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[The epidemiological study of adenovirus in children with respiratory tract infections in Nanjing area from 2010 to 2011].

UNLABELLED: To investigate the epidemiological features and types of human adenoviruses (ADV) in children with acute respiratory tract infec … V), human rhinovirus (HRV), parainfluenza viruses 1-4 (PIV1-4), influenza virus A/B (IFVA/B), human metapneumovirus (HMPV), human coronavirus NL63 and HKU1 (HCoV-HKU1 and HCoV-NL63) were also identified by PCR method. All PCR positive products were sequenced and phylogenetic analysis was conducted. It was showed that adenoviruses were detected in 171 patients out …

Influenza and other respiratory viruses in three Central American countries.

BACKGROUND: Despite the disease burden imposed by respiratory diseases on children in Central America, there is a paucity of data describing … ), influenza B virus (47; 2.7% of cases), and herpes simplex virus 1 (22; 1.3%). In addition, human metapneumovirus and enteroviruses (coxsackie and echovirus) were isolated from patient specimens. DISCUSSION: When compared to the rest of the population, viruses were isolated from a significantly higher percentage of patients age 5 or younger. The prevalence of …

Distribution and seasonality of rhinovirus and other respiratory viruses in a cross-section of asthmatic children in Trinidad, West Indies.

BACKGROUND: Childhood asthma in the Caribbean is advancing in prevalence and morbidity. Though viral respiratory tract infections are report … stinct groups: human rhinovirus, respiratory syncytial virus, parainfluenza virus, influenza virus, metapneumovirus, adenovirus, coronavirus, and enterovirus. RESULTS: Wheezing children had a higher [chi(2 )= 5.561, p = 0.018] prevalence of respiratory viruses compared with stabilized asthmatics (34.3% (24) versus (vs.) 17.5% (14)). Acute asthmatics were thrice …

[Pathogenic agents causing acute respiratory tract infections in pediatric patients in Spring, 2023, in Beijing].

Objective: To explore the pathogenic agents of acute respiratory infection (ARI) in children in Beijing. Methods: In the cross-sectional study, 3 groups of children from different departments were enrolled from Feb 6th, 2023 (6th week) to May 28th (21th week), 2023, including influenza-like case group from emergency department for nucleic acid testing of influenza virus (Flu) and human metapneumovirus (HMPV), the outpatient ARI group under nucleic acid testing for Flu, respiratory syncytial virus (RSV), adenovirus (ADV), and parainfluenza virus (PIV), and the inpatient ARI group under nucleic …

Detecting respiratory viruses in children with protracted bacterial bronchitis.

OBJECTIVE: This study is to investigate the status and clinical significance of respiratory viruses in bronchoalveolar lavage fluid (BALF) of children with PBB. METHODS: Sixty-eight children with PBB aged from 3 months to 5 years were enrolled and retrospectively reviewed from January 2014 to December 2017. Thirty-five children with persistent pneumonia or chronic pneumonia were matched as controls. Bronchoalveolar lavage fluid samples were collected for respiratory virus detection and bacterial culture. RESULTS: The detection rate of bacteria in BALF of children with PBB was 61.8%, which wa

Viral aetiology of bronchiolitis in hospitalised children in Qatar.

BACKGROUND: Bronchiolitis is considered one of the earliest and most common causes of hospitalisation in young children. Development of molecular technologies allowed a better understanding of bronchiolitis aetiology. Results from cohort studies evaluating the association between single, multiple viral infections and clinical outcomes are conflicting. Data on viral bronchiolitis in children were found to be limited in Qatar. This study aimed to determine frequency and seasonal trends of viral pathogens causing acute bronchiolitis, and to explore association between viral pathogens, disease sev

Etiology and Clinical Characteristics of Community-Acquired Pneumonia with Airway Malacia in Children.

OBJECTIVE: The objective of this article is to study the etiology of community-acquired pneumonia in children with airway malacia. METHODS: We retrospectively reviewed the medical records of 428 pneumonia patients. All patients underwent bronchoscopy, and bronchoalveolar lavage samples were processed for microbiological assessment. RESULTS: In a total of 428 cases reviewed, 60 were found to have airway malacia. Pathogens were identified in 44 of the 60 specimens (73.3%), with 32 being single-pathogen infections. The most common pathogen was respiratory syncytial virus (RSV; 20%). Mixed-patho

Key role of Chlamydophila psittaci on Belgian turkey farms in association with other respiratory pathogens.

