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The transcription factor Tcf21 is necessary for adoption of cell fates by Foxd1+ stromal progenitors during kidney development.

The stromal compartment of the developing kidney arises from forkhead box D1 (Foxd1)-expressing progenitors and gives rise to diverse cell types essential for nephrogenesis, including the renal stroma, capsule, mesangial cells, renin cells, pericytes, and vascular smooth muscle cells (VSMCs). However, the molecular mechanisms guiding their fate specification remain incompletely defined. Here, we identify the basic helix-loop-helix transcription factor Tcf21 as a critical determinant of stromal cell identity during kidney development. We performed single-cell RNA sequencing (scRNA-seq) on Foxd1

Abusive supervision and AI adoption in Chinese higher education workplaces: Psychological mechanisms of resource disillusionment and organizational dynamics.

This study employs a sequential mixed-methods design examining how abusive supervision influences Chinese university faculty's intention to … ta (N = 219). Results showed no significant direct or mediated effects of abusive supervision on AI adoption intention. In contrast, resource gains positively predicted adoption but negatively moderated the abusive supervision-adoption relationship, amplifying adverse effects under high gains. This pattern is consistent with a resource disillusionment inte …

Therapeutic evolution: Adoption of newly approved systemic therapies in resected stage IB-IIIA NSCLC in the United States.

OBJECTIVES: Evidence is limited regarding use of immunotherapies and targeted therapies in early-stage and locally advanced non-small cell lung cancer (NSCLC) in clinical practice. This retrospective, observational cohort study used health records from US oncology practices to describe treatment patterns and evaluate outcomes in patients with resected stage IB-IIIA NSCLC. MATERIALS AND METHODS: Adult patients with stage IB-IIIA NSCLC who completed primary surgery from January 2019-December 2023 (n = 14,638) were included, with potential follow-up through August 2024. Subset analyses of stage

Assessment of Candidates' Performance Pre- and Post-Adoption of Standard Setting in College Examinations between 2016 and 2023.

BACKGROUND: Assessment drives candidates' learning and focuses on the main goals and objectives of the course. Over the years, determination of pass scores in medical education has evolved from the arbitrary 50% to the actual determination of the cut-off scores in the standard setting process in order to make a decision to pass/fail candidates presenting for licensure or credentialing purposes. MATERIALS AND METHODS: The study aimed at assessing and comparing candidates' performance pre- and post-adoption of standard setting in the college. This was a comparative cross-sectional study with a …

Community-academic implementation science partnership to examine adoption and impact of a patient-centered approach to sexual history.

Progress toward ending the HIV epidemic has been slowed by suboptimal utilization of effective biomedical interventions (e.g., HIV testing, pre-exposure prophylaxis), especially for populations with the highest incidence. In 2021, the New York City Health Department initiated a multilevel implementation strategy, focused on promoting the GOALS Approach to Sexual History and Health-an antistigmatizing, client-centered strategy for sexual history taking-as a lever for increasing HIV intervention adoption, reach, and equity. Project Partnership to Increase Access, Client-Centered Care, and Equity…

Critical activities for successful implementation and adoption of AI in healthcare: towards a process framework for healthcare organizations.

INTRODUCTION: Absence of structured guidelines to navigate the complexities of implementing AI-based applications in healthcare is recognized by clinicians, healthcare leaders, and policy makers. AI implementation presents challenges beyond the technology development which necessitates standardized approaches to implementation. This study aims to explore the activities typical to implementation of AI-based systems to develop an AI implementation process framework intended to guide healthcare professionals. The Quality Implementation Framework (QIF) was considered as an initial reference framew

Adoption of contract vegetable marketing in Ethiopia, the case of Enebsie Sar Midir District in the Amhara Region.

