Результаты поиска

Maternal and childhood nutrition and later blood pressure levels in young Guatemalan adults.

BACKGROUND: Low birth weight and subsequent rapid child growth are associated with later blood pressure levels. The role of maternal and child nutrition in this association remains unclear. METHODS: We studied 450 men and women (ages 21-29 years) born during a randomized trial of protein-energy supplementation (Atole) vs low energy/no protein supplementation (Fresco) in pregnancy and early childhood in four rural Guatemalan villages from 1969 to 1977. RESULTS: Protein-energy supplementation was not associated with differences in blood pressure in adulthood (diastolic blood pressure (DBP): be…

A randomized double-blind study of caspofungin versus fluconazole for the treatment of esophageal candidiasis.

BACKGROUND: Candida esophagitis remains an important cause of morbidity in patients with advanced human immunodeficiency virus (HIV) infection. Fluconazole is widely regarded as the treatment of choice for this condition. METHODS: The efficacy and safety of caspofungin were compared with fluconazole in adult patients with Candida esophagitis in a double-blind randomized trial. Eligible patients had symptoms compatible with esophagitis, endoscopic demonstration of mucosal plaques, and microscopic demonstration of Candida from the esophageal lesions. Patients were randomly assigned to receive c

The 2023 Latin America report of the Lancet Countdown on health and climate change: the imperative for health-centred climate-resilient development.

In 2023, a series of climatological and political events unfolded, partly driving forward the global climate and health agenda while simulta … its geographical scope adding Mexico and five Central American countries: Costa Rica, El Salvador, Guatemala, Honduras, and Panama, as a response to the need for stronger collaboration in a region with significant social disparities, including research capacities and funding. The centre is an independent and multidisciplinary collaboration that tracks the …

The structure and change of mortality in a Maya community.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Cooking with liquefied petroleum gas or biomass and fetal growth outcomes: a multi-country randomised controlled trial.

BACKGROUND: Household air pollution might lead to fetal growth restriction during pregnancy. We aimed to investigate whether a liquefied petroleum gas (LPG) intervention to reduce personal exposures to household air pollution during pregnancy would alter fetal growth. METHODS: The Household Air Pollution Intervention Network (HAPIN) trial was an open-label randomised controlled trial conducted in ten resource-limited settings across Guatemala, India, Peru, and Rwanda. Pregnant women aged 18-34 years (9-19 weeks of gestation) were randomly assigned in a 1:1 ratio to receive an LPG stove, conti…

Global perspectives on lupus nephritis: a review of clinical trials and therapeutic innovations.

BACKGROUND AND OBJECTIVES: Lupus nephritis (LN) remains a leading cause of morbidity and mortality in systemic lupus erythematosus (SLE). Although recent years have witnessed the approval of several targeted therapies, achieving long-term, drug-free remission remains challenging. This commentary evaluates the global landscape of interventional LN clinical trials from 2001 to 2026 to identify emerging trends and strategic gaps in drug development. METHODS: We analyzed 200 interventional pharmacological trials retrieved from three major global registries: ClinicalTrials.gov, Chinadrugtrials.org

Совпадение в полном тексте источника
… Belgium, Brazil, Czech, Germany, Israel, Italy, Mexico, Holland, Russia, United Kingdom, | III+/- V, IV +/- V, V NCT04181762 (Terminated) | Phase III | 2020 | Secukinumab | United States, Argentina, Australia, Brazil, Canada, Chile, China, Colombia, Croatia, Czech, Denmark, France, Germany, Greece, Guatemala … Completed) | Phase III | 2022 | Abetimus sodium (LJP 394) | United States, Austria, Canada, France, Germany, Italy, Mexico, Spain, Sweden, United Kingdom | CTR20223330 (Terminated) | Phase III | 2022 | Secukinumab Injection | China, Czechia, Japan, Thailand, Spain, Slovakia, South Korea, Portugal, Guatemala …

Невидимый кризис: выявление скрытого воздействия загрязнения воздуха внутри помещений на здоровье человека - аналитическое исследование.