Two hundred turkey sera from eight Belgian and two French farms were tested for the presence of antibodies against avian pneumovirus (APV), Ornithobacterium rhinotracheale (ORT), Mycoplasma gallisepticum, Mycoplasma meleagridis and Chlamydophila psittaci. At slaughter, C. psittaci, APV and ORT antibodies were detected in 94, 34 and 6.5% of the turkeys, respectively. No antibodies against M. gallisepticum or M. meleagridis were present. Additionally, turkeys on three Belgian farms were examined from production onset until slaughter using both serology and antigen or gene detection. All farms ex

[Significance of the multi-pathogen surveillance of pediatric patients with acute respiratory infections in Beijing from 2024 to 2025].

Objective: To delineate the pathogen spectrum and epidemiological features of acute respiratory infections (ARI) among pediatric patients in … quantitative PCR. Specimens positive for influenza virus, respiratory syncytial virus (RSV), human metapneumovirus (HMPV), and human rhinovirus were further subtyped. Patients were categorized into influenza-like illness (ILI) and severe acute respiratory infection (SARI) groups. Positivity rates across different sources, visit periods, and age groups were compa …

Substituted benzimidazoles with nanomolar activity against respiratory syncytial virus.

A cell-based assay was used to discover compounds inhibiting respiratory syncytial virus (RSV)-induced fusion in HeLa/M cells. A lead compound was identified and subsequent synthesis of >300 analogues led to the identification of JNJ 2408068 (R170591), a low molecular weight (MW 395) benzimidazole derivative with an EC(50) (0.16 nM) against some lab strains almost 100,000 times better than that of ribavirin (15 microM). Antiviral activity was confirmed for subgroup A and B clinical isolates of human RSV and for a bovine RSV isolate. The compound did not inhibit the growth of representative vir

Integrating heterogeneous data to address endemic diseases in broiler production: insights from a Polish case study.

BACKGROUND: Endemic contagious diseases in broilers have a significant impact on production performance. However, endemic contagious disease … d lower production performance, indicating strong Eimeria spp. infestation and circulation of avian metapneumovirus. CONCLUSION: The study is an example of how high-dimensional data produced by the broiler industry can be reused and integrated to create contextual knowledge for farmers and veterinarians about endemic contagious diseases. Access to this timely con …

Prevalence of common respiratory viruses in children: insights from post-pandemic surveillance.

INTRODUCTION: The COVID-19 pandemic has significantly affected healthcare systems worldwide, impacting the occurrence and management of resp … ory viruses were detected in 100 (33.0%) of the samples, with 36 (12.0%) testing positive for Human metapneumovirus (HMPV), 27 (8.9%) for Respiratory syncytial virus (RSV), and 20 (6.6%) for Human Adenovirus (HAdV). In 8.0% of the cases, multiple viruses were detected, with HAdV being the most common (75.0%). Children under 6 months (AOR: 4.81, 95% CI: 1.20-24.60 …

Changes in the Distribution of Respiratory Microorganisms before and during the COVID-19 Pandemic, Daegu, Korea.

BACKGROUND: Acute respiratory infection (ARI) is the most common infectious disease in all ages and genders worldwide. Respiratory microorga … Ⅰ and Ⅱ were compared for eight major kinds of respiratory microorganisms: adenovirus (AdV), human metapneumovirus (HMPV), human rhinovirus/enterovirus (Rhino/Entero), influenza virus (Flu) A, Flu B, human parainfluenza virus (HPIV) 3, respiratory syncytial virus, and Mycoplasma pneumoniae. RESULTS: A total of 27,191 respiratory specimens were tested, of which …

Development of DNA Microarray for Indication of Viral Community-Acquired Pneumonia Pathogens.