This study aimed at analyzing determinants influencing contract vegetable marketing adoption. Multi-stage sampling procedure was employed to select 260 sample respondents. Both primary and secondary data were utilized to achieve the objectives of the study. Primary data was gathered from respondent interview, focus group discussion (FGD), key informants interview (KII) and observation. Whereas secondary data was collected from articles and district official documents. Both simple descriptive and econometric model were used to analysis the data. From the total respondents, about 74.23% and 25.7…

Primary ACL repair has limited adoption among experts: Perspectives from the 2024 Freddie Fu Panther Sports Medicine Symposium.

PURPOSE: To provide a commentary on the indications and current state of anterior cruciate ligament (ACL) repair versus ACL reconstruction (ACLR), utilising a case-based discussion among a group of international Orthopaedic surgeons at the 2024 Freddie Fu Panther Sports Medicine Symposium. METHODS: An electronically distributed survey was provided to participants of the 2024 Freddie Fu Panther Sports Medicine Symposium during the meeting with questions regarding their indications for a primary ACL repair and their views on rehabilitation, return to sport, and complications after ACL repair. T

Pharmaceutical Practice Considerations Regarding Adoption of the Race-Free Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) 2021 Equations.

The race-free Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) 2021 estimated glomerular filtration rate-creatinine (eGFRcr) equation is being adopted in the United States. Elsewhere there is debate regarding its validation and adoption. Absence of a perfect solution and a lack of alignment present challenges when considering global clinical trials. While acknowledging these challenges, GSK decided to adopt the CKD-EPI 2021 eGFRcr equation for new adult trials to support health equity and delivery benefits from standardized data management. The eGFRcr obtained using the CKD-EPI 2021…

Adoption of brain injury guidelines in mild traumatic brain injury: challenges at both referring and receiving trauma centers.

INTRODUCTION: Emerging data suggest Brain Injury Guidelines (BIG) can be used to manage patients with mild to moderate traumatic brain injury (TBI) without neurosurgical consultation. However, many Level 3 trauma centers without neurosurgical specialists continue transferring these patients to higher-level facilities. This study aimed to evaluate the transfer outcomes of TBIs and contribute to the discussion on the feasibility of observing mild TBI patients and evaluate barriers to BIG adoption at both smaller and larger hospitals. METHODS: A retrospective chart review was performed on patien…

Adoption, Impact, and Economic Considerations of Pulse Oximetry and Oxygen Systems in African Surgical Care: A Narrative Review.

Reliable medical oxygen and pulse oximetry are fundamental safety components of modern anesthetic practice, providing continuous monitoring and treatment of hypoxemia. Although the World Health Organization (WHO) surgical safety checklist is widely endorsed, many African hospitals still cannot rely on functional pulse oximeters and a stable oxygen supply. These gaps are associated with avoidable perioperative injuries and preventable morbidity and mortality. To evaluate the prevailing adoption, clinical-level, and economic implications of oximetry and oxygen systems in the African surgical pat…

Optimizing the clinical adoption of total joint replacement of the lumbar spine through imaging, robotics and artificial intelligence.

INTRODUCTION: The objective of this article is to assess the potential of imaging, robotics, and artificial intelligence (AI) to significant … precision and safety, personalizing treatment pathways, lowering production costs, and accelerating adoption. However, the key challenges include ensuring continued collaboration between surgeons, researchers, manufacturers, and regulatory bodies to optimize the potential of TJR.

Improved Outcomes Following the Adoption of Targeted Therapies in High-Risk Chronic Lymphocytic Leukemia Treated in Southern Finland.

BACKGROUND: Targeted therapies have replaced chemoimmunotherapy for chronic lymphocytic leukemia (CLL), but high-risk CLL patients with TP53 aberrations continue to represent a significant unmet medical need. We profiled treatment patterns, outcomes, and adverse effects in a large, unselected cohort of high-risk CLL patients. PATIENTS AND METHODS: This study retrospectively analyzed clinical data from 1,720 CLL patients diagnosed between 2012 and 2023 within the Helsinki University Hospital district in Southern Finland. We focused on 543 patients who received first-line (1 L) systemic treatme

The influence of social networks in adoption of integrated health interventions: A qualitative study of fishermen in Malawi.

