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An expanding horizon of complex injectable products: development and regulatory considerations.

There has been a constant evolution in the pharmaceutical market concerning the new technologies imbibed in delivering drug substances for various indications. This is either market-driven or technology-driven to improve the overall therapeutic efficacy and patients' quality of life. The pharmaceutical industry has experienced rapid growth in the area of complex injectable products because of their effectiveness in the unmet market. These novel parenteral products, viz, the nanoparticles, liposomes, microspheres, suspensions, and emulsions, have proven their worth as "Safe and Effective" produ

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… . | Advate ® | Antihemophilic factor (recombinant, plasma/albumin-free method) | rDNA therapy | Lyophilized powder for reconstitution | 250, 500, 1000, 1500, 2000, and 3000 IU | Mannitol, trehalose, sodium chloride, histidine, Tris, calcium chloride, polysorbate 80, glutathione | Control and prevention …

RNA метилтрансферазы METTL8 устанавливает m3C32 в митохондриальном tRNASThr/Ser (UCN) для оптимизации структуры trNA и митохондриального перевода.

Модифицированные нуклеотиды в tRNA являются важными определяющими факторами сворачивания, структуры и функции. Здесь мы идентифицируем METTL8 как митохондриальный белок и активный РНК метилтрансферазы, ответственный за установку m3C32 в митохондриале человека (mt-)tRNAThr и mt-tRNAser (UCN). METTL8 имеет перекрестные связи с антикодоновой стволовой петлей (ASL) многих мт-тРНК в клетках, в связи с чем возникает вопрос о том, каким образом достигается целевая специфичность метилирования. Расчленение элементов распознавания mt-tRNA выявило наличие U34G35 и t6A37/(ms2)i6A37, которые одновременно п

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… Cells were resuspended in homogenisation buffer (300 mM trehalose, 10 mM KCl, 10 mM HEPES–KOH pH 7.4, 1 mM PMSF and 0.2% BSA) and homogenised using a Homogenplus Homogeniser (Schuett-Biotec). …

Genus Sophora: a comprehensive review on secondary chemical metabolites and their biological aspects from past achievements to future perspectives.

Sophora is deemed as one of the most remarkable genera of Fabaceae, and the third largest family of flowering plants. The genus Sophora comprises approximately 52 species, 19 varieties, and 7 forms that are widely distributed in Asia and mildly in Africa. Sophora species are recognized to be substantial sources of broad spectrum biopertinent secondary metabolites namely flavonoids, isoflavonoids, chalcones, chromones, pterocarpans, coumarins, benzofuran derivatives, sterols, saponins (mainly triterpene glycosides), oligostilbenes, and mainly alkaloids. Meanwhile, extracts and isolated compoun

Электрохимические датчики на основе полимера для диагностики нейродегенеративных заболеваний.

Острые и хронические нейродегенеративные заболевания (ND), включая множественный склероз (MS), болезнь Альцгеймера (AD) и болезнь Паркинсона (PD), характеризуются нейродегенерацией, которая представляет собой постепенный сбой и повреждение нейронов и аксонов в центральной нервной системе. Благодаря обнаружению соответствующих биомаркеров нейродегенеративных заболеваний (ND) стало возможным совершенствование клинических диагностических исследований, а также разработка и отслеживание успешных методов лечения заболеваний. Важные биомаркеры, такие, как белки тау, амилоид-β и α-синуклеины, имеют ва

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… Within this framework, researchers investigated several organic compounds (trehalose, ethylenediaminetetraacetic acid, salicylate, metformin, phenylenediamine, and ethylenediaminetetraacetic acid) as well as organic extracts derived from Bacopa monnieri L., a plant with a long history of use in Ayurvedic …

Developments in nanotechnology approaches for the treatment of solid tumors.

Nanotechnology has revolutionized cancer therapy by introducing advanced drug delivery systems that enhance therapeutic efficacy while reducing adverse effects. By leveraging various nanoparticle platforms-including liposomes, polymeric nanoparticles, and inorganic nanoparticles-researchers have improved drug solubility, stability, and bioavailability. Additionally, new nanodevices are being engineered to respond to specific physiological conditions like temperature and pH variations, enabling controlled drug release and optimizing therapeutic outcomes. Beyond drug delivery, nanotechnology pla

Interferon-Based Biopharmaceuticals: Overview on the Production, Purification, and Formulation.

The advent of biopharmaceuticals in modern medicine brought enormous benefits to the treatment of numerous human diseases and improved the well-being of many people worldwide. First introduced in the market in the early 1980s, the number of approved biopharmaceutical products has been steadily increasing, with therapeutic proteins, antibodies, and their derivatives accounting for most of the generated revenues. The success of pharmaceutical biotechnology is closely linked with remarkable developments in DNA recombinant technology, which has enabled the production of proteins with high specific

Biopharmaceutical and pharmacokinetic attributes to drive nanoformulations of small molecule tyrosine kinase inhibitors.

Buoyed by the discovery of small-molecule tyrosine kinase inhibitors (smTKIs), significant impact has been made in cancer chemotherapeutics. However, some of these agents still encounter off-target toxicities and suboptimal efficacies due to their inferior biopharmaceutical and/or pharmacokinetic properties. Almost all of these molecules exhibit significant inter- and intra-patient variations in plasma concentration-time profiles. Thus, therapeutic drug monitoring, dose adjustments and precision medicine are being contemplated by clinicians. Complex formulations or nanoformulation-based drug d

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… Vanza et al. prepared AFA dimaleate loaded liposomes, later lyophilized with trehalose to form dry powder inhalation. A cellular uptake study showed that liposomes were internalized and exhibited lower IC 50 value than plain drug. …

Applications of synthetic biology in medical and pharmaceutical fields.

