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Nitric oxide influences blood flow distribution in renovascular hypertension.

Endothelium-derived nitric oxide contributes to the regulation of regional blood flow. Inhibition of endothelium-derived nitric oxide synthesis increases blood pressure and vascular resistance. Using the substrate antagonist N omega-nitro-L-arginine-methyl ester to block endothelium-derived nitric oxide synthesis, we tested the hypothesis that, in two-kidney, one clip renovascular hypertension, endothelium-derived nitric oxide plays an increased role in maintaining blood flow to the nonclipped kidney and other visceral organs compared with normotensive controls. This could be due to increased

Topical treatment for facial burns.

BACKGROUND: Burn injuries are an important health problem. They occur frequently in the head and neck region. The face is the area central t … urn injuries. Topical agents included antimicrobial agents (silver sulphadiazine (SSD), Aquacel-Ag, cerium-sulphadiazine, gentamicin cream, mafenide acetate cream, bacitracin), non-antimicrobial agents (Moist Exposed Burn Ointment (MEBO), saline-soaked dressings, skin substitutes (including bioengineered skin substitute (TransCyte), allograft, and xenogr …

Graphene-modified CePO4 nanorods effectively treat breast cancer-induced bone metastases and regulate macrophage polarization to improve osteo-inductive ability.

BACKGROUND: Breast cancer bone metastasis has become one of the most common complications; however, it may cause cancer recurrence and bone nonunion, as well as local bone defects. METHODS: Herein, In vitro, we verified the effect of bioscaffold materials on cell proliferation and apoptosis through a CCK8 trial, staining of live/dead cells, and flow cytometry. We used immunofluorescence technology and flow cytometry to verify whether bioscaffold materials regulate macrophage polarization, and we used ALP staining, alizarin red staining and PCR to verify whether bioscaffold material promotes b

Nanoarchitectures of Folate-Functionalized Highly Monodispersed Ce-Tb Doped Core@Shell Nanorods for Targeted and Enhanced Chemotherapy of Human Cervical and Triple-Negative Breast Carcinoma.

The high incidence, aggressiveness, and chemo-refractory nature of cervical and triple-negative breast cancers (TNBC) warrant the development of targeted chemotherapy strategies for improving their therapeutic outcomes. The present study reports the design and preparation of highly monodispersed, biocompatible, and hemocompatible Ce-Tb-doped core@shell NaGdF4:20Ce@NaGdF4:5Tb (CS) nanorods prepared by a thermolysis process with an aim to enhance drug accumulation and site-specific chemotherapy in two aggressive drug-resistant human cancer cell lines, namely, cervical and TNBC. The nanorods were

Biomatrix from goat-waste in sponge/gel/powder form for tissue engineering and synergistic effect of nanoceria.

For tissue engineering (TE), decellularized matrices gained huge potential as they consist of natural biomolecules which help in cell attachment and proliferation. Among various animal tissues, goat tissue has gained least attention in spite of the fact that goat tissue is less susceptible to disease transmission as compared to cadaveric porcine and bovine tissue. In this study, goat small intestine submucosa (G-SIS) was isolated from goat small intestine (G-SI), a waste from goat-slaughterhouse, and decellularized to obtain decellularized G-SIS (DG-SIS) biomatrix in the form of powder, gel an

[Prevalence of thyroid function in pregnant and lactating women in areas with different iodine levels of Shanxi province].

Objective: To investigate the effects of high iodine intake on thyroid function in pregnant and lactating women. Methods: A cross sectional epidemiological study was conducted among 130 pregnant women and 220 lactating women aged 19-40 years in areas with high environment iodine level (>300 μg/L) or proper environment iodine level (50-100 μg/L) in Shanxi in 2014. The general information, urine samples and blood samples of the women surveyed and water samples were collected. The water and urine iodine levels were detected with arsenic and cerium catalysis spectrophotometric method, the blood TS…

[The study of blood serum trace elements in comparison with the structural and functional characteristics of goiter and the carriage of antithyroid antibodies in some regions of Russia].

