Результаты поиска

Fatal hepatic necrosis associated with parenteral gold therapy.

Two young black male patients with seronegative rheumatoid arthritis and treated with nonsteroidal antiinflammatory agents developed fulminant hepatic necrosis following the institution of parenteral gold therapy. These cases, reported from different institutions, may represent a severe form of idiosyncratic gold hepatonecrosis. Awareness of the possible association between gold therapy and severe hepatic injury may become increasingly important as oral gold preparations become widely available.

Production of tumor necrosis factor during murine listeriosis.

During a lethal murine infection with the gram-positive bacterium, Listeria monocytogenes, a factor appears in the serum that is capable of lysing certain tumor cells in vitro. The levels of this serum cytotoxic factor increase with the progression of morbidity. Neutralization of Listeria-induced cytotoxic factor activity with a monospecific antiserum to recombinant murine tumor necrosis factor (TNF) revealed that the cytotoxic factor was antigenically indistinguishable from natural TNF present in endotoxin-induced tumor necrosis serum. In contrast to a lethal infection, no TNF activity was de…

Phencyclidine-induced malignant hyperthermia causing submassive liver necrosis.

This report describes three male patients arrested for aggressive and combative behavior, characteristic of phencyclidine intoxication, in whom severe hyperthermia, respiratory failure, and coma developed. Two days after the malignant hyperthermic event, serum transaminase levels rose acutely to extremely high levels with concomitant elevations in bilirubin levels and a fall in prothrombin activity. Liver biopsy specimens in two patients showed marked perivenular necrosis and collapse. No specific treatment was directed at the phencyclidine intoxication. Two of the three patients survived. Sub…

Retinal detachment following the acute retinal necrosis syndrome.

Twenty-six patients with the acute retinal necrosis involving 32 eyes have been followed at the Bascom Palmer Eye Institute. Sixteen eyes developed retinal detachment and surgical repair was attempted in thirteen. Ten eyes were successfully reattached. Vitreous surgery was necessary in ten eyes and was performed in eight of the ten successful eyes. The clinical characteristics of the retinal detachments as well as the surgical procedures and results are presented.

Myeloid bodies in drug-induced acute tubular necrosis.

A growing list of drugs, metals, and chemicals has been implicated as the cause of functional and structural damage specifically to the proximal tubular epithelium. Renal biopsies were obtained from three patients who had developed nephrotoxic agent-related acute renal failure. Two of the patients had received gentamicin and viomycin; the third patient had heavy exposure to chromium. All three biopsies showed acute tubular necrosis (ATN) on light microscopy. Electron microscopy revealed that the proximal tubular cells and, to a lesser degree, the distal tubular cells, contained abundant, varia…

Muscle fiber necrosis associated with human marathon runners.

This study describes the events occurring in exercise-induced muscular necrosis. Biopsies of the gastrocnemius muscles of volunteer human marathon runners were extracted prior to and at intervals for 7 days following a marathon, and investigated ultrastructurally. Most of the preparations, including the pre-marathon samples, showed evidence of muscle fiber necrosis and inflammation. These preparations had many mitochondria, erythrocytes, leukocytes and other phagocytic cells within the extracellular and extravascular spaces. Less frequently observed were Z-line streaming and degeneration, cont…

Unilateral congenital hip dislocation with contralateral avascular necrosis.

Seventy-six children with previoulsy undiagnosed unilateral congenital dislocation of the hip were examined after 2 years of age. Nine had radiologic signs of dislocation on one side and avascular necrosis of the contralateral femoral head. The incidence of necrosis on the contralateral side in older children with unilateral dislocation is much higher than among the normal population. The cause of these occurrences of aseptic necrosis is not known but could be associated with abnormal stress on an undislocated femoral head from dysfunction of a contralateral unstable dislocated femoral head.

Ischemic papillary muscle necrosis in stressed newborn infants.

