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Инфодемиология и инфовелленс множественных склерозов в Италии

Множественный склероз (MS) является хроническим изнурительным заболеванием вероятной аутоиммунной провокационной природы, аэтология которого не в полной мере понята, несмотря на многочисленные усилия и исследования. В этой рукописи мы пересматриваем концепцию < < мультипликаторного склероза 2.0 > > , т.е. использование Интернета пациентами, страдающими MS, для поиска медицинских и связанных с болезнями материалов для целей самообслуживания и саморегулирования, и внедряем основанный на Google Trends подход к мониторингу связанных с MS запросов и поисков в Google, который называется

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… department influenza rates and crowding metrics Clinical Infectious Diseases 2012 54 4 463 469 2-s2.0-84856717649 22230244 10.1093/cid/cir883 PMC3404718 36 Malik MT Gumel A Thompson LH Strome T Mahmud SM “Google flu trends” and emergency department triage data predicted the 2009 pandemic H1N1 waves in Manitoba …

Mobilization and Exercise Intervention for Patients With Multiple Myeloma: Clinical Practice Guidelines Endorsed by the Canadian Physiotherapy Association.

ObjectiveIndividuals with multiple myeloma (MM) often have reduced functional performance due to the cancer itself or as a direct side effect of cancer treatments. Physical therapy is a part of cancer rehabilitation; however, no guidelines are available to provide information and direction for physical therapists managing patients with MM. The goal of this guideline is to provide recommendations based on a systematic review and consensus process that physical therapists can use to manage patients with MM.MethodsA systematic review of the literature published until August 2018 was performed in

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… Consensus panel members: Trudy Weir, Foothills Medical Center; Kei Nishikawa, Vancouver General Hospital; Karen Dobbin, Cancer Care Manitoba; Lyne Marum, Ottawa Hospital; Jessie Koopman, Juravinski Hospital and Cancer; Marize Ibrahim, Jewish General Hospital; Shirin Mehdi Shallwani, School of Rehabilitation …

Subcutaneous immunoglobulins replacement therapy in secondary antibody deficiencies: Real life evidence as compared to primary antibody deficiencies.

Secondary antibody deficiencies (SAD) may require immunoglobulin replacement therapy (IgRT). While the intravenous route (IVIG) is broadly considered effective in SAD, the use of subcutaneous immunoglobulins (SCIG) is mainly adopted from the experience in primary antibody deficiencies (PAD), where SCIG have been shown to perform as effective as IVIG. However, evidence-based data on SCIG administration in SAD patients are still insufficient. Herein we retrospectively evaluated the efficacy and safety profile of SCIG treatment in 131 SAD patients as compared to a group of 102 PAD patients. We fo

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… Alberta Ministry of Health, Shared Health Manitoba SM of H. Criteria for the Clinical Use of Immune Globulin [Internet]. 2018. Available from: https://www.ihe.ca/download/criteria_for_the_clinical_use_of_immune_globulin_first_edition.pdf 17. …

Estimating summary measures of health: a structured workbook approach.

BACKGROUND: Summary measures of health that combine mortality and morbidity into a single indicator are being estimated in the Canadian context for approximately 200 diseases and conditions. To manage the large amount of data and calculations for this many diseases, we have developed a structured workbook system with easy to use tools. We expect this system will be attractive to researchers from other countries or regions of Canada who are interested in estimating the health-adjusted life years (HALYs) lost to premature mortality and year-equivalents lost to reduced functioning, as well as pop

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… Click here for file Acknowledgements This work is part of the Population Health Impact of Disease in Canada (PHI) research program, a collaboration of Statistics Canada, Public Health Agency of Canada, and researchers from McGill University, the University of Ottawa, the University of Manitoba, the …

Economic Benefits of Switching From Intravenous to Subcutaneous Epoetin Alfa for the Management of Anemia in Hemodialysis Patients.

BackgroundErythropoiesis-stimulating agents including epoetin alfa have been a mainstay of anemia management in patients with chronic kidney disease. Although the standard practice has been to administer epoetin alfa to patients on hemodialysis (HD) intravenously (IV), subcutaneous (SQ) epoetin alfa is longer acting and achieve the same target hemoglobin level to be maintained at a reduced dose and cost.ObjectiveThe primary objective of this study was to determine the economic benefits of change in route of epoetin alfa administration from IV to SQ in HD patients. The secondary objectives were

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… dose of epoetin was 32% lower than treated by the IV route (mean ± SD, 95.1 ± 75.0 vs 140.3 ± 88.5 IU/kg of body weight per week, P < .001); 99% of the participants in the Veterans Affairs study were men and the average difference in the dose was 2671 IU/week. 35 Similarly, 64 patients in a study from Manitoba …

Bridging Perspectives: How Canadian Patients and Caregivers View Quality of Life in Multiple Myeloma Compared to Validated Instruments.