Synthetic biology aims to design or assemble existing bioparts or bio-components for useful bioproperties. During the past decades, progresses have been made to build delicate biocircuits, standardized biological building blocks and to develop various genomic/metabolic engineering tools and approaches. Medical and pharmaceutical demands have also pushed the development of synthetic biology, including integration of heterologous pathways into designer cells to efficiently produce medical agents, enhanced yields of natural products in cell growth media to equal or higher than that of the extract

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… . | Detection of gut inflammations | Pre-Clinical | 452 , 453 Recording of cellular events over time using engineered bacteria | A multiplexing strategy to simultaneously record the temporal availability of three metabolites (copper, trehalose, and fucose) in the environment of a cell population over …

Advances in improving cancer immunotherapy with nanotechnology: from smart nanoparticles to synergistic combination strategies.

Cancer immunotherapy has substantially advanced cancer treatment, achieving durable responses in select malignancies. However, its widespread application is limited by significant challenges: low efficacy in many solid tumors, severe side effects, and immune evasion facilitated by the tumor microenvironment (TME). Nanotechnology offers a promising approach to address these obstacles. By employing nanoparticles (NPs), we can precisely deliver therapeutics to tumor sites, ensure controlled release to minimize side effects, and amplify the immune response, thereby substantially boosting the effec

Mucosal-Associated Invariant T Cells in Health and Disease.

Mucosal-associated invariant T (MAIT) cells are a population of evolutionarily conserved, unconventional innate-like T lymphocytes that are restricted by major histocompatibility complex Class I-related (MR1) molecules. They can be activated either in a T-cell receptor-MR1- or cytokine-dependent manner. Activated MAIT cells play crucial roles in maintaining homeostasis and the fine regulation of the immune system. This review presents a systematic exploration of the development, biological characteristics, and multiple effects of MAIT cells in health and various diseases. In healthy individual

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… During Mtb infection, MA can be esterified to glycerol (Gro‐MM), glucose (GMM), or trehalose (TMM) and presented by CD1b to activate GEM T cells. The conserved TCR within GEM‐T cells can respond to Mtb infection via clonal expansion and the secretion of antimycobacterial cytokines [ 177 ]. …

Ход работы 34th Симпозиум ESVN-ECVN 23rd-24th сентябрь 2022.

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… Genes associated trehalose biosynthesis, ribosomal synthesis and gluconeogenesis were increased, whereas V‐ATPase‐related oxidative phosphorylation genes were decreased. The behavioral assessment showed improvement in stranger‐directed and non‐social fear and trainability 90 days post‐treatment. …

UEG Week 2015 Poster Presentations

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ISEV2020 Резюме

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Премии победителей и резюме 32nd Ежегодный симпозиум Общества протеинов; Бостон, ОЭТ, июль 9-12, 2018.

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2020 ACVIM Forum On Demand Research Abstract Program.

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Абстрактный сборник ISEV2022.

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… EVs were double‐labeled with CD61‐APC and CD235a‐PE or lactadherin‐FITC, isolated by size‐exclusion chromatography to reduce swarm detection, diluted in cryopreservation agent (trehalose), frozen in liquid nitrogen, and stored at 80°C. … Summary/Conclusion : PEVTES can be stably stored in trehalose for up to 12 months at ‐80°C. The PEVTES will be key to validate newly developed reference materials and methods in a global comparison study involving 25 laboratories. …

Минимальная информация для исследований внеклеточной везиклетки (MISEV2023): от базовых до передовых подходов.

Внеклеточные везиклолы (ЭМ) с помощью своего сложного груза могут отражать состояние клетки их происхождения и изменять функции и фенотипы других ячеек. Эти особенности свидетельствуют о значительном биомаркировании и терапевтическом потенциале и вызывают широкий интерес, о чем свидетельствует постоянное увеличение числа научных публикаций об ЭМ за год. Значительные успехи были достигнуты в области ЭВМ, а также в понимании и применении биологии ЭМ. Вместе с тем сохраняются препятствия на пути реализации потенциала ЭМ в различных областях - от базовой биологии до клинического применения - в свя

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… Cryoprotectants may reduce effects of freeze‐thaw (Le Saux et al., 2020 ; Lőrincz Á et al., 2014 ); for example, supplementing phosphate buffered saline (PBS) with human albumin and trehalose (PBS‐HAT) reportedly improved short‐ and long‐term stability for EVs stored at −80°C and through several freeze‐thaw …

Tumor biomarkers for diagnosis, prognosis and targeted therapy.

Tumor biomarkers, the substances which are produced by tumors or the body's responses to tumors during tumorigenesis and progression, have been demonstrated to possess critical and encouraging value in screening and early diagnosis, prognosis prediction, recurrence detection, and therapeutic efficacy monitoring of cancers. Over the past decades, continuous progress has been made in exploring and discovering novel, sensitive, specific, and accurate tumor biomarkers, which has significantly promoted personalized medicine and improved the outcomes of cancer patients, especially advances in molecu

Резюме книги: ISEV2017.

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ECC-4 Abstracts

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