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[Monitoring of viral pathogens in pediatric intensive care unit and analysis of clinical significance].

OBJECTIVE: To study the characteristics of viral spectrum and clinical features of children in pediatric intensive care unit (PICU). METHOD … luenza virus B (Inf B), 3 for WU Polyomavirus (WUPyV), 2 parainfluenza virus type 1(PIV-1), 2 human metapneumovirus (HMPV) and 1 human coronavirus-NL63/229E. But none from 87 healthy controls were positive for any respiratory virus. Among the 130 CSF specimens, in 58 cases the diagnosis was viral encephalitis. There were 22 samples (37.9%) among the 58 CSF specim …

Impact of Multiple Viral Detections by FilmArray® on the Severity of Pediatric Respiratory Infections: A Retrospective Single-Center Study.

Introduction FilmArray® Respiratory Panel (FA) is a rapid multiplex polymerase chain reaction (PCR) assay that can detect various viruses. W … FA detects pathogens, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), human metapneumovirus (hMPV), human rhinovirus/enterovirus, influenza A and B viruses, human parainfluenza virus type 1-4, respiratory syncytial virus (RSV), common coronaviruses, and adenovirus. Clinical severity indicators were compared between the single- and multiple …

[International multi-center evaluation of a rapid antigen test based on gold immunochromatographic assay for detection of severe acute respiratory syndrome coronavirus 2].

Objective: The gold immunochromatographic assay for detection of SARS-CoV-2 antigen was evaluated by international multi-center clinical tri … pe H1N1, influenza B virus, respiratory syncytial virus subgroups A and B, coxsackievirus 16, human metapneumovirus, parainfluenza virus types 1 and 4, Epstein-Barr virus and adenovirus. Conclusion: The SARS-CoV-2 antigen test kit showed excellent authenticity, and there were few differences for its indictors among nine countries, therefore it can meet the needs …

Viral and bacterial co-infection in hospitalised children with refractory Mycoplasma pneumoniae pneumonia.

To investigate the impact of viral and bacterial co-infection in hospitalised children with Mycoplasma pneumoniae pneumonia (RMPP). Retrospective analysis of 396 children with RMPP in our hospital admitted between 1 January 2011 and 31 December 2016 was performed. Nasal aspirate samples were collected for pathogen detection and clinical data were collected. We analysed clinical characteristics, lung imaging characteristics and pathogenic species among these children. Of the 396 RMPP cases, 107 (27.02%) had co-infection with other pathogen, with Streptococcus pneumoniae, Haemophilus influenzae

Respiratory bacterial and viral pathogen spectrum among influenza-positive and influenza-negative patients.

BACKGROUND: Respiratory tract infections are a significant burden on public health worldwide, with influenza being a prominent viral infecti … ia and Neisseria meningitides, and 8 respiratory viruses, including human influenza virus and human metapneumovirus. RESULTS: This study collected samples from 403 influenza-positive patients and 1,193 influenza-negative patients, among which bacterial and viral pathogens were detected. The gender distribution among the influenza-positive and influenza-negative …

Viral etiology of severe acute respiratory infections in hospitalized patients, Shandong, China.

BACKGROUND: Severe Acute Respiratory Infection (SARI) represents a critical global public health challenge, accounting for substantial sever … ), respiratory syncytial virus (RSV), parainfluenza virus (HPIV), human coronaviruses (HCoV), human metapneumovirus (HMPV), rhinovirus (HRV), enterovirus (EV), human bocavirus (HBoV), human adenovirus (HAdV), and SARS-CoV-2 (COVID-19). RESULTS: 501 samples (28.96%) were tested positive for at least one virus. The most frequently detected viruses and their infect …

[Analysis of the pathogen composition and epidemiological characteristics of febrile respiratory syndrome cases in the elderly aged 60 years and above in China from 2009 to 2021].

Objective: To understand the pathogenic composition and epidemiological characteristics of febrile respiratory syndrome (FRS) in elderly peo … enza virus (IFV), respiratory syncytial virus (RSV), adenovirus (HAdV), parainfluenza virus (HPIV), metapneumovirus (HMPV), coronavirus (HCoV), bocavirus and rhinovirus (HRV); 7 bacterias, namely Streptococcus pneumoniae (S.pneumoniae), Staphylococcus aureus (S.aureus), Klebsiella pneumoniae (K.pneumoniae), Pseudomonas aeruginosa (P.aeruginosa), Group A Streptoco …

COVID-19 associated pulmonary aspergillosis.