Background: Validated patient- and caregiver-reported outcome (PRO and CRO) questionnaires are widely used to assess quality of life (QoL) in multiple myeloma (MM). However, most were developed before recent therapeutic advances that have modified disease trajectories and may no longer fully reflect patients' and caregivers' experiences. Methods: A Canadian cross-sectional observational study was conducted in collaboration with the PROxy Network and Myeloma Canada. Patients with MM completed the EORTC QLQ-C30, EORTC QLQ-MY20, EQ-5D-5L, and ESAS-R questionnaires and caregivers of patients with

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… (13.4) | 3 (13.4) Type of Medical Insurance, n (%) | | Private | 127 (41.6) | - Public | 75 (24.6) | - Private and Public | 96 (31.5) | - Unknown | 7 (2.3) | - Province of Residence, n (%) | | British Columbia | 49 (16.1) | 16 (15.4) Alberta | 30 (9.8) | 9 (8.7) Saskatchewan | 9 (3.0) | 5 (4.8) Manitoba …

Multimorbidity Patterns in US Adults with Subjective Cognitive Decline and Their Relationship with Functional Difficulties.

ObjectivesThis study identified different multimorbidity patterns among adults with subjective cognitive decline (SCD) and examined their association with SCD-related functional difficulties.MethodsData were obtained from the 2019 Behavioral Risk Factor Surveillance System. Latent class analysis was applied to identify different patterns of chronic conditions. Logistic regression was implemented to examine relationships between multimorbidity patterns and risk of SCD-related functional difficulties.ResultsFive multimorbidity patterns were identified: severely impaired (14.6%), respiratory/depr

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… financial support for the research, authorship, and/or publication of this article: This work was supported by the Visual and Automated Disease Analytics (VADA) Graduate Training Program of Natural Science and Engineering Research Council of Canada (NSERC), and Children’s Hospital Research Institute of Manitoba …

Levothyroxine dose and risk of fractures in older adults: nested case-control study.

OBJECTIVE: To quantify the effect of levothyroxine dose on risk of fractures in older adults. DESIGN: Nested case-control study. SETTING: Population based health databases, Ontario, Canada. PARTICIPANTS: Adults aged 70 or more prescribed levothyroxine between 1 April 2002 and 31 March 2007 and followed for fractures until 31 March 2008. Cases were cohort members admitted to hospital for any fracture, matched with up to five controls from within the cohort who had not yet had a fracture. MAIN OUTCOME MEASURE: Primary outcome was fracture (wrist or forearm, shoulder or upper arm, thoracic sp

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… Leslie WD, Anderson WA, Metge CJ, Manness LJ: Maximizing Osteoporosis Management in Manitoba Steering Committee. Clinical risk factors for fracture in postmenopausal Canadian women: a population-based prevalence study. Bone 2007;40:991-6. 17. …

The work of managing multiple myeloma and its implications for treatment-related decision making: a qualitative study of patient and caregiver experiences.

BackgroundThe evolving nature of multiple myeloma (MM) therapies, including the introduction of novel oral agents, has produced a shift in the delivery of care from hospital to home. Within this context, patients and their caregivers are becoming increasingly engaged in the work of illness management, however the exact nature of this work as well as the ways in which this work informs treatment preferences and decisions within this population has not been explored. This qualitative study sought to develop an in-depth understanding of patient and caregiver experiences with different MM treatmen

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… Undergraduate degree | 7 | 3 Graduate degree(s) | 2 | 1 Employment status Employed full time | 2 | 4 Part time | 1 | – Retired | 10 | 3 Sick leave | 3 | 1 Private health Insurance Yes | 13 | 5 No | 3 | 3 Province British Columbia (BC) | 9 | 2 Alberta (AB) | 2 | – Ontario (ON) | 3 | 5 Newfoundland (NL) | 1 | – Manitoba …

Treatment preferences of patients with relapsed and refractory multiple myeloma: a qualitative study.

