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Effect of biofeedback electrical stimulation combined with HoLEP on surgical outcomes in patients with benign prostatic hyperplasia complicated with detrusor underactivity: a retrospective cohort study.

OBJECTIVE: To investigate the clinical efficacy and safety of biofeedback electrical stimulation combined with holmium laser enucleation of the prostate (HoLEP) in the treatment of patients with benign prostatic hyperplasia (BPH) complicated by detrusor underactivity (DUA). METHODS: A retrospective analysis was conducted on 100 patients with BPH and DUA who had surgical indications and were treated in the Department of Urology of our hospital from January 2023 to June 2025. Patients were divided into an intervention group (n = 51) and a control group (n = 49) according to the treatment modali…

Prostate morcellation devices: a systematic review and meta-analysis of clinical outcomes and efficiency.

OBJECTIVE: To systematically evaluate the efficiency and safety of different prostate morcellators used during prostate enucleation for beni … conducted. RESULTS: A total of 22 studies comprising 5980 patients were included, most undergoing holmium laser enucleation of the prostate. The most frequently evaluated devices were the Piranha™ (Richard Wolf GmbH, Knittlingen, Germany) and Lumenis VersaCut™ (Lumenis Ltd., Yokneam, Israel; 12 and 13 studies, respectively), followed by DrillCut™ (Karl …

The Impact of Previous Prostate Surgery on Surgical Outcomes for Patients Treated with Robot-assisted Radical Cystectomy for Bladder Cancer.

BACKGROUND: The feasibility and safety of robot-assisted radical cystectomy (RARC) may be undermined by unfavorable preoperative surgical characteristics such as previous prostate surgery (PPS). OBJECTIVE: To compare perioperative outcomes for patients undergoing RARC with versus without a history of PPS. DESIGN, SETTING, AND PARTICIPANTS: The study included 220 consecutive patients treated with RARC and pelvic lymph node dissection for bladder cancer at a single European tertiary centre. Of these, 43 had previously undergone PPS, defined as transurethral resection of the prostate/holmium la…

Robot-assisted simple prostatectomy (RASP): does it make sense?

UNLABELLED: Study Type - Therapy (case series) Level of Evidence 4. What's known on the subject? and What does the study add? The open simple prostatectomy (OSP) is the 'gold standard' for high-volume prostate adenomas. It shows very good functional results despite its invasiveness. Minimally invasive approaches, e.g. laparoscopy or holmium laser enucleation of the prostate, have been 'tested' but none have proved a substitute for the OSP. The robot-assisted approach provides optimal functional results and is easy to perform for experienced robotic surgeons. Extending the indication of robotic…

"In-bore" MRI prostate biopsy is a safe preoperative clinical tool to exclude significant prostate cancer in symptomatic patients with benign prostatic obstruction before transurethral laser enucleation.

INTRODUCTION: Purpose of our study was to investigate the role of a negative in-bore MRI-guided biopsy (MRI-GB) in comparison to a negative multiparametric prostate MRI (mpMRI) and a contextual negative transrectal ultrasound guided biopsy of the prostate with regard to incidental prostate cancer findings in the surgical specimen of men who underwent to Holmium Laser enucleation of prostate (HoLEP) with a preoperative suspicion of prostate cancer. MATERIALS AND METHODS: Data of 117 of symptomatic patients for bladder outflow obstruction who subsequently underwent to HoLEP was retrospectively …

[Micropercutaneous laser nephrolithotripsy].

INTRODUCTION: The least invasive technique of PCNL is micropercutaneous nephrolithotripsy (micro-PCNL). A possibility of kidney puncture und … tients with larger stones, working sheath of 8 Ch was put. For stone disintegration, 50 W and 100 W holmium lasers, as well as the Russian innovative thulium fiber laser were used. RESULTS: The average duration of surgery from the puncture was 30.6+/-11.6 minutes. The effectiveness was determined by use of a non-contrast computed tomography, performed on …

Targeted Palliative Radionuclide Therapy for Metastatic Bone Pain.

