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Sphingosine-1-phosphate restores endothelial barrier integrity in ovarian hyperstimulation syndrome.

STUDY QUESTION: Are follicular fluid (FF) sphingosine-1-phosphate (S1P) levels in patients at risk of developing ovarian hyperstimulation sy … ING, METHODS: Migration assays, confocal microscopy analysis of actin filaments, immunoblotting and quail chorioallantoic membrane (CAM) assays of in-vivo angiogenesis were performed and statistical comparisons between groups were made. MAIN RESULTS AND THE ROLE OF CHANCE: The S1P concentration was significantly lower in FF from patients at risk of OHS …

Ectopic expression of a conditional GATA-2/estrogen receptor chimera arrests erythroid differentiation in a hormone-dependent manner.

The GATA factors are a family of transcriptional regulatory proteins in eukaryotes that share extensive homology in their DNA-binding domains. One enigmatic aspect of GATA factor expression is that several GATA proteins, which ostensibly share the same DNA-binding site specificity, are coexpressed in erythroid cells. To elucidate the roles of individual GATA factors in erythropoiesis, conditional alleles of GATA-1, GATA-2, and GATA-3 were prepared by fusing each of the factors to the hormone-binding domain of the human estrogen receptor (ER). These GATA/ER chimeric factors were shown to be hor

Телемедицина в искусстве для лечения нейроразвитых и неврологических расстройств: аналитическая оценка.

БАКГРУС: Искусственная терапия, охватывающая арттерапию, музыкальную терапию, драматическую терапию и танцевальную терапию с более широкой практикой экспрессивной терапии, продемонстрировала положительные результаты в лечении нейроразвитых и неврологических расстройств (ННД). Все более важное значение для улучшения доступа людей с нарушениями подвижности или людей, проживающих в отдаленных районах, к средствам телемедицины приобретает интеграция методов лечения искусств. Цель этого исследования состоит в том, чтобы составить карту существующей литературы, с тем чтобы дать углубленный обзор тел

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… Skype was used twice in music therapy studies ( Baker and Krout, 2009 ; Quail et al., 2021 ). Live violin sessions were broadcasted using FaceTime ( Bonakdarpour et al., 2021 ). … Psychol. 76, 14–25. doi: 10.1037/amp0000722 Quail Z., Bolton L., Massey K. (2021). Digital delivery of non-pharmacological intervention programmes for people living with dementia during the COVID-19 pandemic. …

Fipronil: environmental fate, ecotoxicology, and human health concerns.

Fipronil is a highly effective, broad-spectrum insecticide with potential value for the control of a wide range of crop, public hygiene, ame … tidae) is 30 micrograms a.i./g bw], and gallinaceous birds (LD50 = 11.3 mg/kg for Northern bobwhite quail), but shows low toxicity to waterfowl (LD50 > 2150 mg/kg for mallard duck). It is moderately toxic to laboratory mammals by oral exposure (LD50 = 97 mg/kg for rats; LD50 = 91 mg/kg for mice). Technical fipronil is in toxicity categories II and III, …

Manipulating Macrophage/Microglia Polarization to Treat Glioblastoma or Multiple Sclerosis.

Macrophages and microglia are implicated in several diseases with divergent roles in physiopathology. This discrepancy can be explained by their capacity to endorse different polarization states. Theoretical extremes of these states are called M1 and M2. M1 are pro-inflammatory, microbicidal, and cytotoxic whereas M2 are anti-inflammatory, immunoregulatory cells in favor of tumor progression. In pathological states, these polarizations are dysregulated, thus restoring phenotypes could be an interesting treatment approach against diseases. In this review, we will focus on compounds targeting ma

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… However, Quail and colleagues showed that although BLZ945 strongly induces tumor regression in mice, after a few weeks of treatment, a resistance to the compound appeared and the tumor rebounded. This resistance is mediated through the TAMs. … Quail D.F., Bowman R.L., Akkari L., Quick M.L., Schuhmacher A.J., Huse J.T., Holland E.C., Sutton J.C., Joyce J.A. The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas. Science. 2016;352:aad3018. doi: 10.1126/science.aad3018. 82. …

Weighted Gene Co-Expression Network Analysis (WGCNA) Reveals the Functions of Syndecan-1 to Regulate Immune Infiltration by Influenced T Cells in Glioma.