The study of the sufficiency with essential trace elements in the context of thyroid pathology is especially relevant, since the development … results with foreign data, as well as with our results on urinary iodine level, obtained by routine cerium-arsenite method, we can assume that iodine content in blood serum corresponded to the lower limit of the normal target values. The median concentration of selenium in blood serum also practically coincided in all three regions, amounting to 68.2, 72 …

Nanoparticles Based Therapeutic Approaches in Oncogenic Viral Infections: A Review.

Nanotechnology has revolutionized biomedical research by providing novel strategies for the prevention, diagnosis, and treatment of oncogenic viral infections. Nanoparticles, possessing tunable physicochemical properties, enable targeted drug delivery, enhance vaccine efficacy, and facilitate advanced viral diagnostics, addressing key limitations of conventional therapies. Oncogenic viruses contribute substantially to the global burden of cancer through persistent infections and are influenced by environmental and lifestyle factors. The objective of this review is to synthesize and critically

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… Inorganic nanoparticles such as silver nanoparticles (AgNPs), gold nanoparticles (AuNPs), zinc oxide, and cerium oxide inactivate viruses through direct binding to viral envelopes or capsids, generation of ROS that damage viral proteins and nucleic acids, and disruption of viral entry into host cells … Metallic nanoparticles including silver, gold, copper oxide, and cerium oxide, are known to generate ROS, which can disrupt the cellular redox equilibrium, induce lipid peroxidation, damage mitochondria, and prompt cell death. 166 , 167 This oxidative stress can activate signaling cascades, for example …

Нанозимы: инновационная терапия в борьбе с нейродегенеративными заболеваниями.

Нейродегенеративные заболевания, включая болезнь Альцгеймера (AD), болезнь Паркинсона (PD), множественный склероз (MS), амиотропический боковой склероз (ALS) и болезнь Хантингтона (HD), представляют собой серьезную проблему для здоровья населения мира из-за их прогрессивного характера и отсутствия лечения. Эти расстройства характеризуются окислительным стрессом, завязыванием белка и нейроинфламмацией, которые в совокупности приводят к нервным повреждениям и смерти. Последние достижения в нанотехнологии позволили внедрить нанозменные наноматериалы, которые имитируют деятельность, похожую на фер

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… Among these, cerium-based nanomaterials have been extensively studied for their antioxidant mechanisms. … The mechanism of superoxide radical dismutation by cerium nanoparticles is illustrated below. …

Biomimetic materials for medical applications.

AbstractRecent advances in biomedical research have facilitated the exploration of biomimetic materials and their potential for diagnosing and treating diseases. This review synthesizes reports of recent research into biomimetic materials and provides a focused analysis of their therapeutic and diagnostic efficacy across multiple physiological systems, including the locomotor, digestive, respiratory, urinary, endocrine, nervous, integumentary, hematopoietic, and circulatory systems. These findings highlight the transformative potential of these materials in the management of systemic diseases.

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… Song et al [ 27 ] used macrophage membranes to encapsulate epigallocatechin gallate-cerium nanoparticles. Cerium ions mimic natural enzyme active sites and scavenge ROS and reactive nitrogen species with efficiency exceeding 90%. … Peng et al [ 103 ] reported a cerium-based tannic acid nanozyme with excellent ROS scavenging ability in a viral pneumonia model. Nanozymes are internalized by activated macrophages and epithelial cells at inflammation sites. …

Methods of Topical Administration of Drugs and Biological Active Substances for Dental Implants-A Narrative Review.

Dental implants are, nowadays, established surgical devices for the restoration of lost teeth. Considered as an alternative for traditional prosthetic appliances, dental implants surpass them in reliability and patient feedback. Local drug delivery around the implants promotes osseointegration and reduces peri-implantitis. However, there are currently no methods of a multiple, precise topical administration of drugs to the implant area. Engineering coatings on the implants, drug application on carriers during implantation, or gingival pockets do not meet all requirements of dental surgeons. Th

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… The new promising material for dental implants may also be cerium oxide-incorporated calcium silicate coatings. One investigation proved that this material has relevant antimicrobial activity on Enterococcus faecalis , promotes osteoblastic differentiation and provides good biocompatibility [ 61 ]. … Chemical Stability and Antimicrobial Activity of Plasma-Sprayed Cerium Oxide-Incorporated Calcium Silicate Coating in Dental Implants. Implant. Dent. 2019;28:564–570. doi: 10.1097/ID.0000000000000937. 62. Yang D.H., Moon S.W., Lee D.W. …

Current Advancement of Immunomodulatory Drugs as Potential Pharmacotherapies for Autoimmunity Based Neurological Diseases.

