Результаты поиска

Construction and validation of nomogram prediction model for anxiety and depression in chemotherapy patients with multiple myeloma.

ObjectiveTo construct and validate a nomogram prediction model for anxiety and depression in chemotherapy patients with multiple myeloma (MM).MethodsFrom May 2021 to May 2023, 333 MM chemotherapy patients treated at our hospital were selected. The patients were randomly divided into a modeling group and a validation group in a 7:3 ratio (using a random number table method). According to whether the modeling group patients had anxiety and depression, they were grouped into a non-anxiety and depression group and an anxiety and depression group; a nomogram model constructed using R software was b

Epidemiology, clinical profile and treatment patterns of venous thromboembolism in cancer patients in Taiwan: a population-based study.

BackgroundVenous thromboembolism (VTE) is a clinically significant complication that is well documented among Caucasian cancer patients. However, evidence regarding VTE incidence and treatment among Asian cancer patients is very limited. The objective of this study is to investigate the incidence, risk factors and management of VTE among Taiwanese cancer patients.MethodsUsing Taiwan's National Health Insurance Research Database, we identified 43,855 newly diagnosed cancer patients between 2001 and 2008. Two alternative algorithms for identifying VTE event were explored to better quantify a ran

Incidence and survival of transthyretin amyloid cardiomyopathy from a French nationwide study of in- and out-patient databases.

BACKGROUND: Precise data about ATTR-CM incidence rates at national level are scarce. Consequently, this study aimed to estimate the annual incidence and survival of transthyretin amyloid cardiomyopathy (ATTR-CM) in France between 2011 and 2019 using real world data. We used the French nationwide exhaustive data (SNDS database) gathering in- and out-patient claims. As there is no specific ICD-10 marker code for ATTR-CM, diagnosis required both amyloidosis (identified by E85. ICD-10 code or a tafamidis meglumine delivery) and a cardiovascular condition (identified by ICD-10 or medical procedure

Integrating Artificial Intelligence, Circulating Tumor DNA, and Real-World Evidence to Optimize Hematologic Clinical Trials: Toward Adaptive and Learning Trial Designs.

The integration of emerging technologies and real-world data is transforming the landscape of hematologic clinical trials. Artificial intelligence (AI) offers remarkable capabilities for predictive modeling, patient stratification, and adaptive trial design, while circulating tumor DNA (ctDNA) provides a minimally invasive biomarker for disease monitoring, the early detection of relapse, and treatment response assessment. Concurrently, real-world evidence (RWE) complements traditional clinical trial data by capturing treatment effectiveness, safety, and patient outcomes in broader, heterogeneo

Опыт женщин в области психосоциальной поддержки после периодических нарушений: качественный анализ содержания.

КОЛИЧЕСТВО: Дородовой уход (АНК) имеет решающее значение для сокращения материнской и неонатальной смертности путем выявления и лечения осложнений во время беременности. В Индонезии политика, предусматривающая, по крайней мере, six Введены посещения АНК (К6) на одну беременность, однако факторы, влияющие на адекватность АНК в рамках этой новой политики, остаются неоцененными. В этом исследовании рассматриваются национальные и субнациональные распространенность надлежащих посещений АНК, а также связанные с ними географические и социально-экономические факторы. МЕТОДЫ: В настоящем перекрестном и

Medication-Related Osteonecrosis of the Jaw: An Evidence-Based 2025 Position Statement from a Korean Multidisciplinary Task Force.

With a rapidly aging population and increasing use of antiresorptive agents, medication-related osteonecrosis of the jaw (MRONJ) represents a growing clinical challenge worldwide. To address the need for tailored clinical guidance, a multidisciplinary task force was convened. Five Korean academic societies-the Korean Society for Bone and Mineral Research, the Korean Association of Oral and Maxillofacial Surgeons, the Korean Society of Maxillofacial Plastic and Reconstructive Surgeons, the Korean Osteoporosis Society, and the Korean Endocrine Society-collaborated to develop this position statem

Демографическое исследование митохондриальных заболеваний и состояния психического здоровья в Онтарио, Канада.

КОЛИЧЕСТВО: Митохондриальное заболевание связано с психическим расстройством в клинических когортах и в послесмертных исследованиях. Однако отсутствие исследований на уровне населения, посвященных изучению взаимосвязи между митохондриальным заболеванием и психическим здоровьем, привело к пробелу в данных и создает проблему для выявления и удовлетворения потребностей в уходе за митохондриальным заболеванием. С использованием многочисленных баз данных о состоянии здоровья населения в системе здравоохранения с одним плательщиком, которая охватывает все население, цель этого исследования заключала

Weight Change after Cancer Diagnosis and Risk of Diabetes Mellitus: A Population-Based Nationwide Study.