Our previous studies shown that syndecan-1 (SDC1) may be a novel class of biomarkers for the diagnosis and treatment of glioma, but its specific roles and the in-depth molecular mechanism remain elusive. Here, we used Estimation of STromal and Immune cells in Malignant Tumor tissues using Expression data (ESTIMATE) algorithms and single-sample Gene Set Enrichment Analysis (ssGSEA) algorithms to evaluate the immune score of tumor samples and quantify the relative infiltration of immune cells in the tumor microenvironment (TME), respectively, in different data sets obtained from the Chinese Glio

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… For the brain, the number of these remarkable features, including the types of brain resident cells, blood–brain barrier, and immunosuppressive environment, constitute the unique characteristics of the organ ( Quail and Joyce, 2017 ). … “WGCNA Application to Proteomic and Metabolomic Data Analysis,” in Methods in Enzymology (Elsevier; ), 135–158. 10.1016/bs.mie.2016.09.016 Quail D. F., Joyce J. A. (2017). The Microenvironmental Landscape of Brain Tumors. …

Combating challenges in CAR-T cells with engineering immunology.

Chimeric antigen receptors (CAR) T cells (CAR-T) mark a significant step towards producing safe and effective personal anticancer treatments. CAR-T strategies engineers the T cells from the patients to allow specific binding to a tumour-specific antigen. CAR-Ts are a second-wave offensive strategy to clear out remaining chemotherapy-resistant tumour cells. Though showing practical antitumor abilities in multiple haematological malignancies and solid tumour cancers, the issues of antigen escape, tumour infiltration/penetration, and toxicity side effects limit the usage of prolonged CAR-T therap

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… Recently, more researchers have been focusing on engineering CAR constructs to resist hostile TMEs caused by TGF-β ( Quail and Joyce, 2013 ). … Cells 10 , 808 . 10.3390/cells10040808 33916369 PMC8067276 Quail Daniela F. Joyce Johanna A. ( 2013 ). Microenvironmental regulation of tumor progression and metastasis . Nat. Med. 19 , 1423 – 1437 . 10.1038/nm.3394 24202395 PMC3954707 Rafiq Sarwish Hackett Christopher S. …

Abstracts of the 12th European Cytogenomics Conference 2019 : Salzburg, Austria. 6-9 July 2019

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Diagnostic Pitfall of Lytic Bone Lesions: A Case of Chromophobe Renal Cell Carcinoma Coexisting With Multiple Myeloma.

The coexistence of renal cell carcinoma (RCC) and multiple myeloma (MM) is rare and presents a significant diagnostic challenge, particularly when patients present with back pain and lytic bone lesions. Several case series and reports have documented a reciprocal relationship between the two malignancies, which may be attributed to shared etiological factors, analogous cytokine-mediated growth mechanisms, and converging clinical presentations. We report the case of a 66-year-old man diagnosed with chromophobe RCC who presented with persistent back pain and was ultimately diagnosed with coexist

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… Interleukin-6 produced by renal-cell carcinoma cells and progression of multiple myeloma N Engl J Med Sakai A Kawano M Kuramoto A 1893 1894 324 1991 https://pubmed.ncbi.nlm.nih.gov/2041555/ 2041555 10.1056/NEJM199106273242613 19 Microenvironmental regulation of tumor progression and metastasis Nat Med Quail …

Oral Candida carriage and resistance against common antifungal agents in hematopoietic stem cell transplantation recipients.

PurposeAllogeneic hematopoietic stem cell transplant (HSCT) recipients receiving long-term and high-dose immunosuppressive medications suffer commonly from oral candida infections. This prospective cohort study examined oral fungal carriage in HSCT recipients and screened the susceptibility against commonly used antifungal agents. An increasing oral occurrence of Candida spp. and the development of resistance against clinically administered fluconazole were hypothesized.MethodsTwo hundred HSCT recipients were included and followed up for 2 years post-HSCT. Oral microbiological specimens were a

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… Jackson AP, Gamble JA, Yeomans T, Moran GP, Saunders D, Harris D, Aslett M, Barrell JF, Butler G, Citiulo F, Coleman DC, de Groot PW, Goodwin TJ, Quail MA, McQuillan J, Munro CA, Pain A, Poulter RT, Rajandream MA, Renauld H, Spiering MJ, Tivey A, Gow NA, Barrell B, Sullivan DJ, Berriman M. …

The protective and chemotherapeutical role of amygdalin in induced mammary cancer in experimental mice and upregulation of related genes.

Breast cancer is a prominent health issue among oncological diseases in emerging nations. The study sought to assess the significant function of amygdalin as a protective and chemotherapeutical substance in combating this lethal condition, either independently or in conjunction with tamoxifen therapy. Breast cancer in mice was induced by 7,12-Dimethylbenz(a)anthracene (DMBA). Mice were divided into six groups, 15 mice in each group. (i) control group, (ii) carcinogenic group, (iii) tamoxifen-treated group, (iv) Amygdalin-treated group, (v) (Amygdalin + tamoxifen) group, (vi) Amygdalin protecti

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… Gasparino E The effect of heat stress on GHR, IGF-I, ANT, UCP and COXIII mRNA expression in the liver and muscle of high and low feed efficiency female quail Br. Poult. Sci. 2014 55 466 473 10.1080/00071668.2014.925090 24848692 Gasparino, E. et al. … The effect of heat stress on GHR, IGF-I, ANT, UCP and COXIII mRNA expression in the liver and muscle of high and low feed efficiency female quail. Br. Poult. Sci. 55 , 466–473. 10.1080/00071668.2014.925090 (2014). 24848692 10.1080/00071668.2014.925090 45. …

Neutrophils unveiled in chronic lymphocytic leukemia.

