Результаты поиска

Vaginal Probiotic Potential of Lactobacillus acidophilus: Population Genomic and Phenotypic Analysis.

Background/Objectives: Certain strains of Lactobacillus acidophilus are widely used as probiotics. However, their functional potential for female reproductive tract health remains insufficiently characterized. While most studies have focused on individual strains, the distribution of putative probiotic-associated genes across the species remains unclear. This study aimed to evaluate the vaginal probiotic potential of Lb. acidophilus using population genomic analysis and comparative phenotypic characterization. Methods: Pan-genomic analysis was performed on 109 Lb. acidophilus genomes (107 publ…

Impact of probiotic supplementation on chemotherapy and radiotherapy-associated diarrhea and quality of life.

OBJECTIVES: To evaluate whether prophylactic oral Lactobacillus supplementation reduces chemotherapy- and radiotherapy-associated diarrhea and helps preserve quality of life (QoL) in adults starting anticancer treatment. MATERIALS AND METHODS: This prospective two-group observational study included adults (18-75 years) receiving their first cycle of chemotherapy and/or radiotherapy at a tertiary cancer center. The Nonprobiotic Group received standard care without probiotics, and the Probiotic Group received standard care plus oral Lactobacillus 60 million colony-forming units twice daily for …

Can probiotic-rich yogurt help prevent colorectal cancer in humans?

•Yogurt consumption is linked to 20-40% lower colorectal cancer risk, especially proximal colon tumors with high Bifidobacterium levels.•Probiotics modulate gut microbiota, reduce inflammation, and produce protective metabolites against cancer development.•Bifidobacterium strains in yogurt suppress tumor growth through various signaling and immune pathway regulation.•Early screening age reduction and increased fiber intake are recommended for enhanced colorectal cancer prevention.•Probiotic therapy shows promise for reducing treatment side effects and improving patient quality of life.

Colonic Submucosa Targeted Delivery of Probiotic and Rhein for Ulcerative Colitis Treatment.

Ulcerative colitis (UC) is a chronic disease. A significant challenge for the management of UC is to achieve delivery of drugs to the multi-layer colonic barriers, as existing drugs are difficult to penetrate these depths. In this study, a novel drug delivery system using yeast cell wall microparticles (YPs) are developed to co-encapsulate Bacillus subtilis (BS) and Rhein (Rh) termed Rh-YBS. This system specifically targets colonic microfold cells, enabling direct delivery of BS to the colonic submucosa. Additionally, Rh enhances BS colonization in the submucosa through floral regulation. Stud

Effect of Probiotic Product Containing Heyndrickxia coagulans TBC169 on Hyperuricemia in Rats.

Hyperuricemia (HUA) is a metabolic disease characterized by elevated serum uric acid, which is closely related to the gut microbiota. Probiotics have great potential in improving HUA. The purpose of this study was to evaluate the effect and mechanism of probiotic product (SQK) containing Heyndrickxia coagulans TBC169 on HUA rats. Forty SD rats (6 weeks old, 200 ± 20 g) were randomly divided into four groups (Ctrl group, HUA group, SQK1 group, and SQK2 group) of 10 rats each. Rats were given potassium oxonate (100 mg potassium oxonate/100 g BW/day) for 12 weeks to establish HUA model and simult…

Probiotic: A Gut Microbiota-Based Therapeutic Approaches for the Treatment of Parkinson's Disease.

The estimated worldwide number of individuals diagnosed with Parkinson's disease (PD) might exceed 10 million by 2040. However, the underlyi … efficacy. Numerous clinical and preclinical studies have substantiated the therapeutic potential of probiotics in treating Parkinson's disease via the gut-brain axis. The technique appears to have benefited from a combination of favorable conditions that led to its success. The present study investigated whether administering the probiotic can be a better th …

Probiotic potential and antimicrobial efficacy of a dairy isolate, Enterococcus faecium MBBL3.

Enterococcus faecium is a promising probiotic with potential antimicrobial effects. This study aimed to evaluate the probiotic and antimicrobial properties of E. faecium MBBL3, isolated from healthy cow milk, against bovine mastitis pathogens Klebsiella pneumoniae MBBL2 (Kp MBBL2) and Escherichia coli MBBL4 (Ec MBBL4), using comprehensive genomic and functional analyses. The genome assembly and functional annotations of MBBL3 unveiled many important probiotic traits, and comparative genomic analysis demonstrated its high degree of genetic similarity with other Enterococcus strains. MBBL3 exhib

Fucoidan as an Encapsulant material: Applications and advantages in active agents and probiotic encapsulations.

