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How Can the Environmental Impact of Orthopaedic Surgery Be Measured and Reduced? Using Anterior Cruciate Ligament Reconstruction as a Test Case.

BACKGROUND: The healthcare sector in the United States has increased its greenhouse gas emissions by 6% since 2010 and today has the highest … ed life cycle greenhouse gas emissions of 47 kg of CO 2 eq, which is analogous to driving a typical gasoline-fueled passenger vehicle for 120 miles. The total mass of all products for one ACLR was estimated at 12.73 kg, including 7.55 kg for disposable materials and 5.19 kg for reusable materials. Concerning material circularity, ACLR had a baseline MCI in …

Personal exposure to mixtures of volatile organic compounds: modeling and further analysis of the RIOPA data.

INTRODUCTION: Emission sources of volatile organic compounds (VOCs*) are numerous and widespread in both indoor and outdoor environments. Co … ficance. Specific Aim 2. Four VOC mixtures were identified and apportioned by PMF; they represented gasoline vapor, vehicle exhaust, chlorinated solvents and disinfection byproducts, and cleaning products and odorants. The last mixture (cleaning products and odorants) accounted for the largest fraction of an individual's total exposure (average of 42% acro …

Personal and ambient exposures to air toxics in Camden, New Jersey.

Personal exposures and ambient concentrations of air toxics were characterized in a pollution "hot spot" and an urban reference site, both i … igher in summer than in winter in both locations, possibly because of higher evaporation rates from gasoline in summer. Similarly, concentrations of heavier PAHs, such as benzo[a]pyrene, were found to be higher in winter in both locations, possibly because of higher emission rates from mobile sources, the use of home heating, and the reduced photochemical …

NTP Toxicology and Carcinogenesis Studies of Propylene (CAS No. 115-07-1) in F344/N Rats and B6C3F1 Mice (Inhalation Studies).

Propylene is used as a starting material in the production of polypropylene plastics and various other chemicals, including acrylonitrile, isopropyl alcohol, propylene oxide, butyraldehyde, cumene, dodecane, nonene, and allyl chloride. The major derivatives are polypropylene (25%), acrylonitrile (15%), isopropyl alcohol (10%), and propylene oxide (10%). It is also a valuable feed-stock chemical for the production of gasoline. Other miscellaneous applications include use as a starting material for polymerization reactions to form vinyl chloride copolymers and low-molecular-weight homopolymers t…

Exposome and unhealthy aging: environmental drivers from air pollution to occupational exposures.

The aging population worldwide is facing a significant increase in age-related non-communicable diseases, including cardiovascular and brain pathologies. This comprehensive review paper delves into the impact of the exposome, which encompasses the totality of environmental exposures, on unhealthy aging. It explores how environmental factors contribute to the acceleration of aging processes, increase biological age, and facilitate the development and progression of a wide range of age-associated diseases. The impact of environmental factors on cognitive health and the development of chronic age

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… Acrolein, a highly reactive unsaturated aldehyde, is generated during the burning of diesel fuels, gasoline, woods, plastics, cigarette smoking, and frying of food with fats. The Environmental Protection Agency classifies acrolein as a high-priority air and water toxicant. … Benzene, a chemical found in gasoline, industrial solvents, and tobacco smoke, is a known carcinogen associated with various cancers, including leukemia and multiple myeloma [ 322 – 329 ]. …

Токсичность тяжелых металлов в клиническом и экологическом здравоохранении: источники, механизмы, диагностика и научно обоснованное управление ртутью, свинцом, кадмием и арсеником.

Тяжелые металлы, включая ртуть (Hg), свинец (Pb), кадмий (Cd) и мышьяк (As), по-прежнему остаются значительными глобальными токсинами в силу их экологической стойкости, широкомасштабного антропогенного высвобождения и серьезного биологического воздействия. Этот обзор укрепляет нынешнее понимание их природных и промышленных источников, круговорота окружающей среды, маршрутов воздействия на человека и факторов уязвимости на уровне населения. Она охватывает их токсикокинетику и токсикодинамику, делая акцент на специфических для каждого вида механизмах поглощения, распределения и травмирования, вк

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… It has been used for centuries in many applications, including the manufacture of drinking water pipes and as an additive to gasoline [ 7 ]. Leaded petrol was one of the most significant sources of atmospheric lead in the 20th century. … Lead compounds were added to gasoline as an anti-knock agent and were also incorporated into paint [ 26 ]. In developed countries, the use of lead is limited, but it remains in lead-containing products, such as gasoline, pigments, ceramics, and batteries [ 7 ]. …

Multiple myeloma, a quintessential malignant disease of aging: a geroscience perspective on pathogenesis and treatment.

