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Synthesis and In Vitro Evaluation of Thiolated Carrageenan.

The aim of this study was to generate and characterize a thiolated carrageenan. Thiolated carrageenan (carrageenan-SH) was synthesized from kappa (κ)- and iota (ι)-carrageenan by bromine replacement of the hydroxyl moieties followed by substitution to thiol groups using thiourea. Thiolated κ- and ι-carrageenan exhibited 176.57 ± 20.11 and 109.51 ± 18.26 μmol thiol groups per gram polymer, respectively. The resazurin test in Caco-2 cells revealed no toxic effect of both thiolated carrageenans at a concentration below 0.1% (w/v). Regarding efflux pump inhibitory effect, cellular accumulation of

Algae-Derived Bioactive Compounds as Platforms for Translational Biotechnology and Health Applications.

Marine macroalgae, microalgae, and associated microorganisms are increasingly recognised as valuable sources of bioactive compounds with applications across biotechnology and health. The environmental and ecological conditions they inhabit shape their metabolite diversity, leading to the production of high-value compounds such as sulphated polysaccharides, lipids, pigments, phenolics, and peptides. These compounds exhibit conserved biological activities that underpin potent antioxidant, anti-inflammatory, cytotoxic, and pro-regenerative effects with strong potential for translation. Although e

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… Marine biodiscovery efforts are increasingly focused on microorganisms and primary producers—particularly microalgae (including cyanobacteria), macroalgae (seaweeds), marine bacteria and fungi. … Together, these green-seaweed-derived polysaccharides are increasingly recognised for their potential in designing biocompatible, sustainable, and multifunctional biomaterials for future biomedical and biotechnological applications [ 66 , 67 ]. …

Fucoidan: An Update on Function, Role in Human Health and Applications.

Fucoidan is a polysaccharide bioactive compound, mainly from brown algae, characterized by multiple biological activities, including anti-inflammatory, anticoagulant, anticancer, antioxidant, antiviral, and cardioprotective properties. In addition, growing scientific evidence supports its epigenetic potential and ability to modulate autophagic mechanisms, two crucial aspects for the treatment and prevention of chronic diseases, such as cancer, inflammation, and aging. For this reason, Fucoidan is a promising candidate for a wide range of applications, both as a bioactive component of drug deli

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… “Sulfated Seaweed Polysaccharides as Multifunctional Materials in Drug Delivery Applications.” Marine Drugs 14, no. 3: 42. 10.3390/md14030042. Damonte, E. , Matulewicz M., and Cerezo A.. 2004. “Sulfated Seaweed Polysaccharides as Antiviral Agents.” … “Brown Seaweeds.” In Nonvitamin and Nonmineral Nutritional Supplements, 171–176. Elsevier. 10.1016/B978-0-12-812491-8.00024-2. Rioux, L. E. , Turgeon S. L., and Beaulieu M.. 2007. “Characterization of Polysaccharides Extracted From Brown Seaweeds.” …

Enteric methane production in response to direct ruminal infusion of synthetic bromoform in cattle.

Methane inhibitors in cattle diets are a promising strategy to reduce enteric methane (CH4) emissions. Bromoform (CHBr3) is effective but not well understood in terms of mechanism, dose response, and side effects such as reduced feed intake. Studies using CHBr3-containing seaweed are inadequate to isolate the effect of CHBr3 from other factors. This study aimed to determine the dose-dependent effects of synthetic CHBr3, delivered via ruminal infusion, on DMI, enteric gas emissions, temporal patterns of gas emissions, and ruminal fermentation in cattle. Four nonlactating, nonpregnant, rumen-fis…

Unlocking the Therapeutic Potential of Algae-Derived Compounds in Hematological Malignancies.

Algae are a rich source of bioactive compounds that have a wide range of beneficial effects on human health and can show significant potential in the treatment of hematological malignancies such as leukemia, lymphoma, and multiple myeloma. These diseases often pose a therapeutic challenge despite recent advances in treatment (e.g., the use of immunomodulatory drugs, proteasome inhibitors, CD38 monoclonal antibodies, stem cell transplant, and targeted therapy). A considerable number of patients experience relapses or resistance to the applied therapies. Algal compounds, alone or in combination

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… Introduction Algae are a diverse group of aquatic organisms classified based on size, morphology, and structural complexity into macroalgae (seaweed) and microalgae [ 1 ]. … Biological Properties and Potential of Compounds Extracted from Red Seaweeds Phytochem. Rev. 2023 22 1509 1540 10.1007/s11101-022-09826-z PMC9247959 35791430 80. Wassie T. Niu K. Xie C. Wang H. Xin W. …

Marine Bioactive Compounds from Functional Seafoods: Pharmacological Mechanisms and Health Applications.

