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A Recent Review on Cancer Nanomedicine.

Cancer is one of the most prevalent diseases globally and is the second major cause of death in the United States. Despite the continuous efforts to understand tumor mechanisms and various approaches taken for treatment over decades, no significant improvements have been observed in cancer therapy. Lack of tumor specificity, dose-related toxicity, low bioavailability, and lack of stability of chemotherapeutics are major hindrances to cancer treatment. Nanomedicine has drawn the attention of many researchers due to its potential for tumor-specific delivery while minimizing unwanted side effects

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… The frequently used surfactants are poloxamers, lecithin, sodium glycocholate, polysorbates, sorbitan esters, and mixtures [ 16 ]. … However, the frequently used surfactants are Tween (e.g., Tween 20, Tween 40, and Tween 80), poloxamer (e.g., Pluronic F68 and Pluronic F127), Solutol HS15, polyvinyl alcohol, sodium salts of oleic, deoxycholic, and glycolic acids, polyglycerol methyl glucose distearate, TegoCare 450, egg lecithin, and …

Monoclonal antibody and protein therapeutic formulations for subcutaneous delivery: high-concentration, low-volume vs. low-concentration, high-volume.

Biologic drugs are used to treat a variety of cancers and chronic diseases. While most of these treatments are administered intravenously by trained healthcare professionals, a noticeable trend has emerged favoring subcutaneous (SC) administration. SC administration of biologics poses several challenges. Biologic drugs often require higher doses for optimal efficacy, surpassing the low volume capacity of traditional SC delivery methods like autoinjectors. Consequently, high concentrations of active ingredients are needed, creating time-consuming formulation obstacles. Alternatives to tradition

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… denaturation in both powder and liquid formulations, and acting as cryoprotectants to improve the long-term stability of frozen formulations. 84 , 131 Salts such as kosmotropic sulfate and phosphate anions increase protein structural stability. 131 Non-ionic surfactants such as polysorbate 20 or 80 or poloxamer … associated with several adverse reactions, including injection site pain, acute hypersensitivity, and systemic immunostimulation reactions. 17 , 47 , 84 Polysorbate 80 is included in a concentration range of 0.1–2 mg/mL (0.01–0.2%), polysorbate 20 in a concentration range of 0.1–4 mg/mL (0.01–0.4%), and poloxamer …

An expanding horizon of complex injectable products: development and regulatory considerations.

There has been a constant evolution in the pharmaceutical market concerning the new technologies imbibed in delivering drug substances for various indications. This is either market-driven or technology-driven to improve the overall therapeutic efficacy and patients' quality of life. The pharmaceutical industry has experienced rapid growth in the area of complex injectable products because of their effectiveness in the unmet market. These novel parenteral products, viz, the nanoparticles, liposomes, microspheres, suspensions, and emulsions, have proven their worth as "Safe and Effective" produ

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… . | Sandostatin LAR ® Depot | Octreotide acetate | Peptide | Microparticle | Equation 10, 20 or 30 mg base/vial | Octreotide distributed within PLGA copolymer; mannitol Diluent: Na-CMC, mannitol, poloxamer 188, WFI | Acromegaly, carcinoid tumor | I.M. | Initial dosing is usually 50 mcg administered twice … Upward dose titration is frequently required | Nov 25, 1998 | Novartis Pharmaceuticals Corp | [ 39 ] 27. | Signifor ® LAR | Pasireotide pamoate | Peptide | Microparticle | Equation 10, 20, 30, 40, and 60 mg base/vial | Pasiriotide pamoate distributed within PLGA copolymer Diluent: Na-CMC, mannitol, poloxamer …

The Glycocalyx and Its Role in Vascular Physiology and Vascular Related Diseases.

PurposeIn 2007 the two senior authors wrote a review on the structure and function of the endothelial glycocalyx layer (Weinbaum in Annu Rev Biomed Eng 9:121-167, 2007). Since then there has been an explosion of interest in this hydrated gel-like structure that coats the luminal surface of endothelial cells that line our vasculature due to its important functions in (A) basic vascular physiology and (B) vascular related diseases. This review will highlight the major advances that have occurred since our 2007 paper.MethodsA literature search mainly focusing on the role of the glycocalyx in the

Late Breaking Orals.

