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Иммунофенотифицирование крови пациентов с множественным склерозом в диагнозе указывает на классическую подгруппу моноцитов, связанную с эволюцией болезней.

ВВЕДЕНИЕ: Торговля миелоидными клетками с периферии в центральную нервную систему является ключевым фактором в многократном склерозе (МС) посредством представления антигенов, секреции цитокинов и процессов ремонта. МЕТОДЫ: Комбинация массовой цитометрии на кровяных клетках от 60 пациентов, проходящих диагностику, и 29 здоровых методов контроля, а также секвенирование с одной клеткой РНК на спаренных образцах крови и цереброспинной жидкости (CSF), взятых из 5 пациентов с миэлоидными клетками. Результаты: Исследование отсека Myeloid показало обогащение специфической классической популяции моноци

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… Intra-cellular staining was therefore done, followed by iridium labeling to discriminate singlets from doublets during analysis. Finally, suspensions of fixed cells were banked at −80°C until acquisition on the Helios™ System (Fluidigm) from the CyPS plateform (Paris Pitié Salpêtrière). …

Prediction of myelosuppression in cervical cancer after concurrent chemoradiotherapy by CT radiomics-based model.

BackgroundConcurrent chemoradiotherapy (CCRT) was highly effective in treating cervical cancer (CC) but raised the risk of bone marrow suppression. However, models to predict the risk of myelosuppression in CC patients after CCRT based on computed tomography (CT) imaging histology are immature.MethodsThe Region of interest (ROI) of the CT images was segmented, and radiomic features were extracted. Next, important features were further selected. The training and test sets were split 7:3, and 8 machine learning algorithms were applied to classify the features in the training set. The model's per

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… For patients receiving brachytherapy, high-dose-rate intracavitary brachytherapy was performed using an iridium-192 source in accordance with the GEC-ESTRO guidelines, delivering 2–4 fractions of 5–6 Gy each to the high-risk clinical target volume (HR-CTV). …

Artificial Neural Network Prediction of Mortality in Cancer Patients Presenting for Radiation Therapy at a Multisite Institution.

IntroductionFor many decades, the management of cancer has utilized radiation therapy, which continues to evolve with technology to improve patient outcomes. However, despite the standardization of treatment plans and the establishment of best clinical practices based on prospective, randomized trials and adherence to National Comprehensive Cancer Network (NCCN) guidelines, the outcomes from radiation therapy are highly variable and dependent on a number of factors, including patient demographics, tumor characteristics/histology, and treatment parameters. In this study, we attempt to use avail

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… N1NOS', 'N1a', 'N1b', 'N1c', 'N1mi', 'N2', 'N2NOS', 'N2a', 'N2b', 'N2c', 'N3', 'N3NOS', 'N3a', 'N3b', 'N3c', 'NX', 'Nx', 'X'] Stage_m | ['0', '1', '1IV', '1a', '1b', '1c', 'I', 'M0', 'M1', 'M1NOS', 'M1a', 'M1b', 'M1c', 'MX', 'Mx', 'O', 'X'] Treatment_energy | ['Cobalt-60', 'Electrons', 'Iodine-125', 'Iridium …

Усовершенствованная последовательность транскриптомов и искусственный интеллект/машинное обучение (AI/ML) в имитируемом псориазом воспалении кератиноцитов человека.

ВВЕДЕНИЕ: Несмотря на то, что модель Keratinocyte HaCAT использовалась в предыдущих исследованиях для изучения воздействия антипсориатических агентов, по-прежнему отсутствует полное понимание механизма имитируемого имимодом распространения и трансдукции сигналов в псориазных кератиноцитах. ЦЕЛИ: Данное исследование было направлено на изучение молекулярных механизмов и путей, связанных с воспалением, подобным псориазу, в результате IMQ в кератиноцитах человека. МАТЕРИАЛЫ И МЕТОДЫ: Клетки HACAT подвергались воздействию различных концентраций IMQ, чтобы вызвать воспаление, аналогичное тому, котор

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… Synthesis of novel chitosan/sodium hyaluronate/iridium hydrogel nanocomposite for wound healing application. Int J Biol Macromol. 2024;270:132351. doi: 10.1016/j.ijbiomac.2024.132351. 46. Chiu YJ, Tsai FJ, Bau DT, Chang LC, Hsieh MT, Lu CC, et al. …

Biomimetic materials for medical applications.