Dramatic advancement has been made in recent decades to understand the basis of autoimmunity-mediated neurological diseases. These diseases create a strong influence on the central nervous system (CNS) and the peripheral nervous system (PNS), leading to various clinical manifestations and numerous symptoms. Multiple sclerosis (MS) is the most prevalent autoimmune neurological disease while NMO spectrum disorder (NMOSD) is less common. Furthermore, evidence supports the presence of autoimmune mechanisms contributing to the pathogenesis of amyotrophic lateral sclerosis (ALS), which is a neurodeg

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… Cerium Oxide Nanoparticles Cerium nanoparticles are also known as nanoceria. They are regarded as multifunctional nanopolymers that have high catalase or dismutase activity and higher bioavailability. … Yeast cell viability significantly increases after the implementation of cerium oxide nanoparticles due to Alpha -synuclein (α-syn) expression. …

Устранение неврологических расстройств путем борьбы с нейродегенеративными ассоциированными ферментами: естественные и синтетические молекулы.

Неврологические расстройства, включая нейродегенеративные и нейро-воспалительные заболевания, создают значительные проблемы в области здравоохранения и клинических проблем. Недавние исследования показали, что различные ферменты играют ключевую роль в наступлении и развитии этих расстройств. В этом обзоре изучается терапевтический потенциал адресации этих ферментов естественными и синтетическими молекулами. К таким заболеваниям, как болезнь Альцгеймера, болезнь Паркинсона и множественный склероз, причастны основные ферменты, включая ацетилхолинестеразу, оксидазу моноамина, бета-секретазу, тау к

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… The effects of many enzymes that help reduce oxidative stress, like phosphatase, catalase, and superoxide dismutase (SOD), can be accurately mimicked by cerium oxide (CeO) nanoparticles [ 310 ]. … Gil et al. examined the advantageous and antioxidant properties of nanocrystalline cerium dioxide (CeO2) under the condition that it is conjugated with CAT and SOD enzymes. The findings showed that nanoceria and antioxidant enzymes were sufficiently stable [ 311 ]. …

Skin cancer: understanding the journey of transformation from conventional to advanced treatment approaches.

Skin cancer is a global threat to the healthcare system and is estimated to incline tremendously in the next 20 years, if not diagnosed at an early stage. Even though it is curable at an early stage, novel drug identification, clinical success, and drug resistance is another major challenge. To bridge the gap and bring effective treatment, it is important to understand the etiology of skin carcinoma, the mechanism of cell proliferation, factors affecting cell growth, and the mechanism of drug resistance. The current article focusses on understanding the structural diversity of skin cancers, tr

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… TEM images of ZnO nanoparticles in which Low magnification FESEM image, ( F ) high-magnification FESEM image, ( G ) Low magnification TEM image of ZnO, and ( H ) high-magnification TEM image of ZnO showing distance between lattice fringes around 0.265 nm [ 252 ], ( I and J ) TEM and FESEM image of cerium …

Антивоспламенительный макропхаж-сухие экзосомы, модифицированные с помощью самоантигенных пептидов для лечения экспериментального аутоиммунного энцефаломелита.

