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Examining health-related quality of life in pediatric cancer patients with febrile neutropenia: Factors predicting poor recovery in children and their parents.

BACKGROUND: The impact febrile neutropenia (FN) has on the health-related quality of life (HRQoL) of children with cancer and their families is poorly understood. We sought to characterize the course of child and parent HRQoL during and following FN episodes. METHOD: Data on HRQoL were collected in the multisite Australian Predicting Infectious ComplicatioNs in Children with Cancer (PICNICC) study. Participants were enrolled between November 2016 to January 2018. The Child Health Utility (CHU9D) was used to assess HRQoL in children (N = 167 FN events) and the Assessment of Quality of Life (AQ

What Is the Evidence Behind Sarcoid Treatments?

Despite the ubiquitous nature of sarcoids, robust data regarding the selection of treatment modalities are scarce, with many treatments having little or no published data to support their use. Treatment options are numerous and vary with the location and type of sarcoid, treatment accessibility, and the financial status of the owner. Many treatments are expensive and time-consuming, and some have health and safety implications. It is this author's belief that, based on the limited evidence base, appropriate treatment options vary with the location and type of the sarcoid, and no one treatment

Challenges Related to Safety and Independence.

Advancing age is associated with increasing risk of activities important for independence, such as driving and living alone. Cognitive impairment is more common with older age; financial resources and social support may dwindle. Risk, cognitive impairment, and decisional capacity each change over time. Transparent decision making and harm reduction help balance risk and safety. When a patient lacks decisional capacity, an option that considers the patient's preferences and shows respect for the person is favored. Vulnerable patients making choices that are high risk, and patients for whom othe

Unmet needs and quality of life in multiple myeloma patients.

This cross-sectional study analysed the contributors and moderators of quality of life. The sample comprised 124 Portuguese multiple myeloma patients assessed on social support, spirituality, unmet needs, psychological morbidity and quality-of-life measures. Results showed that being older and a woman, as well as psychological morbidity and unmet emotional needs were significant predictors of worse quality of life as measured by the QLQ-C30. Unmet financial needs moderated the relationship between psychological morbidity and quality of life. Results emphasize the importance of intervening in p

Clinical practice guidance for juvenile dermatomyositis (JDM) 2018-Update.

Juvenile dermatomyositis is the most common type of juvenile idiopathic inflammatory myopathy mainly affecting the skin and proximal muscles. We have published the Japanese version of 'Clinical practice guidance for juvenile dermatomyositis (JDM) 2018 'consisting of a review of articles in the field and evidence-informed consensus-based experts' opinion on the treatment strategy in collaboration with The Pediatric Rheumatology Association of Japan and The Japan College of Rheumatology under the financial support by 'Research on rare and intractable diseases, Health and Labor Sciences Research …

Drug-Resistant Tuberculosis: Challenges and Progress.

Antimicrobial resistance is a natural evolutionary process, which in the case of Mycobacterium tuberculosis is based on spontaneous chromosomal mutations, meaning that well-designed combination drug regimens provided under supervised therapy will prevent the emergence of drug-resistant strains. Unfortunately, limited resources, poverty, and neglect have led to the emergence of drug-resistant tuberculosis throughout the world. The international community has responded with financial and scientific support, leading to new rapid diagnostics, new drugs and regimens in advanced clinical development

Opportunities and challenges in antiparasitic drug discovery.

New antiparasitic drugs are urgently needed to treat and control diseases such as malaria, leishmaniasis, sleeping sickness and filariasis, which affect millions of people each year. However, because the majority of those infected live in countries in which the prospects of any financial return on investment are too low to support market-driven drug discovery and development, alternative approaches are needed. In this article, challenges and opportunities for antiparasitic drug discovery are considered, highlighting some of the progress that has been made in recent years, partly through scient

Violence and the older adult: the role of the acute care nurse practitioner.

