Результаты поиска

Chronic hypersensitivity pneumonitis in Japan: a nationwide epidemiologic survey.

BACKGROUND: Pulmonary fibrosis inevitably develops in patients with chronic hypersensitivity pneumonitis (HP). OBJECTIVE: We conducted a nationwide epidemiologic study in Japan to evaluate the frequency and clinical characteristics of chronic HP. METHODS: This report is on 36 cases of chronic HP, including 10 patients with summer-type HP, 5 patients with home-related HP, 7 patients with bird fancier's lung, 5 patients with isocyanate-induced HP, 4 patients with farmer's lung, and 5 patients with other types of chronic HP. Chronic HP was further subgrouped into 2 types: one type of patients w…

[HIV Infection/AIDS and respiratory tract infections in Japan].

Recent advances in the chemotherapeutic agents against HIV enabled us to conduct combination therapies using two nucleoside reverse transcri … ing PCR and other molecular technology. Multi-drug resistant tuberculosis is fortunately rare among Japanese HIV-positive patients. Early and correct diagnosis of opportunistic infections markedly improves the prognosis of the patients.

Current status of gnathostomiasis dorolesi in Miyazaki Prefecture, Japan.

Gnathostomiasis is an important food-borne parasitic zoonosis caused mainly by ingesting uncooked or undercooked flesh of freshwater fishes. Although four distinct species of the genus Gnathostoma were identified as the causative agents for human gnathostomiasis, human infections with G. doloresi have been found only in Japan, concentrated in Miyazaki Prefecture. So far we have found 25 cases in Miyazaki Prefecture. Although most of these patients were of cutaneous gnathostomiasis, two patients presented to the hospital with unusual clinical manifestations; one case was a pulmonary gnathostomi…

[Prevalence of endogenous uveitis in Kagoshima Prefecture, Southwest Japan].

To estimate the current trend in prevalence of endogenous uveitis and HTLV-I-associated uveitis (HAU) in a local area, we sent questionnaires to all ophthalmologic clinics in Kagoshima Prefecture, southern Japan, which has a population of 1.8 million, with reference to uveitis patients seen during May-July 1993 and May-June 1994. Answers to the questionnaires were obtained from about half of the ophthalmologists in each survey session. The proportion of uveitis cases was on the average 0.4% of outpatients, and the prevalence of uveitis was estimated to be 40.4 x 10(-5). The major uveitis entit…

Antiepiligrin cicatricial pemphigoid: the first case report from Japan.

We describe a Japanese man with antiepiligrin cicatricial pemphigoid and typical clinical features, including ocular involvement. Direct immunofluorescence showed IgG deposition at the basement membrane zone. Indirect immunofluorescence of 1M sodium chloride-split skin showed circulating antibasement membrane zone antibodies of IgG class reactive with the dermal side of the split. Immunoblotting of human epidermal and dermal extracts, as well as a bacterial fusion protein of BP180 NC16a domain, showed no specific reactivity. In contrast, with immunoprecipitation of either culture medium or cel…

[Current status of pediatric home mechanical ventilation in Japan].

The first nationwide survey of pediatric home mechanical ventilation (HMV) was conducted. From 35 out of 149 medical centers investigated, 4 … have been sent home every year. However, home mechanical ventilation is not yet well recognized in Japan as an option for pediatric patients with chronic respiratory failure, and there are many problems to be solved. Firstly, very few, if any, hospitals have a designated home care team composed of physicians and other specialists. Secondly, the current …

Recent trends of paragonimiasis westermani in Miyazaki Prefecture, Japan.

Miyazaki Prefecture has long been known as one of the endemic areas of paragonimiasis westermani. The prevalence of this disease peaked around 1956 and then drastically decreased. A few sporadic cases are still occasionally found in Miyazaki Prefecture; however, the number of new cases has gradually increased during the last 5 years. One important point to be noted is the change of clinical manifestations in the patients. A classically known form of paragonimiasis westermani is characterized by persisting cough, bloody sputum, and nodular or ring shadows in the lung field by chest x-ray. Howev

Current status of food-borne parasitic zoonoses in Japan.

Progress in public sanitation over the past four decades has greatly decreased the prevalence of soil-transmitted gastrointestinal parasites in Japan. Although food-borne zoonotic parasites also show a similar trend, there continues to be a steady flow of patients infected with the latter parasites. This stems from the traditional popularity among the Japanese of eating raw food, coupled with an increasing fondness for rare delicacies, overseas travel, and consumption of exotic food. These factors have given rise to many reports of anisakiasis, angiostrongyliasis, trichinellosis, capillariasis…

Causative agent of spotted fever group rickettsiosis in Japan.

Since 1984, it has been known that spotted fever group rickettsiosis exists in Japan. We isolated three strains of the causative rickettsiae, designated Katayama, Misaka, and Abe, from patients with the disease and studied the characteristics of the isolates. Nude mice and cyclophosphamide-treated mice died after infection with the isolates. However, infected normal mice recovered and acquired immunity. Infected adult male guinea pigs had fever, a scrotal reaction, and seroconversion. The isolates propagated well in tissue-cultured Vero cells. Analysis by the cross-immunofluorescence antibody …

Molecular analysis of Lesch-Nyhan syndrome found in Japan.