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… Whereas the total concentration of EVs was unaffected by the presence of Poloxamer‐188 or Tween 20, the size distribution in Tween 20 differed from DPBS, and DPBS containing BSA or Poloxamer‐188. … Thus, Poloxamer‐188 can safely be used in MRPS to size particles, including EVS, in suspension. Funding : M. …

Isatuximab, lenalidomide, dexamethasone and bortezomib in transplant-ineligible multiple myeloma: the randomized phase 3 BENEFIT trial.

CD38-targeting immunotherapy is approved in combination with lenalidomide and dexamethasone in patients with newly diagnosed multiple myeloma (NDMM) that are transplant ineligible (TI) and is considered the best standard of care (SOC). To improve current SOC, we evaluated the added value of weekly bortezomib (V) to isatuximab plus lenalidomide and dexamethasone (IsaRd versus Isa-VRd). This Intergroupe Francophone of Myeloma phase 3 study randomized 270 patients with NDMM that were TI, aged 65-79 years, to IsaRd versus Isa-VRd arms. The primary endpoint was a minimal residual disease (MRD) nega

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… Subject has known allergies, hypersensitivity or intolerance to steroids, mannitol, pregelatinized starch, sodium stearyl fumarate, histidine (as base and hydrochloride salt), arginine hydrochloride, poloxamer 188, sucrose or any of the other components of study intervention that are not amenable to …

Anti-PEG Antibodies and Their Biological Impact on PEGylated Drugs: Challenges and Strategies for Optimization.

Polyethylene glycol (PEG) has been widely utilized in optimizing therapeutics due to its excellent biocompatibility and chemical stability. However, multiple dosing of PEGylated drugs may result in toxicity due to PEG accumulation in tissues, leading to the formation of anti-PEG antibodies (APAs), which can accelerate drug clearance, reduce efficacy, and alongside enhanced side effects, such as allergic reactions. Notably, pre-existing APAs have also been detected in individuals with no prior exposure to PEGylated drugs, raising additional clinical concerns. This review summarizes the mechanis

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… For instance, poloxamer 188 (F68), which contains poly (ethylene oxide) segments structurally similar to PEG, significantly induced anti-PEG IgM and IgG in mice. This immune response can lead to the ABC effect upon subsequent administration of PEGylated nanodrugs [ 47 ]. …

Polyphenols: Chemoprevention and therapeutic potentials in hematological malignancies.

Polyphenols are one of the largest plant-derived natural product and they play an important role in plants' defense as well as in human health and disease. A number of them are pleiotropic molecules and have been shown to regulate signaling pathways, immune response and cell growth and proliferation which all play a role in cancer development. Hematological malignancies on the other hand, are cancers of the blood. While current therapies are efficacious, they are usually expensive and with unwanted side effects. Thus, the search for newer less toxic agents. Polyphenols have been reported to po

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… Nirachonkul et al. showed that anti-CD123-curcumin-loaded PLGA/poloxamer nanoparticles (anti-CD123-Cur-NPs) exhibited more cytotoxicity than curcumin-loaded PLGA/poloxamer nanoparticles (Cur-NPs) in leukemia stem cells ( 317 ). …

Piperine: From Green Extraction to Clinical Translation-A Review.

BACKGROUND: Piperine has diverse pharmacological and bioenhancing activities, but poor aqueous solubility, variable exposure, interaction liability, and discontinuity across production, formulation, and clinical evaluation limit translation. This review integrates these frequently separated stages. METHODS: A structured narrative PubMed search covered English-language studies published from 1 January 2021 to 27 April 2026, supplemented by ClinicalTrials.gov records checked through 13 June 2026, backward citation searching, and selected earlier seminal studies. Evidence was synthesized by expe

Искусственный интеллект основывается на достижениях в области наномедицины для лечения мозговых расстройств: обновленный обзор повествования.

Наномедицина - это наномасштабные, биосопоставимые материалы, которые предлагают перспективные альтернативы традиционным методам лечения расстройств мозга. Технологические достижения в области искусственного интеллекта (АИ), в частности машинного обучения (МЛ) и глубокого обучения (ДЛ), трансформируют область наномедицины путем совершенствования диагностики заболеваний, биомаркировки, прогнозирования и мониторинга заболеваний, целевых поставок наркотиков и терапевтического вмешательства, а также содействия расчетным и методологическим разработкам. Эти успехи могут быть достигнуты за счет анали

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… In this study, artificial neural network was used to optimize formulation by considering various parameters including formulation variables (glycerol monooleate, Poloxamer 407, Tween 80) and output variables (particle size, entrapment efficiency (EE), and drug release). …

Strategies to Mitigate Cisplatin-Induced Ototoxicity: A Literature Review of Protective Agents, Mechanisms, and Clinical Gaps.