This review explores neutrophils' roles in chronic lymphocytic leukemia (CLL), highlighting their functions within the immune system. While neutrophils are known for fighting infections, their altered behavior in CLL significantly impacts disease progression. This review notes the reduced phagocytic abilities of neutrophils and the increased formation of neutrophil extracellular traps (NETs) in patients with CLL. It also examines the effects of CLL treatments, including chemotherapy, immunotherapy and targeted therapies, on neutrophils' count and function, stressing the need for improved strat

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… Adrover JM, McDowell SAC, He XY, Quail DF, Egeblad M. NETworking with cancer: The bidirectional interplay between cancer and neutrophil extracellular traps. Cancer Cell. (2023) 41:505–26. doi: 10.1016/j.ccell.2023.02.001, PMID: 92. Aroca-Crevillen A, Adrover JM, Hidalgo A. … Quail DF, Amulic B, Aziz M, Barnes BJ, Eruslanov E, Fridlender ZG, et al. Neutrophil phenotypes and functions in cancer: A consensus statement. J Exp Med. (2022) 219:e20220011. doi: 10.1084/jem.20220011, PMID: 108. Wculek SK, Bridgeman VL, Peakman F, Malanchi I. …

An Italian cartography of VEXAS-related thrombosis.

Thrombotic events (TEs) occur in up to 40% of patients with vacuoles, E1 enzyme, X-linked, autoinflammatory, and somatic (VEXAS) syndrome, but data on its clinical-genomics features and anticoagulation strategies are limited. To gain more insight into this, we conducted a two-step study evaluating the prevalence and outcome of TE in VEXAS. First, among 1086 patients followed for TEs, 198 were men aged >40 years with unprovoked thrombosis and no known thrombophilia; 21 also had at least one VEXAS-compatible feature and underwent UBA1 exon 3 testing. No UBA1 mutation was detected in these 21 pat

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… Adrover JM, McDowell SAC, He XY, Quail DF, Egeblad M. NETworking with cancer: the bidirectional interplay between cancer and neutrophil extracellular traps. Cancer Cell. 2023;41(3):505‐526. 10.1016/j.ccell.2023.02.001 15. Mekinian AM, Georgin‐Lavaille S, Ferrada MA, et al. …

New Insights Into the Role of Neutrophils in Lymphoma.

Under physiological conditions, neutrophils exhibit remarkable tissue surveillance capabilities, infiltrating interstitial spaces within secondary lymphoid organs such as lymph nodes and spleen, and even actively patrolling nodal tissues. These observations provide groundbreaking insight into the functional heterogeneity of neutrophils while offering new perspectives on the tumor microenvironment (TME) in lymphomas. A critical question arises: what roles might these specialized, lymphoid tissue-resident neutrophils play in lymphomagenesis through their unique phenotypic and functional adaptati

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… Y., Quail D. F., and Egeblad M., “NETworking With Cancer: The Bidirectional Interplay Between Cancer and Neutrophil Extracellular Traps,” Cancer Cell 41, no. 3 (2023): 505–526. 19. … Quail D. F., Amulic B., Aziz M., et al., “Neutrophil Phenotypes and Functions in Cancer: A Consensus Statement,” Journal of Experimental Medicine 219, no. 6 (2022): e20220011. 130. …

Molecular mechanisms of the preventable causes of cancer in the United States.

Annually, there are 1.6 million new cases of cancer and nearly 600,000 cancer deaths in the United States alone. The public health burden associated with these numbers has motivated enormous research efforts into understanding the root causes of cancer. These efforts have led to the recognition that between 40% and 45% of cancers are associated with preventable risk factors and, importantly, have identified specific molecular mechanisms by which these exposures modify human physiology to induce or promote cancer. The increasingly refined knowledge of these mechanisms, which we summarize here,

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… cytokines have broad action relevant to cancer; for example, experiments in a mouse model suggested that elevated IL-5 and GM-CSF (granulocyte–macrophage colony-stimulating factor) in the lungs of obese mice conditioned the microenvironment, enhancing the homing of mammary tumor metastases to this site ( Quail … As only one example, inflammatory signals associated with obesity alter the landscape of immune cells in a manner that promotes metastasis ( Quail et al. 2017 ). …

Drug Repurposing at the Interface of Melanoma Immunotherapy and Autoimmune Disease.

