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Minimally invasive retroperitoneal approach for lumbar corpectomy and anterior reconstruction. Technical note.

The anterior decompressive procedure in which spinal fusion is performed is considered an effective treatment for thoracolumbar fractures and tumors. However, it is also known to be associated with considerable surgery-related trauma. The purpose of this study was to show that lumbar corpectomy and anterior reconstruction can be performed via a minimally invasive retroperitoneal approach (MIRA) and therefore the surgical approach-related trauma can be reduced. The authors studied retrospectively the hospital records and radiological studies obtained in five patients (mean age 67.4 years, range

Acoustic nerve in peripheral neuropathy: a BAEP study. Brainstem Auditory Evoked Potentials.

We performed BAEP study to evaluate acoustic nerve involvement in 102 patients affected by peripheral neuropathies of different etiology, predominantly hereditary and inflammatory acquired neuropathies. Prolonged latency of early waves, indicative of slowing in VIII nerve conduction, was found in a high percentage of cases. Abnormalities were far more frequent (44% vs 14%) and severe in patients with demyelinating rather than axonal neuropathy. Among demyelinating neuropathy, the most severe latency delay was found in Hereditary Motor and Sensory Neuropathy type III. The pattern of acoustic ne

Brazilian Academy of Neurology recommendations for diagnosis, management, and treatment of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP).

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an acquired autoimmune disorder that leads to progressive motor and sensory impairment, resulting in significant morbidity. While the incidence rates vary, CIDP remains a challenging condition requiring a standardized and optimized approach to diagnosis and management. In Brazil, a middle-income country with substantial regional disparities in healthcare access, the availability of specialized neuromuscular centers is uneven, creating obstacles to timely and effective treatment. To address these challenges, the Brazilian Acade

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… neuropathy and disialosyl antibodies; CANOMAD, chronic ataxic neuropathy, ophthalmoplegia, immunoglobulin M paraprotein, cold agglutinins, and disialosyl antibodies; CASPR, contactin-associated protein; CIDP, chronic inflammatory demyelinating polyradiculoneuropathy; CIMP, chronic inflammatory motor polyradiculopathy … ; CISMP, chronic inflammatory sensorimotor polyradiculopathy; CISP, chronic inflammatory sensory polyradiculopathy; CNTN1, contactin 1; CSF, cerebrospinal fluid; hATTRv, hereditary transthyretin-related amyloidosis; HB1AC, glycated hemoglobin; HNPP, hereditary neuropathy with liability to pressure palsies …

[Segmental mediolytic arteriopathy (SMA) of central, visceral and peripheral vessels].

HISTORY AND CLINICAL FINDINGS: A 27-year-old man had been admitted to hospital with acute neurological defects involving his legs and urinary system. An intervertebral disk was removed surgically, because a herniation had been suspected. But symptoms increased postoperatively. Further imaging showed a ruptured aneurysm of the internal iliac artery which was treated with coil embolization. INVESTIGATIONS: Further diagnostic tests excluded hematological, rheumatic and endocrinological causes for the development of the aneurysm. Genetic differentiation was normal. Imaging then demonstrated "stri

Paraneoplastic Neuropathies: What's New Since the 2004 Recommended Diagnostic Criteria.

The diagnostic criteria published by the PNS (Paraneoplastic Neurological Syndromes) Euronetwork in 2004 provided a useful classification of PNS, including paraneoplastic neuropathies. Subacute sensory neuronopathy (SSN) was the most frequently observed peripheral PNS, whereas other forms of neuropathy, as sensory polyneuropathy, sensorimotor polyneuropathy, demyelinating neuropathies, autonomic neuropathies, and focal nerve or plexus lesions, were less frequent. At the time of publication, the main focus was on onconeural antibodies, but knowledge regarding the mechanisms has since expanded.

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… Peripheral involvement includes sensory neuronopathy, sensorimotor neuropathy, polyradiculopathy, and neuromyotonia ( 14 , 15 ). Table 2 Onconeural antibodies reported in 2004 classification and associated with paraneoplastic neuropathy. … Very recently, a further antibody reaction against Leucine Zipper 4 (LZUP4) was described in 28 patients with germ cell tumors (e.g., seminoma); four patients were affected with motor neuronopathy and polyradiculopathy ( 29 ). …

Rho kinase inhibitor improves motor dysfunction and hypoalgesia in a rat model of lumbar spinal canal stenosis.