Bone metastasis develops in multiple malignancies with a wide range of incidence. The presence of multiple bone metastases, leading to a multitude of complications and poorer prognosis. The corresponding refractory bone pain is still a challenging issue managed through multidisciplinary approaches to enhance the quality of life. Radiopharmaceuticals are mainly used in the latest courses of the disease. Bone-pain palliation with easy-to-administer radionuclides offers advantages, including simultaneous treatment of multiple metastatic foci, the repeatability and also the combination with other

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… Ho]holmium-Ethylene Diamine Tetramethylene Phosphonate ([ 166 Ho]Ho-EDTMP) Different phosphonate complexes have been labelled with [ 166 Ho]holmium targeting bone and bone marrow lesions [ 111 , 112 , 113 , 114 ]. [ 166 Ho]holmium is an inexpensive β¯-emitter, majorly used in the treatment of multiple … Production of Holmium-166 DOTMP: A promising agent for bone marrow ablation in hematologic malignancies. Iran. J. Nucl. Med. 2011 117. Klaassen N.J.M., Arntz M.J., Gil Arranja A., Roosen J., Nijsen J.F.W. The various therapeutic applications of the medical isotope holmium-166: A narrative review. …

Clinical outcomes and risk factor analysis of early endoscopic puncture decompression for ureterocele associated with duplex kidney in children: a single-center retrospective study.

PURPOSE: The aims of this study were to analyze the clinical outcomes of treating duplex system ureteroceles with early endoscopic puncture … s. RESULTS: A total of 36 patients with ureteroceles related to duplex kidney underwent endoscopic holmium laser puncture from 2015 to 2023 at our institution. After a median follow-up of 21.6 months, unfavorable outcomes developed in 17 patients (47.2%). Three patients underwent ipsilateral common-sheath ureter reimplantation and one patient underwent l …

Acute results, complications, and effect of lesion characteristics on outcome with the solid-state, pulsed-wave, mid-infrared laser angioplasty system: final multicenter registry report. Holmium:YAG Laser Multicenter Investigators.

BACKGROUND AND OBJECTIVE: The solid-state, mid-infrared holmium:YAG laser (2.1 microm wavelength) is a relatively new percutaneous device that has recently been evaluated in a multicenter study. Because of its unique wavelength and photoacoustic effects on atherosclerotic plaques, this laser may be useful in treatment of symptomatic patients with coronary artery disease. This study sought to evaluate the safety and efficacy of mid-infrared laser angioplasty in the treatment of coronary artery lesions. PATIENTS AND METHODS: Laser angioplasty was performed on 2,038 atherosclerotic lesions in 1,…

[Recent progress in the treatment of intractable sialolithiasis].

Sialolithiasis occurs in approximately 0.45% to 1.20% of the general population. The typical clinical symptom manifests as a painful swellin … ones. Laser lithotripsy has been applied in the treatment of sialolithiasis in the past decade, and holmium ∶YAG laser is reported to have the best therapeutic effects. During the past 3 years, our research group has performed laser lithotripsy for a few cases with intractable salivary stones. From our experiences, withdrawal of the endoscopic tip 0.5-1.0 …

Diagnosis and management of ureteral fibroepithelial polyps in children: a new treatment algorithm.

INTRODUCTION: Fibroepithelial polyps are benign mesenchymal tumors arising from the urinary tract. With the advent of endoscopy in the pedia … ong the ureter and evaluation of the macroscopic polyp appearance. Based on ureteroscopic findings, Holmium laser polypectomy was performed in two patients with single, pedunculated polyps. Anderson-Hynes dismembered pyeloplasty was performed in three patients with broad based, multilobulated polyps too large for endoscopic treatment and in one patient fo …

Influence of Strengthening Elements and Heat Treatment on Microstructure and Fracture Toughness of NiAl-Cr(Mo)-Based Eutectic Alloy.

Due to their potential improvement of high-temperature properties, the refractory metal hafnium (Hf) and the rare earth holmium (Ho) have attracted much attention. In the present research, NiAl-Cr(Mo) eutectic alloys with different Ho and Hf additions were fabricated by conventional smelting method and heat-treated to study the synergetic influence of strengthening elements and heat treatment. The samples were characterized using XRD, SEM, and TEM, and the three-point bending test was performed to obtain fracture toughness. The results demonstrate that Hf addition leads to the formation of Ni2…

[Endoscopic marsupialization of parapelvic renal cysts].

INTRODUCTION: Parapelvic renal cysts are very common. Indications for surgical treatment are upper urine tract obstruction, pain and recurre … ts recurrent gross hematuria was also an indication for surgical treatment. For marsupialization, a holmium (Ho:YAG) laser Auriga XL (Boston Scientific, USA) was used in 4 patients, and in other cases (n=7) a procedure was performed using a thulium fiber laser (Tm Fiber) Fiberlase U1 (IRE-Polus, Russia). In 3 patients, to clarify the site of incision of t …

[The use of ultrasound imaging in minimally invasive percutaneous nephrolithotomy. Can we completely abandon fluoroscopy?].