BackgroundCisplatin, a widely used chemotherapeutic agent, is associated with significant ototoxicity, leading to progressive and irreversible sensorineural hearing loss in up to 93% of patients. Cisplatin generates reactive oxygen species (ROS) in the cochlea, activating apoptotic and necroptotic pathways that result in hair cell death. Inflammatory processes and nitrative stress also contribute to cochlear damage.MethodsThis literature review was conducted to explore the mechanisms underlying cisplatin-induced ototoxicity and evaluate protective strategies, including both current and emergin

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… Intratympanic Application of Poloxamer 407 Hydrogels Results in Sustained N-Acetylcysteine Delivery to the Inner Ear. Eur. J. Pharm. Biopharm. 2020;150:143–155. doi: 10.1016/j.ejpb.2020.03.005. 50. …

Modeling and addressing on-target/off-tumor toxicity of claudin 18.2 targeted immunotherapies.

Successfully extending immunotherapies to solid tumors involves addressing several key challenges, importantly the "antigen dilemma", the expression of a solid tumor target antigen on the normal tissue of tumor origin. Claudin 18.2 (CLDN18.2) has emerged as an important target for upper gastrointestinal (GI) cancer therapies (such as Zolbetuximab, a naked antibody, recently approved; or CT041, a second-generation chimeric antigen receptor (CAR) T cell therapy with promising clinical data). However, GI toxicities are reported from clinical use of both Zolbetuximab and CT041. Here, we describe c

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… Transduction efficiency could be enhanced using 1 mg/mL Poloxamer 338 (P338) (Sigma Aldrich #P2164021). vexGFP expression was measured to determine transduction efficiency in each CAR T cell batch 5–6 days after transduction by flow cytometry analysis using the 2 (V-B) or 3-laser (V-B-R) Northern Lights …

From Innate Immunity to Cancer Therapy: Antimicrobial Peptides as Emerging Anticancer Agents.

The potential for the use of antimicrobial peptides (AMPs) as anticancer agents has garnered much interest because of their selective cytotoxicity to tumor cells and ability to evade multidrug resistance mechanisms. AMPs are shorter cationic amphiphilic molecules, part of our innate immune system, with direct membrane-disruptive activity and immunomodulatory effects. Anticancer peptides (ACPs) can be derived from natural biophysical sources or synthetically engineered, taking advantage of the unique biophysical properties of cancer cell membranes to exert their anti-tumor activities rapidly an

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… Strategies to Reduce Toxicity Toxicity can be reduced by nano formulations: Melittin encapsulation in Poloxamer 188 preserved antitumor activity while reducing systemic toxicity and inflammatory allergic reactions in mice [ 112 ]. …

Current approach to the diagnosis and treatment of femoral-popliteal arterial disease. A systematic review.

Peripheral arterial disease (PAD) is a common manifestation of atherosclerosis affecting 5 million adults in the United States, with an age-adjusted prevalence of 4% to 15% and increasing up to 30% with age and the presence of cardiovascular risk factors. In this article we focus on lower extremity PAD and specifically on the superficial femoral and proximal popliteal artery (SFPA), which are the most common anatomic locations of lower extremity atherosclerosis. We summarize current evidence and perform a systematic review on the diagnostic evaluation as well as the medical, endovascular and s

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… Plasmid adjuncts, such as poloxamers, have also been used to enhance gene expression [ 77 ]. However, more studies will be needed to address the overall efficacy and safety as well as the mode and frequency of administration of angiogenic growth factors in the treatment of PAD. …

[Effects and mechanism of Lactococcus lactis thermo-sensitive hydrogel on the wound healing of full-thickness skin defects in diabetic mice].

Objective: To explore the effects and mechanism of Lactococcus lactis (L. lactis) thermo-sensitive hydrogel on the wound healing of full-thi … actic acid detection and analysis kit (n=3). (2) To prepare a simple thermo-sensitive hydrogel, the poloxamer thermo-sensitive polymer and M17GS liquid medium were mixed thoroughly according to the mass-volume ratio of 0.2 g∶1 mL. L. lactis was added to the simple thermo-sensitive hydrogel according to the volume ratio of bacteria to hydrogel of 1∶100, and …

Exploring Affordable Curative Therapy for Sickle Cell Disease in Africa: A Comprehensive Overview.