The United States population has an increasing number of older adults. One health problem often unrecognized in this aging population is elder abuse. Elder abuse can be classified into six categories: (1) physical abuse, (2) sexual abuse, (3) financial exploitation, (4) neglect, (5) psychological abuse, and (6) violation of rights. The abused older adult often lives with the abuser, has no outside support, and may live with intergenerational family violence. The acute care nurse practitioner is in an excellent position to become a patient advocate by recognizing the abused older adult, initiat

Restoration Contexts and Trends in the Brazilian Atlantic Forest: Evidence from Science and Practice.

Large-scale restoration in the Brazilian Atlantic Forest is expected to recover biodiversity, carbon stocks, and other ecosystem functions while also supporting rural livelihoods. Yet the evidence supporting these claimed outcomes remains uneven, especially when distinguishing reported outcomes from causal evidence based on baselines, controls, counterfactuals, or long-term monitoring. We assessed peer-reviewed studies and a contextual set of documented initiatives to synthesize reported environmental, social, and economic findings together with governance and financing conditions associated w

How emergency departments are responding to the opioid crisis: Results from a statewide survey in Kentucky.

OBJECTIVE: There is a rising effort for hospital emergency departments (EDs) to offer and expand substance use disorder (SUD) services. This state-wide evaluation studies SUD services offered along the continuum of implementation across Kentucky's EDs to inform future state efforts to build ED bridge programs. METHODS: We conducted a mixed-methods study using an online survey of all Kentucky Emergency Department Directors between January and May of 2023. We created a hospital-level dataset which we used to summarize quantitative questions and thematically analyze open-ended responses. RESULT

Health and economic impact of caregiving on informal caregivers of people with chronic diseases in sub-Saharan Africa: A systematic review.

With a disproportionate burden of chronic diseases and severe shortage of health workers in sub-Saharan Africa, the region implicitly relies on informal caregivers (ICGs) to support the patients both within and outside the health facilities. The aim of this review is to systematically summarise evidence on the health and economic impact of caregiving on informal caregivers of patients with chronic diseases in sub-Saharan Africa. Medline (Ovid), CINAHL (EBSCOhost), PsycINFO (Ovid), Embase (Ovid), Global Health, and Web of Science databases were systematically searched to identify original artic

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… Their response to such challenges included taking loans to get money to care for the patient [ 37 , 59 , 63 , 65 , 66 ], seeking additional financial support from relatives and institutions like churches [ 58 , 59 ], sale of family properties [ 58 , 63 , 66 , 68 ] and requesting for premature discharge …

Characterizing the context of spinal cord injury-inclusive community-based organizations to build capacity for research partnerships: An environmental scan.

CONTEXT: Spinal cord injury (SCI) community-based organizations (CBOs) have the potential to inform research so that findings are more relevant and applicable. To support SCI CBOs to meaningfully engage in research partnerships, an understanding of their context is needed. OBJECTIVE: Identify and describe the context of Canadian and American SCI CBOs that offer programs and services to people with SCI. METHODS: An environmental scan was conducted using an integrated knowledge translation approach. A list of Canadian and American SCI CBOs was created using community partners' networks and nat

From economic burden to patient-centered solutions: the evolving landscape of financial toxicity in oncology.

BackgroundFinancial burden has emerged as a significant challenge in oncology, adversely affecting patients' quality of life, treatment adherence, and long-term outcomes. While research on cancer-related financial toxicity (FT) has grown rapidly, a comprehensive bibliometric analysis of its knowledge structure, thematic evolution, and emerging trends remains scarce.MethodsPublications on FT among cancer patients, published from 2003 to January 19, 2026, were retrieved from the Web of Science Core Collection and Scopus databases. Bibliometric and science mapping analyses were conducted using Ci

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… The largest cluster #0 oncology included recent keywords such as pilot feasibility tertiary care center and financial support. Cluster #1 burden featured emerging terms like ECOG performance status drug therapy and annual household income. … Keywords such as pilot feasibility financial support and health policy indicate a shift toward designing and evaluating interventions aimed at mitigating FT. …

"We Weren't Taught How to Cope With Tragedy": Early Childhood Trauma, Grief, and Learned Coping Mechanisms Among People Who Inject Drugs.

