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Linking Air Pollution and Hematologic Malignancies: From Epidemiology to Molecular Mechanisms.

PURPOSE OF REVIEW: Outdoor air pollution (OAP) is a major global environmental health threat associated with respiratory disease and solid tumors, with growing evidence linking it to hematologic malignancies. This review summarizes the molecular mechanisms and epidemiologic evidence connecting OAP exposure to acute and chronic leukemias, lymphomas, myelodysplastic syndromes (MDS), clonal hematopoiesis of indeterminate potential (CHIP), and multiple myeloma (MM). RECENT FINDINGS: Pollutants implicated in hematologic carcinogenesis include particulate matter (PM), benzene, nitrogen dioxide (NO₂

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… Janitz AE Campbell JE Magzamen S Pate A Stoner JA Peck JD Benzene and childhood acute leukemia in Oklahoma Environ Res 2017 158 167 73 10.1016/j.envres.2017.06.015 28645022 PMC5554454 Janitz AE, Campbell JE, Magzamen S, Pate A, Stoner JA, Peck JD. Benzene and childhood acute leukemia in Oklahoma. … Traffic-related air pollution and childhood acute leukemia in Oklahoma. Environ Res. 2016;148:102–11. 10.1016/j.envres.2016.03.036. 27038831 10.1016/j.envres.2016.03.036 PMC4874884 79. …

Medicaid Formulary Decisions and the Institute for Clinical and Economic Review: Abandoning Pseudoscience in Imaginary Pharmaceutical Pricing Claims.

Medicaid formulary committees and other gatekeepers face a difficult task. On the one hand they can utilize technical expertise in evaluating the real world evidence for clinical, quality of life and resource utilization claims for competing products while on the other hand they may be asked to assess claims built by simulation models for pricing and product access. A common option has been to take modeled claims from third parties such as the Institute for Clinical and Economic Review (ICER) at face value without challenging the model structure, its assumptions and its incremental cost-per-QA

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… In May 2020 Oklahoma, in response to criticisms that the I-QALY was discriminatory, enacted the Nondiscrimination in Health Care Coverage Act (HB2587) which required state agencies to confer with disability groups prior to making decisions on coverage, reimbursement and utilization management. … If the Oklahoma legislature members had had any understanding of the axioms of fundamental measurement, it should have been obvious that the I-QALY was automatically disqualified in any submission for product pricing and access. …

Surveillance for Violent Deaths - National Violent Death Reporting System, 32 States, 2016.

PROBLEM/CONDITION: In 2016, approximately 65,000 persons died in the United States as a result of violence-related injuries. This report sum … usetts, Michigan, Minnesota, New Hampshire, New Jersey, New Mexico, New York, North Carolina, Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, South Carolina, Utah, Vermont, Virginia, Washington, and Wisconsin). NVDRS collates information for each death and links deaths that are related (e.g., multiple homicides, homicide followed by suicide, or multipl …

Risk and Outcome of Breakthrough COVID-19 Infections in Vaccinated Patients With Cancer: Real-World Evidence From the National COVID Cohort Collaborative.

PurposeTo provide real-world evidence on risks and outcomes of breakthrough COVID-19 infections in vaccinated patients with cancer using the largest national cohort of COVID-19 cases and controls.MethodsWe used the National COVID Cohort Collaborative (N3C) to identify breakthrough infections between December 1, 2020, and May 31, 2021. We included patients partially or fully vaccinated with mRNA COVID-19 vaccines with no prior SARS-CoV-2 infection record. Risks for breakthrough infection and severe outcomes were analyzed using logistic regression.ResultsA total of 6,860 breakthrough cases were

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… Volz, Anita Walden • Publication Committee Review Team: Carolyn Bramante, Jeremy Richard Harper, Wenndy Hernandez, Farrukh M Koraishy, Federico Mariona, Amit Saha, Satyanarayana Vedula Data Partners with Released Data Stony Brook University—U24TR002306 • University of Oklahoma Health Sciences Center—U54GM104938 … : Oklahoma Clinical and Translational Science Institute (OCTSI) • West Virginia University—U54GM104942: West Virginia Clinical and Translational Science Institute (WVCTSI) • University of Mississippi Medical Center—U54GM115428: Mississippi Center for Clinical and Translational Research (CCTR) • University …

Reporting of Patient-Reported Outcome Measures in Randomized Controlled Trials on Shoulder Rotator Cuff Injuries Is Suboptimal and Requires Standardization.

