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Mobilization and Exercise Intervention for Patients With Multiple Myeloma: Clinical Practice Guidelines Endorsed by the Canadian Physiotherapy Association.

ObjectiveIndividuals with multiple myeloma (MM) often have reduced functional performance due to the cancer itself or as a direct side effect of cancer treatments. Physical therapy is a part of cancer rehabilitation; however, no guidelines are available to provide information and direction for physical therapists managing patients with MM. The goal of this guideline is to provide recommendations based on a systematic review and consensus process that physical therapists can use to manage patients with MM.MethodsA systematic review of the literature published until August 2018 was performed in

The impact of early integrated palliative care on symptom burden and quality of life in patients with advanced breast cancer.

UNLABELLED: Patients with advanced breast cancer endure a high symptom burden and impaired quality of life. This study evaluated the impact of Early Integrated Palliative Care (EIPC) on these outcomes. METHODS: A retrospective cohort study analyzed patients with advanced breast cancer treated between November 2018 and December 2021. Patients were categorized into an EIPC group or a usual care group based on the care model received. Symptom burden (SDS) and sleep quality (PSQI) were assessed at baseline, 6, 12, 18, and 24 weeks. Quality of life (FACT-B), hope (HHI), and anxiety/depression (HAD

Decision Fatigue and Associated Factors Among Patients with Hematologic Malignancies: Implications for Patient-Centered Decision Support.

BACKGROUND: Patients with hematologic malignancies frequently face complex, repeated treatment decisions that may increase decision fatigue (DF) risk. However, evidence on DF and its correlates in this population remains scarce. This study aimed to investigate the level of DF and identify associated factors among patients with hematologic malignancies. METHODS: A cross-sectional study was conducted with 322 patients receiving treatment at a tertiary hospital in Anhui, China, between October 2024 and May 2025. Participants completed validated scales assessing DF, decision preparation, decision

Обзор системы ухода на дому за пренатальными детьми.

Адекватный уход на дому имеет важнейшее значение для улучшения состояния здоровья беременных детей при поддержке родителей и лиц, обеспечивающих уход. Поэтому было бы интересно ознакомиться с известными данными о подходах к уходу на дому, включая телемедицину, планы питания, кенгуру и обучение по уходу за детьми. Известные данные свидетельствуют о преимуществах в области питания, прогресса в области развития и охраны психического здоровья матерей, однако такие ограничения, как различные методологии, короткие периоды последующей деятельности и риски, связанные с предубеждением, сдерживают вывод

The "Palliative Care Quality of Life Instrument (PQLI)" in terminal cancer patients.

BackgroundThis paper describes the development of a new quality of life instrument in advanced cancer patients receiving palliative care.MethodsThe Palliative Care Quality of Life Instrument incorporates six multi-item and one single-item scale. The questionnaire was completed at baseline and one-week after. The final sample consisted of 120 patients.ResultsThe average time required to complete the questionnaire, in both time points, was approximately 8 minutes. All multi-item scales met the minimal standards for reliability (Cronbach's alpha coefficient > or =.70) either before or during pall

Elements for assistance to patients with hematological malignancies to propose care lines: a scoping review.

Objectivesto identify the elements for assistance to patients with hematological malignancies to propose a care line.Methodsthis is a scoping review, anchored in the JBI theoretical framework, with searches carried out in April 2021, in eight electronic databases and 10 repositories of theses and dissertations.Resultsthe final sample consisted of 93 studies, and the main forms of assistance provided that can support a care line for this public were imaging tests, immunophenotyping, chemotherapy regimens, radiotherapy, infection management, assessment of nutritional status, maintenance of oral

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… Post-treatment Generate incentive to preventive health, with the practice of healthy life habits, recommendations for regular physical activity, maintenance of optimal body mass index, vaccination, routine screening for fatigue, routine screening and pain assessment, and sleep hygiene education. …

Effect of counseling intervention on symptoms, pain acceptance and psychological wellbeing among patients with fibromyalgia.

BACKGROUND: Nurses to assist patients make the best choices in challenging circumstances, counseling is crucial. Patients' health and quality of life can be enhanced by healthcare providers, particularly nurses, through counseling and educational initiatives. Fibromyalgia is characterized by widespread pain that negatively impacts an individual's ability to work. People may be able to improve their physical and mental health and accept suffering with the use of nursing counseling methods. AIM: This study aimed to investigate the effect of counselling intervention on symptoms, pain acceptance,

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… The fourth counselling session included instructions regarding healthy nutrition, managing gastrointestinal problems, sleep hygiene. The fifth counselling session included instructions regarding cognitive improvement and controlling of psychological pressures. …

Устойчивые выгоды мультидоменального стиля жизни при множественном склерозе в исследовании LIMS: A 24-Month Продолжайте.