Текущее лечение аутоиммунных заболеваний часто сопряжено с широкодействующими иммунодепрессантами, которые сопряжены с такими рисками, как инфекционные заболевания и болезни. В ходе этого исследования изучается вопрос о том, могут ли экзосомы, полученные из антивоспалительных макрофаг (АЭ) и украшенные миэлином олигодендроцитом гликопротеином (МОГ) пептидом (АЭ/М), способствовать иммунной терпимости при аутоиммунных заболеваниях. Экспериментальный аутоиммунный энцефаломиэлит (EAE), модель мыши для множественных склерозов, служит моделью аутоиммунных заболеваний. Экзосомы, получаемые из миоблас

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… Synthetic nanomaterials, including cerium oxide nanoparticles and carbon‐based materials, offer unique mechanisms in the treatment of autoimmune diseases. … Cerium oxide nanoparticles, known for their reactive oxygen species (ROS) scavenging activity, have shown effectiveness in the experimental autoimmune encephalomyelitis mouse model. [ 2 ] Additionally, graphene oxide nanosheets are effective in modulating neuroinflammation, chiefly by diminishing …

Pectin: A Bioactive Food Polysaccharide with Cancer Preventive Potential.

Pectin is an acidic heteropolysaccharide found in the cell walls and the primary and middle lamella of land plants. To be authorized as a food additive, industrial pectins must meet strict guidelines set forth by the Food and Agricultural Organization and must contain at least 65% polygalacturonic acid to achieve the E440 level. Fruit pectin derived from oranges or apples is commonly used in the food industry to gel or thicken foods and to stabilize acid-based milk beverages. It is a naturally occurring component and can be ingested by dietary consumption of fruit and vegetables. Preventing lo

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… Toxicological Profile An erythrocyte hemolysis assay was used to determine the cytotoxicity of pectin cerium oxide nanoparticles (Pe-CeO 2 NPs), finding for the first time that when Pe-CeO 2 NPs are detected in their natural habitat, they are biocompatible with living creatures [ 99 ]. … Bio-therapeutic Potential and Cytotoxicity Assessment of Pectin-Mediated Synthesized Nanostructured Cerium Oxide Appl. Biochem. Biotechnol. 2016 180 638 654 10.1007/s12010-016-2121-9 27234032 100. Bagliotti Meneguin A. Stringhetti Ferreira Cury B. Evangelista R.C. …

Innovative Biomaterials for the Treatment of Bone Cancer.

Bone cancer is a demanding challenge for contemporary medicine due to its high frequency of presentation and significant heterogeneity of malignant lesions developing within the bone. To date, available treatments are rarely curative and are primarily aimed at prolonging patients' survival and ameliorating their quality of life. Furthermore, both pharmacological and surgical therapies are aggravated by a consistent burden of adverse events and subsequent disability due to the loss of healthy bone structural and functional properties. Therefore, great research efforts are being made to develop

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… Here, calcium phosphate (CaP), calcium carbonate (CaCO 3 ), mesoporous silica (MS), and cerium oxide (CeO 2 ) are reported among the most used inorganic materials for the production of delivery systems. … Webster T.J. pH-Dependent Activity of Dextran-Coated Cerium Oxide Nanoparticles on Prohibiting Osteosarcoma Cell Proliferation ACS Biomater. Sci. Eng. 2015 1 1096 1103 10.1021/acsbiomaterials.5b00194 33429551 69. Tapeinos C. Battaglini M. Prato M. La Rosa G. Scarpellini A. Ciofani G. …

TrkB promotes laryngeal cancer metastasis via activation PI3K/AKT pathway.

ObjectivesThe aim of our study was to investigate the role of TrkB pathway in tumor occurrence and development for in order to provide theoretical basis to laryngeal cancer therapy.Materials and methodsBiological characteristics of the cells were studied by migration tests and colony forming assay. Gene and protein expression analysis was performed by RT-PCR or western blot. in vivo experiments were conducted in syngeneic BALB/c mice.ResultsSignificant changes in protein and gene expression, including higher expression level of TrkB, were found in cells and laryngeal cancer specimens. we demon

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… Evaluation of in vitro cytotoxicity, biocompatibility, and changes in the expression of apoptosis regulatory proteins induced by cerium oxide nanocrystals. Sci Technol Adv Mater. 2017;18:364–73. doi: 10.1080/14686996.2017.1319731. https://doi.org/10.1080/14686996.2017.1319731 . 38. …