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The gut-bone axis: microbial metabolism and nutritional interventions for bone health.

Osteoporosis is a prevalent condition characterized by a rapid decline in bone mineral density and distorted microarchitecture, which leads to increased bone fragility. The gut microbiota and its metabolites play a crucial role in the development and progression of osteoporosis by influencing gut permeability, nutrient digestion and absorption, pH balance, and immune regulation. Nutritional interventions aimed at modulating gut microbiota, through postbiotics (butyrate), probiotics (Bifidobacterium animalis or Lacticaseibacillus rhamnosus LGG), prebiotics (fructo-oligosaccharides), synbiotics,…

Dietary modulation of the gut microbiome as a supportive strategy in the treatment of amyotrophic lateral sclerosis - a narrative review.

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease leading to permanent damage to the central and peripheral motor neu … focusing on changing the microbial composition of the gut. It has been noted that diet, probiotics, prebiotics and vitamins can all influence the course of ALS. Another interesting issue is fecal microbiota transplantation, which is already used in the treatment of certain intestinal diseases and could potentially be useful in the treatment of ALS. This revi …

The Immune Mind: Linking Dietary Patterns, Microbiota, and Psychological Health.

Background/Objectives: Nutritional patterns influence the gut-brain axis and immune signaling with potential consequences for depression and … and depressive outcomes in large prospective cohorts. Psychobiotics (specific probiotic strains and prebiotics) show small-to-moderate benefits on depressive symptoms across clinical and nonclinical samples, with heterogeneity in strains, dosing, and duration. Mechanistic reviews implicate microbiota-derived metabolites (short-chain fatty acids) and immune-i …

The Interplay Between Gut Microbiota, Adipose Tissue, and Migraine: A Narrative Review.

BACKGROUND: Migraine, a prevalent neurovascular disorder, affects millions globally and is associated with significant morbidity. Emerging e … onectin. Dietary patterns, such as low glycemic index diets and Mediterranean diets, and the use of prebiotics, probiotics, and postbiotics show potential in migraine management. CONCLUSIONS: This review underscores the need for integrative approaches targeting the microbiota-gut-brain axis and adipose tissue in migraine therapy. Future studies should explo …

Nutrient acquisition of gut microbiota: Implications for tumor immunity.

The gut microbiota is essential in colorectal cancer (CRC) development, progression, and therapeutic responsiveness through its metabolic acquisitions and immunomodulatory functions. The composition of gut microbiota is shaped by habitat filters such as oxygen availability, dietary components, and host-derived factors, which influence both bacterial colonization and metabolic strategies. Furthermore, microbial metabolism of carbohydrates, proteins, and lipids produces metabolites, including short-chain fatty acids (SCFAs), polyamines, ammonia, hydrogen sulfide, and secondary bile acids (BAs).

Gut Microbiota in Women with Eating Disorders: A New Frontier in Pathophysiology and Treatment.

Emerging evidence highlights the critical role of the gut microbiota in the development and progression of eating disorders (EDs), particula … ction. This evolving understanding suggests that microbiota-targeted therapies, such as probiotics, prebiotics, dietary modulation, and fecal microbiota transplantation (FMT), could complement conventional psychological and pharmacological treatments in women with EDs. Furthermore, precision nutrition and personalized microbiome-based interventions tailored …

Точное питание и обезьяна кут-брэйна в профилактике нейродегенеративных заболеваний.

В последние годы ускорение глобального демографического перехода к старению населения сопровождалось заметным увеличением распространенности нейродегенеративных расстройств, в частности болезни Альцгеймера, болезни Паркинсона, амиотропического бокового склероза и множественного склероза. Среди новых подходов значительное внимание привлекло диетическое вмешательство, направленное на ось кишечника, в силу их потенциала модуляции ключевых патогенных путей, лежащих в основе нейродегенеративных процессов. В этом обзоре обобщены современные концепции точного питания и разъяснены нейрохуморальные, им

Совпадение в аннотации оригинала
In the recent years, the accelerating global demographic shift toward population aging has been accompanied by a marked increase in the prev … of neurodegenerative disorders. Particular attention is devoted to key bioactive components such as prebiotics, probiotics, psychobiotics, dietary fiber, omega-3 fatty acids, and polyphenols that critically participate in regulating the gut-brain axis. Contemporary evidence on the contribution of the gut microbiota to the pathogenesis of Alzheimer's disease, …

Dietary polyphenols represent a phytotherapeutic alternative for gut dysbiosis associated neurodegeneration: A systematic review.