UNLABELLED: The aim of the study is to develop a DNA microarray for the indication of viral pathogens causing community-acquired pneumonia. … gn included 544 DNA probes for the detection of adenovirus, bocavirus, respiratory syncytial virus, metapneumovirus, parainfluenza virus, rhinovirus, and coronavirus. The DNA probes were synthesized on slides. The optimal DNA hybridization temperature on microarrays was established (47°C). A list of probes for specific detection of adenovirus group B, bocavirus, …

Impact of COVID-19 pandemic measures on hospitalizations and epidemiological patterns of twelve respiratory pathogens in children with acute respiratory infections in southern China.

OBJECTIVES: To investigate the impact of COVID-19 pandemic measures on hospitalizations and the alterations and persistence of the epidemiol … patterns of most pathogens were altered by the COVID-19 pandemic. Human Parainfluenza Virus, Human Metapneumovirus, Human Bocavirus (HBOV), and Human Coronavirus remained active during Phase 1, while Mycoplasma pneumoniae (Mp) and Adenovirus (ADV) were low, and Respiratory Syncytial Virus (RSV) lacked a seasonal peak in 2022. In Phase 2, Mp, ADV, and RSV experie …

Epidemiology of Respiratory Viruses in Korean Children Before and After the COVID-19 Pandemic: A Prospective Study From National Surveillance System.

BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic led to a decrease in the seasonal incidence of many respiratory viruses worldwi … 2023. We included data on adenovirus (AdV), human bocavirus (HBoV), human coronavirus (HCoV), human metapneumovirus (HMPV), human rhinovirus (HRV), influenza virus (IFV), parainfluenza virus (PIV), and respiratory syncytial virus (RSV), which were detected in children and adolescents younger than 20 years. We analyzed the weekly detection frequency of individual …

Clinical Evaluation of Metagenomic Next-Generation Sequencing for the detection of pathogens in BALF in severe community acquired pneumonia.

BACKGROUND: Rapid and accurate identification of pathogens is very important for the treatment of Severe community-acquired pneumonia (SCAP) … 8.2% [2/11], P = 0.004). The mNGS test can detect viruses, such as bocavirus, rhinovirus, and human metapneumovirus, which are not frequently recognised using CT. However, the mNGS detection rate was lower than that of the CT (52.4% [11/21] vs. 95.2% [20/21], P = 0.004) for Mycoplasma pneumoniae (MP). The detection rate of mNGS for mixed infection was greater tha …

Эпидемиологические особенности инфекции дыхательных путей с использованием мультиплексных пандемий, обнаруженных во время пандемии COVID-19 в провинции Шаньдун, Китай.

Инфекция дыхательных путей является одной из наиболее распространенных причин как заболеваемости, так и смертности во всем мире. С момента появления COVID-19 большое внимание уделяется этиологическому отслеживанию инфекции дыхательных путей. В этом исследовании мы стремились оценить эпидемиологические особенности патогенов в инфекциях дыхательных путей, особенно во время пандемии COVID-19. В общей сложности 7668 пациентов с инфекцией дыхательных путей, попавших в больницу Цилу в Шаньдунском университете с марта 2019 года по декабрь 2021 года, были ретроспективно включены. Образцы дыхательных п

Совпадение в аннотации оригинала
Respiratory tract infection is one of the most common reasons for both morbidity and mortality worldwide. High attention has been paid to th … V), respiratory syncytial virus (RSV), adenovirus (ADV), Boca virus (Boca), human Rhinovirus (HRV), Metapneumovirus (MPV), Coronavirus (COV), Mycoplasma pneumoniae (MP), and Chlamydia (Ch). The positive rates were compared using a chi-square test. Compared with 2019, the positive rate of pathogen detection during from January 2020 to December 2021 was significant …

Role of hydrogen sulfide in paramyxovirus infections.

UNLABELLED: Hydrogen sulfide (H2S) is an endogenous gaseous mediator that has gained increasing recognition as an important player in modula … Y4137 also significantly reduced replication and inflammatory chemokine production induced by human metapneumovirus (hMPV) and Nipah virus (NiV), suggesting a broad inhibitory effect of H2S on paramyxovirus infections. GYY4137 treatment had no effect on RSV genome replication or viral mRNA and protein synthesis, but it inhibited syncytium formation and virus asse …