsive antibiotic release, and synergistic anti-inflammatory activity. The carrier, formed by coordination-driven self-asse…

Bioaccessibility and Gut Microbiota Modulation of Phenolics in Prunus mume vs. Fructus mume.

Fructus mume (FM), the processed product of Prunus mume (PM), is a traditional Chinese medicine. The release characteristics and bioactivities of phenolics from PM and FM were compared in the present study. In oral and gastric digestion, both the total polyphenols content released and the antioxidant activities of PM were much higher than those of FM, whereas the opposite trend was observed in intestinal digestion and colonic fermentation. Specifically, during colonic fermentation, the total polyphenols content released of FM was 1.43-fold higher than that of PM, with corresponding antioxidant…

Natural Phenolic Compounds against Trichothecenes: From Protective Mechanisms to Future Perspectives.

Trichothecenes (TCNs), Fusarium-derived mycotoxins exemplified by deoxynivalenol and T-2 toxin, threaten global health through multisystem toxicity and widespread contamination. Natural phenolic compounds (NPCs), leveraging their intrinsic safety and natural abundance, demonstrate multimechanistic efficacy in counteracting TCN toxicity. This article reviews both domestic and international research on the protective mechanisms of NPCs against TCN-induced toxicity. NPCs exert protective effects against TCN toxicity through multitiered mechanisms: (1) molecular regulation via Nrf2-centric antioxi…

Two-Step Flow Amidation of Natural Phenolic Acids as Antiradical and Antimicrobial Agents.

Natural hydroxycinnamic acid amides (HCAAs) and riparins offer significant health benefits. However, their extraction from natural sources is difficult, and traditional synthetic methods remain wasteful, raising the need for more efficient alternatives. In this work, a two-step chemo-enzymatic flow method for the efficient esterification and amidation of phenolic acids was developed and successfully applied to the synthesis of riparin derivatives and HCAAs. The flow Fischer esterification was optimized using vanillic acid as a model starting material and SiliaBond Tosic Acid (SCX-3) as an immo…

Investigating Coriander Leaf Phenolics With HPLC-UV and Their Role in Modulating Nitrogen Metabolism.

Coriander leaves (Coriandrum Sativum L.) contain quercetin, a flavanol from the flavonoid polyphenol group that helps prevent various metabolic disorders. This study aimed to use HPLC-UV to investigate phenolic compounds in coriander leaves and their impact on nitrogen metabolism. Twenty-four healthy Wistar albino rats weighing 160 ± 10 g were divided into four groups: NC (no coriander), CT1, CT2, and CT3. They received coriander leaf powder at levels of 12.2, 16, and 20.33 g/100 g of feed, respectively, based on the availability of quercetin on a dry matter (DM) basis. Feed intake was found h…

Tailored Metal-Phenolic Network with Hypoglycemic Polyphenol for Promoting Diabetic Wound Healing.

Diabetic foot ulcer is a common and serious complication of diabetes, with a high risk of amputation, recurrence, and mortality. Aiming at the characteristics of diabetic wounds and based on the result of network pharmacology, a tailored ligand cyanidin-3-O-glucoside (C3G) was selected to construct a metal-phenolic network (CM) through the self-assembly reaction with manganese ions. CM integrates the pharmacological advantages of C3G in antidiabetes and the anti-inflammatory activity of metal-phenolic networks by simulating the metal coordination structure of antioxidant enzymes. Reasonably, t…

Anti-Inflammatory Activity and In Silico Approach of Phenolics From the Roots of Aganonerion polymorphum.

A study on the chemical components from the roots of Aganonerion polymorphum resulted in the isolation of a new and six first isolated compounds. The structure of the new compound was definitively determined by the employment of multiple spectroscopic techniques, hydrolysis reaction, followed by high-performance liquid chromatography-mass spectrometry analysis in comparison with those reported in the literature. All compounds were evaluated for inhibitory effect in lipopolysaccharide (LPS)-induced nitric oxide (NO) production on RAW264.7 cells. Compounds 1, 4, 6, and 7 demonstrated IC50 values

Pre- and post-treatment effects of date fruit phenolics in cisplatin-induced hepatotoxicity.

