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Benign Prostatic Hyperplasia Patient Outcomes in Various Robotic-Assisted Simple Prostatectomy Approaches vs Prostate Enucleation in Large Prostates: A Systematic Review and Bayesian Network Meta-Analysis.

BACKGROUND AND OBJECTIVE: Benign prostatic hyperplasia (BPH) represents a common condition in aging males. For prostates exceeding 80 g, rob … with transvesical (TV), transperitoneal, or transcapsular techniques. Enucleation methods included holmium laser (HoLEP), thulium laser, bipolar, and GreenLight laser vapo-enucleation.Key Findings and Limitations:We included data from 25 studies with 3924 patients. Network meta-analysis showed no significant difference in overall complication rates betwe …

Meta-analysis of postoperative urinary incontinence incidence and risk factors in HoLEP.

OBJECTIVE: To systematically identify and quantify the incidence and risk factors of postoperative urinary incontinence (UI) in holmium laser enucleation of the prostate (HoLEP), aiming to provide a basis for intervention strategies. METHODS: Relevant studies on postoperative UI in HoLEP were searched in databases including PubMed, Web of Science, EMBase, CNKI, Wanfang Data Knowledge Service Platform, VIP and CBMdisc, with the search period up to April 2024. Titles, abstracts and full texts were screened using the Endnote application. Studies meeting the inclusion and exclusion criteria under…

Associations between maternal urinary rare earth elements during pregnancy and birth weight-for-gestational age: Roles of cord blood vitamin D levels.

Prenatal exposure to rare earth elements (REEs) may contribute to adverse birth outcomes in previous studies. Cord blood vitamin D has been … Higher maternal average urinary concentrations of europium (Eu), gadolinium (Gd), dysprosium (Dy), holmium (Ho), erbium (Er), and ytterbium (Yb) across three trimesters, either individually or jointly, were significantly associated with lower BW-for-GA Z-scores and higher odds of small for gestational age (SGA) [β = -0.092; 95 % confidence interval (CI): …

Prevalence and risk factors of incidental prostate cancer in certain surgeries for benign prostatic hyperplasia: A systematic review and meta-analysis.

BACKGROUND: This study aimed to explore the prevalence and clinical risk factors in patients diagnosed with incidental prostate cancer (IPC) during certain surgeries (transurethral resection of the prostate [TURP], open prostatectomy [OP], and holmium laser enucleation of the prostate [HoLEP]) after clinically suspected benign prostatic hyperplasia (BPH). MATERIALS AND METHODS: Literature search of the MEDILINE, Web of Science, Embase, and Cochrane Library databases was performed to identify eligible studies published before June 2021. Multivariate adjusted odds ratios (ORs) and associated 95…

Thulium Fiber Laser Enucleation of the Prostate: Prospective Study of Mid- and Long-Term Outcomes in 1328 Patients.

Objective: The objective of our study was to estimate the long-term efficacy and safety of thulium fiber laser enucleation of the prostate ( … ollow-up. In the hands of an experienced surgeon, ThuFLEP can rightly be a promising alternative to holmium laser enucleation of the prostate for treatment of LUTS associated with BPO.

[Application of narrow-band imaging flexible ureteroscopy in the diagnosis, treatment and follow-up of upper tract urothelial carcinomas].

Objective: To investigate application value of narrow-band imaging (NBI) flexible ureteroscopy in the diagnosis, treatment and follow-up of … I and NBI flexible ureteroscopy were imaged, recorded, and then biopsied or subsequently treated by holmium laser resection with pathological examination. The diagnosis results of NBI flexible ureteroscopy were compared with WLI flexible ureteroscopy results. All the patients underwent 2(nd)-look ureteroscopy after 4 to 6 weeks since the first ureteroscop …

Combined use of flexible ureteroscopic lithotripsy with micro-percutaneous nephrolithotomy in pediatric multiple kidney stones.

BACKGROUND: We investigated the clinical value of treating pediatric multiple kidney stones with extensive distribution using flexible urete … F "all-seeing needle" with ultrasound guidance, and stone fragmentation was performed with a 200-μm holmium laser at different settings to disintegrate 1- to 2-mm fragments. RESULTS: All 21 pediatric patients with multiple kidney stones underwent combined FUL and micro-PNL. The stone free rate (SFR) was 85.7% (18/21). The mean surgical time was 45 min (r …

Prostatic stromal inflammation is associated with bladder outlet obstruction in patients with benign prostatic hyperplasia.