Загрязнение воздуха внутри помещений представляет собой серьезную проблему для здоровья населения, особенно в таких странах, как Индия, где миллионы людей подвергаются воздействию вредных загрязнителей в своих домах и на рабочих местах. В этом аналитическом обзоре рассматриваются многогранные последствия загрязнения воздуха внутри помещений для здоровья людей, обобщены данные, полученные в ходе различных проектов исследований и в географических регионах. На основе всеобъемлющей стратегии поиска, которая позволила 320 записи, в которых 120 в Паубмеде, 108 Веб-сайт науки, и 92 В SCOPUS. Ten были

Совпадение в полном тексте источника
… (McCracken et al ., 2011)[ 28 ] | Guatemala | Complementary study designs | 119 | Stove intervention | Exposure to wood smoke in the home can alter ventricular repolarization and perhaps compromise cardiovascular health. … McCracken J Smith KR Stone P Díaz A Arana B Schwartz J Intervention to lower household wood smoke exposure in guatemala reduces ST-segment depression on electrocardiograms Environ Health Perspect 2011 119 1562 8 21669557 10.1289/ehp.1002834 PMC3226487 29. …

The ABA-1 allergen of Ascaris lumbricoides: sequence polymorphism, stage and tissue-specific expression, lipid binding function, and protein biophysical properties.

The ABA-1 protein of Ascaris lumbricoides (of humans) and Ascaris suum (of pigs) is abundant in the pseudocoelomic fluid of the parasites and also appears to be released by the tissue-parasitic larvae and the adult stages. The genes encoding the polyprotein precursor of ABA-1 (aba-1) were found to be arranged similarly in the two taxa, comprising tandemly repeating units encoding a large polyprotein which is cleaved to yield polypeptides of approximately 15 kDa which fall into 2 distinct classes, types A and B. The polyprotein possibly comprises only 10 units. The aba-1 gene of A. lumbricoides

Descriptions of three hundred new species of Hesperiidae (Lepidoptera: Papilionoidea).

Genomic sequencing and analysis offer a fast track to cataloguing biodiversity and facilitating species discovery. A comprehensive genomic s … octenus stenopapias Grishin, new species (Peru: Madre de Dios), Phocides tema Grishin, new species (Guatemala), Bungalotis lotis Grishin, new species (Belize), Dyscophellus porsenica Grishin, new species (Peru: Madre de Dios), Dyscophellus santamarta Grishin, new species (Colombia: Magdalena), Euriphellus huellus Grishin, new species (Colombia: Vaupés), Cec …

Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants.

BACKGROUND: Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age traj … th the shortest populations (Timor-Leste, Laos, Solomon Islands, and Papua New Guinea for boys; and Guatemala, Bangladesh, Nepal, and Timor-Leste for girls). In the same year, the difference between the highest mean BMI (in Pacific island countries, Kuwait, Bahrain, The Bahamas, Chile, the USA, and New Zealand for both boys and girls and in South Africa for …

Replication of genome-wide association study (GWAS) susceptibility loci in a Latino bipolar disorder cohort.

OBJECTIVES: Recent genome-wide association studies (GWASs) have identified numerous putative genetic polymorphisms associated with bipolar disorder (BD) and/or schizophrenia (SC). We hypothesized that a portion of these polymorphisms would also be associated with BD in the Latino American population. To identify such regions, we tested previously identified genetic variants associated with BD and/or SC and ancestral haploblocks containing these single nucleotide polymorphisms (SNPs) in a sample of Latino subjects with BD. METHODS: A total of 2254 Latino individuals were genotyped for 91 SNPs

Low-dose aspirin for the prevention of preterm delivery in nulliparous women with a singleton pregnancy (ASPIRIN): a randomised, double-blind, placebo-controlled trial.

BACKGROUND: Preterm birth remains a common cause of neonatal mortality, with a disproportionately high burden in low-income and middle-incom … tes in six countries (two sites in India and one site each in the Democratic Republic of the Congo, Guatemala, Kenya, Pakistan, and Zambia). Participants were randomly assigned (1:1, stratified by site) to receive aspirin or placebo tablets of identical appearance, via a sequence generated centrally by the data coordinating centre at Research Triangle Insti …

Association of Genetic Ancestry With the Molecular Subtypes and Prognosis of Childhood Acute Lymphoblastic Leukemia.

IMPORTANCE: Racial and ethnic disparities persist in the incidence and treatment outcomes of childhood acute lymphoblastic leukemia (ALL). H … ontline trials from the United States, South East Asia (Singapore and Malaysia), and Latin America (Guatemala), representing diverse populations of European, African, Native American, East Asian, and South Asian descent. Statistical analysis was conducted from February 3, 2020, to April 19, 2021. MAIN OUTCOMES AND MEASURES: Molecular subtypes of ALL and ge …

Proteomic analysis of venom variability and ontogeny across the arboreal palm-pitvipers (genus Bothriechis).