STUDY DESIGN: Immunohistochemical and behavioral study using a rat cauda equina compression model. OBJECTIVE: To investigate, after cauda equina compression by spinal canal stenosis (SCS), Rho activation in the spinal cord and cauda equina, and the effect of intrathecal administration of a Rho kinase inhibitor on hypoalgesia and motor dysfunction. SUMMARY OF BACKGROUND DATA: Compression of the cauda equina caused by SCS is a common clinical disorder associated with sensory disturbance and intermittent claudication. Cauda equina compression is thought to reduce blood flow and result in nerve

Уровень крови в световой цепи нейрофильтрации в качестве биомаркера неврологических расстройств.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… AD= Alzheimer's disease; ALS=amyotrophic lateral sclerosis; BD=bipolar disorder; CBS=corticobasal syndrome; CIDP-GBS=chronic inflammatory demyelinating polyradiculopathy and Guillain-Barré syndrome; CIS=clinically isolated syndrome; DLB=dementia with Lewy bodies; DNS=dementia not specified; FTD=frontotemporal …

Unraveling the Neurological Complexity of Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Protein, and Skin Changes Syndrome: A Report of a Challenging Case of a Young Woman and Cutting-Edge Advancements in the Field.

POEMS syndrome-characterized by polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes-is an uncommon and complex paraneoplastic disorder encompassing a diverse array of symptoms. Here we report the challenging case of a 34-year-old female who sought medical attention at the emergency department due to distal lower limb weakness. She was breastfeeding her first child at that time. Her condition rapidly deteriorated, making it difficult for her to perform simple tasks independently. Initially, she struggled with activities like jumping or climbing stairs. Eventually, her abil

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… In some cases, patients might be misdiagnosed with a primary neurologic disorder, such as chronic inflammatory demyelinating polyradiculoneuropathy or, rarely, subacute demyelinating polyradiculopathy [ 1 ]. …

AAV1.NT3 генная терапия смягчает остроту аутоиммунного энцефаломиэлита в модели мыши для множественных склерозов.

Множественный склероз (MS) — хроническое воспалительное и нейродегенеративное заболевание центральной нервной системы (КНС), которое оказывает воздействие более чем на организм человека. 2.5 million Пациенты по всему миру. Хроническое обезвоживание в ЦНС играет важную роль в увековечении аксоновых потерь и увеличивает трудности в поощрении воспоминаний. Поэтому стратегии регенерации и нейрозащиты имеют важное значение для преодоления этого препятствия для сохранения аксоновой целостности и функции. Нейропофин 3 (В тыс.NT-3) обладает иммунодуляционными и антивоспалительными свойствами, помимо ш

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… The efficacy of the immunomodulatory and anti-inflammatory properties of NT-3 was previously demonstrated in the spontaneous autoimmune peripheral polyneuropathy mouse model [ 18 ] for chronic inflammatory polyradiculopathy in humans, using the AAV1.NT-3 gene therapy approach [ 19 – 23 ]. …

Осложнения периферального нерва в результате применения лекарств для потери веса: систематический обзор.

ЦЕНТРАЛЬНАЯ ИНФОРМАЦИЯ: Существует глобальная эпидемия ожирения, и в этом контексте разработка новых агентов для снижения веса является своевременной. Поступали сообщения о периферийных осложнениях нервной системы, и это исследование было направлено на систематический анализ всех сообщенных случаев, связанных с лекарственными препаратами, используемыми для снижения веса. МЕТОДЫ: Был проведен систематический поиск баз данных PubMed, Embase и CINAHL с момента создания по 30 июня 2026 года в целях выявления исследований, в которых сообщается о новых или ухудшающихся периферийных осложнениях нервн

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… Wernicke’s encephalopathy, antiphospholipid syndrome, severe diffuse sensorimotor axonal polyradiculopathy Zahir et al. report an unusual case with multiple complications from weight loss [ 47 ]. …

The Risk of Sarcoidosis Misdiagnosis and the Harmful Effect of Corticosteroids When the Disease Picture Is Incomplete.

Sarcoidosis is a complex granulomatous disease of unknown etiology. Due to the heterogeneity of the disease, the diagnosis remains challenging in many cases, often at the physician's discretion, requiring a thorough and complex investigation. Many other granulomatous diseases have the potential to mimic sarcoidosis, whether infectious, occupational, or autoimmune diseases and starting an unnecessary corticosteroid treatment can worsen the patient's prognosis, leading to side effects that can be harder to treat than the actual disease.

