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Molecular biomarkers in cerebrospinal fluid of multiple sclerosis patients.

Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system, usually occurring in young adults and leading to disability. Despite the progress in technology and intensive research work of the last years, diagnosing MS can still be challenging. A heterogenic and complex pathophysiology with various types of disease courses makes MS unique for each patient. There is an urgent need to identify markers facilitating rapid and accurate diagnosis and prognostic assessments with regard to optimal therapy for each MS patient. Cerebrospinal fluid (CSF) is an outstanding so…

Soluble egg antigen from Schistosoma japonicum modulates the progression of chronic progressive experimental autoimmune encephalomyelitis via Th2-shift response.

Soluble egg antigen (SEA) is strongly antigenic and inherently induces Th2-biased immune responses. In this study, we tested whether SEA from Schistosoma japonicum is able to prevent experimental autoimmune encephalomyelitis (EAE) induced by MOG(35-55) peptide, an established animal model of multiple sclerosis (MS). Intraperitoneal administration with SEA before EAE induction and in the preclinical phase after EAE induction successfully ameliorated the severity and progression of EAE on mice compared with phosphate buffered saline (PBS) controls, while no protective effect was shown when SEA i…

Regional mapping of CSF1R-positive microglia in neurodegenerative diseases and progressive MS, with exploratory presynaptic marker analyses.

BACKGROUND: Microglial colony-stimulating factor-1 receptor (CSF1R) is a therapeutic and imaging target, yet the regional, disease-specific distribution of CSF1R-positive microglia in the human brain remains incompletely defined, limiting interpretation of emerging CSF1R-PET signals. We sought to build a cross-disease, multi-region, quantitative map of CSF1R-positive microglia in neurodegenerative conditions and progressive multiple sclerosis (MS) lesions, with an exploratory comparison to presynaptic marker burden. METHODS: CSF1R mRNA‑positive microglia were quantified by RNAscope across six…

Клеточная терапия с мезентичными стволовыми клетками, изготовленными плацентой, для вторичных прогрессивных пациентов с множественным склерозом в а фазы 1 Клинические испытания.

Мезенхимальные стволовые клетки (МСЦ) привлекли значительное внимание к клиническим исследованиям в связи с их иммуномодулятивными свойствами и потенциалом уменьшения воспаления при аутоиммунных расстройствах, таких, как множественный склероз (МС). В настоящем исследовании оценивается безопасность и осуществимость использования МСЦ-В (МСЦ-В) на основе плаценты в five - участники с множественным склерозом второго этапа (СФМ). Основные результаты были сосредоточены на безопасности и терпимости, которые были оценены на основе мониторинга неблагоприятных явлений. six месяцев. Вторичные результаты

Совпадение в аннотации оригинала
Mesenchymal stem cell (MSC) has attracted significant attention in clinical research due to their immunomodulatory properties and potential to reduce inflammation in autoimmune disorders, such as multiple sclerosis (MS). This study evaluates the safety and feasibility of placenta-derived MSCs (PLMSCs) in five participants with secondary-progressive multiple …

Longitudinal changes in magnetisation transfer ratio in secondary progressive multiple sclerosis: data from a randomised placebo controlled trial of lamotrigine.

Sodium blockade with lamotrigine is neuroprotective in animal models of central nervous system demyelination. This study evaluated the effect of lamotrigine on magnetisation transfer ratio (MTR), a putative magnetic resonance imaging measure of intact brain tissue, in a group of subjects with secondary progressive multiple sclerosis (MS). In addition, the utility of MTR measures for detecting change in clinically relevant pathology was evaluated. One hundred seventeen people attending the National Hospital for Neurology and Neurosurgery or the Royal Free Hospital, London, UK, were recruited in…

Menarche, oral contraceptives, pregnancy and progression of disability in relapsing onset and progressive onset multiple sclerosis.

Female gender and hormones have been associated with disease activity in multiple sclerosis (MS). We investigated age at menarche, use of oral contraceptives and pregnancy in relation to progression of disability in relapsing onset and progressive onset MS. We conducted a cross-sectional survey among individuals with MS, registered by the Flemish MS Society in Belgium. A time-to-event analysis and Cox proportional hazard regression were performed with time to Expanded Disability Status Score (EDSS) of 6 (requires a cane) as outcome measure. Hazard ratios for the time from onset and the time fr…

[Emerging research progress on Epstein-Barr virus-related clinical diseases].

