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Synovial T lymphocyte-specific immune response to Chlamydia trachomatis in Reiter's disease.

We studied the lymphocyte proliferative response to Chlamydia trachomatis in Reiter's syndrome (RS) compared with that in other rheumatic diseases. RS patients showed significantly increased C trachomatis-specific synovial fluid (SF) T cell proliferation. Proliferating cells were found in both CD4+ and CD8+ T cell subsets. The SF lymphocyte proliferative response to C trachomatis in RS was inhibited by anti-class I and class II major histocompatibility complex monoclonal antibodies, while the response to tuberculin purified protein derivative was inhibited only by anti-class II monoclonal anti…

Pelvic inflammatory disease associated with Neisseria gonorrhoeae and Chlamydia trachomatis: clinical correlates.

The purpose of this study was to determine whether selected clinical features can distinguish salpingitis associated with endocervical Neisseria gonorrhoeae from that caused by Chlamydia trachomatis in black, inner-city adolescents. We reviewed retrospectively the charts of teenagers presenting to a university hospital outpatient department between January 1982 and January 1984 who were diagnosed as having salpingitis. We included all teenagers who presented with a history of low abdominal pain plus (1) either cervical motion tenderness (n = 15), adnexal tenderness (n = 13), or both (n = 57); …

Pelvic inflammatory disease after hysterosalpingography associated with Chlamydia trachomatis and Mycoplasma hominis.

A total of 116 women were referred for hysterosalpingography because of primary or secondary infertility. Chlamydia trachomatis was isolated from the cervix of four (3.4%) of the patients whereas Mycoplasma hominis was isolated from 39 (33.6%) of them. Four patients developed acute pelvic inflammatory disease after hysterosalpingography; two of them were chlamydia culture-positive and developed a significant chlamydial antibody response during the course of the disease. One of the other two patients, who developed upper genital-tract infection, was culture positive for M. hominis and developed…

[Interstitial pneumonia due to Chlamydia trachomatis in infants. Three cases (author's transl)].

The early onset of the disease (between the 13th and 15th days of life) and its long duration in 2 out of 3 cases, the absence of infectious symptoms and the efficacy of erythromycin treatment were characteristic features. The diagnosis was confirmed by positive (greater than 1/32th) serological tests in both infants and parents. Chlamydia trachomatis lung infection should be suspected in infants presenting, during the first weeks of life, with cough and dyspnoea unaccompanied by fever, radiological evidence of interstitial pneumonia, blood eosinophilia and raised immunoglobulin levels. The di…

Comparison of Methods for Assessing Chlamydia trachomatis Transmission Intensity: A Systematic Review.

Field-graded trachomatous inflammation-follicular (TF) has limitations as the sole indicator of Chlamydia trachomatis (Ct) transmission for trachoma programmatic decision-making. To assess the relationship between field-graded TF and other methodologies for evaluating Ct transmission intensity, a systematic review was conducted. A total of 35,764 studies were screened, yielding 235 included studies from 49 countries spanning the years of data collection from 1991 to 2021 and the years of publication from 1991 to 2022. The relationship between TF and other indicators was stronger before mass dr…

Impact of Chlamydia trachomatis treatment with azithromycin or doxycycline on Mycoplasma genitalium in women.

OBJECTIVES: In women being screened for Chlamydia trachomatis (CT) infection, Mycoplasma genitalium (MG) testing is not recommended. Among women positive for CT, studies reported that 7% to 28% had concurrent urogenital MG. The aim of this study was to investigate the impact on MG of a single 1-g dose of azithromycin or a 7-day course of doxycycline regimens as part of CT treatment. METHODS: MG was tested in vaginal swabs from the Chlazidoxy cohort collected at baseline and the 6-week follow-up visit after CT treatment. MG genotype and antibiotic resistance were analysed by sequencing the mgp…

Cervicovaginal microbiome and natural history of Chlamydia trachomatis in adolescents and young women.

This study investigated the cervicovaginal microbiome's (CVM's) impact on Chlamydia trachomatis (CT) infection among Black and Hispanic adolescent and young adult women. A total of 187 women with incident CT were matched to 373 controls, and the CVM was characterized before, during, and after CT infection. The findings highlight that a specific subtype of bacterial vaginosis (BV), identified from 16S rRNA gene reads using the molBV algorithm and community state type (CST) clustering, is a significant risk factor for CT acquisition. A microbial risk score (MRS) further identified a network of b…

A platform supporting generation and isolation of random transposon mutants in Chlamydia trachomatis.

Chlamydia species represent a paradigm for understanding successful obligate intracellular parasitism. Despite limited genetic malleability, … ducible expression of the Himar1-derived C9 transposase. Our pOri-Tn(Q) construct was maintained in Chlamydia trachomatis cultivated with antibiotics but was rapidly cured in the absence of antibiotic selection. pOri-Tn(Q) supported transposition events when transposase expression was induced during infection. Induction was accompanied by loss of the plasmid backbone w …

Combination of Individual Tests to Improve Diagnostic Accuracy in Chlamydia trachomatis Detection.

Background and Objectives: Chlamydial infection is the most common asymptomatic infection worldwide. Despite all national programs, strategies and guidelines, chlamydial infection is still the leading infection worldwide, especially in young populations. We have tried to summarize the best diagnostic tools for its detection. Materials and Methods: In the study, 225 sexually active patients who were tested for chlamydial infection at the Institute of Public Health Kragujevac participated. Results: Combinations of direct immunofluorescence (DIF) and a rapid lateral immunochromatographic test (RT

Вакцинация как стратегия борьбы с хламидией трахоматисом: глобальный математический анализ моделирования.