AIM: To determine the possibility of performing minimally invasive percutaneous nephrolithotomy (PCNL) under ultrasound guidance with the us … n of tract was done using X-ray guidance for the safe formation of the working channel, followed by holmium lithotripsy. At the end a nephrostomy or JJ-stent was left. RESULTS: The mean age of the patients was 53.13+/-12.9, while average BMI was 29.3+/-6.5. In total, there were 44.1% of women. The average stone size was 20.7+/-10.9 mm; 45.1% of stones we …

Advances in Radionuclides and Radiolabelled Peptides for Cancer Therapeutics.

Radiopharmaceutical therapy, which can detect and treat tumours simultaneously, was introduced more than 80 years ago, and it has changed medical strategies with respect to cancer. Many radioactive radionuclides have been developed, and functional, molecularly modified radiolabelled peptides have been used to produce biomolecules and therapeutics that are vastly utilised in the field of radio medicine. Since the 1990s, they have smoothly transitioned into clinical application, and as of today, a wide variety of radiolabelled radionuclide derivatives have been examined and evaluated in various

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… Holmium-166 ( 166 Ho)-labelled microspheres with high activity are utilised in interventional radioembolization, along with SPECT (single-photon emission computed tomography) imaging, for dosimetry purposes. … The Various Therapeutic Applications of the Medical Isotope Holmium-166: A Narrative Review. EJNMMI Radiopharm. Chem. 2019;4:19. doi: 10.1186/s41181-019-0066-3. 51. …

Two-dimensional computational fluid dynamics study of urine flow in the prostatic fossa after benign prostatic hyperplasia surgery: a single-patient model.

BACKGROUND: Transurethral enucleation techniques such as holmium laser enucleation of the prostate (HoLEP) have become increasingly popular as an alternative to conventional transurethral resection of the prostate (TURP). Yet enucleation leaves a wider prostatic fossa than tissue-sparing TURP, and whether a larger post-operative lumen consistently yields better voiding remains uncertain. To address this question, we used a single-patient, two-dimensional computational fluid dynamics (CFD) model to investigate how prostatic fossa geometry modulates urinary flow and energy loss during mid-voidin…

[Results of the first multicenter study assessing the efficiency of a tissue sensor during thulium fiber laser lithotripsy].

INTRODUCTION: Currently, the main surgical approach for urinary stone removal is minimally invasive endoscopic procedures. Various laser systems compatible with most modern instruments are used for stone disintegration. Due to high efficacy and minimal fragment retropulsion during fragmentation, the domestic thulium fiber laser has become a serious alternative to the conventional holmium laser. At the same time, the safety profile of thulium fiber lithotripsy remains debatable because of the potential risk of irrigation fluid heating and damage to surrounding tissues during fragmentation. Impl…

Clinical presentation and management patterns of ureteral calculi in pregnancy: a 14-year single-institution retrospective study.

OBJECTIVE: This study aimed to describe the clinical presentation, diagnostic pathway, and management patterns of ultrasound-confirmed urete … stpartum ureteroscopic lithotripsy. Among the 120 analyzed patients, neither ESWL nor ureteroscopic holmium laser lithotripsy (URS-HLL) was performed during pregnancy. Among eight febrile patients, mean white blood cell (WBC) count decreased from 14.9 ± 0.19 × 109/L to 6.7 ± 0.30 × 109/L (paired t-test, P < 0.001). Mean procalcitonin (PCT) was 13.86 ± 3.5 …

Laser prostatectomy for benign prostatic obstruction.

BACKGROUND: Symptomatic benign prostatic obstruction is a common problem for older men. The gold standard treatment, transurethral resection … stitial laser coagulation with transurethral microwave thermotherapy (TUMT), and one study compared holmium contact lasers (HoLRP) with open prostatectomy. Among the studies comparing laser prostatectomy with TURP, follow-up duration ranged from 6 to 36 months. Mean age (67.2 yrs), mean baseline symptom score (20.2), and mean baseline peak urinary flow (9 …

Mixed Reality Ultrasound-Guided Mini-ECIRS with Apple Vision Pro™ - First Case Report.

INTRODUCTION: Some endourological surgeries require multiple screens to perform combined procedures, which can present ergonomic challenges … ure was performed in the Barts flank-free position. Initially, ureterolithotomy was performed using holmium laser. After the dusting phase, an ultrasound-guided renal puncture was performed using a virtual screen, providing enhanced comfort and ergonomics for the surgeon. Throughout the procedure, the surgeon had simultaneous access to both screens (nephr …