UNLABELLED: Bothriechis is a genus of eleven currently recognized slender and arboreal venomous snakes, commonly called palm-pitvipers that … e northern Middle American highland palm-pitvipers, B. thalassinus, B. aurifer, and B. bicolor from Guatemala, B. marchi from Honduras, and neonate Costa Rican B. lateralis and B. schlegelii, were investigated. B. thalassinus and B. aurifer venoms are comprised by similar toxin arsenals dominated by SVMPs (33-39% of the venom proteome), CTLs (11-16%), BPP-l …

The relationship between knowledge and behaviour.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Head injury and neuropsychiatric sequelae in asylum seekers.

OBJECTIVE: Asylum seekers experience a high burden of physical and psychological trauma, yet there is a scarcity of literature regarding the epidemiology and sequelae of head injury (HI) in asylum seekers. We examined HI prevalence and association with neuropsychiatric comorbidities in asylum seekers. METHODS: A retrospective cross-sectional study was performed through review of 139 medical affidavits from an affidavit database. Affidavits written from 2010 to 2018 were included. Demographic and case-related data were collected and classified based on the presence of HI. For neuropsychiatric

Multiple myeloma in Latin America: A systematic review.

The incidence of multiple myeloma (MM) has surged globally, particularly in Latin American countries, and is attributable to an aging population and increased life expectancy. This systematic review analyzes the epidemiology, patient characteristics, and treatment outcomes for MM in selected Latin American countries: Brazil, Mexico, Colombia, Argentina, Chile, Peru, and Uruguay. PubMed and the Latin American and Caribbean Health Sciences Literature (LILACS), conference abstracts (between June 2019 and June 2022), and GLOBOCAN registry (January 2010 to June 2022) were electronically searched. Q

Совпадение в полном тексте источника
… | Country/countries | Total score/8 | Quality of included study Abello et al. [ 15 ] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | Colombia | 1 | High Hungria et al. [ 16 ] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | Argentina, Brazil, Chile, Colombia, Mexico, Panama, and Guatemala | 1 | High Cowan et al. [ 17 ] | 1 | 1 | … According to the Haemato‐Oncology Latin America Observational Study (HOLA) conducted between 2008 and 2016 across the Latin American countries of Argentina, Brazil, Chile, Colombia, Mexico, Panama, and Guatemala, the first‐line therapy was largely thalidomide‐ (54.9%) and bortezomib‐based (29%). …

Consensus Statement: Importance of Timely Access to Multiple Myeloma Diagnosis and Treatment in Central America and the Caribbean.

BackgroundIn Central America and the Caribbean, multiple myeloma (MM) patients face significant barriers to diagnosis and treatment. The aim of this study is to describe the current situation of MM in the region, discuss the current barriers to timely diagnosis and proper treatment, and develop consensus recommendations to address these issues.MethodsNine experts from five countries took part in a virtual consensus meeting on MM in Central America and the Caribbean. During the meeting, experts analyzed the disease burden, the current conditions for disease management, and access to treatment i

Совпадение в полном тексте источника
… A 2019 study of patients in Brazil, Panama, Mexico, Guatemala, Chile, and Colombia reported high rates of comorbidity in MM patients, including a variety of chronic diseases and other medical conditions. … The 2019 study undertaken in Brazil, Panama, Mexico, Guatemala, Chile, and Colombia found that hematologists were the first point of contact for 24.9% of MM patients, followed by internists and general practitioners at 15.4%. …

Breastfeeding promotion: the right start.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Vaccines for preventing enterotoxigenic Escherichia coli (ETEC) diarrhoea.

BACKGROUND: Infection with enterotoxigenic Escherichia coli (ETEC) bacteria is a common cause of diarrhoea in adults and children in develop … e recombinant cholera toxin B-subunit, was evaluated in people travelling from the USA to Mexico or Guatemala, and from Austria to Latin America, Africa, or Asia. We did not identify any statistically significant differences in ETEC-specific diarrhoea or all-cause diarrhoea (two trials, 799 participants), and the vaccine was associated with increased vomiti …