Multiple myeloma (MM) is an incurable plasma cell malignancy, which is predominantly a disease of older adults (the median age at diagnosis is 70 years). The slow progression from asymptomatic stages and the late-onset of MM suggest fundamental differences compared to many other hematopoietic system-related malignancies. The concept discussed in this review is that age-related changes at the level of terminally differentiated plasma cells act as the main risk factors for the development of MM. Epigenetic and genetic changes that characterize both MM development and normal aging are highlighted

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… Benzene is present in petrol, and inhalation of benzene with petrol fumes (e.g., taxicab drivers [ 64 ], workers in gasoline stations [ 65 ], and refineries) results in a significantly increased risk for malignancies. … Risk Assessment on benzene exposure among gasoline station workers. Int J Environ Res Public Health. 2019;16(14):2545. 10.3390/ijerph16142545. 10.3390/ijerph16142545 PMC6678808 31315313 66. …

Summary for clinicians: ERS guidelines on pulmonary alveolar proteinosis.

Pulmonary alveolar proteinosis (PAP) is a rare lung disease caused by accumulation of surfactant in the alveoli, leading to debilitating respiratory symptoms and impaired gas exchange. The recent European Respiratory Society guidelines provide evidence-based recommendations for its diagnosis and management. Autoimmune PAP (aPAP) is the most common form, driven by granulocyte-macrophage colony-stimulating factor (GM-CSF) autoantibodies. Recommended diagnostic tools include bronchoalveolar lavage and quantitative GM-CSF antibody testing. Whole lung lavage and inhaled GM-CSF are first-line treatm

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… syndrome, amyloidosis, Fanconi's syndrome, agammaglobulinaemia, juvenile dermatomyositis, renal tubular acidosis, severe combined immunodeficiency disease Occupational and environmental exposures | Aluminium, cement, silica, titanium, indium, flour, fertiliser, sawdust, chlorine fumes, cleaning products, gasoline …

Assessment of a Systematic Screening of Occupational Exposures in Malignant Hemopathies in the Rhone-Alpes Area: Prolymphome Study.

BACKGROUND: Several studies have highlighted the role of environmental exposures in malignant hemopathies etiology. Some patients with malignant hemopathies can be compensated as occupational diseases. The Prolymphome research aimed to assess a systematic screening of occupational exposures in patients with lymphoma or myeloma treated in three hospitals in the Rhône-Alpes region. METHODS: Patients received a self-administered questionnaire to fill in at home to collect their job history and potential occupational exposures to carcinogens. A physician assessed the questionnaire to determine if

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… Exposure to benzene through contact with gasoline-containing parts. | Trichloroethylene | GS | Accepted Diffuse large B-cell lymphoma | From 1967 to 1979 pipe fitter and welder for several companies. Installation of industrial sites in the chemical sector and maintenance work on heating systems. …

Environmental Factors, Lifestyle Risk Factors, and Host Characteristics Associated With Philadelphia Negative Myeloproliferative Neoplasm: A Systematic Review.

Myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell disorders characterized by the overproduction of mature myeloid cells and are often associated with an acquired genetic mutation of Janus Kinase2V617F. Various epidemiological studies have indicated associations between environmental factors, lifestyle factors, and host characteristics with developing MPNs. This review aims to collect and summarize the existing information on these risk factors and establish their association with pathogenesis MPNs. Medline, Embase, PubMed, and grey literature were systematically searched u

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… Benzene is an aromatic hydrocarbon and a natural component of crude oil, gasoline, and tobacco. 37 Individuals who work in the petroleum industry have a higher level of exposure to benzene. …

Ambient Air Pollution and COVID-19 in California.

INTRODUCTION: As of December 2023, more than 6.9 million people globally had died from COVID-19, including more than 1.165 million deaths in … e (HR, 1.12), PM2.5 elemental carbon (HR, 1.07), PM2.5 on-road diesel (HR, 1.06), and PM2.5 on-road gasoline (HR, 1.07). Humidity and temperature in the month of diagnosis were significant negative predictors of COVID-19 mortality and negative modifiers of the air pollution effects. Results of the multistate analysis were consistent with these findings and …

Update on Occupational Cancer for Better Cancer Prevention and Control.

Occupational cancer remains an ongoing and emerging issue in cancer prevention and control and is more easily preventable in practice than other causes. As of 2024, changes in various aspects, such as methods for estimating the burden of cancer, evidence on novel carcinogens and classification systems, modernization of working conditions, job characteristics, occupational exposure, and societal changes have played a significant role. Furthermore, advances in technology, including wearable devices, exposome, and biomedical technology, offer more precise methods for identifying the associations

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… 21362498 10.1016/j.jbi.2011.02.010 40 Hasin Y Seldin M Lusis A Multi-omics approaches to disease Genome Biol 2017 18 1 83 28476144 10.1186/s13059-017-1215-1 PMC5418815 41 Polyong CP Roytrakul S Sirivarasai J Yingratanasuk T Thetkathuek A Novel serum proteomes expressed from benzene exposure among gasoline …

NTP Toxicology and Carcinogenesis Studies of Toluene (CAS No.108-88-3) in F344/N Rats and B6C3F1 Mice (Inhalation Studies).