The recent association of transient tricuspid insufficiency in newborn infants with ischemic papillary muscle necrosis prompted a detailed retrospective clinical and histologic analysis of autopsied infants who died within seven days of birth between 1973 and 1977. Infants with congenital heart disease, erythroblastosis fetalis, and known congenital viral infections were excluded. Thirty-one of 82 infants had at least one site of ischemic myocardial necrosis: 11 had lesions only in the right ventricle, 13 had lesions only in the left ventricle, and seven had bilateral lesions. The apical regio…

Смертельный массивный некроз печени от варицелла-зостерного гепатита.

Сообщается о необычайном случае гепатита варицелла-зостера, который привел к смертельному массовому некрозу печени у 64-летней белой женщины. У пациента была ветрянка за 30 лет до смерти, но никогда не было каучуконосных зостеров. Печень показала типичные эозинофильные внутриядерное включение, а герпесвирусные вироны были продемонстрированы электронной микроскопией. Косвенные иммунофлюоресцентные сероологические исследования подтвердили удалённую и недавнюю инфекцию вирусом варицелла-зостер. Обсуждается потенциальное значение случайной селелектомии, проведенной за 14 месяцев до смерти, и общая

Совпадение в аннотации оригинала
An unusual case of varicella-zoster hepatitis is reported which resulted in fatal massive hepatic necrosis in a 64-year old white female. The patient had had chickenpox 30 years prior to death but no cutaneous zoster at any time. The liver showed typical eosinophilic intranuclear inclusions and herpesvirus virions were demonstrated by electron microscopy. In…

Case report: benign liver tumor with central necrosis.

A 38 year old previously well woman had sudden onset of upper abdominal pain and fever. Ultrasound examination revealed a necrotizing lesion in the liver. Arteriography revealed findings consistent with an adenoma or focal nodular hyperplasia. A right lobectomy and wedge resection of a similar lesion in the left lobe were done. Microscopy of both lesions indicated focal nodular hyperplasia. Adenoma is said to be related to the contraceptive oral hormone; focal nodular hyperplasia not. But it is possible that both may have an increased incidence of bleeding in the users of the oral contraceptiv

Möbius syndrome due to brain stem tegmental necrosis.

Möbius syndrome undoubtedly results from a variety of disorders affecting central or peripheral portions of appropriate cranial nerves or their target muscles. Pathological alterations observed in cranial nuclei are most often viewed as aplastic or dysplastic lesions. Two patients with Möbius syndrome with associated facial and skeletal malformations showed mineralized necrotic foci in multiple brain stem nuclei. Prenatal encephalomalacic lesions represent the pathological basis for some cases of congenital static Möbius syndrome.

Death from massive hepatic necrosis in infectious mononucleosis.

A case is reported of a 19-year-old youth who developed infectious mononucleosis and died 17 days after the onset of the illness. At autopsy massive hepatic necrosis was found, associated with enlargement of the liver.

Sclerosing hyaline necrosis in noncirrhotic chronic alcoholic hepatitis.

A group of 18 chronic alcoholic patients who had sclerosing hyaline necrosis in noncirrhotic livers was compared with a group of 12 similar individuals with acute alcoholic hepatitis, but no centrilobular fibrosis. In cases with sclerosing hyaline necrosis, the most characteristic features were portal hypertension with very large, tender livers and unusually high glutamic-oxalacetic transaminase values; these were associated with centrilobular fibrosis and abundant alcoholic hyalin. Three of these patients died within two years and in two of these, early cirrhosis was found at necropsy. In the…

Subtotal vesical necrosis as a result of infected traumatic bladder hematoma: A rare case with a literature review of bladder necrosis due to hematoma.

Subtotal bladder necrosis following bladder hematoma is rare. We report such a case following blunt abdominal injury. The urologic presentation was delayed hematuria which settled with conservative management but was followed by the development of urosepsis. Computed tomography scan showed full bladder due to long-standing liquified bladder hematoma. Suprapubic exploration revealed a bladder wall abscess which was drained (secondarily infected hematoma). Excision of the subtotal necrotic bladder and ileal conduit with left ureteroileal anastomosis was done later. The patient also had a simulta…