OBJECTIVES: Patients with acute respiratory distress syndrome (ARDS) due to viral infection are at risk for secondary complications like invasive aspergillosis. Our study evaluates coronavirus disease 19 (COVID-19) associated invasive aspergillosis at a single centre in Cologne, Germany. METHODS: A retrospective chart review of all patients with COVID-19 associated ARDS admitted to the medical or surgical intensive care unit at the University Hospital of Cologne, Cologne, Germany. RESULTS: COVID-19 associated invasive pulmonary aspergillosis was found in five of 19 consecutive critically ill

Inside the lungs of COVID-19 disease.

In the setting of the coronavirus disease 2019 (COVID-19) pandemic, only few data regarding lung pathology induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is available, especially without medical intervention interfering with the natural evolution of the disease. We present here the first case of forensic autopsy of a COVID-19 fatality occurring in a young woman, in the community. Diagnosis was made at necropsy and lung histology showed diffuse alveolar damage, edema, and interstitial pneumonia with a geographically heterogeneous pattern, mostly affecting the central pa

[Analysis of the clinical epidemiological characteristics of rhinovirus in hospitalized children aged 14 years and younger with acute respiratory tract infection in a maternal and child health hospital in Hubei Province from 2023 to 2024].

To explore the clinical epidemiological characteristics of rhinovirus (RV) infection in children hospitalized due to acute respiratory infec … , followed by parainfluenza virus (PIV), respiratory syncytial virus (RSV), adenovirus (ADV), human metapneumovirus (HMPV), and influenza A virus H3N2. Among the 6 814 RV-positive children included in this study, pneumonia (60.29%) was the most common clinical manifestation following RV infection.The pneumonia incidence rate in the RV mixed detection group was 68 …

Comparison of acute pneumonia caused by SARS-COV-2 and other respiratory viruses in children: a retrospective multi-center cohort study during COVID-19 outbreak.

BACKGROUND: Until January 18, 2021, coronavirus disease-2019 (COVID-19) has infected more than 93 million individuals and has caused a certain degree of panic. Viral pneumonia caused by common viruses such as respiratory syncytial virus, rhinovirus, human metapneumovirus, human bocavirus, and parainfluenza viruses have been more common in children. However, the incidence of COVID-19 in children was significantly lower than that in adults. The purpose of this study was to describe the clinical manifestations, treatment and outcomes of COVID-19 in children compared with those of other sources of…

Global Viral Lower Respiratory Disease Episodes, Hospitalisations, and Clinical Outcomes by Aetiology, 2010-2021.

INTRODUCTION: Viral lower respiratory tract disease (LRTD) is a major cause of global morbidity and mortality, but pathogen-specific estimat … mates were generated for five viral categories: influenza, respiratory syncytial virus (RSV), human metapneumovirus (hMPV), SARS-CoV-2, and "other" viral pathogens. Data inputs included surveillance systems, clinical informatics, published literature, surveys, and vital registration. Viral LRTD incidence was estimated using DisMod-MR 2.1, a GBD Bayesian meta-regr …

Characterization of bacterial and viral pathogens in the respiratory tract of children with HIV-associated chronic lung disease: a case-control study.

INTRODUCTION: Chronic lung disease is a major cause of morbidity in African children with HIV infection; however, the microbial determinants … and eight viruses, including human rhinovirus (HRV), respiratory syncytial virus A or B, and human metapneumovirus, using nanofluidic qPCR (Standard BioTools formerly known as Fluidigm). Fisher's exact test and logistic regression analysis were used for between-group comparisons and risk factors associated with common respiratory microbes, respectively. RESULTS …

Etiological and epidemiological characteristics of severe acute respiratory infection caused by multiple viruses and Mycoplasma pneumoniae in adult patients in Jinshan, Shanghai: A pilot hospital-based surveillance study.

BACKGROUND: Severe acute respiratory infection (SARI) results in a tremendous disease burden worldwide. Available research on active surveil … pe NL63 (2.0%, 8/397), HCoV 229E (1.5%, 6/397), HCoV HKU1 (1.5%, 6/397), PIV 3 (1.5%, 6/397), human metapneumovirus (HMPV) (1.5%, 6/397), PIV 4 (1.3%, 5/397), HCoV OC43 (1.0%, 4/397), influenza virus B/Victoria (Flu B/Victoria) (0.5%, 2/397), respiratory syncytial virus (RSV) type B (0.5%, 2/397), and human bocavirus (HBoV) (0.3%, 1/397). The seasonality of patho …

Viral Respiratory Infections in Hematological Patients.