СПРАВОЧНАЯ ИНФОРМАЦИЯ И ЦЕЛИ: Множественный склероз (МС) часто приводит к физическим, когнитивным и психологическим расстройствам, существенно влияющим на повседневное функционирование и качество жизни. Поскольку нынешняя медикаментозная медикаментозная терапия не в полной мере предотвращает прогресс в развитии заболеваний, интерес к потенциальной роли изменяемых факторов образа жизни растет. Мы провели оценку.1) сохранялось ли воздействие на результаты, представляемые пациентами 24 месяцев и2) долгосрочные изменения в образе жизни после завершения программы MS.МЕТОДЫ: УЧАСТНИКИ СООБЩЕНИЙ 3-mo

The mediating role of health anxiety, resilience, and body image in the relationship between pain and sleep in hematopoietic stem cell transplantation patients.

IntroductionBio-psychological factors may affect the relationship between pain and sleep, but they are understudied in hematopoietic stem cell transplantation (HSCT) patients. This study investigated the mediating role of health anxiety, resilience, and body image in the relationship between pain and sleep in HSCT patients.MethodsIn this cross-sectional study, 210 HSCT patients from Motahari clinic, Shiraz University of Medical Sciences were recruited using convenience sampling. Demographic and clinical characteristics, Pittsburgh Sleep Quality Index, Numeric Rating Scale of Pain, Health Anxie

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… Cognitive-behavioural pathways from pain to poor sleep quality and emotional distress in the general population: the indirect effect of sleep-related anxiety and sleep hygiene. PLoS ONE. 2022;17(1):e0260614. 40. Whibley D, AlKandari N, Kristensen K, Barnish M, Rzewuska M, Druce KL, Tang NK. …

Длительное использование цинка для дисгейзии, вызывающее нехватку меди.

Цинк является микроэлементом, необходимым для восприятия вкуса и может быть прописан для дисгейзии у больных раком, проходящих лечение. Однако чрезмерное потребление цинка может привести к дефициту меди, который, скорее всего, недооценивается и может представлять собой усталость, тошноту, анемию и миэлопатию. КИСЛОТА: Пациент в 70-летнем возрасте с несколькими миэломой и гастропарезом, принимающий добавки цинка для лечения дисгейсии в прошлом. 2 Годы, порожденные общей усталостью, головокружением, тошнотой, нейтрализмом, анемией, походом, а также ухудшением онемения и покалыванием в нижних кон

The microbiota-gut-brain-axis theory: role of gut microbiota modulators (GMMs) in gastrointestinal, neurological, and mental health disorders.

The modulation of gut microbiota presents promising therapeutic possibilities for various health conditions, ranging from gastrointestinal infections to neurodegenerative and mental health disorders. Among the available interventions, gut microbiota modulators (GMMs) such as probiotics and prebiotics have demonstrated significant potential in infection prevention and neuroprotection. Despite these encouraging findings, the clinical application of GMMs remains challenging due to safety concerns and inconsistent effectiveness across diverse patient populations. These factors create substantial b

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… Non-pharmacological repurposing Non-pharmacological gut microbiota modulators, including dietary modulation, FMT, exercise, sleep hygiene, stress management, and gastric bypass surgery, play a significant role in maintaining or restoring a healthy gut microbiome (Table 5 ). … Exercise enhances gut microbiota diversity and promotes metabolic health, while good sleep hygiene improves gut barrier function. Stress management and mindfulness help reduce gut inflammation and improve the gut-brain axis. …

Experiences of Multiple Myeloma Patients With Treatment in the Palestinian Practice: A Multicenter Qualitative Study in a Resource-Limited Healthcare System.

Background Multiple myeloma is a crippling cancer that puts a significant strain on patients and their families alike. The long and exhausting treatment journey with the disease is challenging not only for patients but also for healthcare systems. This exploratory study was conducted to look into these patients' experiences with their treatment and explore their recommendations and views to improve the Palestinian healthcare system, which can be viewed as an evolving healthcare system within a resource-limited and developing country. Methods The consolidated criteria for reporting qualitative

A narrative review on trazodone as a multimodal and multifunctional antidepressant: clinical relevance of formulations, dosing, and pharmacokinetic/pharmacodynamic targets.

BackgroundTrazodone, an antidepressant, has only been approved for use in major depressive disorder (MDD), but has demonstrated potent therapeutic potential in various conditions, such as insomnia and anxiety. It targets multiple serotonergic, adrenergic, and histaminergic receptors. Given this multimodal and multifunctional profile, we aimed to provide a comprehensive overview of the pharmacodynamic and pharmacokinetic properties of trazodone and its clinical applications across various conditions.Main textTrazodone demonstrates sedative and anxiolytic effects even at a low dose (25-75 mg) an

Managing fatigue in patients with primary Sjögren's syndrome: challenges and solutions.