BACKGROUND: Benign prostatic hyperplasia (BPH) is a common urologic disease in older men. Prostatic inflammation research has focused on the magnitude of inflammation; its location has received little attention. We investigated whether the anatomic location of prostatic inflammation is related to the severity of lower urinary tract symptoms (LUTS), measured subjectively and objectively. METHODS: We retrospectively analyzed hematoxylin+eosin-stained tissue specimens from 179 BPH patients who underwent transurethral resection of the prostate (TURP) or holmium laser enucleation of the prostate (…

Osteonecrosis of the knee after laser or radiofrequency-assisted arthroscopy: treatment with minimally invasive knee arthroplasty.

BACKGROUND: Osteonecrosis of the knee after various arthroscopic procedures associated with the use of laser or radiofrequency devices has b … five men with a mean age of sixty-nine years. Six patients underwent an arthroscopy with associated holmium or yttrium-aluminum-garnet laser treatment, ten patients had associated radiofrequency treatment, and three patients had microfracture surgery. Subsequent arthroplasty procedures included four unicompartmental knee arthroplasties and fifteen tricomp …

[Study of the efficiency of thulium fiber laser enucleation of the prostate using a modulated pulse].

INTRODUCTION: The thulium fiber laser (TFL) is a relatively new certified system with unique physical properties that make it a potentially ideal energy source for endoscopic enucleation of the prostate (EEP). A specially designed modulated pulse has recently been introduced to enhance mechanical tissue dissection, similar to what is clearly observed during holmium laser enucleation. Evaluating the efficiency of this new pulse mode was designated as the primary endpoint of our study. Secondary endpoints included the quality of mechanical dissection, degree of carbonization, and hemostasis. The…

Will Aquablation Be the New Benchmark for Robotic Minimally Invasive Surgical Treatment for Benign Prostatic Hyperplasia?

BACKGROUND AND OBJECTIVE: Aquablation is included in the European Association Urology guidelines as an alternative surgical technique for pr … ures make Aquablation an attractive minimally invasive technique and show that it is noninferior to holmium laser enucleation. CONCLUSIONS AND CLINICAL IMPLICATIONS: Aquablation is a valid alternative to standard resection techniques, showing excellent long-term functional outcomes, good preservation of sexual function, a good safety profile, and good co …

Ureteroscopy from the recent past to the near future.

Stone surgery is one of oldest surgical practices undertaken by man. Hippocrates refused to let his followers "cut for the stone" and it was … This development is not only due to technological advancements, but also to the routine use of the Holmium: YAG LASER for intracorporeal lithotripsy, capable of destroying any stone regardless of its composition or location, surpassing the ability of any other lithotripter. It is also due to the development of devices that allow access to the ureter and …

Radionuclide therapy for hepatocellular carcinoma: indication, cost and efficacy.

A large number of patients with hepatocellular carcinoma (HCC) will have large and/or multiple inoperable tumours, precluding percutaneous a … uld be as low as possible. A variety of radioisotopes, such as lodine-131, Yttrium-90, Rhenium-188, Holmium-166 etc. can be used for this purpose and targeting of the therapeutic agent to the tumour may be achieved by 1) direct intra-tumour implantation of the radioisotope, 2) parenteral injection of radiolabelled antibodies specific to HCC antigens (radi …

[Old and new interventional therapies in the treatment of symptomatic benign prostate hyperplasia (BPH)].

Benign Prostatic Hyperplasia is a common entity among the aging male population. Its prevalence is increasing with age and is around 80% in … and the learning curve for the operator is long. The most promising of the newer techniques is the Holmium-Laser-Enucleation of the prostate (Laser-TUR-P), showing at least identical short- and median-term results, but a lower perioperative morbidity than TUR-P For several minimally-invasive techniques, indications are limited. TUMT TUNA, WIT and laser-c …

Acute radiotoxicity studies and safety assessment of 166Ho-EDTMP and 166Ho-DOTMP for the palliative treatment of bone metastases.

