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Dose effect of bilateral transcranial magnetic stimulation for depression and anxiety in a real-world clinical setting.

UNLABELLED: Transcranial Magnetic Stimulation (TMS) is a non-invasive intervention for treatment-resistant depression (TRD). Comorbid anxiety is common in TRD patients. We examined the effect of single-dose versus high-dose bilateral TMS on depression and anxiety. METHODS: Seventy-eight patients received 1 Hz right dorsolateral prefrontal cortex (DLPFC) stimulation combined with left single-dose or high-dose iTBS to the left DLPFC at a nonprofit clinic. Depression and anxiety symptoms were measured at baseline, after 10 and 20 sessions, and final (30-36) TMS sessions. RESULTS: Bilateral TMS …

Effect of transcranial magnetic stimulation on the limb function of stroke patients: a systematic review and meta-analysis.

OBJECTIVE: This study aims to evaluate the effects of transcranial magnetic stimulation (TMS) on Fugl-Meyer Assessment for Upper Limb (FMA-UL), Fugl-Meyer Assessment for Lower Limb (FMA-LL), Modified Ashworth Scale (MAS), Box and Block Test (BBT), Action Research Arm Test (ARAT), and Wolf Motor Function Test (WMFT) in stroke patients. DATA SOURCES: A systematic search of PubMed, Web of Science, Embase, and Ovid databases was conducted to identify relevant studies. METHODS: Only randomized controlled trials (RCTs) investigating TMS interventions in stroke patients were included. Data analysis…

Transcranial Static Magnetic Stimulation Dissociates the Causal Roles of the Parietal Cortex in Spatial and Temporal Processing.

Accurate time estimation is essential for optimizing our perception and actions. Previous neuroimaging and transcranial magnetic stimulation (TMS) studies have suggested that the right inferior parietal lobule (IPL) and supplementary motor area (SMA) are involved in time perception. However, it remains inconclusive whether the activity in these regions is crucial for time perception, partly due to the possible spread of TMS effects across anatomically connected brain regions. Such a remote effect is less likely to happen with transcranial static magnetic stimulation (tSMS), as the static magne…

Innovations in repetitive transcranial magnetic stimulation: a review of clinical evidence and patient-reported outcomes for ExoTMS.

INTRODUCTION: Transcranial magnetic stimulation (TMS) is a non-invasive neuromodulation technique with demonstrated efficacy in the treatment of multiple psychiatric and neurological disorders. ExoTMS represents an evolution in TMS system design, developed to optimize focused brain stimulation while enhancing patient comfort and operational efficiency. By leveraging established neuroplastic mechanisms in a more patient-centered format, ExoTMS may represent a scalable advancement when compared to conventional TMS systems. This review examines the technological characteristics, safety profile, a…

The antidepressant effectiveness of transcranial magnetic stimulation is not impacted by comorbid neurotic, stress-related or somatoform disorders.

INTRODUCTION: Depression is frequently accompanied by neurotic, stress-related and somatoform disorders (F4 diagnoses, ICD-10), which are linked to greater severity and poorer treatment outcomes. Transcranial magnetic stimulation (TMS) is a non-invasive neuromodulation technique used for treatment-resistant depression. We investigated whether comorbid F4 diagnoses affect the antidepressant efficacy of different TMS protocols under real-world conditions. METHODS: We retrospectively analyzed data from 416 in- and outpatients with unipolar or bipolar depression at a German tertiary hospital betw…

Identifying neural oscillation and phase synchronization abnormalities in migraine and their predictive values in transcranial magnetic stimulation.

BACKGROUND: Migraine is a prevalent neurological disorder that may substantially disrupt daily function. Repetitive transcranial magnetic stimulation (rTMS) has been shown to be a promising treatment for migraine, but its treatment efficacy still needs to be optimised. This study aimed to identify abnormal neural oscillations in patients with migraines and evaluate their predictive value for TMS treatments to obtain insights for the optimisation of rTMS paradigms. METHODS: Patients with migraine received a course of rTMS delivered over the left dorsolateral prefrontal cortex (DLPFC). Resting-…

The effects of repetitive transcranial magnetic stimulation on sleep in individuals with substance use disorders: A systematic review.