AbstractRecent advances in biomedical research have facilitated the exploration of biomimetic materials and their potential for diagnosing and treating diseases. This review synthesizes reports of recent research into biomimetic materials and provides a focused analysis of their therapeutic and diagnostic efficacy across multiple physiological systems, including the locomotor, digestive, respiratory, urinary, endocrine, nervous, integumentary, hematopoietic, and circulatory systems. These findings highlight the transformative potential of these materials in the management of systemic diseases.

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… Wang et al [ 130 ] reported the therapeutic effects of iridium nanozymes on kidney injury under high-altitude hypoxic conditions. … They reported that the iridium nanozymes reduce inflammatory responses and protect renal function by decreasing plasma IL-6, succinate, and indoxyl sulfate concentrations. This synergistic mechanism enhances the therapeutic effects by regulating gut microbiota distribution and plasma metabolites. …

Management of keratinocyte carcinoma - Special considerations in the elderly.

Keratinocyte carcinomas (KCs) are now an epidemic in The United States of America, especially in elderly patients. KCs, including basal cell carcinoma and squamous cell carcinoma, can lead to disfigurement and occasionally death. However, the lower mortality rate associated with KC compared with melanoma allows for increased flexibility in the selection of treatment. Flexibility in treatment is particularly important in the elderly given that this patient population often has medical comorbidities that should be considered. These patients may have multiple KCs, higher risk tolerance to recurre

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… Local control rates of KCs treated with ionized (iridium) or electronic HDR-BT are high, ranging from 72% to 100%, and many studies report success rates of well over 90% ( Ballester-Sánchez et al., 2017 , Delishaj et al., 2016 , Olek Jr et al., 2018 , Tormo et al., 2014 ). …

Novel Short PEG Chain-Substituted Porphyrins: Synthesis, Photochemistry, and In Vitro Photodynamic Activity against Cancer Cells.

This work presents the synthesis and characterization of metal-free, zinc (II), and cobalt (II) porphyrins substituted with short PEG chains. The synthesized compounds were characterized by UV-Vis, 1H and 13C NMR spectroscopy, and MALDI-TOF mass spectrometry. The origin of the absorption bands for tested compounds in the UV-Vis range was determined using a computational model based on the electron density functional theory (DFT) and its time-dependent variant (TD-DFT). The photosensitizing activity was evaluated by measuring the ability to generate singlet oxygen (ΦΔ), which reached values up

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… Moreover, several compounds excited at 425–500 nm are still considered photosensitizers for PDT, including natural compounds, e.g., curcumin [ 62 ], berberine [ 63 ], parietin [ 64 ], or synthetic PSs, e.g., iridium(III)-based complexes [ 65 ]. …

RVd и CyBord терапии ремоделируют созревание клеток B и изменяют иммунную и клональную архитектуру в множестве миеломы.

Множественная миелома (ММ) характеризуется неоднородностью плазменных клеток (ПХ) и изменениями в дифференциации В-клеток и иммунной регламентации. Хотя линалидомид/бортезомиб/дексатон (RV) и циклофосфамид/бортезомиб/дексамасон (CyBorD) являются клинически эффективными, их точное воздействие на созревание ПК/B-клеток остается неясным. МЕТОДЫ: Мы провели профилирование КИТОФ на образцах костного мозга из RVd (n = 47) и пациентов MM, проходящих лечение CyBorD (n = 15), каждый по сравнению с неочищенной когортой (n = 43). Внутри каждого терапевтического рукава ответные устройства (RV, n = 35; CyB

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… The cells were then washed twice in CSM and stained with intracellular antibody cocktails specific to each panel, along with 1 μL of 191/193 Iridium (Ir) DNA intercalator (Fluidigm, San Francisco, CA) in 100 μL of CSM for 1 h at RT. …

DHCR24 in Tumor Diagnosis and Treatment: A Comprehensive Review.