PurposeCancer survivors are at increased risk of diabetes mellitus (DM). Additionally, the prevalence of obesity, which is also a risk factor for DM, is increasing in cancer survivors. We investigated the associations between weight change after cancer diagnosis and DM risk.Materials and methodsThis retrospective cohort study used data from the Korean National Health Insurance Service. Participants who were newly diagnosed with cancer from 2010 to 2016 and received national health screening before and after diagnosis were included and followed until 2019. Weight change status after cancer diag

Impact of population ageing on cancer-related disability-adjusted life years: A global decomposition analysis.

BACKGROUND: As the global population ages, the burden of cancer is increasing. We aimed to assess the impact of population ageing on cancer-related disability-adjusted life years (DALYs). METHODS: We used the decomposition method to estimate the impact of ageing, population growth, and epidemiological change on cancer-related DALYs from 1990 to 2019, stratified by 204 countries/territories and by their sociodemographic index (SDI). This approach separates the net effect of population ageing from population growth and change in age-specific DALY rates. RESULTS: Cancer-related DALYs among indi

Анализ негативных явлений, происшедших после COVID-19 вакцинация и инфекция: Ретроспективное сравнительное когортное исследование с использованием базы данных о претензиях организации " Discovery Health " , управляемой организацией по уходу в Южной Африке.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Неблагоприятные события, COVID-19 В последние годы широко изучался вопрос о вакцинации. Вместе с тем по-прежнему ощущается нехватка данных, непосредственно сопоставляющих неблагоприятные явления COVID-19 вакцины и лица, SARS-CoV-2 - инфекция внутри застрахованного населения Южной Африки (ЮА). Кроме того, масштабы описанных в настоящем исследовании условий превышают масштабы большинства существующих исследований, обеспечивая уникальный взгляд на потенциальные иммунные последствия. Таким образом, данное исследование способствует более глубокому пониманию характеристик риск

Health economic evidence for the use of molecular biomarker tests in hematological malignancies: A systematic review.

ObjectivesMolecular biomarker tests can inform the clinical management of genomic heterogeneous hematological malignancies, yet their availability in routine care largely depends on the supporting health economic evidence. This study aims to systematically review the economic evidence for recent molecular biomarker tests in hematological malignancies.MethodsWe conducted a systematic search in five electronic databases for studies published between January 2010 and October 2020. Publications were independently screened by two reviewers. Clinical study characteristics, economic methodology, and

Cost-effectiveness of cancer interventions in Rwanda: literature review and expert elicitation for health benefits package design.

IntroductionPrioritising health benefits packages (HBPs) that specify which health services are covered under insurance is sometimes done in disease-specific clusters. Cancer is a good candidate for this, given its high cost and rising disease burden, particularly in low- and middle-income countries.The Government of Rwanda assessed 49 cancers against nine criteria to inform the design of its HBP. Each cancer had a basic, core and enhanced package of services, and one preventive intervention was assessed, totalling 148 interventions. This paper focuses on the results of one criterion: cost-eff

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… This was part of a wider government effort aimed at ensuring the financial sustainability of its community-based health insurance (CBHI) scheme, while responding to demand for coverage of new services. … Government of rwanda Ministerial instructions n° 20/7017 of 31/08/2021 determining the methodology to define the community-based health insurance benefit package. 2021 11. Glassman A, Giedon U, Smith P. Washington DC: Center for Global Development; 2017. …

Residential green spaces and neurodegenerative diseases in middle-aged and older adults: a systematic review and dose-response meta-analysis.

BackgroundThe potential protective role of residential green space against neurodegenerative diseases (NDs) is a topic of growing interest, yet evidence remains inconsistent. This systematic review and meta-analysis aimed to synthesize the current evidence on this association in middle-aged and older adults.MethodsWe searched PubMed, Embase, Web of Science, and the Cochrane Library through March 15, 2025, for observational studies that evaluated the association between objectively measured residential green space and the incidence of NDs in middle-aged and older adults. Risk of bias was assess

Scientific Advancements in Gene Therapies: Opportunities for Global Regulatory Convergence.