Cisplatin is a popular chemotherapy drug effective in treatment of many solid tumours, however, it is limited by its liver toxicity essentially induced by oxidative stress and inflammation. Meanwhile plant phenolics have a long history of antioxidative and anti-inflammatory capabilities, but, information on the ability of phenolics derived from Date (Phoenix dactylifera) Fruits to modulate this condition remains underexplored. This study investigates the effects of Date Fruit Phenolics (DFP) against cisplatin-induced hepatic damage in male Wistar rats. Wistar rats were administered DFP (200 mg…

Phenolic Acid Composition of Coffee Cascara in Connection with Antioxidant Capacity: A Geographic Assessment.

Coffee cascara is an underutilized byproduct of coffee processing that has the potential for value-added applications due to its rich phytochemical content and antioxidant properties. The aim of this study was to characterize the phytochemical composition and antioxidant activity of coffee cascara sourced from seven geographic regions, and where possible, a variety of farms in different regions. We compared two different extraction methods: hot water/sonication-assisted extraction and methanol-water extraction to generate phytochemical content. The antioxidant capacity of extracts was assessed

Unveiling the therapeutic potential of phenolic compounds from Boletus edulis in osteoarthritis treatment.

Osteoarthritis (OA) is a joint disease characterized by inflammation, cartilage degeneration, and pain. Recent studies have focused on the potential of active phenolic compounds as a treatment for OA, owing to their anti-inflammatory, antioxidant, and chondroprotective effects. Specifically, Boletus edulis (BE) extracts, a natural product from mushrooms, have been shown as significantly active compounds against oxidative stress and inflammation. Our aim was to evaluate the anti-inflammatory and chondroprotective potential of BE extracts, primarily composed of phenolic compounds and flavonoids,…

Distribution of Environmental Phenols into Follicular Fluid and Urine of Women Attending Infertility Clinic.

Infertility and environmental pollution are two globally prevalent and related issues. To explore women's reproductive health, the composition of follicular fluid (FF) has been studied and it was found that changes to its composition, including the presence of exogenous chemicals, can adversely affect the fertilization process. Two groups of women (idiopathic infertility and controls) who were patients at a fertility clinic were recruited for this study. Samples of urine and FF were gathered from each participant to determine the concentration of 14 common phenols (four parabens, six bisphenol…

Iridoid glycosides and phenolic glycosides from Gentiana rhodantha and their anti-inflammatory activities.

Seven previously undescribed glycosides, including four iridoid glycosides (1, 2, 4, and 5), three phenolic glucosides (18, 21, and 22), together with nineteen known compounds, were isolated from the ethanol extract of Gentiana rhodantha Franch. Their structures were determined by analysis of 1D and 2D NMR, HRESIMS, X-ray diffraction, NMR calculation, and electronic circular dichroism (ECD) calculation. Among them, compound 21 was a novel highly rearranged endo-phenolic analogue with a unique skeleton. Moreover, the absolute configuration of compound 3 was determined by a single-crystal X-ray …

Cooperative Lewis Acid/Metal Dual Catalysis for the Selective ortho-Alkylation of Phenols.

Alkylated phenols hold significant importance in industrial chemistry, as many pharmaceuticals and polymer additives are based on these scaffolds. However, synthesizing these products in a sustainable way is still challenging because stoichiometric amounts of Lewis acids to promote Friedel-Crafts reactions on benzene and phenol derivatives are often employed, together with drastic and unsafe reaction conditions. In this paper, we present a regioselective process to produce ortho-alkylated phenols, with high atom- and step-economy that minimizes the formation of waste associated with it. The ke…

Microbially degradable phenolic foams based on depolymerized Kraft lignin for hydrophilic applications.

