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Наблюдение за финансовыми трудностями пациентов с множественной миеломой и хронической лимфоцитической лейкемией, проходящих лечение в онкологических клиниках США (Alliance A231602CD).

ЦЕЛИ: Оценка доли и корреляции финансовых трудностей, о которых сообщают сами пациенты с множественной миеломой (ММ) или хронической лимфоцитической лейкемией (КЛ). Вечеринка: Sixty-six Общинная практика США и практики меньшинств в области онкологии связана с Программой общинных онкологических исследований Национального института раковых заболеваний (НКОРП). Участники: в целом 521 (больные)≥18 С согласия MM или CLL и 416 :: ответы на опрос (процент завершения)79.8%). Респонденты имели диагноз MM (MM-диагностика)74.0%), степень бакалавра или выше (53.4%), белые (или белые).89.2%), застрахованны

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… : Ohio, Michigan, Indiana, Wisconsin, Illinois, Minnesota, Iowa, Missouri, North Dakota, South Dakota, Nebraska and Kansas; South: Delaware, Maryland, Virginia, West Virginia, Kentucky, North Carolina, South Carolina, Tennessee, Georgia, Florida, Alabama, Mississippi, Arkansas, Louisiana, Texas and Oklahoma … Ohio, Michigan, Indiana, Wisconsin, Illinois, Minnesota, Iowa, Missouri, North Dakota, South Dakota, Nebraska and Kansas; South: Delaware, Maryland, Virginia, West Virginia, Kentucky, North Carolina, South Carolina, Tennessee, Georgia, Florida, Alabama, Mississippi, Arkansas, Louisiana, Texas, and Oklahoma …

Proceedings to the 2020 Online Conference of the Particle Therapy Cooperative Group (PTCOG2020Online): 13-14 September 2020Organized by the Particle Therapy Cooperative Group (PTCOG), this special online meeting featured abstracts and programs that enabled the communication and cross fertilization for which PTCOG meetings are known.

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The burden of diseases, injuries, and risk factors by state in the USA, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021.

BACKGROUND: The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 provides a comprehensive assessment of health and ris … tates had higher age-standardised YLD rates than any country in the world: West Virginia, Kentucky, Oklahoma, Pennsylvania, New Mexico, Ohio, Tennessee, and Arizona. Low back pain was the leading cause of YLDs in the USA in 1990 and 2021, although the age-standardised rate declined by 7·9% (1·8-13·0) from 1990. Depressive disorders (56·0% increase [48·2-64 …

Surveillance for Violent Deaths - National Violent Death Reporting System, 42 States, the District of Columbia, and Puerto Rico, 2019.

PROBLEM/CONDITION: In 2019, approximately 67,000 persons died of violence-related injuries in the United States. This report summarizes data … ntana, Nebraska, Nevada, New Hampshire, New Jersey, New Mexico, North Carolina, North Dakota, Ohio, Oklahoma, Oregon, Rhode Island, South Carolina, Utah, Vermont, Virginia, Washington, West Virginia, Wisconsin, and Wyoming), three states with data from counties representing a subset of their population (30 California counties, representing 57% of its popul …

Эпидемиология множественного склероза: глобальные, региональные, национальные и субнациональные оценки и будущие прогнозы.

ИСТОРИЯ ВОПРОСА: Эпидемиология множественных склерозов (МС) является сложной в силу взаимодействия различных факторов риска. В настоящем исследовании дается оценка глобального, регионального, национального и субнационального бремени НР и прогнозируются будущие тенденции. МЕТОДЫ: Данные, полученные в ходе глобального исследования бремени болезней 2021 был проанализирован с целью оценки эпидемиологии MS 1990 в адрес 2021. Данные Всемирного банка использовались для определения социально-демографических прогнозов распространенности НР с использованием многовариантного анализа. РЕЗУЛЬТАТЫ: НА глоба

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… Idaho 4.57 4.93 8.0 Colorado 4.46 4.73 6.1 Michigan 4.26 4.55 6.8 New Hampshire 4.34 4.48 3.3 South Dakota 4.05 4.45 10.0 Washington 4.45 4.45 0.1 Wisconsin 4.44 4.44 0.1 Vermont 4.15 4.40 6.0 States with the lowest rates Tennessee 3.03 3.22 6.6 South Carolina 2.79 3.08 10.2 Georgia 2.63 2.90 10.0 Oklahoma …

Case series: Odontohypophosphatasia or missed diagnosis of childhood/adult-onset hypophosphatasia? - Call for a long-term follow-up of premature loss of primary teeth.