PurposeTo evaluate the completeness of patient-reported outcomes (PROs) reporting using Consolidated Standards of Reporting Trials Patient-Reported Outcome (CONSORT-PRO) in randomized controlled trials (RCTs) involving rotator cuff injuries.MethodsWe performed a comprehensive search of MEDLINE, Embase, and Cochrane Central Register of Controlled Trials for published RCTs focused on rotator cuff injuries that included at least one PRO measure. We included RCTs published from 2006 to 2020. Investigators extracted data from RCTs using the CONSORT-PRO and evaluated each RCT using the Cochrane Risk

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… Office of Research Integrity, Oklahoma Center for Advancement of Science and Technology, and internal grants from 10.13039/100007069 Oklahoma State University Center for Health Sciences, all outside of the present work. …

Средний показатель воздействия выборочной обработки на анализ обработанных веществ (САТТ) с использованием контрфактического объяснения указывает на БМТ и SARS-CoV-2 вакцинация как защитные факторы риска, связанные COVID-19 Сильность и выживаемость у пациентов с множественной миеломой.

Пациенты с множественной миеломой (ММ), возрастной неоплазмой плазменных клеток, производящих антитела, скомпрометировали иммунную систему и могут подвергаться повышенному риску сильного воздействия COVID-19 :: результаты. Это исследование характеризует факторы риска, связанные с клиническими показателями COVID-19 Суровая и всепричинная смертность у пациентов миэломы с использованием национальной базы данных по сотрудничеству в области КОВИД (N3C). Консорциум N3C представляет собой крупный централизованный ресурс данных, представляющий собой крупнейшую многоцентровую группу COVID-19 - случаи и

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… Mississippi Center for Clinical and Translational Research (CCTR) • University of Nebraska Medical Center—U54GM115458: Great Plains IDeA-Clinical & Translational Research • University of North Carolina at Chapel Hill—UL1TR002489: North Carolina Translational and Clinical Science Institute • University of Oklahoma … Health Sciences Center—U54GM104938: Oklahoma Clinical and Translational Science Institute (OCTSI) • University of Rochester—UL1TR002001: UR Clinical & Translational Science Institute • University of Southern California—UL1TR001855: The Southern California Clinical and Translational Science Institute …

Surveillance for Violent Deaths - National Violent Death Reporting System, 34 States, Four California Counties, the District of Columbia, and Puerto Rico, 2017.

PROBLEM/CONDITION: In 2017, approximately 67,000 persons died of violence-related injuries in the United States. This report summarizes data … Michigan, Minnesota, Nevada, New Hampshire, New Jersey, New Mexico, New York, North Carolina, Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, South Carolina, Utah, Vermont, Virginia, Washington, West Virginia, and Wisconsin), four California counties (Los Angeles, Sacramento, Shasta, and Siskiyou), the District of Columbia, and Puerto Rico. NVDRS colla …

Downregulation of SLC40A1 leads to iron accumulation in fibrotic lung fibroblasts.

Iron is an essential nutrient for almost all organisms. However, excess iron generates reactive oxygen species and causes tissue injuries. Iron is implicated in idiopathic pulmonary fibrosis (IPF). In this study, we examined iron accumulation in fibrotic lung fibroblasts and the underlying mechanisms. We hypothesize that the downregulation of Solute Carrier Family 40 Member 1 (SLC40A1) results in iron accumulation in lung fibroblasts of IPF patients. Using a Prussian Blue iron staining, we found that iron accumulated in the fibrotic region of the lungs from IPF patients and bleomycin- and asbe

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… All vector sequences were confirmed by sequencing (DNA Protein Facility, Oklahoma State University, OK, USA). Lentivirus production Lentiviruses were produced in HEK293T cells [ 20 ]. … Declarations Ethics approval and consent to participate All animal experimental protocols were reviewed and approved by the Institutional Animal Care and Use Committee (IACUC) of Oklahoma State University (Approval number: VM-21-81). …

Surveillance for Violent Deaths - National Violent Death Reporting System, 39 States, the District of Columbia, and Puerto Rico, 2018.

PROBLEM/CONDITION: In 2018, approximately 68,000 persons died of violence-related injuries in the United States. This report summarizes data … Missouri, Nebraska, Nevada, New Hampshire, New Jersey, New Mexico, New York, North Carolina, Ohio, Oklahoma, Oregon, Rhode Island, South Carolina, Utah, Vermont, Virginia, Washington, West Virginia, and Wisconsin), three states with data from counties representing a subset of their population (21 California counties, 28 Illinois counties, and 39 Pennsylva …