Cancer cells have a remarkable ability to evade recognition and destruction by the immune system. At the same time, cancer has been associated with chronic inflammation, while certain autoimmune diseases predispose to the development of neoplasia. Although cancer immunotherapy has revolutionized antitumor treatment, immune-related toxicities and adverse events detract from the clinical utility of even the most advanced drugs, especially in patients with both, metastatic cancer and pre-existing autoimmune diseases. Here, the combination of multi-omics, data-driven computational approaches with

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… Quail D.F., Joyce J.A. Microenvironmental regulation of tumor progression and metastasis. Nat. Med. 2013;19:1423–1437. doi: 10.1038/nm.3394. 18. Quail D.F., Siegers G.M., Jewer M., Postovit L.-M. Nodal signalling in embryogenesis and tumourigenesis. Int. J. Biochem. …

Modulating glycosphingolipid metabolism and autophagy improves outcomes in pre-clinical models of myeloma bone disease.

Patients with multiple myeloma, an incurable malignancy of plasma cells, frequently develop osteolytic bone lesions that severely impact quality of life and clinical outcomes. Eliglustat, a U.S. Food and Drug Administration-approved glucosylceramide synthase inhibitor, reduced osteoclast-driven bone loss in preclinical in vivo models of myeloma. In combination with zoledronic acid, a bisphosphonate that treats myeloma bone disease, eliglustat provided further protection from bone loss. Autophagic degradation of TRAF3, a key step for osteoclast differentiation, was inhibited by eliglustat as ev

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… Quail DF Joyce JA Microenvironmental regulation of tumor progression and metastasis Nat. Med. 2013 19 1423 1437 24202395 10.1038/nm.3394 PMC3954707 Quail, D. F. & Joyce, J. A. Microenvironmental regulation of tumor progression and metastasis. Nat. …

The role of tumor types in immune-related adverse events.

Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that block inhibitors of T cell activation and function. With the widespread use of ICIs in cancer therapy, immune-related adverse events (irAEs) have gradually emerged as urgent clinical issues. Tumors not only exhibit high heterogeneity, and their response to ICIs varies, with "hot" tumors showing better anti-tumor effects but also a higher susceptibility to irAEs. The manifestation of irAEs displays a tumor-heterogeneous pattern, correlating with the tumor type in terms of the affected organs, incidence, median onset time, and se

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… Quail DF Joyce JA Microenvironmental regulation of tumor progression and metastasis Nat Med 2013 19 11 1423 1437 24202395 10.1038/nm.3394 PMC3954707 Quail DF, Joyce JA. Microenvironmental regulation of tumor progression and metastasis. …

Application of Next Generation Sequencing in Laboratory Medicine.

The rapid development of next-generation sequencing (NGS) technology, including advances in sequencing chemistry, sequencing technologies, bioinformatics, and data interpretation, has facilitated its wide clinical application in precision medicine. This review describes current sequencing technologies, including short- and long-read sequencing technologies, and highlights the clinical application of NGS in inherited diseases, oncology, and infectious diseases. We review NGS approaches and clinical diagnosis for constitutional disorders; summarize the application of U.S. Food and Drug Administr

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… Coupland P, Chandra T, Quail M, Reik W, Swerdlow H. Direct sequencing of small genomes on the Pacific Biosciences RS without library preparation. Biotechniques. 2012;53:365–72. doi: 10.2144/000113962. 53. Baker EAG, Goodwin S, McCombie WR, Ramos OM. … Quail MA, Smith M, Coupland P, Otto TD, Harris SR, Connor TR, et al. A tale of three next generation sequencing platforms: comparison of Ion Torrent, Pacific Biosciences and Illumina MiSeq sequencers. BMC Genomics. 2012;13:341. doi: 10.1186/1471-2164-13-341. 56. …

The updated landscape of tumor microenvironment and drug repurposing.

Accumulating evidence shows that cellular and acellular components in tumor microenvironment (TME) can reprogram tumor initiation, growth, invasion, metastasis, and response to therapies. Cancer research and treatment have switched from a cancer-centric model to a TME-centric one, considering the increasing significance of TME in cancer biology. Nonetheless, the clinical efficacy of therapeutic strategies targeting TME, especially the specific cells or pathways of TME, remains unsatisfactory. Classifying the chemopathological characteristics of TME and crosstalk among one another can greatly b

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… For example, treatment of BLZ945 (colony-stimulating factor-1 receptor inhibitor) inhibits macrophages, induces tumors regression, and prolongs survival in glioblastoma-bearing mice, whereas over 50% glioblastomas recur. 157 , 158 Quail et al. 158 demonstrated that the high relapse rate is due to acquired …