BACKGROUND AND OBJECTIVES: Early traumatic exposure to factors such as household substance use, violence, and familial death increase the likelihood of substance use across a person's lifespan. Our qualitative analysis sought to explore the social and relational drivers of substance use among people who inject drugs (PWID). DESIGN AND METHODS: We conducted qualitative interviews with 30 PWID (n = 30) in Los Angeles, CA from July 2021 to April 2022. To be eligible for this study, participants had to report being 18 years of age or older and self-report any opioid and injection drug use within

A mixed-methods study on healthcare workers' perceptions of treatment adherence among HIV-TB co-infected patients in a multi-disease prevention policy context.

BACKGROUND: Integrated service models aim to improve HIV-tuberculosis (TB) comorbidity management, yet little is known about how frontline providers perceive adherence challenges under China's Integrated Prevention and Control of Four Diseases (IPC4D) policy. This mixed-methods study explored healthcare workers' assessments of adherence, perceived barriers, and policy effects in Liangshan Prefecture-a high-burden, resource-limited, multi-ethnic region. METHODS: Between May and June 2025, an online survey of 492 healthcare workers and 30 in-depth interviews were conducted. Quantitative data we

Testing the Spillover Effect of Intimate Partner Violence Victimization on Emotionally Abusive and Harsh Parenting Practices: The Application of Propensity Score Matching.

Prior research reported a significant association between intimate partner violence (IPV) victimization and negative parenting, but there was an overreliance on U.S. samples and families from low socioeconomic status backgrounds. Therefore, this quasi-experimental study examined the association between recent IPV victimization and abusive parenting practices in a sample of community-based women from Poland. Participants were mothers of children aged 2 to 5 years (N = 610) attending an outpatient clinic located in a city in south-eastern Poland. Mothers were asked about their IPV experiences in

The Low-Income and Middle-Income Countries' Perspective on Global Neurosurgery Collaborations.

BACKGROUND AND OBJECTIVES: Access to neurosurgical care is limited in low-income and middle-income countries (LMICs) and in marginalized com … ential to expanding HICs-LMICs collaborations and improving access to neurosurgical care worldwide. Financial support and targeted interventions are needed to address barriers and promote equitable partnerships in GN.

Lived experience, social support, and challenges to health service use during the COVID-19 pandemic among HIV key populations in Indonesia.

The COVID-19 pandemic has greatly affected the lives, health, and social well-being of people globally including presenting special challenges in low to middle income countries for people living with HIV. This study investigates the pandemic experiences of the four key HIV-positive populations in Indonesia: men who have sex with men, transgender women, female sex workers, and people who use drugs. In-depth interviews were conducted with a convenience sample of 22 key population members recruited through 9 nongovernment HIV agencies in Jakarta and Bali, Indonesia. Indonesia's Large-scale Social

Barriers to prophylactic treatment among patients with haemophilia A in Shandong Province, China: a qualitative study.

BACKGROUND: Haemophilia A is a rare, hereditary haemorrhagic disease that manifests as induced spontaneous bleeding and leads to disability … lysis, which were further clustered into three themes: (1) poor primary health care, (2) inadequate financial support, and (3) a lack of patient-centred care. CONCLUSION: The findings presented in this descriptive qualitative study offer a unique view of Chinese patients with haemophilia A and their barriers to prophylactic treatment. Our findings not only provide …

Key participant characteristics influencing completion of a phase II cardiac rehabilitation program: A cross-sectional analysis.

STUDY OBJECTIVE: Cardiac rehabilitation (CR) programs are effective at reducing cardiovascular disease risk factors, yet programs in the United States (US) have poor participation and completion. The current study evaluates characteristics related to completion and drop-out for CR participants. DESIGN: A cross-sectional study design compared participants who completed the program (finishers) and those did not finish (non-finishers). Variables were compared to determine differences between the dichotomous groups included demographic data, initial six-minute walk test, Zung Depression Index, an