The practical aspects of developing curative treatments for sickle cell disease (SCD) in Africa, such as gene therapy and hematopoietic stem cell transplantation, involve strengthening healthcare infrastructure, training healthcare professionals, establishing regional treatment centers, and creating national SCD programs. The costs associated with gene therapy and stem cell transplants can be prohibitive, especially in low- and middle-income countries. Strategies to address affordability, including local manufacturing, government funding, and partnerships with global health agencies, are essen

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… Improving gene transfer into HSC‐enriched populations via small molecules, such as UM171 [ 117 ] and SR1 [ 118 ], along with transduction enhancers, such as poloxamer F108, cyclosporin H, and prostaglandin E2, can significantly enhance HSC gene transfer [ 119 , 120 ]. …

Adjuvant Properties of Caffeic Acid in Cancer Treatment.

Caffeic acid (CA) is a polyphenol belonging to the phenylpropanoid family, commonly found in plants and vegetables. It was first identified by Hlasiwetz in 1867 as a breakdown product of caffetannic acid. CA is biosynthesized from the amino acids tyrosine or phenylalanine through specific enzyme-catalyzed reactions. Extensive research since its discovery has revealed various health benefits associated with CA, including its antioxidant, anti-inflammatory, and anticancer properties. These effects are attributed to its ability to modulate several pathways, such as inhibiting NFkB, STAT3, and ERK

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… formulations are being developed for CA administration in different pathologies, such as transferrin (Tf)-modified nanoparticles (NPs) loaded with CA for Alzheimer’s disease (AD) [ 152 ], topical cream with nanostructured lipid carriers (NLCs) loaded with CA for anti-inflammatory action [ 153 ], and poloxamer …

A Review of Recent Curcumin Analogues and Their Antioxidant, Anti-Inflammatory, and Anticancer Activities.

Curcumin, as the main active component of turmeric (Curcuma longa), has been demonstrated with various bioactivities. However, its potential therapeutic applications are hindered by challenges such as poor solubility and bioavailability, rapid metabolism, and pan-assay interference properties. Recent advancements have aimed to overcome these limitations by developing novel curcumin analogues and modifications. This brief review critically assesses recent studies on synthesising different curcumin analogues, including metal complexes, nano particulates, and other curcumin derivatives, focused o

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… Recently, solid dispersions (SDs) of DiMC were prepared with polyethylene glycol (PEG) 4000, PEG 6000, and poloxamer 188 as carriers using the fusion method and polyvinylpyrrolidone (PVP K30) as a carrier using the solvent evaporation method, respectively. …

Metastatic Breast Cancer: Review of Emerging Nanotherapeutics.

Metastases of breast cancer (BC) are often referred to as stage IV breast cancer due to their severity and high rate of mortality. The median survival time of patients with metastatic BC is reduced to 3 years. Currently, the treatment regimens for metastatic BC are similar to the primary cancer therapeutics and are limited to conventional chemotherapy, immunotherapy, radiotherapy, and surgery. However, metastatic BC shows organ-specific complex tumor cell heterogeneity, plasticity, and a distinct tumor microenvironment, leading to therapeutic failure. This issue can be successfully addressed b

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… A similar study published in 2015 investigated the use of triblock copolymer poloxamer (P188)-based NPs to improve the bioavailability of inherently insoluble succinobucol and successfully delivered the drug to the target site [ 137 ]. …

Common gamma chain cytokines-driven optimization of chimeric antigen receptor T cells: Mechanistic insights and future directions.

Malignant tumors represent a major threat to human life and health, posing persistent challenges in medical research. While chimeric antigen receptor T (CAR-T) cell therapy has demonstrated breakthrough efficacy in hematological malignancies such as leukemia and lymphoma, its application in solid tumors, including hepatocellular carcinoma, lung cancer, and pancreatic cancer, remains constrained by multiple bottlenecks. These limitations encompass the immunosuppressive tumor microenvironment, insufficient in vivo persistence of CAR-T cells, long-term treatment-induced exhaustion, and off-target

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… In H22 tumor models, the poloxamer 407/ Mycobacterium smegmatis -IL15 hydrogel achieves a 4-day in vitro release of IL-15 while reducing systemic toxicity in vivo . …