Globally, neurodegeneration and cerebrovascular disease are common and growing causes of morbidity and mortality. Pathophysiology of this group of diseases encompasses various factors from oxidative stress to gut microbial dysbiosis. The study of the etiology and mechanisms of oxidative stress as well as gut dysbiosis-induced neurodegeneration in Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, autism spectrum disorder, and Huntington's disease has recently received a lot of attention. Numerous studies lend credence to the notion that changes in the

The Role of Nutritional Factors in the Modulation of the Composition of the Gut Microbiota in People with Autoimmune Diabetes.

Type 1 diabetes mellitus (T1DM) is a disease marked by oxidative stress, chronic inflammation, and the presence of autoantibodies. The gut m … increased daily intake of soluble and non-soluble fibers, as well as the inclusion of pro-biotics, prebiotics, herbs, spices, and teas that are sources of phytobiotics, in the diet, could be important in improving the composition and activity of the microbiota and thus in the prevention of metabolic disorders. Understanding how the microbiota interacts with …

Psoriasis: Interplay between dysbiosis and host immune system.

With advancement in human microbiome research, an increasing number of scientific evidences have endorsed the key role of both gut and skin … lso, the studies highlighting the potential of bacteriotherapeutic approaches including probiotics, prebiotics, metabiotics, and fecal microbiota transplantation for the management of psoriasis have been discussed.

Exploring the role of gut microbiome in male reproduction.

BACKGROUND: The impact of the gut microbiome on the organism has become a growing research focus with the development of 16S rRNA sequencing … influence male reproductive function. This study discusses therapeutic options such as probiotics, prebiotics, and fecal microbiota transplantation, as well as the challenges and opportunities behind ongoing research, and emphasizes the need for additional research in the future to demonstrate the links and underlying mechanisms between the gut microbiome a …

The impact of alteration in gut microbiome in the pathogenesis of nonalcoholic fatty liver disease.

PURPOSE OF REVIEW: We have increasing evidence that alterations of the intestinal microbiome have a strong influence on human health. Previo … ventions of the microbiome to slow or prevent NAFLD progression, including antibiotics, probiotics, prebiotics, fecal microbiota transplant, and farnesoid × receptor agonism. SUMMARY: Much of the evidence supporting dysbiosis-mediated NAFLD progression has been gathered in high-quality animal trials. There remains a need for additional observational and ran …

Aquaporin5-Targeted Treatment for Dry Eye Through Bioactive Compounds and Gut Microbiota.

Dry eye and dry mouth are the principal sources of morbidity for patients with Sjögren's syndrome (SS). There are few effective treatments, … symptoms through modulation of AQP5 activity are presented within this review. Supplementation with prebiotics (such as polyphenols with high bioavailability) in SS patients with lower Firmicutes/Bacteroides (F/B) community ratio phenotype, through administration of butyrate-producing diets, is proposed as ancillary strategy for dry eye and mouth. The potent …

Implications of Gut Microbiota in Complex Human Diseases.

Humans, throughout the life cycle, from birth to death, are accompanied by the presence of gut microbes. Environmental factors, lifestyle, age and other factors can affect the balance of intestinal microbiota and their impact on human health. A large amount of data show that dietary, prebiotics, antibiotics can regulate various diseases through gut microbes. In this review, we focus on the role of gut microbes in the development of metabolic, gastrointestinal, neurological, immune diseases and, cancer. We also discuss the interaction between gut microbes and the host with respect to their bene…

Assessing effects of yeast cell wall supplementation on threonine requirements in broilers as measured by performance and intestinal morphology.