INTRODUCTION: Social networks play a vital role in influencing individual and collective health behaviors and facilitating the diffusion of health interventions. Fishing communities in sub-Saharan Africa face socio-cultural and occupational challenges such as low literacy rates and high mobility. However, their high social cohesion creates a unique social environment for spreading health interventions. We explored the role of social relationships in mediating health intervention adoption in these communities, to inform future intervention strategies. METHODS: We conducted an exploratory pheno…

Показатели заболеваемости среди лиц, страдающих эпилепсией или множественным склерозом, могут отражать сокращение масштабов внедрения медицинских технологий.

Различные технологии и цифровые услуги предоставляют пациентам многочисленные возможности для контроля за состоянием их здоровья и управления им. Внедрение этих технологий требует мотивации и грамотности в области электронного здравоохранения. Хотя в исследованиях по внедрению медицинских технологий значительное внимание уделяется технологическим факторам, влияние факторов, связанных со здоровьем, по-прежнему в значительной степени недооценивается. Цель этого исследования состояла в том, чтобы ответить на следующий исследовательский вопрос: связаны ли связанные со здоровьем стресс, навыки прео

Совпадение в аннотации оригинала
A variety of technologies and digital services offer numerous opportunities for patients to monitor and manage their health. Adopting these technologies calls for motivation and eHealth literacy. While technology-related factors have received considerable attention in health technology adoption studies, the influence of health-related circumstances remains g…

Healthcare innovation adoption in Africa: the case of long-lasting insecticide nets in Ghana using protection motivation theory.

OBJECTIVE: Studies have shown that healthcare innovation adoption is complex. Using Long-lasting insecticidal nets (LLINs), an innovation for malaria prevention, the study aimed to understand factors considered in the adoption of healthcare innovations in Africa. METHODS AND MEASURES: Using qualitative methods, we interviewed 10 household heads in Ghana who had freely received LLINs during a malaria campaign. We analyzed our data using a deductive thematic analysis approach utilizing the protection motivation theory (PMT) as our framework. RESULTS: We found that the constructs of PMT: percei…

A Strategy for Bone Conduction Device Adoption: Study of Non-Usage Challenges, Skin-Deep Insights and Patient Satisfaction.

BACKGROUND: This study aimed to evaluate patient satisfaction and usage patterns of bone conduction devices (BCDs) for hearing rehabilitation, focusing on both users and non-users. Specific objectives included assessing reasons for non-use, exploring patient perceptions of BCD efficacy, and examining complications associated with BCD implantation. METHODS: A monocentric investigation was conducted at the Department of Ear, Nose, and Throat Diseases, Head and Neck Surgery at General Hospital Sint-Jan, Bruges. Patients who underwent BCD implantation between 2009 and 2020 were included. A questi

Aortic valve replacement for aortic stenosis: Influence of centre volume on TAVR adoption rates and outcomes in France.

BACKGROUND: Transcatheter (TAVR) has supplanted surgical (SAVR) aortic valve replacement (AVR). AIM: To evaluate whether adoption of this technology has varied according to centre volume at the nationwide level. METHODS: From an administrative hospital-discharge database, we collected data on all AVRs performed in France between 2007 and 2019. Centres were divided into terciles based on the annual number of SAVRs performed in 2007-2009 ("before TAVR era"). RESULTS: A total of 192,773 AVRs (134,662 SAVRs and 58,111 TAVRs) were performed in 47 centres. The annual number of AVRs and TAVRs incr…

Towards women's digital health equity: A qualitative inquiry into attitude and adoption of reproductive mHealth services in Bangladesh.

Health equity in Bangladesh faces a large chasm over the economic conditions, socio-cultural factors and geographic location despite the pus … itude toward reproductive health services in Bangladesh is generally favorable resulting increasing adoption and use. Because such information-related mobile services (apps, websites, and social media) served as a first base of knowledge on reproductive health among many young girls and women in Bangladesh, who are generally shy to share or talk about thei …