IntroductionHypophosphatasia, a metabolic bone disease caused by a tissue-nonspecific alkaline phosphatase deficiency, leads to undermineralization of bone and/or teeth, impaired vitamin B6 metabolism, and a spectrum of disease presentation. At the mild end of the spectrum, it presents as pathologic fractures in later adulthood. Patients with isolated dental manifestations, typically presenting as premature loss of primary teeth, are classified as having odontohypophosphatasia (odontoHPP). A subset of patients diagnosed with odontoHPP in childhood can later develop extra-dental manifestations

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… Variable penetrance of hypophosphatasemia in a large Oklahoma kindred. Am. J. Med. 1982;72:631–641. doi: 10.1016/0002-9343(82)90474-0. Whyte M., Greenberg C., Salman N., Bober M., McAlister W., Wenkert D. Enzyme-replacement therapy in life-threatening hypophosphatasia. N. Engl. J. …

Oral cancer therapy: policy implications for the uninsured and underinsured populations.

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… 2009), Vermont (2010), Connecticut (2010), Kansas (2010), Colorado (2010), Minnesota (2010), Illinois (2011), New Mexico (2011), Texas (2011), New York (2011), Washington (2011), New Jersey (2012), Maryland (2012), Virginia (2012), Delaware (2012), Louisiana (2012), Massachusetts (2013), Utah (2013), Oklahoma …

Emerging trends and disparities in mortality due to coexisting non-Hodgkin's lymphoma and respiratory infections: A U.S. nationwide retrospective analysis from 1999 to 2020.

Non-Hodgkin lymphoma (NHL) patients are highly susceptible to respiratory infections due to immunosuppression from both the disease and its treatments. Understanding mortality trends and disparities in this population is crucial for improving care and reducing the burden of coexisting conditions. This study analyzed death certificates from the Center of Disease Control Wide-Ranging Online Data for Epidemiologic Research database for individuals aged ≥ 25 years who died between 1999 and 2020 with both NHL and respiratory infections. Age-adjusted mortality rates (AAMRs) and annual percent change

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… States in the top 90th percentile (Oklahoma, West Virginia, Kentucky, South Dakota, Nebraska, Rhode Island, Vermont) had AAMRs nearly twice as high as those in the bottom 10th percentile (District of Columbia, Louisiana, Georgia, Arizona, Nevada, Virginia, Florida) (Fig. 4 , Table S7, Supplemental Digital …

Воздействие дефицита витамина D до трансплантации на иммунную реабилитацию и клинические результаты у многих пациентов с миеломой, проходящих аутологическую трансплантацию стволовых клеток.

В этом исследовании анализируется воздействие дефицита витамина D перед трансплантацией на иммунную реабилитацию и клинические результаты у многих пациентов с миэломой, проходящих аутологическую трансплантацию стволовых клеток (ASCT). Учитывая известное иммунодуляторное воздействие витамина D, исследование описывает его влияние на нейтрофиль и энграфацию тромбоцитов, восстановление лимфоцитов и общие коэффициенты реагирования после ASCT. Анализируя ретроспективную когорту, исследование показывает потенциальные связи между состоянием витамина D и восстановлением иммунной системы после трансплан

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… Ethics statement The studies involving humans were approved by University of Oklahoma institutional review board. The studies were conducted in accordance with the local legislation and institutional requirements. …

Predictors of functional health status of end stage renal disease patients.

Potential predictors of the functional health status of 125 end stage renal disease (ESRD) patients were studied cross-sectionally. When health status was assessed by the physician with the Karnofsky Index, younger patient age, lower ESRD severity of illness, lower comorbidity severity, and higher albumin levels were predictors of better health [R-square = 0.48]. When patients self-reported their health status with the Duke Health Profile, African-American race, higher family support, lower family stress, and lower ESRD severity were positive predictors [R-square = 0.23]. The importance of mea

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… compared with those of 413 primary care patients (mean age = 40.4 ± 13.1 SD years, 58.6 percent women) from a community health center located about 50 miles from the dialysis units, and with 3,525 policyholders (mean age = 52.2 ± 12.0 SD years, 59.2 percent women) from a health insurance company in Oklahoma …

PROMIS® Health Organization (PHO) 2021 Conference Abstracts.

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Assisted Reproductive Technology Surveillance - 
United States, 2013.

PROBLEM/CONDITION: Since the first U.S. infant conceived with assisted reproductive technology (ART) was born in 1981, both the use of ART a … n Rhode Island to 26.9% in West Virginia) among singletons to 61.0% (range: 47.8% in DC to 78.8% in Oklahoma) among twins; the corresponding percentages among all infants were 10.1% for singletons (range: 6.8% in Vermont to 14.8% in Mississippi) and 56.6% for twins (range: 44.7% in New Hampshire to 68.9% in Louisiana). INTERPRETATION: The percentage of in …

An Update in Drug-Induced Thrombotic Microangiopathy.

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… Drug-induced thrombotic microangiopathy: experience of the oklahoma registry and the bloodcenter of wisconsin . Am J Hematol . ( 2015 ) 90 : 406 – 10 . 10.1002/ajh.23960 25639727 PMC4409501 13. Kazi S Preston GC . Drug induced thrombotic microangiopathy caused by levofloxacin . …

Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015.