Epstein-Barr virus (EBV) infects over 95% of the global population and is closely associated with various tumor and non-tumor diseases. In r … post-transplant lymphoproliferative diseases and demonstrate good efficacy in treating progressive multiple sclerosis; Immune checkpoint inhibitors have shown outstanding efficacy in EBV associated gastric cancer and Hodgkin lymphoma; Allogeneic hematopoietic stem cell transplantation has increased the long-term survival rate of chronic active EB virus disease to 5 …

Dual-Targeting miR-219 and miR-146a in Multiple Sclerosis: Bridging Myelin Repair and Neuroinflammation for Novel Therapeutic Insights.

Multiple sclerosis (MS) is a debilitating neurological disorder involving concurrent immune-mediated demyelination and progressive neurodegeneration. Although disease-modifying therapies (DMTs) effectively modulate peripheral immune responses and reduce relapse rates, they are ineffective at halting disease progression and promoting central nervous system (CNS) repair. This review outlines a new therapeutic approach that targets two important microRNAs: miR-219, which stimulates oligodendrogenesis and remyelination, and miR-146a, which regulates innate immune responses and neuroinflammation. W…

Dimethyl fumarate as a promising therapeutic candidate for virus-associated myelopathy.

Human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic, progressive neuroinflammatory disease with no effective treatment. In this study, we investigated whether dimethyl fumarate (DMF), an immunomodulatory agent approved for treating multiple sclerosis, exerts therapeutic effects relevant to HAM/TSP. Peripheral blood mononuclear cells (PBMCs) from 16 people living with HAM/TSP were used to evaluate the effects of DMF on cell viability, spontaneous proliferation, inflammatory cytokine production and HTLV-1 proviral load (PVL). …

T cell-mediated immunodysregulation in multiple sclerosis: from pathogenic subsets to therapeutic advances.

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) caused by chronic inflammation. It is the leading cause of neurologic symptoms in young people and leads to progressive neurodegenerative disability. Accumulating evidence indicates that MS arises from the coordinated and co-dominant actions of peripheral immune cells, meningeal tertiary lymphoid structures (TLS), and CNS-resident immune compartments. Within this complex immunopathological network, dysregulated T-cell-mediated adaptive immune responses play a pivotal role in initiating and organizing autoimm…

Opioid Signaling in Multiple Sclerosis: Emerging Targets for Repair.

Multiple sclerosis (MS) is a chronic immune-mediated disorder of the central nervous system (CNS) characterized by persistent inflammation, demyelination, and progressive neurodegeneration, driven largely by aberrant activation of T and B lymphocytes that infiltrate the CNS and cause myelin and axonal damage, leading to neurological impairment. Although current therapies broadly suppress immune activity and reduce relapse rates, their effects on neurodegenerative processes remain limited. Also, the safety profile of disease-modifying therapies (DMTs) may become problematic, especially in older…

TLR3 polymorphism protects against multiple sclerosis onset but not progression in Egyptian patients.

INTRODUCTION: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the CNS that results from complex interactions between the peripheral and the central immune systems through proinflammatory cytokine secretion. AIMS: The present study aimed to 1: estimate the associated risk of single nucleotide polymorphisms (SNPs) in genes regulating the immune responses, namely, Toll like receptor 3 (TLR3), TLR7, and Suppressor of cytokine signaling 3 (SOCS3), with MS incidence, 2: correlate the SNPs frequencies with some patient demographics. MATERIALS AND METHODS: A total of 192 M…

A Stage-Dependent Translational Signature in Peripheral Blood Mononuclear Cells from Clinically Isolated Syndrome to Relapsing-Remitting Multiple Sclerosis: An Exploratory Cross-Sectional Study.

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system characterized by inflammatory demyelination, neurodegeneration, and progressive disability. Clinically isolated syndrome (CIS) often represents the first overt presentation of MS. We performed an exploratory cross-sectional transcriptomic investigation of peripheral blood mononuclear cells (PBMCs) from healthy controls (HC, n = 40), CIS patients (n = 49), and Relapsing-Remitting MS (RRMS, n = 53) patients using the ArrayExpress dataset E-MTAB-11415. Differential expression analysis was performed using limma, …

Учёба в области сегментации повреждений в множестве склерозов: технико-экономическое обоснование с использованием различных центров в реальном мире.

Множественный склероз (MS) — хроническое нервно-воспалительное заболевание, вызванное повреждением центральной нервной системы с иммунной помощью, часто приводящее к постепенной инвалидности. Точные сегментации повреждений MS на МРТ имеют решающее значение для мониторинга заболеваний и эффективности лечения; однако ручная сегментация по-прежнему занимает много времени и подвержена колебаниям. Несмотря на то, что углубленное обучение позволило усовершенствовать автоматизированную сегментацию, высокие показатели эффективности получают пользу от использования крупномасштабных, разнообразных набор

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is a chronic neuroinflammatory disease driven by immune-mediated central nervous system damage, often leading to progressive disability. Accurate segmentation of MS lesions on MRI is crucial for monitoring disease and treatment efficacy; however, manual segmentation remains time-consuming and prone to variability. While deep learning …

ANKRD55 is a key regulator of T cell inflammation in multiple sclerosis.