As an important nutrient in the human body, cholesterol can not only provide structural components for the body's cells, but also can be transformed into a variety of active substances to regulate cell signaling pathways. As an important cholesterol synthase, DHCR24 participates in important regulatory processes in the body. The application of DHCR24 in tumor clinical diagnosis and treatment also attracts much attention. This article reviews the structure and regulatory characteristics of DHCR24, and the research of DHCR24 on tumor progression. We summarize the possible mechanisms of DHCR24 pr

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… Bioactive iridium nanoclusters with glutathione depletion ability for enhanced sonodynamic-triggered ferroptosis-like cancer cell death. Adv Mater. 2022;34(45):e2206286. doi: 10.1002/adma.202206286 159. Dong Q, Li D, Zhao H, et al. …

The various therapeutic applications of the medical isotope holmium-166: a narrative review.

Over the years, a broad spectrum of applications of the radionuclide holmium-166 as a medical isotope has been established. The isotope holmium-166 is attractive as it emits high-energy beta radiation which can be used for a therapeutic effect and gamma radiation which can be used for nuclear imaging purposes. Furthermore, holmium-165 can be visualized by MRI because of its paramagnetic properties and by CT because of its high density. Since holmium-165 has a natural abundance of 100%, the only by-product is metastable holmium-166 and no costly chemical purification steps are necessary for pro

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… It was shown that the spatial dose distribution of 166 Ho was confined to the implanted volume, whereas this is not the case for brachytherapy using iridium-192, which is frequently used (de Campos et al. 2016 ). …

Regulation of immunogenic cell death and potential applications in cancer therapy.

Immunogenic cell death (ICD), a type of regulatory cell death, plays an important role in activating the adaptive immune response. Activation of the tumor-specific immune response is accompanied by the cell surface exposure of calreticulin and heat-shock proteins, the secretion of adenosine triphosphate, and the release of high mobility group box-1. In this review, we summarize and classify the latest types of ICD inducers and their molecular mechanisms, and discuss the effects and potential applications of inducing ICD by chemotherapy drugs, targeted drugs, and oncolytic viruses in clinical r

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… Iridium(III)-based PD-L1 agonist regulates p62 and ATF3 for enhanced cancer immunotherapy. J Med Chem. (2024) 67:6810–21. doi: 10.1021/acs.jmedchem.4c00404 6. Hossain DMS, Javaid S, Cai M, Zhang C, Sawant A, Hinton M, et al. …

Mitochondrial Genetic and Epigenetic Regulations in Cancer: Therapeutic Potential.

Mitochondria are dynamic organelles managing crucial processes of cellular metabolism and bioenergetics. Enabling rapid cellular adaptation to altered endogenous and exogenous environments, mitochondria play an important role in many pathophysiological states, including cancer. Being under the control of mitochondrial and nuclear DNA (mtDNA and nDNA), mitochondria adjust their activity and biogenesis to cell demands. In cancer, numerous mutations in mtDNA have been detected, which do not inactivate mitochondrial functions but rather alter energy metabolism to support cancer cell growth. Increa

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… Another way of overcoming CDDP resistance through mitochondrial targeting can be achieved with dinuclear Ir-CDDP complexes, in which an iridium(III) moiety is introduced to a terpyridyl CDDP derivative. …

Radiotherapy based management during Covid-19 pandemic - A systematic review of presented consensus and guidelines.