Fucoidans are branched sulfated polysaccharides primarily derived from brown seaweed, especially the Fucus genus, as well as other algae and marine invertebrates. With pseudoplastic behavior, they offer promising applications in cosmetics, pHarmaceuticals, and food industries. While traditional drug delivery materials are well-studied, fucoidans have gained attention as encapsulants, particularly in combination with chitosan and whey protein concentrate, which enhances their biocompatibility, biodegradability, and bioactivity. These combinations enable effective encapsulation of bioactive comp

Encapsulation of a Probiotic Bacterial Strain in a Biocompatible Iron(III) Fumarate Matrix.

The encapsulation of bacteria in metal-organic frameworks (MOFs) is being studied for use in biomedicine and bioremediation. However, biocompatibility could be improved, as much of the research focuses on ZIF-8 and Escherichia coli. MIL-88A, composed of fumaric acid and iron, offers a safer alternative. This study investigates encapsulation of the probiotic strain Lactiplantibacillus plantarum 299v in a nanocrystalline matrix via a simple one-pot synthesis. The encapsulated bacteria show improved stability in saline, lysozyme and pepsin compared to uncoated cells. These findings highlight the

Theranostic Probiotic Engineered Living Materials That Dynamically Respond to Inflammation Markers.

The development of smart, implantable devices localized at the site of inflammation to conditionally and proactively combat active inflammation for inflammatory bowel disease (IBD), has the potential to transform the patient's quality of life compared to conventional treatment modalities. Engineered probiotic organisms can enable dynamic production of therapeutic compounds in response to inflammatory biomarkers. However, delivery and localization of these engineered organisms to the site of inflammation requires their integration into a material or device that sustains their viability and meta

Description of probiotic use in preterm infants in England and Wales 2016-2022.

OBJECTIVE: To describe the use of probiotics among preterm infants in neonatal units and explore factors that influence exposure. DESIGN: Observational study using prospectively recorded health data. SETTING: England and Wales. PATIENTS: 48 048 infants born at <32 weeks gestational age (GA) and admitted to a neonatal unit between 1 January 2016 and 31 December 2022. MAIN OUTCOME MEASURES: Measures of probiotic use (number and proportion of infants exposed to probiotics, postnatal age of first probiotic exposure and discontinuation). RESULTS: The proportion of infants who received probioti…

Probiotic Modulation in Aging: Strain-Specific Geroprotective Effects in Caenorhabditis elegans.

Elderly individuals are more vulnerable to disease due to their increased frailty. Emerging evidence highlights the potential of probiotics as geroprotective agents by maintaining gut health and modulating key physiological processes involved in aging, such as inflammation, cognitive functions, and metabolism. Here, we investigated the geroprotective potential of four probiotic strains (Lacticaseibacillus paracasei LPC1114, Limosilactobacillus reuteri PBS072, Bifidobacterium breve BB077, and Bifidobacterium animalis subsp. lactis BL050) using Caenorhabditis elegans as an aging model. Mid-life …

Drugs Versus Microbiota: How Pharmacotherapy Affects Gut and Probiotic Bacteria.

The gut microbiota plays a key role in digestion, nutrient absorption, immune system regulation and metabolite production, significantly imp … e gut microbiota, causing dysbiosis, which in turn may lead to other diseases. Dietary supplements, probiotics, prebiotics and certain medications alter the composition of the gut microbiota, which plays an essential role in alleviating metabolic disorders. This study discusses the effects of the long-term use of selected pharmaceuticals on the gut and probi …

The Home Use of Probiotics and Paraprobiotics for the Maintenance of Tongue Eubiosis: A Case Report.

Aim: Halitosis is the unpleasant odor emitted from the oral cavity during exhalation and phonation. Using oral care products containing specific probiotics and paraprobiotics, combined with lifestyle changes, this study is aimed at resolving the patient's altered breath odor. Case Report: A 49-year-old male patient suffered from retronasal discharge, bacterial plaque on the back of his tongue, and bad breath. He underwent a professional oral hygiene session, received instructions in proper home oral hygiene techniques, and was advised on appropriate lifestyle changes. The use of oral care prod…

Assessment of Antibiotic Resistance and Microbial Contamination in Commercial Veterinary Probiotic Products.