Molecular analysis of four unrelated patients with Lesch-Nyhan (L-N) syndrome was performed. All four cases had typical clinical features of L-N syndrome, and the activities of hypoxanthine-guanine phosphoribosyltransferase (HPRT) were absent. No structural gene abnormalities were found by Southern blot analysis in all cases, and a decrease of HPRT mRNA was not detected by dot blot analysis in two of the four cases. However, HPRT enzyme proteins were detected by Western blot analysis in all cases. Our results showed that the production of immunologically reactive but enzymatically inactive mut

Анализ отпечатков олигонуклеотида коксакивируса А10, изолированного в Японии.

Восемь штаммов коксакивируса А10, изолированных в 1978 и 1981 и 1982 годах от пациентов с ручной, ящурной и герпангиной в аптеке города Мацуе, сравнивались с методами отпечатков пальцев РНК. Карты олигонуклеотида из четырех изолированных от 1978 года были связаны друг с другом на 85-93% по отношению к их крупным олигонуклеотидам T1. Напротив, олигонуклеотидные карты четырех изолированных в 1981 и 1982 годах были очень отличны друг от друга. Эксперименты по совместному отбору кадров показали, что штаммы 1981 и 1982 годов делились только 17-34% от их больших олигонуклеотидов. Кроме того, некотор

Clinical experience with Oka live varicella vaccine in Japan.

A live varicella vaccine (Oka strain) has been developed and used since 1974 in normal and diseased children, particularly those at high risk. Children with acute leukaemia were usually vaccinated while in remission when showing a normal cell-mediated immunity as assessed with phytohaemagglutinin (PHA) or other reagents, and during suspension of all anticancer therapy, except 6-mercaptopurine from 1 week before to 1 week after vaccination. While clinical reactions were observed in only 40 out of 263 (15.2%) of these patients, they were noted in 30 out of 72 (41.7%) children immunized without s

Характеристика агента скрипки, изолированного от овец в Японии.

Было отмечено, что патогенный агент, изолированный в мышах от мозга овцы, пораженной скрипчатой болезнью. Период инкубации болезни при первичной передаче от овец к мышам был более продолжительным, чем во вторичной и третичной передаче в том же штамме мышей. Прогрессивное разбавление инокулы вызвало продление периода инкубации. Инфекция вещества в 10% однородности головного мозга сохранялась, но снизилась примерно в 10 (3)−10(4) раза после нагрева при температуре 100 C в течение 30 минут. Гистологические изменения в мышечном мозге были связаны с вакуолизацией нервных клеток и дегенерацией губки

Совпадение в аннотации оригинала
A pathogenic agent isolated in mice from the brain of a sheep affected by scrapie-like disease was characterized. The incubation period of t … eriments. These findings demonstrate that the disease of the sheep was the first case of scrapie in Japan.

Spheroid degeneration, keratopathy, pinguecula, and pterygium in Japan (Kyoto).

The prevalences of various possibly sunlight-induced degenerations of the exposed section of the eye have been studied in a series of 189 Japanese (Mongols) in Kyoto (subtropical climate, 35 degrees N. lat.). The results were compared with those of the author's examinations, using the same method and apparatus, in Jordan near the Red Sea (Arabs, N = 127) in Greenland (Eskimos, N = 659), and in Denmark (Caucasians, N = 810). In the Japanese series conjunctival spheroid degeneration was noticed in 31% and pinguecula in 60%, i.e. less frequently than in the sunny Jordan, but more frequently than …

Postoperative deep venous thrombosis in Japan. Incidence and prophylaxis.

The incidence of postoperative deep venous thrombosis was investigated using the iodine-125-fibrinogen method in 256 patients undergoing major surgery. Deep venous thrombosis was found in 49 patients (15.3 percent), and nonfatal pulmonary embolism developed in one of seven patients in whom the thrombus extended to the popliteal vein. The same investigation was performed in 110 patients who wore a graduated compression stocking on one leg, with the other leg serving as a control. Deep venous thrombosis was found in 4 of 110 stockinged legs (3.6 percent) and in 16 of 110 control legs (14.5 perce

Three glucose 6-phosphate dehydrogenase variants found in Japan.

Three Japanese glucose 6-phosphate dehydrogenase (G6PD) variants were investigated. G6PD 'Mediterranean-like' had markedly decreased activity, normal electrophoretic mobility, low Km G6P, low Km NADP, increased utilization of all three substrate analogues (2-deoxy-G6P, Gal-6P, and deamino-NADP) and slightly decreased heat stability and slightly biphasic pH curve. G6PD 'Ogori' had markedly decreased activity, but otherwise normal characteristics. G6PD 'Hofu' had moderately decreased activity, normal electrophoretic mobility, slightly reduced Km G6P, normal Km NADP, normal utilization of 2-deoxy…

Tricho-rhino-phalangeal syndrome. The first case in Japan.

The case of a 13-year-old girl with tricho-rhino-phalangeal syndrome is presented. It is characterized by sparse and slow growing hair, pear-shaped nose and cone-shaped epiphyses of hands and feet. The inheritance pattern is probably autosomal dominant transmission.