BACKGROUND: Multiple myeloma is a haematological malignancy characterized by significant morbidity and mortality. This study sought to develop an in-depth understanding of patients' lived experiences of relapsed or refractory multiple myeloma (RRMM) and its treatment, and to identify which features of treatment were most important to them. METHODS: Qualitative interviews and focus groups (FGs) were conducted with 32 people living with RRMM across Canada. In Phase 1, interviews focused on participants' accounts of their experiences with the disease and its treatment and laid the groundwork for

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… Table 1 Participant characteristics ( N = 32) Sex | 22 Men 10 Women Age | Range: 51–83 yrs. old Average: 66 Marital Status | 29 Married or Common-law 3 Divorced Province | 5 British Columbia 11 Alberta 2 Manitoba 9 Ontario 4 Quebec 1 Newfoundland Year Diagnosed | Range: 1991–2015 10 Diagnosed in 2005 …

UK clinical guideline for the prevention and treatment of osteoporosis.

UNLABELLED: The National Osteoporosis Guideline Group (NOGG) has revised the UK guideline for the assessment and management of osteoporosis and the prevention of fragility fractures in postmenopausal women, and men age 50 years and older. Accredited by NICE, this guideline is relevant for all healthcare professionals involved in osteoporosis management. INTRODUCTION: The UK National Osteoporosis Guideline Group (NOGG) first produced a guideline on the prevention and treatment of osteoporosis in 2008, with updates in 2013 and 2017. This paper presents a major update of the guideline, the scope

Daratumumab (Darzalex SC): Therapeutic area: Multiple myeloma in patients ineligible for autologous stem cell transplant: Reimbursement Review

What is multiple myeloma?Multiple myeloma is a cancer of plasma cells (the white blood cells that make immunoglobulins) found in the bone ma … r ability to implement a recommendation. • Two hematologists with representation from the Prairies (Manitoba and Alberta) were consulted as part of the review process.What were the findings?CLINICAL EVIDENCE: • CDA-AMC reviewed the following clinical evidence: o.. 1 randomized controlled phase III trial (the CEPHEUS study) comparing D-VRd with VRd in 395 p …

Ассоциация между респираторными вакцинами и риском когнитивного расстройства, слабоумия и болезни Альцгеймера: обзор.

Справочная информация/цели: Нейрокогнитивные расстройства представляют собой растущее бремя для пожилых людей. Хотя респираторные вакцины доказали свою эффективность и безопасность в предотвращении острых респираторных явлений, их потенциальное воздействие на развитие таких хронических нейрокогнитивных расстройств, как когнитивное расстройство, слабоумие и болезнь Альцгеймера (АБ), не было тщательно изучено. Цель этого аналитического обзора заключалась в обобщении и анализе имеющихся данных о взаимосвязи между вакцинацией органов дыхания и риском развития когнитивного расстройства, слабоумия и

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… Risk Factors for Alzheimer’s Disease: A Population-Based, Longitudinal Study in Manitoba, Canada Int. J. Epidemiol. 2001 30 590 597 10.1093/ije/30.3.590 11416089 24. Verreault R. Laurin D. Lindsay J. Serres G.D. …

Анализ иммунологической памяти Джона Каннингема о мексиканском населении пациентов с множественным склерозом под лечением.

Фон/цели: Множественный склероз (MS) - это болезнь, характеризующаяся демиелинацией и аксонным повреждением центральной нервной системы. Несмотря на наблюдаемые преимущества, высокоэффективная терапия на основе ВИЧ-инфекции имеет негативные последствия, включая повышенный риск развития прогрессивной многофукальной лейкоэнцефалопатии (ПМП). Кроме того, риск возрастает, если пациент имеет антитела для вируса Джона Каннингема (JCV). Появляется ПМЛ редко, и в Мексике имеется лишь один доклад. Цель этого исследования состояла в том, чтобы определить и проанализировать иммунологическую память ОЖЦ у

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… Bhan et al. [ 39 ] recruited 4198 MS patients from Quebec, Ontario, the Atlantic provinces (Nova Scotia, New Brunswick, and Newfoundland), the western provinces (Manitoba, Saskatchewan, Alberta, and British Columbia), and the rest of Canada. Seropositivity was determined by ELISA (two steps). …

Approach to the Patient With Bone Fracture: Making the First Fracture the Last.