On 4 September 2024, the Reagan-Udall Foundation for the FDA (FDA Foundation) in collaboration with the Food and Drug Administration (FDA) and the Gates Foundation hosted a workshop titled "Scientific Advancements in Gene Therapies: Opportunities for Global Regulatory Convergence". The event brought together a diverse group of experts, including international regulatory bodies, regulated industries, healthcare professionals, patients, academic researchers and global health advocates, to discuss the rapid advancements in gene therapy and the pressing need for equitable access in low-and middle-

Quality of life assessment & out-of-pocket expenditure in multiple myeloma: An observational study.

BACKGROUND & OBJECTIVES: Prognosis of patients with multiple myeloma (MM) has improved significantly in the past two decades. However, the symptoms burden is high at onset and treatment is generally prolonged with significant financial burden. This study was undertaken to assess the quality of life (QoL) and to analyse out-of-pocket expenditure (OOPE) incurred on MM patients being treated at a tertiary care cancer centre in north India. METHODS: This observational, cross-sectional study included 116 patients (aged >18 yr) of MM (both newly diagnosed and those with recurrent disease). For QoL

Опыт автоматической трансплантации стволовой клетки в Множественной миеломе: взгляд пациента и сторожа.

Было проведено качественное исследование опыта пациентов, получивших аутологическую трансплантацию стволовых клеток (ASCT) для лечения множественной миеломы (MM), с тем чтобы лучше понять их болезнь MM, включая первые симптомы, диагностику, ASCT и восстановление. Sixteen Участники, включая 12 пациентов с ММ и 4 В ходе совещаний целевых групп были проведены беседы с лицами, обеспечивающими уход за пациентами, имеющими MM. Боль, слабость и боль в костях были распространенными первыми симптомами среди пациентов. Диагноз MM часто делал гематолог или онколог. Пациенты после диагноза направляются к

Accelerating novel therapies for sickle cell disease with RWE: ASH RC Data Hub as a strategically coordinated registry network.

AbstractReal-world evidence (RWE) has been used to improve quality of care, accelerate innovation, and evaluate emerging therapies for drugs, devices, and biologics. The Coordinated Registry Network (CRN), aggregating and linking highly curated patient data, has emerged as a model for RWE generation that has guided the development of the American Society of Hematology Research Collaborative (ASH RC) Data Hub. With the aim of bolstering research, enhancing clinical care, and expediting evidence generation using RWE, the ASH RC and the Innovative Genomics Institute launched a joint initiative, "

Post-infusion Costs Associated with Idecabtagene Vicleucel Treatment for Patients with Relapsed/Refractory Multiple Myeloma in the KarMMa Trial.

IntroductionPatients with triple-class exposed relapsed/refractory multiple myeloma (RRMM) have poor outcomes with substantial healthcare costs. Idecabtagene vicleucel (ide-cel), a B-cell maturation antigen (BCMA)-directed chimeric antigen receptor (CAR) T cell therapy, showed deep, durable responses in patients with RRMM in the pivotal phase 2 KarMMa trial (NCT03361748). Healthcare resource utilization (HCRU) and costs were estimated for ide-cel-treated patients in the KarMMa trial.MethodsPost-infusion costs were estimated based on HCRU data, including facility care, diagnostics, medications,

Valorising and creating access to innovative medicines in the European union.

This Perspective describes (a) the current situation, (b) challenges and initiatives, (c) and formulates recommendations to valorize and create access to innovative medicines in the EU. We are currently still far away from optimal assessment of value for money in the EU. On the one hand, valorizing innovative medicines involves a local appraisal by health technology assessment (HTA) bodies and competent authorities about the value for money, the budget impact, and the local medical need that can be filled with new medicines. Therefore, local priorities and national health care policy environme

Обоснование 4-month, параллельные, выборочно контролируемые испытания для оценки осуществимости и эффективности дистанционного обучения испаноязычных/латиноязычных лиц с множественным склерозом (FERLA MS).

ИСТОРИЯ ВОПРОСА: Испаноязычные/латиноязычные лица с множественным склерозом (МС) сталкиваются с бóльшим бременем болезней и коморбидностью из-за ограниченного доступа к медицинскому обслуживанию, недостаточной представленности в научных исследованиях и социальных факторов, определяющих состояние здоровья (SDOH). Профессиональная подготовка могла бы способствовать достижению результатов в области здравоохранения, однако в существующих исследованиях, посвященных мерам вмешательства, не представлены испаноязычные/латиноязычные страны. МЕТОДЫ: Мы предлагаем провести технико-экономическое обоснован