The objective of this study was to evaluate whether or not the use of a prebiotic yeast cell wall (YCW) affects threonine requirements in starter broilers. Two hundred and forty 1-d-old Ross 308 broiler chickens were distributed among 2 Petersime battery brooder units (48 pens; 5 birds per pen). Different threonine to lysine ratios (0.60, 0.65, and 0.70 to 1.0) with 1.22% available lysine with and without YCW at 250 ppm was fed to the chickens in order to evaluate performance and intestinal morphology over a 21-d trial. A basal diet with 22% protein and 2,980 kcal/kg ME was prepared to create

Intestinal inflammation is associated with higher cadmium burden, potentially via compromised gut barriers: Evidence from NHANES and colitic mouse model.

Rapid industrialization increases the risks of intestinal disorders and heavy metal exposure. Although existing studies have demonstrated that cadmium (Cd) induces intestinal inflammation, whether inflammation is associated with higher Cd absorption remains unexplored. Using NHANES 2005-2010 data and a Cd-contaminated rice-fed colitic mouse model, we found a positive association between intestinal inflammation and blood Cd levels. Compared with healthy individuals in NHANES, those with bowel leakage symptoms had 21.4% higher blood Cd levels (95% CI: 8.72%, 35.4%), whereas those with inflammato

Comparative effectiveness of biotic-based toothpastes in children with special health care needs: A randomized controlled trial.

CONTEXT: Over the years, dental caries management strategies have evolved tremendously, and a recent paradigm shift toward the preventive approach has been observed. The use of biotics with conventional preventive measures has been reported to have beneficial effects, especially in children with special healthcare needs (SHCN) having increased oral health risks. AIM: To compare and evaluate the effects of toothpastes containing xylitol and xylitol- Bacillus coagulans, on levels of Streptococcus mutans and Lactobacilli in the saliva of children with SHCN. MATERIALS AND METHODS: A randomized c

Lion's Mane Medicinal Mushroom Hericium erinaceus (Agaricomycetes) Polysaccharides for Improved In Vitro Probiotic Growth, Adhesion, Antioxidant Activity, and Cryoprotective Properties.

Hericium erinaceus, commonly known as lion's mane mushroom, is a rare edible and medicinal fungus that is highly valued in both the culinary … e at -20°C following freeze-drying. H. erinaceus-derived crude polysaccharides hold promise as both prebiotics and cryoprotectants, making them a potentially valuable functional ingredient for use in food products.

Physicochemical and Bioactive Characterization of a Neotropical Calothrix Strain.

Despite the biotechnological potential of cyanobacteria, the antibacterial, antifungal, and prebiotic properties of the genus Calothrix remain largely unexplored. This study characterizes the composition and biological activity of a neotropical strain Calothrix sp. CBUCES-K 9914 from Antioquia, Colombia, and evaluates growth under varying light and nutrient treatments. The strain achieved its highest biomass yield (0.75 g L⁻¹) under white light supplemented with 0.3 g L⁻¹ glucose and 0.2 g L⁻¹ nitrogen. Characterization revealed 16 amino acids, dominated by aspartic acid (20.4%), alanine (14.5

Inulin alleviates vascular cognitive impairment by restoring prefrontal GABAergic function via microbiota-SCFA-GPR41/43 axis.

BACKGROUND: Vascular cognitive impairment (VCI) impairs medial prefrontal cortex (mPFC) function, a cognitive hub reliant on intact GABAergic transmission. Although prebiotics may counteract VCI by remodeling the gut microbiota, the underlying mechanisms remain unclear. This study investigated whether the prebiotic inulin could improve VCI by restoring mPFC GABAergic function via the gut-brain axis. RESULTS: In a mouse model of VCI induced by bilateral carotid artery stenosis (BCAS), inulin supplementation ameliorated cognitive deficits and anxiety-like behaviors and reshaped the gut microbio…