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Burden of All Cancers Along With Attributable Risk Factors in China From 1990 to 2019: Comparison With Japan, European Union, and USA.

BackgroundUnderstanding the epidemiological characteristics of various cancers can optimize the prevention and control strategies in the national cancer control plan. This study aimed to report the burden differences, pattern trend, and potential risk factors of all neoplasm types in China in recent 30 years, and further compared with top economies in the world.MethodsThe disability-adjusted life-years (DALYs) and age-standardized DALY rate (ASDR) of all neoplasms with the attributable risk factors from 1990 to 2019 in China, Japan, European Union, USA, and the world were extracted from the Gl

Disparities in survival of hematologic malignancies in the context of social determinants of health: a systematic review.

Social determinants of health (SDHs) have been reported as relevant factors responsible for health inequity. We sought to assess clinical data from observational studies conducted in the United States evaluating the impact of SDHs on the outcomes of patients with hematologic malignancies. Thus, we performed a systematic review in 6 databases on 1 September 2021, in which paired reviewers independently screened studies and included data from 41 studies. We assessed the risk of bias using the Joanna Briggs Institute appraisal tools and analyzed the data using a descriptive synthesis. The most co

Patients' Perspective of Medication Adherence in Chronic Conditions: A Qualitative Study.

IntroductionAbout 50% of patients do not take their long-term therapy for chronic conditions as prescribed. Many studies have centered on patients' adherence to a specific treatment or single conditions, but few have taken all chronic conditions into consideration from a patient's perspective. This study aims to explore factors that impact on drug compliance and to identify strategies to improve this from the perspective of patients with at least one chronic condition.MethodsPatients were recruited by healthcare professionals from a hospital pharmacy, four community pharmacies, patient associa

Глобальная эпидемиология и бремя множественной миеломы 1990 в адрес 2021 с прогнозами 2045 на основе глобального исследования бремени болезней 2021.

Множественная миелома (ММ) — сложная гематологическая гелингология, характеризующаяся аномальным распространением злокачественных плазменных клеток в костном мозге. Цель этого исследования состоит в том, чтобы дать всеобъемлющую оценку глобальной эпидемиологии, бремени болезней и связанных с ними факторов риска, связанных с ММ. 1990 в адрес 2021, с прогнозами 2045. МЕТОДЫ: Был проведен описательный эпидемиологический анализ с использованием данных Глобального бремени болезней (ГБЗ) 2021 исследование, включающее в себя 204 странами и территориями. Были проанализированы ключевые показатели, таки

The State of Obesity in Kansas: A Community Based Approach to Chronic Care Management.

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… Despite the increasing prevalence of obesity within the state of Kansas, accurate data are limited due to the majority of data consisting of self-reports of height and weight through the Behavioral Risk Factor Surveillance System (BRFSS). 1 Adjustments for self-reporting bias in body mass index (BMI) …

Genome agnostic, multi-level non-oncogene addiction-based systems pharmacology for rescuing metastatic relapsed/refractory neoplasias.

Rescue therapies for relapsed/refractory (r/r) metastatic neoplasias present significant unmet needs. Tumor tissue editing regimen for 13 r/r tumor types, carcinomas, sarcomas and hematologic neoplasias, included in 15 phase I/II trials, nuclear/cytokine receptor agonists, pioglitazone, plus/minus dexamethasone or all-trans retinoic acid or interferon-α to counterbalance tumor tissue homeostasis and reprogramming of cancer hallmarks, stress response inhibitors, COX-2 inhibitor, everolimus, lenalidomide, or clarithromycin, and a stress response inducer, low-dose metronomic chemotherapy with tre

Высокоэффективное соблюдение Леналидомида в Множестве миелом.

Предыстория и цель оральной антираковой терапии соотносятся с результатами. Lenalidomide (LEN) — оральное лечение миеломы (MM), применяемое в 21-day/7-day (выключено/выключено) циклы. Данные о соблюдении LEN ограничены. Электронная система мониторинга (ЭМ) представляет собой наиболее надежный метод оценки соблюдения. Циклы включения и выключения определяются полуавтоматически. Соблюдение обязательств по осуществлению было рассчитано как доля прописываемых лекарственных средств в течение каждого цикла и по всем циклам. Ежедневные прогнозы соблюдения были проанализированы с использованием логист

Facing financial barriers to healthcare: patient-informed adaptation of a conceptual framework for adults with a history of cancer.