Functional seafoods derived from marine organisms, including fish, shellfish and algae, are gaining increasing attention due to their high content of bioactive compounds, such as omega-3 fatty acids, peptides, polysaccharides and antioxidants, which provide health benefits beyond basic nutrition. These marine-derived compounds exhibit a wide range of biological activities and have been investigated for their potential roles in the prevention and management of chronic diseases, including cardiovascular, neurodegenerative, cancer and gastrointestinal disorders. Their effects are largely mediated

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… For example, fucoidan isolated from brown seaweeds has been shown to improve motor function in preclinical PD models and to protect dopaminergic neurons in vivo. … Bioactive peptides and carbohydrates from seaweed for food applications: Natural occurrence, isolation, purification, and identification. Algal Res. 2020;48:101909. doi: 10.1016/j.algal.2020.101909. 14. Link J.S., Watson R.A. …

Integration of In Vitro and In-Silico Analysis of Gracilaria edulis on Anti-Cancer Potential and Apoptotic Signaling Pathway Activity.

Breast cancer, the most common malignancy in females, and rhabdomyosarcoma (RMS), the most prevalent soft tissue sarcoma in children, remain significant clinical challenges. This study evaluated the anticancer potential and apoptotic signaling pathways of Gracilaria edulis extracts and identified their mechanisms of action against RMS and breast adenocarcinoma (MCF-7) cell lines. Cytotoxicity was assessed using MTT assays, while apoptotic potential was evaluated through phase contrast and fluorescence microscopy, caspase 3/7 activity, DNA fragmentation, and gene expression analysis of apoptosi

Prophylactic administration of fucoidan represses cancer metastasis by inhibiting vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) in Lewis tumor-bearing mice.

Fucoidan, a heparin-like sulfated polysaccharide, is rich in brown algae. It has a wide assortment of protective activities against cancer, for example, induction of hepatocellular carcinoma senescence, induction of human breast and colon carcinoma apoptosis, and impediment of lung cancer cells migration and invasion. However, the anti-metastatic mechanism that fucoidan exploits remains elusive. In this report, we explored the effects of fucoidan on cachectic symptoms, tumor development, lung carcinoma cell spreading and proliferation, as well as expression of metastasis-associated proteins in

Естественные соединения серы в состоянии психического здоровья и неврологических расстройств: наблюдения и исследования.

За прошедшие годы глобальное бремя неврологических и психических расстройств значительно возросло, в результате чего они стали одной из наиболее серьезных проблем и вызовов для здоровья человека. В рамках новых методов лечения от болезней и болезней все больше внимания уделяется вопросам питания и здравоохранения. Питание серы, главным образом полученное из различных природных источников, играет решающую роль в многочисленных физиологических процессах, включая функцию мозга. В настоящем обзоре содержится обзор химического состава ряда естественных источников таких богатых серой веществ, как из

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… Seaweeds are plentiful sources of polysaccharides containing sulfate, which have several commercial applications in the culinary, cosmetic, and medicinal sectors ( 39 ). Seaweeds include sulfated polysaccharides with concentrations ranging from 4 to 76%. … Marine macroalgae, commonly referred to as seaweed, contain high amounts of sulfated polysaccharides. The majority of the seaweed cell wall consists of over 40% of SP, which is substantially higher than the average found in other sources ( 134 ). …

Biotechnological Innovations from Ocean: Transpiring Role of Marine Drugs in Management of Chronic Disorders.

Marine drugs are abundant in number, comprise of a diverse range of structures with corresponding mechanisms of action, and hold promise for the discovery of new and better treatment approaches for the management of several chronic diseases. There are huge reserves of natural marine biological compounds, as 70 percent of the Earth is covered with oceans, indicating a diversity of chemical entities on the planet. The marine ecosystems are a rich source of bioactive products and have been explored for lead drug molecules that have proven to be novel therapeutic targets. Over the last 70 years, m

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… Seaweeds Seaweed is another marine compound that is believed to have exceptional bioactive properties due to its antioxidant nature. The different extracts of seaweeds were tested, and their neuroprotective effect was elucidated as being owed to their anti-apoptotic mechanism. … Phlorotannins, exclusively found in brown seaweeds, are responsible for the antioxidant activity of this compound. Codium Tomentosum has emerged as a promising neuroprotective seaweed that has anti-genotoxic and anti-oxidative properties. …

Ten Years of Research on Fucoidan and Cancer: Focus on Its Antiangiogenic and Antimetastatic Effects.