Toluene is used to back-blend gasoline, as a chemical intermediate, and as a solvent; 920 million gallons were produced in the United States in 1988. Toxicology studies were conducted by administering toluene (greater than 99% pure) in corn oil by gavage to groups of F344/N rats and B6C3F1 mice of each sex for 13 weeks or by whole-body inhalation exposure for 14 or 15 weeks. NTP Toxicology and Carcinogenesis studies were conducted by whole-body inhalation exposure of F344/N rats and B6C3F1 mice of each sex for 15 months or 2 years. Genetic toxicology studies were conducted in Salmonella typhim…

Epidemiological science and cancer control.

Epidemiological methods are essential for the discovery of cancer risks and prognostic factors as well as for the evaluation of cancer prevention measures. In this review, we discuss epidemiological surveillance procedures for data collection and processing to guide and evaluate the consequences of anticancer efforts for populations, assess the identification of cancer risk factors, examine barriers to cancer screening and recommended rules for early diagnosis programs. Epidemiological studies have shown that hindrances to cancer information assessment are currently encountered in developing c

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… Benzene is a colorless and highly flammable liquid with a sweet smell; this aromatic hydrocarbon is a natural constituent of crude oil and a component of gasoline that has also been identified in industrial emissions and tobacco smoke. …

Воздействие нефтеперерабатывающих и биотопливных заводов на здоровье человека: карта систематических доказательств и обзор скопирования.

ЦЕЛЬ ОБЗОРА: Нефтеперерабатывающие заводы являются важными источниками выбросов токсичных загрязнителей во всем мире, которые угрожают здоровью работников нефтеперерабатывающих предприятий и близлежащего населения. Мы провели обзор эпидемиологических данных об остром и хроническом воздействии нефтеперерабатывающих и биотопливных заводов на здоровье окружающих общин. Мы провели оценку доказательств с использованием оценок риска предубеждений и зафиксировали полученные результаты на карте доказательств для выявления пробелов в литературе. Мы систематически искали исследования, опубликованные к а

Impacts of Regulations on Air Quality and Emergency Department Visits in the Atlanta Metropolitan Area, 1999-2013.

INTRODUCTION: The United States and Western Europe have seen great improvements in air quality, presumably in response to various regulation … Budget Trading Program (NBP), and the Clean Air Interstate Rule (CAIR) - and mobile sources: Tier 2 Gasoline Vehicle Standards and the 2007 Heavy Duty Diesel Rule. METHODS: Each step in the classic accountability process was addressed using one or more methods. Linking regulations to emissions was accomplished by identifying major federal regulations and …

NTP Toxicology and Carcinogenesis Studies of t -Butyl Alcohol (CAS No. 75-65-0) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies).

t -Butyl alcohol is widely used in the manufacture of perfumes and a variety of cosmetics. It is also used as a raw material in the production of isobutylene, which may be used to produce methyl tertiary butyl ether, a common gasoline additive, or to produce butyl elastomers used in the production of automobile tires. Male and female F344/N rats and B6C3F1 mice were given t -butyl alcohol (greater than 99% pure) in drinking water for 13 weeks or 2 years. The genetic toxicity of t -butyl alcohol was assessed by testing the ability of the chemical to induce mutations in various strains of Salmon…

NTP Toxicology and Carcinogenesis Studies of Dimethyl Methylphosphonate (CAS No. 756-79-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies).

Dimethyl methylphosphonate (98% pure) is one of four chemicals nominated by the U.S. Army for toxicology and carcinogenesis studies because it was being considered for use to simulate the physical and spectroscopic (but not the biologic) properties of anticholinesterase (nerve) agents. Dimethyl methylphosphonate is also used as a flame retardant, a preignition additive for gasoline, an antifoam agent, a plasticizer and stabilizer, a textile conditioner and antistatic agent, and an additive for solvents and low-temperature hydraulic fluids. The United States produces 0.2-2 million pounds (91,00…

NTP Toxicology and Carcinogenesis Studies of Benzene (CAS No. 71-43-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies).

Benzene ranks 16th in production volume for chemicals produced in the United States, with approximately 9.9 billion pounds being produced in … ther light, high-octane aromatic hydrocarbons, such as toluene and xylenes, is a component of motor gasoline. Benzene is also used as a solvent, but for most applications, it has been replaced by less hazardous solvents. During the 17-week studies, groups of 10 or 15 male and female F344/N rats and B6C3F1 mice were gavaged 5 days per week with benzene in c …

Humanistic Health Management and Cancer: Associations of Psychology, Nutrition, and Exercise with Cancer Progression and Pathogenesis.

The incidence rate of cancer is increasing year by year due to the aging of the population, unhealthy living, and eating habits. At present, surgery and medication are still the main treatments for cancer, without paying attention to the impact of individual differences in health management on cancer. However, increasing evidence suggests that individual psychological status, dietary habits, and exercise frequency are closely related to the risk and prognosis of cancer. The reminder to humanity is that the medical concept of the unified treatment plan is insufficient in cancer treatment, and a

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… apoptosis of PC‐3 cells through decreased Bcl‐2 expression and increased cytochrome c expression to activate caspase‐3, caspase‐8, and caspase‐9. [ 164 ] Tumorigenesis is a multistep process that can be activated by any of various environmental carcinogens (such as cigarette smoke, industrial emissions, gasoline …