Comprehensive studies on the acute toxicity and safety profiles of therapeutic doses of 166Ho-EDTMP and 166Ho-DOTMP in the bone tissue and bone marrow of animals are limited, particularly when 166Ho produced in low-power reactors is used. These bone-specific complexes were synthesized through the coordination of 166Ho3+ ions in a neutral buffer. Acute toxicity studies were conducted at a dose of 1850 MBq/kg over 14 days, whereas safety assessments were performed at therapeutic doses of 18.5, 37, and 74 MBq/kg over 30 days in ICR mice. Hematological, biochemical, and histopathological toxicitie

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… Quantitative imaging of holmium-166 with an anger camera. Phys. Med. Bid . 39 , 265–279 (1994). 14. Bayouth, J. E. et al. Pharmacokinetics, dosimetry and toxicity of holmium-166 DOTMP for bone marrow ablation in multiple myeloma. J. Nucl. Med. 36 , 730–737 (1995). 15. Rajendran, J. G. et al. … Production of Holmium-166 DOTMP: A promising agent for bone marrow ablation in hematologic malignancies. Iran. J. Nucl. Med. 19 , 12–20 (2011). 24. Martina et al. Gamma camera characterization at high holmium-166 activity in liver radioembolization. …

Analysis of prostatic spindle cell lesions: Three case reports and literature review.

RATIONALE: Spindle cell lesions of the prostate originate from the specialized stroma or prostate epithelium. At present, these lesions are … ostatic synovial sarcoma in the other. INTERVENTIONS: One patient elected to undergo transurethral holmium laser-induced prostatectomy. Another patient received targeted therapy with anlotinib. The third patient received liposome doxorubicin combined with ifosfamide chemotherapy. OUTCOMES: For the cases of nodular hyperplasia of prostatic interstitial s …

Endoscopic Management of Adult Primary Obstructive Megaureter: Techniques and Long-term Outcomes.

BACKGROUND AND OBJECTIVE: Few studies on endoscopic management of primary obstructive megaureter (POM) in adult patients have been reported. Our objective was to describe our technique and long-term outcomes for endoscopic management of adult POM. METHODS: We included 76 adult POM patients undergoing endoscopic management between September 2015 and January 2024. Under endoscopic control, the stricture was dilated to 24-30 Fr while maintaining a balloon pressure of 25-35 atm for 3 min. An additional incision of the stenotic ring using either an electrode or holmium laser was performed in 39 pa…

Outcomes of Single-Operator Cholangioscopy-Guided Lithotripsy in Patients with Difficult Biliary and Pancreatic Stones.

BACKGROUND AND AIMS: Endoscopic retrograde cholangiopancreatography is the preferred strategy for the management of biliary and pancreatic d … reatic stones who underwent single-operator cholangioscopy-guided lithotripsy using two techniques: holmium laser lithotripsy (HL) or bipolar EHL. We analyzed complete ductal clearance as well as the impact of the location and number of stones on clinical success and evaluated the efficacy of the two techniques used for cholangioscopy-guided lithotripsy a …

Combined antegrade and retrograde endoscopic approach for the management of urinary diversion-associated pathology.

BACKGROUND: Endourologic management of stones and strictures in patients with a urinary diversion is often cumbersome because of the absence … ed antegrade and retrograde approach allowed successful access to pathologic areas in all patients. Holmium laser/Acucise incision of stenotic segments or ballistic fragmentation of stones was achieved in all cases without perioperative complications. None of the strictures with an initially successful outcome has recurred; however, in one patient, the pr …

Alternative treatment for recurrent keloids: initial clinical experience with Rhenium-188 using a specialized device.

INTRODUCTION: Keloids have proved challenging to manage with various therapies providing variable success rates and recurrences. Alternative therapies or a multimodal approach is often necessary to ensure complete eradication and prevent recurrence. The use of radioactive creams or patches embedded with Holmium-166, Phosphorus-32 for superficial skin lesions has been documented to be safe and effective. The use of Rhenium-188 has proved effective in non-melanoma skin cancers. We report on the initial experience with Rhenium-188 SCT in the treatment of recurrent keloid lesions. METHODS: Patien…