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… to 20% of cases | Granulomatous interstitial nephritis, nephrocalcinosis, nephrolithiasis Neurologic involvement 3–10% of cases | Involvement of the cranial nerves: II, VII, VIII Central nervous system or peripheral nervous system involvement Meningeal irritation Symmetrical mono/polyneuropathies, polyradiculopathy …

Viruses

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… Pancreatitis Fever, abdominal pain, and peritonitis, infection of the biliary tract [ 39 ] Myocarditis Congestive heart failure Central/Peripheral Nervous System Meningoencephalitis Vasculitis with fever, headache, nausea/vomiting, photophobia, impaired consciousness, seizures, focal neurologic deficits Polyradiculopathy … Pancreatitis | Fever, abdominal pain, and peritonitis, infection of the biliary tract [ 39 ] Myocarditis | Congestive heart failure Central/Peripheral Nervous System Meningoencephalitis | Vasculitis with fever, headache, nausea/vomiting, photophobia, impaired consciousness, seizures, focal neurologic deficits Polyradiculopathy …

Изучение цереброваскулярных проявлений нейроборлиоза: обзор.

Заболевание Lyme - это зоонотическая инфекция, передающаяся Боррелией Бурдорфери, и, если ее не диагностировать, она может появиться на более поздних этапах с неврологическими проявлениями. Цель этого обзора заключается в обобщении данных о инсультовом или аналогичном цереброваскулярном исходе нейроборрелиоза Лайма (НБ) для содействия раннему распознаванию и лечению. 90 - пациенты, отвечающие критериям Европейской федерации неврологических обществ/Американской академии неврологических заболеваний/Американской школы ревматологии (EFNS/IDSA/AAN/ACR) для ЛНБ с радиологически или серологически под

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… Early disseminated Lyme disease: Cranial neuropathy, meningitis, and polyradiculopathy. Infect Dis Clin North Am. 2022;36:541–51. doi: 10.1016/j.idc.2022.02.006. 7. McEntire CRS, Chwalisz BK. Cranial nerve involvement, visual complications and headache syndromes in Lyme disease. …

Brazilian consensus for diagnosis, management and treatment of hereditary transthyretin amyloidosis with peripheral neuropathy: second edition.

Hereditary transthyretin amyloidosis with peripheral neuropathy (ATTRv-PN) is an autosomal dominant inherited sensorimotor and autonomic polyneuropathy with over 130 pathogenic variants identified in the TTR gene. Hereditary transthyretin amyloidosis with peripheral neuropathy is a disabling, progressive and life-threatening genetic condition that leads to death in ∼ 10 years if untreated. The prospects for ATTRv-PN have changed in the last decades, as it has become a treatable neuropathy. In addition to liver transplantation, initiated in 1990, there are now at least 3 drugs approved in many

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… differentiate which type of misfolded protein is deposited on tissues, and DNA analyses should always be requested in ATTRv-PN-suspected cases ( Table 2 ). 15 Table 2 Differential diagnosis of hereditary transthyretin amyloidosis with peripheral neuropathy Abbreviations: CIDP, chronic inflammatory polyradiculopathy …

Autoimmune Neuromuscular Disorders at a Molecular Crossroad: Linking Pathogenesis to Targeted Immunotherapy.

Myasthenia gravis, chronic inflammatory demyelinating polyneuropathy, and idiopathic inflammatory myopathies are among the most widely recognized autoimmune neuromuscular disorders. Although they differ in clinical presentation, shared immunopathogenic mechanisms place them at a molecular crossroads. Evidence of overlapping pathways has led to the development of targeted strategies including complement inhibition, FcRn antagonism, B-cell depletion, and the CAR-T cell approach. In this review, we analyze current knowledge regarding pathogenic mechanisms and their link to immunotherapy, extensiv

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… The updated EAN/PNS criteria have replaced the term “atypical CIDP” with CIDP variants, encompassing five clinical forms, which include pure sensory CIDP, pure motor CIDP, focal CIDP, chronic immune sensory polyradiculopathy (CISP), distal acquired demyelinating symmetric neuropathy (DADS), and multifocal …

ИАНКОН 2023 Выдержки из плаката

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Genetic and Mechanistic Insights Inform Amyotrophic Lateral Sclerosis Treatment and Symptomatic Management: Current and Emerging Therapeutics and Clinical Trial Design Considerations.

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder affecting both upper and lower motor neurons. ALS is classically characterized by painless progressive weakness, causing impaired function of limbs, speech, swallowing, and respiratory function. The disease is fatal within 2-4 years, often the result of respiratory failure. The pathologic hallmark for a majority of ALS cases is aberrant cytoplasmic accumulations of the nuclear protein TAR-DNA binding protein (TDP-43). A total of 10-15% of ALS can be attributed to a single gene mutation, known as genetic or "familia

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… Though there is not a single specific serum or plasma biomarker for ALS, higher levels of serum neurofilament light chain (NfL), a neuron-specific marker of axonal degeneration, have been found to differentiate ALS from disease mimics, such as inflammatory demyelinating polyneuropathy or structural polyradiculopathy …