BackgroundCancer-related financial hardship is associated with negative clinical outcomes, which may be partially explained by cost-related delayed or forgone care in response to financial barriers. We sought to understand patient experiences facing financial barriers to medical care following a cancer diagnosis.MethodsWe conducted virtual, semi-structured interviews in Fall 2022 with 20 adults with a history of cancer who had experienced cancer-related financial hardship in the prior year. We used template analysis within a pragmatic paradigm, combining constructivist and critical realist the

Оценка риска и прогнозирование самоубийств у нескольких пациентов с миэломой.

ЦЕЛЬ: Несмотря на успехи в лечении, позволившие выжить, множество миеломы (ММ) по-прежнему является тревожным диагнозом со значительными последствиями для здоровья, включая повышенный риск самоубийства. Целью этого исследования является изучение риска самоубийств среди пациентов с ОМ и разработка модели прогнозирования для выявления лиц с высокой степенью риска. Методы: Мы проанализировали 83,333 Случаи MM из последней базы данных наблюдения, эпидемиологии и конечных результатов (SEER)2001-2020) для выявления предсказателей риска самоубийства и разработки предсказуемых номограмм. Эта группа бы

Core Patient-Centered Outcomes for Adolescents and Young Adults with Cancer: A Comprehensive Review of the Literature from the STRONG-AYA Project.

BackgroundIn adolescents and young adults (AYAs) with cancer, the importance of patient-centered research outcomes is increasingly acknowledged and there is a need for consensus on the most relevant outcomes. This review provides a comprehensive overview of outcomes relevant to AYAs with cancer in order to develop an AYA-specific core outcome set (COS) as part of the European project STRONG-AYA.MethodsA literature search was conducted to identify relevant articles in five databases. Each article was reviewed by two independent researchers, using Rayyan (an online tool) to screen articles by th

Surveillance of the current situation regarding influenza vaccination according to medical oncologists in Japan.

This study aimed to clarify the attitude of oncologists toward influenza vaccination and the current situation and issues regarding influenza vaccination for patients on chemotherapy in Japan. A web-based survey of medical oncologists certified by the Japanese Society of Medical Oncology was conducted between November 1 and December 31, 2019. Of the 1369 medical oncologists who were invited to participate, 415 (30.3%) responded to our survey. The questionnaire comprised 4 sections: "oncologist characteristics," "oncologist attitude toward influenza vaccines and the current status of influenza

Детские трудности и аутоиммунные заболевания: глобальный исследовательский ландшафт, < < горячие точки > > , связанные с иммунизацией, и новые тенденции, вытекающие из библиометрического анализа трех баз данных.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Детские трудности все чаще признаются в качестве важного психосоциального воздействия в раннем возрасте, которое может формировать долгосрочную иммунную функцию и способствовать аутоиммунным заболеваниям посредством хронического стресса, регулирования нейроэндокринной дистрибьюции и провокационной активации. Однако структура знаний, " горячих точек " исследований и тенденции в области развития в этой области остаются недостаточно характерными. МЕТОДЫ: С момента создания базы данных по 31 декабря 2025 года публикации, посвященные детским недугам и аутоиммунным з

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… Behavioral Risk Factor Surveillance System (BRFSS), Qinxin Zhou et al. found that adverse childhood experiences were significantly associated with arthritis risk in adulthood and showed a clear dose-response relationship: compared with individuals without ACEs, those exposed to four or more ACEs had … Adverse childhood experiences and arthritis risk: exploring behavioral and psychological mediators in the behavioral risk factor surveillance system. Front Public Health. (2025) 13:1697021. doi: 10.3389/fpubh.2025.1697021 41. Olivieri P, Solitar B, Dubois M. …

Solitary extramedullary plasmacytoma of the tongue: a case report.

INTRODUCTION AND IMPORTANCE: Extramedullary plasmacytomas are rare solitary plasma cell neoplasms that occur outside the bone marrow. Primary tongue involvement is exceptionally uncommon and presents a significant diagnostic challenge. Their clinical presentation is often subtle and may closely mimic more common neoplastic processes. CASE PRESENTATION: We report the case of a 35-year-old man who presented with a gradually enlarging, firm, and painless mass on the ventral surface of the tongue that had been evolving for 5 months. Histopathological and immunohistochemical analyses revealed shee

Distress in a Pandemic: Association of the Coronavirus Disease-2019 Pandemic with Distress and Quality of Life in Hematopoietic Stem Cell Transplantation.