Treatment management of cancer patients in the radiation oncology departments during the current COVID-19 pandemic is challenging. A systematic review of published consensus/guidelines on the role of radiotherapy prioritization, suggested treatment protocols, and set up management was undertaken based on the PRISMA protocol and through PubMed/PMC, Scopus, Google Scholar, Web of Science databases until 01/20/2021. One hundred and sixty-eight publications or regional consensus were included. Summary of recommendations contained: (1) using hypo-fractionated (Hypo-F) regimens for therapeutic/palli

Резюме книги: Тема: 13th Международный симпозиум на тему " Ходжкин лимфома " ; октябрь 2024

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… Universitario Donostia–Osakidetza, Spain, 15 Department of Haematology, Antwerp University Hospital, Antwerp, Belgium, 16 Haaglanden Medical Centre, The Hague, The Netherlands, 17 Department of Hematology, Amsterdam University Medical Centers, Amsterdam, The Netherlands, 18 Department of Radiation Oncology, Iridium …

SUBJECT INDEX Volume 125 (JANUARY–JUNE, 2004)

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Porokeratoses-A Comprehensive Review on the Genetics and Metabolomics, Imaging Methods and Management of Common Clinical Variants.

Porokeratosis is a heterogeneous group of keratinising disorders characterised by the presence of particular microscopic structural changes, namely the presence of the cornoid lamella. This structure develops as a consequence of a defective isoprenoid pathway, critical for cholesterol synthesis. Commonly recognised variants include disseminated superficial actinic porokeratosis, disseminated superficial porokeratosis, porokeratosis of Mibelli, palmoplantar porokeratosis (including porokeratosis palmaris et plantaris disseminata and punctate porokeratosis), linear porokeratosis, verrucous porok

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… A single report on the use of high-dose-rate iridium-192 brachytherapy in one DSAP patient shows that this method can also be useful in selected limited areas and well tolerated [ 131 ]. …

Преобразование фотоэнергетики в наноматериалах для точной терапостики.

Быстро развивающаяся область тераностистики направлена на интеграцию терапевтических и диагностических функций в единую платформу для точной медицины, позволяющую одновременно лечить и контролировать болезни. Наноматериалы, основанные на преобразовании фотоэнергии, стали разносторонней платформой, использующей уникальные свойства света для активации тераностистики с высокой пространственной и временной точностью. В настоящем обзоре содержится всеобъемлющий обзор последних изменений в области преобразования фотоэнергетики с использованием наноматериалов с уделением особого внимания их применени

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… Traditional metal‐based phosphorescent nanomaterials, including iridium (Ir), [ 109 ] ruthenium (Ru), [ 110 ] and palladium (Pd) [ 111 ] based compounds, remain the most extensively studied class. …

ESMO / ASCO Recommendations for a Global Curriculum in Medical Oncology Edition 2016.

The European Society for Medical Oncology (ESMO) and the American Society of Clinical Oncology (ASCO) are publishing a new edition of the ESMO/ASCO Global Curriculum (GC) thanks to contribution of 64 ESMO-appointed and 32 ASCO-appointed authors. First published in 2004 and updated in 2010, the GC edition 2016 answers to the need for updated recommendations for the training of physicians in medical oncology by defining the standard to be fulfilled to qualify as medical oncologists. At times of internationalisation of healthcare and increased mobility of patients and physicians, the GC aims to p

Current advance of nanotechnology in diagnosis and treatment for malignant tumors.

Cancer remains a significant risk to human health. Nanomedicine is a new multidisciplinary field that is garnering a lot of interest and investigation. Nanomedicine shows great potential for cancer diagnosis and treatment. Specifically engineered nanoparticles can be employed as contrast agents in cancer diagnostics to enable high sensitivity and high-resolution tumor detection by imaging examinations. Novel approaches for tumor labeling and detection are also made possible by the use of nanoprobes and nanobiosensors. The achievement of targeted medication delivery in cancer therapy can be acc

63rd Annual Conference of the Indian Society of Gastroenterology, ISGCON 2022-January 5th - 8th, 2023 in Jaipur.

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