INTRODUCTION: Substance use disorders (SUDs) are associated with significant sleep disturbances, which contribute to increased relapse risk and poorer treatment outcomes. Repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising intervention for SUDs and has been shown to improve sleep in other clinical populations. However, its influence on sleep in individuals with SUDs has not been systematically examined. Understanding this relationship is critical, as improving sleep could enhance treatment outcomes and reduce relapse risk. MATERIALS AND METHODS: A systematic literat…

Effects of repetitive transcranial magnetic stimulation on electroencephalogram and memory function in patients with mild cognitive impairment.

BACKGROUND: Mild cognitive impairment (MCI) is a high-risk precursor to Alzheimer's disease characterized by declining memory or other progressive cognitive functions without compromising daily living abilities. AIM: To investigate the efficacy of repetitive transcranial magnetic stimulation (rTMS) in patients with MCI. METHODS: This retrospective analysis involved 180 patients with MCI who were admitted to The First Hospital of Shanxi Medical University from January 2021 to June 2023. Participants were allocated into the research (n = 98, receiving rTMS) and control groups (n = 82, receivin…

Global trends and research hotspots in the treatment of mental disorders with transcranial magnetic stimulation: a bibliometric analysis.

BACKGROUND: Transcranial Magnetic Stimulation (TMS) is increasingly utilized in the treatment of mental disorders (MD). The exploration and expanding application of various new TMS mode have significantly propelled the advancement of related clinical research. METHODS: We reviewed research published in the Science Citation Index Expanded of Web of Science Core Collection database. Using Citespace 6.1, Vosviewer 1.6.20, and Scimago Graphica 1.0.38 software, we conducted a comprehensive visual analysis of TMS on MD from multiple dimensions, including influential countries/regions, institutions,…

Broad repetitive transcranial magnetic stimulation (rTMS) of the precuneus in Alzheimer's disease: A rationale and study design.

INTRODUCTION: Brain network dysfunction, particularly within the default mode network (DMN), is an increasingly apparent contributor to the clinical progression of Alzheimer's disease (AD). Repetitive transcranial magnetic stimulation (rTMS) can target key DMN hubs, maintain signaling function, and delay or improve clinical outcomes in AD. Here, we present the rationale and design of a study using off-the-shelf equipment and the latest clinical evidence to expand on prior rTMS work and reduce participant burden in the process. METHODS: We will conduct a two-stage trial of large-coil rTMS targ…

Cerebellar transcranial magnetic stimulation in essential tremor: a systematic review and meta-analysis of safety and efficacy.

BACKGROUND: Essential tremor (ET) is a common neurological disorder that significantly impacts daily activities. This meta-analysis aims to evaluate the safety and efficacy of cerebellar repetitive Transcranial Magnetic Stimulation (rTMS) and cerebellar Theta Burst Stimulation (TBS) in treating ET. METHODS: We searched through June 14, 2024, four databases (Scopus, PubMed, Web of Science, and Cochrane CENTRAL) to identify clinical trials investigating cerebellar rTMS or TBS in ET patients. Eligibility criteria included clinical trials reporting on safety and efficacy outcomes. Six reviewers s…

Воздействие сексуальных гормонов на транскраниальную магнитную стимуляцию против окисляющего стресса в патогенезе множественного склероза.

Множественный склероз (MS) — аутоиммунное нейродегенеративное заболевание с более высоким уровнем заболеваемости среди женщин. Несмотря на то, что половое созревание, по всей видимости, является одним из факторов, лежащих в основе НР, менопауза не оказывает четкого воздействия на прогрессию заболеваний. Многие исследования показали, что транскраниальная магнитная стимуляция (TMS) является потенциальной антиоксидантной терапией для MS, однако сексуальные гормоны были определены как потенциальный фактор, влияющий на реакцию TMS путем воздействия на корковую фортификацию и, возможно, клинические

Совпадение в аннотации оригинала
BACKGROUND: Multiple sclerosis (MS) is an autoimmune neurodegenerative disease with a higher prevalence in women. While puberty appears to act as a trigger for MS, menopause has no clear effects on disease progression. Many studies have shown that transcranial magnetic stimulation (TMS) is a potential antioxidant treatment for MS, but the sexual hormones hav…

The Efficacy of Transcranial Magnetic Stimulation in the Treatment of Obsessive-Compulsive Disorder: An Umbrella Review of Meta-Analyses.

BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS) has been increasingly used for treating obsessive-compulsive disorder (OCD). Although several meta-analyses have explored its effectiveness and safety, there is no umbrella review specifically focused on rTMS for OCD. This umbrella review followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and analyzed relevant meta-analyses on rTMS for OCD. METHODS: Twenty-three articles were identified from PubMed, and after screening, 12 meta-analyses were included in the review. The studies analyzed…

The Role of Magnetic Transcranial Stimulation in the Diagnosis and Post-Surgical Follow-Up of Cervical Spondylotic Myelopathy.

Degenerative cervical myelopathy (DCM) consists of spinal cord damage due to its compression through the cervical spine. The leading cause is degenerative. The diagnosis is clinical, and the therapeutic approach is usually surgical. Confirmation of the diagnostic suspicion is done by magnetic resonance imaging (MRI); however, this test lacks functional information of the spinal cord, the abnormality of which may precede involvement in neuroimaging. Neurophysiological examination using somatosensory evoked potentials (SSEPs) and transcranial magnetic stimulation (TMS) allows for an evaluation o…

Research progress on the application of transcranial magnetic stimulation in spinal cord injury rehabilitation: a narrative review.

Traumatic or non-traumatic spinal cord injury (SCI) can lead to severe disability and complications. The incidence of SCI is high, and the rehabilitation cycle is long, which increases the economic burden on patients and the health care system. However, there is no practical method of SCI treatment. Recently, transcranial magnetic stimulation (TMS), a non-invasive brain stimulation technique, has been shown to induce changes in plasticity in specific areas of the brain by regulating the activity of neurons in the stimulation site and its functionally connected networks. TMS is a new potential …

Impact of repetitive transcranial magnetic stimulation on the directed connectivity of autism EEG signals: a pilot study.

To compare the differences in directed connectivity between typically developing (TD) and autism spectrum disorder (ASD) children and identify the potential effects of repetitive transcranial magnetic stimulation (rTMS) on brain connectivity and behavior of children with ASD; 26 TD children (18 males/8 females; the average age was 6.34 ± 0.45) and 30 ASD children (21 males/9 females; the average age was 6.42 ± 0.17) participated in the experiment. ASD children were divided randomly into an experimental group and a control group. The experimental group received 18 rTMS sessions (twice a week fo…

Evidence and expert consensus based German guidelines for the use of repetitive transcranial magnetic stimulation in depression.

INTRODUCTION: Non-invasive brain stimulation techniques such as repetitive transcranial magnetic stimulation (rTMS) offer a promising alternative to psychotherapeutic and pharmacological treatments for depression. This paper aims to present a practical guide for its clinical implementation based on evidence from the literature as well as on the experience of a group of leading German experts in the field. METHODS: The current evidence base for the use of rTMS in depression was examined via review of the literature. From the evidence and from clinical experience, recommendations for the use of…

Repetitive Transcranial Magnetic Stimulation as a Potential Tool to Reduce Sexual Arousal: A Proof of Concept Study.

BACKGROUND: Hypersexuality and hyposexuality occur frequently, often in a variety of psychiatric disorders, and are difficult to treat. While there is meta-analytic evidence for the significant effect of non-invasive brain stimulation on drug and food craving, no study has investigated the potential of this technique to modulate sexual behavior. AIM: Here, we tested the hypothesis that a single session of high-frequency repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex (DLPFC) would reduce sexual arousal. METHODS: We employed a randomized, double-bli…

Transcranial Magnetic Stimulation: A review about its efficacy in the treatment of alcohol, tobacco and cocaine addiction.

Substance Use Disorder (SUD) is a chronic and relapsing disease characterized by craving, loss of control, tolerance and physical dependence. At present, the combination of pharmacotherapy and psychosocial intervention is the most effective management strategy in preventing relapse to reduce dropout rates and promote abstinence in SUD patients. However, only few effective medications are available. Transcranial Magnetic Stimulation (TMS) is a non-invasive brain stimulation technique that modulates the cellular activity of the cerebral cortex through a magnetic pulse applied on selected brain a…