The global burden of osteoporosis and osteoporotic fractures will increase significantly as we enter a rapidly aging population. Osteoporotic fractures lead to increased morbidity, mortality, and risk of subsequent fractures if left untreated. However, studies have shown that the majority of patients who suffer an osteoporotic fracture are not investigated or treated for osteoporosis, leading to an inexcusable "osteoporosis care gap." Systematic and coordinated models of care in secondary fracture prevention known as fracture liaison services (FLS) have been established to streamline and impro

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… Curr Osteoporos Rep . 2017 ; 15 ( 2 ): 88 ‐ 95 . 28258372 10.1007/s11914-017-0352-5 4 Giangregorio LM , Leslie WD; Manitoba Bone Density Program . Time since prior fracture is a risk modifier for 10-year osteoporotic fractures . …

Устные доклады

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Using Administrative Health Care Databases to Identify Patients With End-Stage Kidney Disease With No Recorded Contraindication to Receiving a Kidney Transplant.

BackgroundAdministrative health care databases can be efficiently analyzed to describe the degree to which patients with end-stage kidney disease (ESKD) have access to kidney transplantation. Measures of access to transplantation are better represented when restricting to only those patients eligible to receive a kidney transplant. The way administrative data can be used to assess kidney transplant eligibility in the absence of clinical data has not been well described.ObjectiveTo demonstrate a method that uses administrative health care databases to identify patients with ESKD who have no rec

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… Previous studies have demonstrated regional variations in rates of kidney transplantation and transplant referral. 29 - 31 In Canada, a 3-fold disparity in transplant referral rates was noted between Atlantic provinces and Manitoba. 29 Similarly, transplant rates ranged from 0% to 75% across 308 dialysis …

Secondary fracture prevention in primary care: a narrative review.

The global burden of osteoporosis continues to rise with an ageing population. Untreated osteoporotic fractures not only heighten the risk of subsequent fractures but are associated with excess mortality. Although primary care guidelines consistently stress the importance of secondary fracture prevention, fewer than 20% of patients are appropriately treated for osteoporosis following an initial osteoporotic fracture. This worldwide phenomenon is known as the osteoporosis care gap. This literature review examines the barriers to secondary fracture prevention in primary care and evaluates the ef

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… Giangregorio LM Leslie WD Manitoba Bone Density P Time since prior fracture is a risk modifier for 10-year osteoporotic fractures J Bone Miner Res. 2010 25 6 1400 5 20200950 10.1002/jbmr.35 Giangregorio LM, Leslie WD, Manitoba Bone Density P (2010) Time since prior fracture is a risk modifier for 10- …

Гематологические болезни у пожилых пациентов: уделение особого внимания потенциальной роли управления гериатрической оценкой.

Управление гериатрической оценкой представляет собой многомерный инструмент, используемый для оценки прогнозов в отношении клинических результатов и целевых показателей в отношении мероприятий для пожилых людей, в которых рак проходит химиотерапию. В ходе этого обзора мы провели оценку возможного применения методов управления гериатрической оценкой (GAM) в гематологических паразитах. У пожилых пациентов с диффузной клеточной лимфомой B GAM может быть полезным как в прогнозировании запланированных госпитализаций, так и в улучшении качества жизни. В хронической миелоидной лейкемии индекс коморби

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… Ovarian Cancer in the Older Manitoban Population-Treatment Tolerance and Cancer-Related Outcomes: A Manitoba Ovarian Cancer Outcomes (MOCO) Group Study. Curr. Oncol. 2024;31:1348–1358. doi: 10.3390/curroncol31030102. 50. Nigussie S., Demeke F. …

Cost-Effectiveness of Brexucabtagene Autoleucel versus Best Supportive Care for the Treatment of Relapsed/Refractory Mantle Cell Lymphoma following Treatment with a Bruton's Tyrosine Kinase Inhibitor in Canada.

For patients with Mantle Cell Lymphoma (MCL), there is no recognized standard of care for relapsed/refractory (R/R) disease after treatment with a Bruton's tyrosine kinase inhibitor (BTKi). Brexucabtagene autoleucel (brexu-cel) represents a promising new treatment modality in MCL. We explored whether brexu-cel was cost-effective for the treatment of R/R MCL. We developed a partitioned survival mixture cure approach to model the costs and outcomes over a lifetime horizon. The clinical data were derived from the ZUMA-2 clinical trial. The costs were estimated from the publicly available Canadian

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… Long-term time trends in incidence, survival and mortality of lymphomas by subtype among adults in Manitoba, Canada: A population-based study using cancer registry data. Br. Med. J. Open. 2017;7:e015106. doi: 10.1136/bmjopen-2016-015106. 5. Pan-Canadian Oncology Drug Review . …