Hydrophilic phenol-formaldehyde (PF) foams, widely used in floral and hydroponic applications, are produced using phenol typically derived from non-renewable petroleum-based resources. This study examines the potential of depolymerized Kraft lignin (DKL) as a sustainable substitute for phenol in the synthesis of hydrophilic biobased foams. At 50 % DKL substitution, the foams demonstrated excellent water absorption capacities (up to 2557 %), relatively low densities (∼62 kg/m3), and nearly 100 % open-cell content. Its compressive strength (20.64 kPa at 10 % deformation) is comparable to commerc…

Synergistic Enhancement of Capacitive Performance in Porous Carbon by Phenolic Resin and Boric Acid.

The study of pore structure regulation methods has always been a central focus in enhancing the capacitance performance of porous carbon electrodes in lithium-ion capacitors (LICs). This study proposes a novel approach for the synergistic regulation of the pore structure in porous carbon using phenol-formaldehyde (PF) resin and boric acid (BA). PF and BA are initially dissolved and adsorbed onto porous carbon, followed by hydrothermal treatment and subsequent heat treatment in a N2 atmosphere to obtain the porous carbon materials. The results reveal that adding BA alone has almost no influence…

Zn Microenvironment Engineering for Aryl-C(sp2) Cleavage to Phenols and Tertiary Amines.

Cleaving inert aryl-C(sp2) bonds present a fundamental catalytic challenge due to their intrinsic robustness, yet it is essential for valorizing lignin into value-added chemicals. Current strategies predominantly convert aromatic rings to phenols at the expense of side-chain carbon utilization, compromising the atom economy. We report zinc coordination microenvironment engineering to achieve efficient aryl-C(sp2) cleavage in phenolic substrates with transformable side chains (e.g., ketones and alkenes), concurrently yielding phenols and tertiary amines. A nitrogen-coordinated zinc catalyst (Zn…

ThermoMicrowave-sonication improves the stability and digestive bioaccessibility of phenolic compounds in parsley juice.

UNLABELLED: These are indications of the effects of ThermoMicrowave Sonication (TMS) on the bioactive compounds of parsley (Petroselinum crispum) juice and their bioaccessibility during in vitro digestion. Total phenolic content (TPC), iron-reducing antioxidant power (FRAP), chlorophyll, and ascorbic acid levels were measured in TMS-treated and pasteurized samples. TMS minimized the loss of heat-sensitive proteins and significantly increased the phenolic content and antioxidant structure (p < 0.05). By following simulated oral, gastric, and intestinal digestion, TPC, chlorophyll, and FRAP leve…

Small phenolic inhibitors of PfATP6, a Plasmodium falciparum calcium ATPase, as prototype antimalarials.

Malaria, an infectious disease caused by Plasmodium parasites, continues to pose a serious global health problem. PfATP6, a calcium-transpor … high costs that restrict their availability. A notable exception is a group of structurally simple phenolic compounds that feature hydroquinone and naphthoquinone scaffolds. In order to assess the potential of this compound class as future antimalarials, we characterized a small library of these molecules in P. falciparum blood stage viability and PfATP …

(Поли) фенолы и множественный склероз: результаты межсекционного исследования наблюдений.

(Поли) фенолы представляют собой широкий и разнородный класс веществ с рядом потенциальных преимуществ для здоровья. Их роль в нейрозащите и когниции по-прежнему вызывает сомнения. Цель этого исследования заключается в изучении возможной взаимосвязи между общим и индивидуальным (поли)поглощением фенола, основными источниками питания и остротой множественного склероза (МС) в группе пациентов, страдающих НР. Были собраны демографические данные, данные о физической активности участников, данные о курении и рационе питания наряду с клиническими параметрами, включая Расширенный цикл оценки инвалидн

Совпадение в аннотации оригинала
(Poly)phenols are a wide and heterogeneous class of substances with several potential health benefits. Their role in neuroprotection and cognition is still questionable. This study's scope is to examine the possible association between total and individual (poly)phenol intake, major dietary sources, and the severity of multiple sclerosis (MS) in a cohort of …