Probiotics are widely used as feed additives in livestock production, yet the overall safety of commercially available veterinary probiotics remains insufficiently assessed. In this study, 33 probiotic products marketed in Northern China were systematically evaluated with respect to strain composition, label accuracy, antimicrobial resistance, and the diversity of resistance genes. A total of 32 Bacillus spp. were isolated, many of which showed resistance to multiple antibiotics. Labeling inaccuracies were prevalent: none of the products specified strain names and numbers, 33% (11/33) failed t…

Novel Enterococcus faecium P2 as a probiotic for mitigating Clostridioides difficile infection.

Clostridioides difficile (C. difficile) is a well-recognized pathogen responsible for severe intestinal disorders, including pseudomembranous colitis and toxic megacolon. Probiotics have shown considerable promise in the prevention and management of gastrointestinal diseases. In this study, we isolated Enterococcus faecium (E. faecium) P2 from the feces of a healthy child and evaluated its probiotic efficacy against C. difficile infection (CDI) using a mouse model. In vitro assessments demonstrated that E. faecium P2 exhibits high safety, tolerates gastrointestinal stressors, forms robust biof…

Effect of the Multi-Strain Probiotic SYN-53 in the Management of Allergic Rhinoconjunctivitis.

Dysbiosis is increasingly linked to allergy development. This study evaluates the efficacy of the multi-strain probiotic SYN-53 in the management of allergic rhinoconjunctivitis (ARC). Eighty-four subjects with confirmed grass pollen allergy underwent up to three bi-weekly 3-day intake cycles with SYN-53 or placebo. After each cycle, subjects were exposed to grass pollen in an allergen exposure chamber. ARC symptoms were assessed using the Total Symptom Score (TSS) before and after each use of SYN-53. After one intake cycle, SYN-53 already showed a trend towards greater efficacy over placebo,

The impact of probiotic administration on experimental in vitro and in vivo infection by Trypanosoma cruzi.

BACKGROUND: Chagas disease (CD) caused by Trypanosoma cruzi has limited therapy. Probiotics sustain healthy microbiota, playing roles in biological events. OBJECTIVES: Our aim was to determine the impact of probiotics on T. cruzi infection in vitro and in mouse acute experimental models. METHODS: The multi strain - PB8 and the Lactobacillus rhamnosus (LR) were orally administered [106-109 colony-forming units (CFU)] for seven days prior to mice infection followed for 14 daily administrations. Peritoneal mouse macrophages (PMM) were obtained from mice treated with 109 probiotics one day befor…

Всеобъемлющий обзор воздействия пробиотики, предбиотики и синтиотики на ось кишечника.

Ось кишечника представляет собой сложную двунаправленную систему связи, соединяющую желудочно-кишечный тракт и центральную нервную систему через нейронные, эндокринные, иммунные и метаболические пути. Появляющиеся данные свидетельствуют о том, что диетические вмешательства, особенно пробиотики, предбиотики и синтиотики, могут влиять на состав и активность кишечного микробиота, тем самым видоизменяя функцию ГБА. Такая модуляция связана с потенциальными выгодами для когнитивных функций, эмоционального регулирования и устойчивости к нейродегенеративным и нейропсихиатрическим расстройствам. Кроме

Совпадение в аннотации оригинала
The gut-brain axis (GBA) represents a complex bidirectional communication system connecting the gastrointestinal tract and the central nervous system through neural, endocrine, immune, and metabolic pathways. Emerging evidence suggests that dietary interventions, particularly probiotics, prebiotics, and synbiotics, can influence the composition and activity …

The Health Benefits of Probiotic Lactiplantibacillus plantarum: A Systematic Review and Meta-Analysis.

To ensure effective administration of probiotics in clinical practice, it is crucial to comprehend the specific strains and their association with human health. Therefore, we conducted a systematic review and meta-analysis to evaluate the scientific evidence on the impact of Lactiplantibacillus plantarum probiotic consumption on human health. Out of 11,831 records, 135 studies were assessed qualitatively, and 18 studies were included in the meta-analysis. This systematic review demonstrated that probiotic supplementation with L. plantarum, either alone or in combination, can significantly impr…