Viral infections of the respiratory system represent one of the most important complications in hematological patients in terms of both the severity of the clinical picture and its related impact on the duration of hospitalization, and of mortality. The most implicated viruses are those that commonly cause community-based respiratory diseases: respiratory syncytial virus, Influenza virus and rhinovirus. However, in some cases the clinical picture may be triggered by first infection with or reactivation of pathogens normally not responsible for clinically relevant diseases in immunocompetent su

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… Human Metapneumovirus (hMPV) Human metapneumovirus is a major cause of infection in children worldwide [ 37 ]. … There is currently no specific recommended treatment for rhinovirus [ 6 , 11 ], bocavirus [ 11 ], metapneumovirus [ 5 ] and coronavirus [ 5 , 6 , 11 ]. …

[Analysis of non-bacterial respiratory pathogens in children in Shijiazhuang City from 2023 to 2024].

Objective: To analyze the prevalence of 13 non-bacterial respiratory pathogens in hospitalized children in Shijiazhuang City from 2023 to 20 … 0) and respiratory syncytial virus (RSV) (15.07%, 4 654/30 890). The detection rate of Mp and human metapneumovirus (HMPV) in female children was higher than that in male children, and the difference was statistically significant (OR=1.157, 95%CI: 1.097-1.220, P<0.001; OR=1.098, 95%CI:1.006-1.198, P=0.035). There was a statistically significant difference in the …

Bacterial and viral etiology of acute respiratory infection among the Forcibly Displaced Myanmar Nationals (FDMNs) in fragile settings in Cox's Bazar- a prospective case-control study.

The leading infectious cause of death in children worldwide is lower acute respiratory infection (LARI), particularly pneumonia. We enrolled … ant in the control group. Pathogen correlation analysis showed RSV positively correlated with human metapneumovirus (HMPV), S. aureus and H. influenza b while S. pneumoniae was negatively correlated with other pathogens in ≤5 years age group of ARI cases. However, in >5 years age group, S. aureus and H. influenza b were positively correlated with IFVs, and S. pne …

Changes in infant respiratory pathogens pre-, during, and post-COVID-19 non-pharmacological interventions in Beijing.

BACKGROUND: To explore the effect of non-pharmacological interventions (NPIs) on respiratory pathogen profiles among hospitalized infants ag … influenza virus B, respiratory syncytial virus, parainfluenza virus (PIV), adenovirus (ADV), human metapneumovirus (HMPV), human bocavirus, human rhinovirus (HRV), coronavirus, Chlamydia trachomatis, Chlamydia pneumoniae (C.pn), Mycoplasma pneumoniae, Bordetella pertussis, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). RESULTS: A total of 1,1 …

[Evaluation of the Epidemiological, Clinical and Radiological Features of Pneumonia Cases Caused by Mycoplasma pneumoniae in Childhood].

The current study aimed to investigate the clinical, laboratory and radiological findings of the pneumonia cases in children that were confi … the rate of 40.3%. The most common accompanying viruses were rhinovirus, adenovirus, bocavirus and metapneumovirus. The 55.8% of the patients had lobar-segmental consolidation, 46.8% had parahilar-peribronchial thickening, 18.2% had atelectasis, 11.7% had pleural effusion, 9.1% had increase in reticulonodular density, 6.5% had lymphadenopathy whereas no abnormal …

Human parainfluenza virus type 3 (HPIV 3) viral community-acquired pneumonia (CAP) mimicking swine influenza (H1N1) during the swine flu pandemic.

BACKGROUND: The swine influenza (H1N1) pandemic began in Mexico in 2009 and quickly spread worldwide. During the H1N1 pandemic, many patient … gative. His respiratory fluorescent antibody viral panel was negative for influenza A, influenza B, metapneumoviruses, respiratory syncytial virus, and adenoviruses but positive for human parainfluenza virus type 3 (HPIV 3). CONCLUSIONS: Clinicians should be aware of other causes of community-acquired pneumonia that may mimic H1N1 pneumonia. In our experience, t …