Multiple sclerosis (MS) is a progressive, chronic, and highly disabling neuroinflammatory disorder characterized by demyelination and T cell-driven inflammation. Pathogenic T cells play a central role in MS, but effective therapeutic targeting remains challenging. Here, we identified ankyrin repeat domain-containing protein 55 (ANKRD55) as a key regulator of T cell function by single-cell transcriptomic analysis of cerebrospinal fluid and blood from MS patients. ANKRD55 was predominantly expressed in CD4+ T cells in both compartments. Genetic ablation of Ankrd55 led to a robustly reduced disea…

Протеиновая киназа C Modolor bryosstatin-1 в терапевтическом порядке направлена на уменьшение нейроинфламмации и поощрение ремиэлизации.

В множестве склерозов (MS) микроглиа и макрофаги в центральной нервной системе (CNS) играют важную роль в определении баланса между демиелинацией, нейродегенерацией и ремонтом миелина. Фагоцитичные и регенерационные функции этих врожденных иммунных клеток поддерживают ремиелионацию, в то время как хроническая и неадаптационная провокационная активация способствует расширению масштабов поражения и инвалидности, особенно в прогрессивных формах MS. В настоящее время ни одно из утвержденных лекарственных средств не нацелено на микроглию и макрофаги в рамках ЦНС, что ведет к отсутствию методов лече

Совпадение в аннотации оригинала
In multiple sclerosis (MS), microglia and macrophages within the central nervous system (CNS) play an important role in determining the balance among demyelination, neurodegeneration, and myelin repair. Phagocytic and regenerative functions of these CNS innate immune cells support remyelination, whereas chronic and maladaptive inflammatory activation promote…

Лазерно-приводимые кортики в мышах в качестве модели прогрессивной многоклерозной патологии.

Справочная информация: В нынешних моделях склероза (MS) для животных основное внимание уделяется воспалению белой материи, отражающему раннее заболевание. Однако прогрессивные MS (PMS) характеризуются кортикальной патологией, включая подпиальное демиэлирование, хроническое менингеальное воспаление и микроглиальную активацию, которые недопредставлены в существующих моделях. В то время как альтернативные модели мыши воспроизводят релапсирующий фенотип и серую патологию материи, патология часто рассеивается по мозгу, что осложняет анализ конкретных участков поражения. Методы: Для устранения этого

Совпадение в аннотации оригинала
Background: The current animal models of multiple sclerosis (MS) predominantly emphasize white matter inflammation, reflecting early-stage disease. However, progressive MS (PMS) is characterized by cortical pathology, including subpial demyelination, chronic meningeal inflammation, and microglial activation, which are underrepresented in the existing models.…

Unusual demyelinating disease in a patient with HIV infection.

Demyelinating central nervous system (CNS) disorders are a diverse group of conditions characterised by damage to the myelin sheath. These include not only primary autoimmune disorders such as multiple sclerosis (MS) or neuromyelitis optica spectrum disorder (NMOSD), but secondary demyelinating conditions caused by infection and neoplasm, where immunosuppressive therapy may worsen the condition or delay definitive treatment. We describe a young man with an unusual presentation of CNS demyelinating disease associated with HIV infection and positive syphilis serology. MRI brain and spine showed …

[Genetic diffuse cystic lung disease in adults].

Multiple cystic lung diseases comprise a wide range of various diseases, some of them of genetic origin. Lymphangioleiomyomatosis (LAM) is a disease occurring almost exclusively in women, sporadically or in association with tuberous sclerosis complex (TSC). Patients with LAM present with lymphatic complications, renal angiomyolipomas and cystic lung disease responsible for spontaneous pneumothoraces and progressive respiratory insufficiency. TSC and LAM have been ascribed to mutations in TSC1 or TSC2 genes. Patients with TSC are variably affected by cutaneous, cognitive and neuropsychiatric ma

miR-181a-5p is a potential candidate epigenetic biomarker in multiple sclerosis.

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) characterized by demyelination and axonal degeneration. Abnormal expression of microRNAs (miRNAs) plays an important role in MS pathology. In this cohort study, differential expression of the four miRNAs (hsa-miR-155-5p, hsa-miR-9-5p, hsa-miR-181a-5p, and hsa-miR-125b-5p) was investigated in 69 individuals, including 39 MS patients (relapsing-remitting MS (RRMS), n = 27; secondary progressive MS (SPMS), n = 12) and 30 healthy controls. In silico analyses revealed possible genes and pathways specific t…