Primary Sjögren's syndrome (pSS) patients identify fatigue as their most important symptom and the one most difficult to cope with, but there are still many challenges and few solutions to manage this debilitating symptom. Promising pharmacological treatments, such as rituximab, have failed in more stringent tests including randomized controlled trials (RCTs) and meta-analysis. While non-pharmacological interventions may be safer, less costly, and address other common comorbidities, to date only aerobic exercise seems to be effective at reducing fatigue in pSS. All interventions, pharmacologic

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… Cognitive-behavioral therapy for insomnia and sleep hygiene in fibromyalgia: a randomized controlled trial . J Behav Med . 2014 ; 37 ( 4 ): 683 – 697 . doi: 10.1007/s10865-013-9520-y 23744045 96. Usmani ZA , Hlavac M , Rischmueller M , et al. …

Bromelain has significant clinical benefits after extraction of the third molar during chemotherapy in patients with hematologic tumor.

The purpose of this study was to investigate the application of bromelain in the treatment of pain, swelling, and limited mouth opening in patients with hematologic tumor after extraction of the third molar during chemotherapy. We recruited 72 patients with hematologic tumor who were treated by oral and maxillofacial surgery in our hospital, and third molar extraction was performed under local anesthesia. After extraction, patients in the control group were treated with cold - hot compress and patients in the experimental group were treated by oral administration of bromelain. One, three, and

Цифровые биомаркеры и АИ для дистанционного мониторинга утомительного прогресса в области неврологических расстройств: подключение механизмов к клиническому применению.

Цифровые биомаркеры для мониторинга усталости в неврологических расстройствах представляют собой новаторский подход к преодолению разрыва между механистическим пониманием и клиническим применением. В настоящем перспективном документе рассматривается вопрос о том, каким образом меры, разработанные с помощью смартфонов и проанализированные с помощью искусственных методов интеллекта, могут трансформировать оценку усталости из субъективной, эпизодической отчетности в непрерывный, объективный мониторинг. Предлагаемые рамки для цифровой фенотификации на основе смартфонов содержат пассивные данные (о

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… Closed-loop intervention systems should trigger specific responses based on predefined thresholds: gait variability increases exceeding 20% might prompt mobility exercises, typing speed decreases beyond 30% could suggest cognitive rest periods, and sleep efficiency below 70% would activate sleep hygiene …

A multidisciplinary perspective on the complex interactions between sleep, circadian, and metabolic disruption in cancer patients.

Sleep is a basic need that is frequently set aside in modern societies. This leads to profound but complex physiological maladaptations in the body commonly referred to as circadian disruption, which recently has been characterized as a carcinogenic factor and reason for poor treatment outcomes, shortened survival, and reduced quality of life in cancer patients. As sleep and circadian physiology in cancer patients spans several disciplines including nursing science, neurology, oncology, molecular biology and medical technology, there is a lack of comprehensive and integrated approaches to deal

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… This survival benefit is significantly larger than the approximately 3 months achieved by medical treatment in most clinical trials done in this patient group [ 16 ], clearly demonstrating the importance of ensuring good sleep hygiene of the patients. …

Clinical Practice Guidelines for Menopause: An Executive Summary and Recommendations: Indian Menopause Society 2026.

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… Management: First-line management includes TLM and supportive measures such as exercise, sleep hygiene, balanced diet, weight management, analgesics, and physiotherapy for musculoskeletal symptoms. [65-68] 31. … Sleep hygiene measures – Refer to Section 6. 58. CBT: According to the American-European clinical practice guidelines, CBT for insomnia is the first-line treatment for chronic insomnia and should also be considered in menopausal women (Grade A). [88,100,101] 59. …

A Comprehensive Analysis of the Cancer Chronic Pain Experience: A Narrative Review.

Cancer-related chronic pain (CP) represents a critical clinical issue through the disease, severely compromising the quality of life (QoL) of patients and the family environment. The current review employed a narrative method to synthesize the main results about the impact of cancer-related CP on QoL, adopting a multidimensional and threefold vision: patients, caregivers, and patient-caregiver perspective. Evidence emphasizes the importance of considering a bidirectional perspective (patient-caregiver) to understand better the pain experience throughout the cancer continuum and its consequence

Characteristics and Components of Self-Management Interventions for Improving Quality of Life in Cancer Survivors: A Systematic Review.

Self-management can improve clinical and psychosocial outcomes in cancer survivors. Which intervention characteristics and components are beneficial is unclear, hindering implementation into practice. We systematically searched six databases from inception to 17 November 2021 for studies evaluating self-management interventions for adult cancer survivors post-treatment. Independent reviewers screened for eligibility. Data extraction included population and study characteristics, intervention characteristics (TIDieR) and components (PRISMS), (associations with) quality of life (QoL), self-effic

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… . | The user’s web page covers 7 education areas: a general introduction to CRF (which allowed participants to evaluate their CRF status), energy conservation, physical activity, nutrition, sleep hygiene, pain control and distress management. … Areas contained personally tailored sections based on the TTM model (physical activity, sleep hygiene, and pain control) and education sections based on the CBT model (general introduction, energy conservation, nutrition, and distress management). …