BACKGROUND: Healthy life expectancy (HALE) and disability-adjusted life-years (DALYs) provide summary measures of health across geographies and time that can inform assessments of epidemiological patterns and health system performance, help to prioritise investments in research and development, and monitor progress toward the Sustainable Development Goals (SDGs). We aimed to provide updated HALE and DALYs for geographies worldwide and evaluate how disease burden changes with development. METHODS: We used results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 20

Acute Kidney Injury in the Patient with Cancer.

Over the last three decades, advancements in the diagnosis, treatment, and supportive care of patients with cancer have significantly improved their overall survival. However, these advancements have also led to a higher rate of cancer-related complications. Acute kidney injury (AKI) and chronic kidney disease (CKD) are highly prevalent in patients with cancer, and they are associated with an increased risk of all-cause mortality. This bidirectional interplay between cancer and kidney, termed "the kidney-cancer connection" has become a very active area of research. This review aims to provide

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… The Oklahoma Thrombotic Thrombocytopenic Purpura-Hemolytic Uremic Syndrome (TTP-HUS) Registry: A Community Perspective of Patients with Clinically Diagnosed TTP-HUS Semin. Hematol. 2004 41 60 67 10.1053/j.seminhematol.2003.10.001 14727260 54. Moake J.L. Chow T.W. …

Временные тенденции и различия в показателях смертности от сердечно-сосудистых заболеваний среди взрослых с множественными миеломами в Соединенных Штатах, 1999-2023.

Новелловые лечебные агенты существенно улучшили выживание многих миэлома (ММ), в результате чего сердечно-сосудистые заболевания (КВД) стали основной причиной смертности, не связанной с раком. Потому что MM в основном затрагивает пожилых людей (средний возраст) 69 ) при повышенном сердечно-сосудистом риске мы сосредоточили внимание на взрослых ≥ 45 Годы. Комплексные национальные данные о временных тенденциях и демографических диспропорциях в смертности, связанной с КЖР, среди пациентов с ОМ остаются ограниченными. Methods Мы провели ретроспективный анализ с использованием данных базы данных CD

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… States with suppressed counts are labeled NA Several states demonstrated pronounced late-2010s increases with statistically significant trends, including Illinois, South Carolina, Oklahoma, Maryland, Minnesota, Wisconsin, Virginia, and Mississippi (Supplemental Table 1). … Several states demonstrated significant late-2010s increases (Illinois, South Carolina, Oklahoma, Maryland, Minnesota, Wisconsin, Virginia, Mississippi), while others sustained long-term declines (New York, Connecticut, Missouri, West Virginia, Alabama, Ohio). …

Clinical Manifestations, Treatment Characteristics, and Clinical Outcomes in Patients with Immune Thrombotic Thrombocytopenic Purpura (iTTP) in a Real-World Setting: An Interim Analysis of the Turkish iTTP Registry

OBJECTIVE: This study aimed to investigate the clinical manifestations, treatment patterns, and clinical outcomes of patients with immune thrombotic thrombocytopenic purpura (iTTP) across Türkiye via an interim analysis of the Turkish iTTP Registry. MATERIALS AND METHODS: A total of 215 patients with iTTP (median age at diagnosis: 41 years; 58.6% female) diagnosed between 2001 and 2023 were retrospectively analyzed in the interim analysis of a prospective non-interventional observational multicenter iTTP registry study (ClinicalTrials.gov Identifier: NCT05950750) conducted at 19 tertiary hema

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… Data from the Oklahoma Registry revealed the typical clinical presentation of acquired TTP patients to include gastrointestinal symptoms (69%), weakness (63%), bleeding or purpura (54%), major (41%) and minor (26%) neurological findings, and fever (10%) [ 19 ]. …

Risk Factors Analysis of Phantom Limb Pain in Amputees with Malignant Tumors.

PurposePostamputation neuropathic pain is a common disease in patients with malignant tumor amputation, seriously affecting amputees' quality of life and mental health. The objective of this study was to identify independent risk factors for phantom limb pain in patients with tumor amputation and to construct a risk prediction model.MethodsPatients who underwent amputation due to malignant tumors from 2013 to 2023 were retrospectively analyzed and divided into phantom limb pain group and non-phantom limb pain group. To determine which preoperative factors would affect the occurrence of phantom

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… The relationship between experienced discrimination and pronociceptive processes in native americans: results from the Oklahoma study of native American pain risk. J Pain . 2022;23(6):1006–1024. doi: 10.1016/j.jpain.2021.12.010 34. Larbig W, Andoh J, Huse E, et al. …

Invited Lectures : Overviews Purinergic signalling: past, present and future.

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Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015.

BACKGROUND: Non-fatal outcomes of disease and injury increasingly detract from the ability of the world's population to live in full health, a trend largely attributable to an epidemiological transition in many countries from causes affecting children, to non-communicable diseases (NCDs) more common in adults. For the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015), we estimated the incidence, prevalence, and years lived with disability for diseases and injuries at the global, regional, and national scale over the period of 1990 to 2015. METHODS: We estimated incid