The global coronavirus disease 2019 (COVID-19) pandemic has drastically disrupted cancer care, potentially exacerbating patients' distress levels. Patients undergoing hematopoietic stem cell transplantation (HSCT) may be especially vulnerable to this pandemic stress. However, the associations of the COVID-19 pandemic with distress, fatigue, and quality of life (QoL) are not well understood in this population. In a cross-sectional analysis of data from 205 patients undergoing HSCT enrolled in a supportive care trial, we compared baseline pre-HSCT distress symptoms (depression, anxiety, and post

Low-, moderate-, and high-risk obesity in association with cost drivers, costs over the lifecycle, and life expectancy.

BackgroundThe prevalence of low-, moderate-, and high-risk obesity has been increasing globally. Our aim was to estimate the societal burden of these three obesity classes in the Austrian population by taking a societal-annual perspective and an individual-life-cycle perspective. Secondly, we sought to identify the respective cost drivers and the effects on life expectancy.MethodsWe used population-weighted survey data on the distribution of body mass index (BMI) and data on relative risks regarding 83 diseases. Using fractional polynomial regressions, we estimated relative risks per BMI unit

Osteoporosis in Childhood Cancer Survivors: Physiopathology, Prevention, Therapy and Future Perspectives.

The improvement of chemotherapy, radiotherapy, and surgical interventions, together with hematopoietic stem cell transplantation, increased childhood cancer survival rate in the last decades, reaching 80% in Europe. Nevertheless, anti-cancer treatments are mainly responsible for the onset of long-term side effects in childhood cancer survivors (CCS), including alterations of the endocrine system function and activity. In particular, the most frequent dysfunction in CCS is a metabolic bone disorder characterized by low bone mineral density (BMD) with increased skeletal fragility. BMD loss is al

Взаимосвязь между историей аутоиммунной болезни и развитием рака поджелудочной железы: тематическое исследование 32,640 Пациенты.

Рак поджелудочной железы - это очень смертельный рак с ростом заболеваемости и плохим прогнозом из-за позднего диагноза. Хотя известно несколько факторов риска, данные о потенциальной роли аутоиммунных заболеваний остаются ограниченными. С учетом растущей распространенности аутоиммунных заболеваний и их связи с различными вредителями цель этого исследования заключается в изучении их потенциальной связи с раком поджелудочной железы. МЕТОДЫ: 5,440 у пациентов с первым диагнозом рака поджелудочной железы и 27,200 В базе данных " Analyzer " (IQVIA) были выявлены лица, не страдающие раком

Modeling the Bone Marrow Niche in Multiple Myeloma: From 2D Cultures to 3D Systems.

Multiple myeloma is a hematologic malignancy characterized by the clonal proliferation of plasma cells within the bone marrow. The tumor microenvironment plays a crucial role in multiple myeloma pathogenesis, progression, and drug resistance. Traditional two-dimensional cell culture models have been instrumental in multiple myeloma research. However, they fail to recapitulate the complex in vivo bone marrow microenvironment, leading to limited predictive value for clinical outcomes. Three-dimensional cell culture models emerged as more physiologically relevant systems, offering enhanced insigh

Effect of Distress, Anxiety, and Depressive Symptoms on SARS-CoV-2 mRNA BNT162b2 Vaccine Efficacy in Cancer Patients.

Background/objectivesOur previous study of 291 cancer patients, we showed that 20% did not respond to two doses of COVID-19 vaccine administered six weeks apart.MethodsHere, we investigated if psychological factors (distress, anxiety, and depressive symptoms) affected antibody response and markers of vaccine activation (D-dimer) after 6 months from initial vaccination.ResultsOverall, 31 subjects (14.2%) had no antibody response at 6 months. Our analysis revealed significant predictors of vaccine failure, including the stage of metastatic disease and high-stress levels (OR = 2.46, 95% CI, 1.05-

Second-Class Care: How Immigration Law Transforms Clinical Practice in the Safety Net.

This article examines how U.S. immigration law extends into the health care safety net, enacting medical legal violence that diminishes noncitizens' health chances and transforms clinical practices. Drawing on interviews with health care workers in three U.S. states from 2015 to 2020, I ask how federal citizenship-based exclusions within an already stratified health care system shape the clinical trajectories of noncitizens in safety-net institutions. Focusing specifically on cancer care, I find that increasingly anti-immigrant federal policies often reshape clinical practices toward noncitize