КОЛИЧЕСТВО: Хламидия трахоматис (КТ) относится к числу наиболее распространенных инфекций, передаваемых половым путем, и связана со значительным бременем для здоровья и экономики. Вакцинация может стать перспективной стратегией для ее глобального контроля. МЕТОДЫ: Для оценки глобального воздействия гипотетической вакцины КТ использовалась детерминистская, возрастной математическая модель. В ходе анализа был изучен целый ряд предположений в отношении эффективности вакцин против приобретения инфекции (VE S), продолжительности защиты и охвата в рамках как стратегий наверстывания отставания взросл

Совпадение в аннотации оригинала
BACKGROUND: Chlamydia trachomatis (CT) is among the most common sexually transmitted infections and is associated with substantial health and economic burdens. Vaccination may offer a promising strategy for its global control. METHODS: A deterministic, age-structured mathematical model was applied to assess the global impact of a hypothetical CT vaccine. Th…

Characterization of the Cell Division-Associated Peptidoglycan Amidase AmiA of Chlamydia trachomatis.

UNLABELLED: Chlamydia is an obligate intracellular bacterium that differentiates between infectious, non-dividing EBs and non-infectious, di … ng in the division septum. Here, we characterized the cell division-associated amidase, AmiA_Ct, of Chlamydia trachomatis both in vitro and in vivo . Our in vitro data show that AmiA_Ct is a bona fide , metal-dependent amidase capable of cleaving peptidoglycan. AmiA_Ct complemented an E. coli amidase deficient strain and supported the growth and separation of daughter …

The Impact of Chlamydia trachomatis on Male Infertility: A Systematic Review and Meta-Analysis.

BACKGROUND: Chlamydia trachomatis (CT) is a common sexually transmitted infection, yet its contribution to male infertility remains incompletely understood. METHODS: A systematic review and meta-analysis of case-control studies were conducted following PRISMA guidelines. Literature from PubMed/MEDLINE, Scopus, Cochrane, and Embase (2000 onward) was screened. Random-effects models were used in R, with subgroup analyses by geography, case definition, diagnostics, and matching criteria. RESULTS: Out of 2941 records, 26 case-control studies (11 706 participants) met inclusion criteria. Most stud…

Predictors of Chlamydia trachomatis conjunctivitis in neonates: a 10-Year retrospective study.

BACKGROUND: Ophthalmia neonatorum (ON) is a common neonatal ocular condition with potentially serious ocular and systemic complications. The spectrum of causative organisms varies by geographical regions, maternal health practices, and over time. Chlamydia trachomatis remains a significant pathogen with non-specific symptoms that overlap with other infections. This study aims to assess local burden of Chlamydia trachomatis and identify clinical predictors. METHODS: We conducted a 10-year retrospective review (2014-2023) of neonates presenting with suspected ON at a tertiary paediatric eye cen…

Addressing Challenges in Chlamydia trachomatis Detection: A Comparative Review of Diagnostic Methods.

Chlamydial infections are one of the most common sexually transmitted bacterial infections worldwide, which is related to serious consequences for the mental, sexual, and reproductive health of women and men. The infection is commonly asymptomatic; consequently, screening programs for infection control have been introduced in some countries. The detection methods of Chlamydia trachomatis infections have evolved since the establishment of the first gold-standard detection method in the 1970s, the culture assay. Over the decades, many efforts were made to find methods with a higher sensitivity, …

Neonatal conjunctivitis at a Brazilian tertiary center: the current relevance of Chlamydia trachomatis.

PURPOSE: The microbiology pattern of neonatal conjunctivitis has changed over time, and the incidence of gonococcal conjunctivitis is almost nil. This study aimed to determine the etiology of neonatal conjunctivitis cases referred to a tertiary health center in Brazil. METHODS: From 2017 to 2020, conjunctival swabs were taken from neonates with clinical signs of conjunctivitis and tested with bacterial culture and polymerase chain reaction for Neisseria gonorrhoeae and Chlamydia trachomatis. RESULTS: A total of 51 neonates were included in the 3-year study. Chlamydial conjunctivitis was diag…

Chlamydia trachomatis RsbU Phosphatase Activity Is Inhibited by the Enolase Product, Phosphoenolpyruvate.

The intracellular pathogen Chlamydia temporally regulates the expression of its genes, but the upstream signals that control transcription are not known. The best-studied regulatory pathway is a partner-switching mechanism that involves an anti-sigma factor, RsbW, which inhibits transcription by binding and sequestering the sigma subunit of RNA polymerase. RsbW is itself regulated by an anti-anti-sigma factor, RsbV, whose phosphorylation state is controlled by the phosphatase RsbU. In this study, we showed that Chlamydia trachomatis RsbU requires manganese or magnesium as a cofactor and dephos…

Знания о хламидиотрахоматисе и о принятии на тесты среди молодых студентов в Китае.

КОЛИЧЕСТВО: Активное обследование на предмет выявления хламидиотрахомата (КТ) имеет важное значение для молодежи ввиду широкого распространения асимптоматической инфекции среди этой группы населения. Цель этого исследования заключалась в изучении знаний о КТ и предпочтительности услуг по отбору на КТ среди молодых студентов в Китае. МЕТОДЫ: В период с июня по июль 2022 года было проведено онлайновое обследование с целью сбора информации о социально-демографических характеристиках, сексуальном поведении, знаниях о КТ, предыдущих тестах на КТ и предпочтительной платформе для тестирования на КТ с

Совпадение в аннотации оригинала
BACKGROUND: Actively screening for Chlamydia trachomatis (CT) is important for young people because of a high prevalence of asymptomatic infection in this population. This study aimed to investigate knowledge on CT and preference to the screening services for CT among young students in China. METHODS: From June to July 2022, a web-based questionnaire survey…