Angiogenesis and metastasis represent two challenging targets to combat cancer development in the later stages of its progression. Numerous studies have indicated the important role of natural products in blocking tumor angiogenesis signaling pathways in several advanced tumors. In recent years, the marine polysaccharides fucoidans emerged as promising anticancer compounds showing potent antitumor activity in both in vitro and in vivo models of different types of cancers. The objective of this review is to focus on the antiangiogenic and antimetastatic activities of fucoidans with special emph

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… Fucoidans are extracted from the cell walls of different species of brown seaweeds such as Fucus vesiculosus , Cladosiphon okamuranus , Sargassum polycystum , Laminaria japonica , and Undaria pinnatifida . … Their main function consists of sustaining cell membrane stability and protecting seaweeds against dehydration [ 14 ]. Figure 1 Fucoidan from brown seaweed. …

Biomaterials from the sea: Future building blocks for biomedical applications.

Marine resources have tremendous potential for developing high-value biomaterials. The last decade has seen an increasing number of biomaterials that originate from marine organisms. This field is rapidly evolving. Marine biomaterials experience several periods of discovery and development ranging from coralline bone graft to polysaccharide-based biomaterials. The latter are represented by chitin and chitosan, marine-derived collagen, and composites of different organisms of marine origin. The diversity of marine natural products, their properties and applications are discussed thoroughly in t

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… Marine seaweeds have been used to synthesize a wide range of bioactive substances in accordance with their maturity and ability to interact with environmental changes. … Among the abundant pool of compounds derived from seaweed, terpenes, polysaccharides and polyphenols are of clinical relevance in terms of their anti-cancer activities [ 247 ]. Fucoidans refer to an array of sulfated polysaccharides that originate from the cell wall of brown seaweeds. …

Promising Activities of Marine Natural Products against Hematopoietic Malignancies.

According to the WHO classification of tumors, more than 150 typologies of hematopoietic and lymphoid tumors exist, and most of them remain incurable diseases that require innovative approaches to improve therapeutic outcome and avoid side effects. Marine organisms represent a reservoir of novel bioactive metabolites, but they are still less studied compared to their terrestrial counterparts. This review is focused on marine natural products with anticancer activity against hematological tumors, highlighting recent advances and possible perspectives. Until now, there are five commercially avai

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… In particular, fucoxanthin and fucoxanthinol, extracted from brown seaweed Cladosiphon okamuranus Tokida , have been shown to decrease cell viability in human primary effusion lymphoma BCBL-1 and TY-1 cells [ 74 ]. … Antitumor Activity of Edible Marine Algae: Effect of Crude Fucoidan Fractions Prepared from Edible Brown Seaweeds against L-1210 Leukemia. In: Bird C.J., Ragan M.A., editors. Proceedings of the Eleventh International Seaweed Symposium. Springer; Dordrecht, The Netherlands: 1984. pp. 145–148. 81. …

The Role of Vitamin C in Cancer Prevention and Therapy: A Literature Review.

Vitamin C is a water-soluble antioxidant associated with the prevention of the common cold and is also a cofactor of hydrolases that participate in the synthesis of collagen and catecholamines, and in the regulation of gene expression. In cancer, vitamin C is associated with prevention, progression, and treatment, due to its general properties or its role as a pro-oxidant at high concentration. This review explores the role of vitamin C in cancer clinical trials and the aspects to consider in future studies, such as plasmatic vitamin C and metabolite excretion recording, and metabolism and tra

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… Vitamin C from seaweed: A review assessing seaweed as contributor to daily intake. Foods. 2021;10:198. doi: 10.3390/foods10010198. 19. Hoffer L.J., Levine M., Assouline S., Melnychuk D., Padayatty S.J., Rosadiuk K., Rousseau C., Robitaille L., Miller W.H., Jr. …

Recent Advances in the Development and Utilization of Nanoparticles for the Management of Malignant Solid Tumors.

The purpose of nanotechnology-based drug delivery systems or novel drug delivery systems is to improve the effectiveness of therapy, and their promising properties have led to their increasing significance in the management of cancer. The researchers have primarily focused on designing novel nanocarriers, like nanoparticles (NPs), that can effectively deliver drugs to target cells and respond specifically to conditions particular to cancer. Whether passive or active targeting, these nanocarriers can deliver therapeutic cargoes to the tumor site to release the drug from the drug delivery system

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… Researchers used an aqueous extract from brown seaweed to manufacture magnetic IONPs. These NPs induce apoptosis in cervical cancer cells, which has lethal consequences [ 100 ]. … Cytotoxic effect of magnetic iron oxide nanoparticles synthesized via seaweed aqueous extract. Namvar F, Rahman HS, Mohamad R, et al. Int J Nanomedicine. 2014;9:2479–2488. doi: 10.2147/IJN.S59661. 101. …

Marine Natural Products as Potent Anticancer Agents (2020-2024): Structural Diversity, SARs and Target Prediction.

In recent years, Marine Natural Products (MNPs) have emerged as a significant source for anticancer drug discovery, as many natural products can offer structural diversity, unique mechanisms of action, and relatively low toxicity. This article provides a systematic review of MNPs with reported anticancer activities from 2020 to 2024. These compounds are classified into seven major categories: terpenoids, alkaloids, sterols, polyketides, peptides and proteins, polysaccharides, and macrolides. For each category, we elaborate on the marine sources, structural identification, in vitro anticancer a

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… Marine-Derived Polysaccharides Marine-derived polysaccharides are structurally diverse macromolecules from seaweeds, fungi, and microorganisms, composed of monosaccharides with varied linkages, sulfation, and branching. …

Research progress on the anti-cancer mechanisms of edible salty-flavored Chinese materia medica.

Edible salty-flavored Chinese materia medica (ESCM) refers to a category of traditional Chinese medicine (TCM) that also serve as food, characterized by their salty flavor. According to the TCM theory, ESCM can soften and disperse knots, thus potentially offering benefits for cancer prevention and treatment. With cancer remaining a major global health challenge, its primary prevention strategies, especially through dietary modification, are crucial. ESCM have recently garnered substantial attention, due to their remarkable clinical efficacy and low side-effect profile. Researches on ESCM demon

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… Pantotrichum, Cinnamomi Cortex | G20130530 Weixiong Brand Horse Deer Antler and Western Ginseng Wine | Testudinis Carapax Et Plastrum, Acanthopanacis Senticosi Radix Et Rhizoma Seu Caulis, Lycii Frustus, Longan Arillus, Cervi Cornu Pantotrichum, Panacis Quinquefolii Radix | G20220341 Haizao | Foucauld’s Seaweed …

Marine-Derived Compounds: A New Horizon in Cancer, Renal, and Metabolic Disease Therapeutics.

Marine-derived compounds represent a rich source of structurally diverse molecules with therapeutic potential for cancer, renal disorders, metabolic-associated fatty liver disease (MAFLD), and atherosclerosis. This review systematically evaluates recent advances, highlighting compounds such as Microcolin H, Benzosceptrin C, S14, HN-001, Equisetin, glycosides (e.g., cucumarioside A2-2), ilimaquinone, and Aplidin (plitidepsin). Key mechanisms include autophagy modulation, immune checkpoint inhibition, anti-inflammatory effects, and mitochondrial homeostasis. Novel findings reveal glycosides' dua

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… Fucoidan extract from brown seaweed (Sargassum echinocarpum): Molecular weight, elemental composition, selectivity and anticancer activity against breast cancer cells. Nat. Prod. Res. 2024;39:3093–3101. doi: 10.1080/14786419.2024.2326978. 40. Chan C.-H., Deng Y.-H., Peng B.-Y., Chiang P.-C., Wu L. …

From laboratory to clinic: opportunities and challenges of functional food active ingredients in cancer therapy.

This review provides a comprehensive analysis of the potential of functional food active ingredients in cancer prevention and therapy. It outlines the multifaceted anticancer mechanisms of bioactive compounds-such as polyphenols, carotenoids, omega-3 fatty acids, phytosterols, alkaloids, isothiocyanates, polysaccharides, phenolic acids, flavonols, and amide-bearing compounds-which include antioxidant and anti-inflammatory activities, induction of apoptosis and autophagy, modulation of the tumor microenvironment, interference with cell cycle regulation and signaling pathways, and regulation of

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… Representative anticancer polysaccharides include β-glucans (from yeast and fungi) and fucoidan (from brown seaweed), among others. These bioactive polysaccharides exhibit multifaceted anticancer mechanisms. …

Proceedings of the CIMAGO Congress - Environment, Genetics and Oncobiology in the 21st Century - Challenges and Opportunities.

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… Seaweeds contain fundamental components for human nutrition (e.g., proteins, minerals, fibres & fatty acids). … The main aim of the project is to study the cytotoxic effects of seaweed extracts (SE) (e.g., alginate from Phaeophyceae and carrageenans from Calliblepharis jubata, Rhodophyta), on CRC in vitro and in vivo . …