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Transition-Metal Chemistry of the Heavier Alkaline Earth Atoms Ca, Sr, and Ba.

ConspectusAlkaline earth elements beryllium, magnesium, calcium, strontium, and barium with an ns2 valence-shell configuration are usually classified as main-group elements that belong to the s-block atoms. For a long time, the elements were considered to be rather chemically uninteresting atomic species due to preconceived ideas about bonding, structure, and reactivity. They typically use the two ns valence electrons in forming ionic salt compounds with the metal in a formal oxidation state of +2. For the heavier alkaline earth atoms, calcium, strontium, and barium, their (n - 1)d atomic orbi…

Effect of repeated firings on the color of opaque porcelain applied on different dental alloys.

STATEMENT OF PROBLEM: Although metal ceramic fixed restorations are commonly preferred by clinicians, there remain a limited number of studi … loy CC, chromium cobalt (B-MCC); Heraenium NA, nickel chromium (B-HNA); Argeloy NP, nickel chromium beryllium (B-ANP); 3 noble metals: Ceradelta, palladium silver (N-CD); Cerapall 2, palladium (N-CP2); V-Delta SF, gold palladium (N-VDSF); and 1 high noble metal: V-Gnathos Plus, gold platinum (HN-GP)) were used to support a 0.1-mm-thick layer of opaque porce …

Structural insights into G domain dimerization and pathogenic mutation of OPA1.

The fusion of mammalian inner mitochondrial membranes (IMMs) is mediated by dynamin-like GTPase OPA1. Mutations in human OPA1 cause optic atrophy, but the molecular basis for membrane fusion and pathogenesis is not clear. Here, we determined the crystal structure of the minimal GTPase domain (MGD) of human OPA1. A three-helix bundle (HB) domain including two helices extending from the GTPase (G) domain and the last helix of OPA1 tightly associates with the G domain. In the presence of GDP and BeF3-, OPA1-MGD forms a dimer, the interface of which is critical for the maintenance of mitochondrial

Association between trace metal element concentrations in human blood plasma and early MAR embryological outcomes: a couple-based prospective cohort study.

STUDY QUESTION: What are the effects of plasma trace metal element exposure on early embryological outcomes of IVF in couples? SUMMARY ANSW … .22) years for females and 33.79 (5.89) for males. The detection rates for all elements, except for beryllium (Be), exceeded 90%. High exposure to trace metal element mixtures in couples and male partners was associated with decreased numbers of best-quality embryos and blastocysts. Using QGC and groupWQS, we identified both harmful and beneficial metal mix …

Effects of Subchronic Manganese and Iron Exposure, Alone or in Combination, on Elemental Distribution in Rats.

Overexposure to manganese (Mn) or iron (Fe) may lead to neurological damage. The aim of this study was to investigate the effects of subchro … 5 days a week for 8 weeks. The levels of Mn, Fe and other metallic elements [including barium (Ba), beryllium (Be), strontium (Sr), antimony (Sb), lead (Pb), vanadium (V) and copper (Cu)] in whole blood and brain tissue (including the globus pallidus, hippocampus, striatum and substantia nigra) were determined by inductively coupled plasma-mass spectrometry …

Mortality among mound workers exposed to polonium-210 and other sources of radiation, 1944-1979.

Polonium-210 is a naturally occurring radioactive element that decays by emitting an alpha particle. It is in the air we breathe and also a … Mound nuclear facility near Dayton, OH where polonium-210 was used (1944-1972) in combination with beryllium as a source of neutrons for triggering nuclear weapons. Other exposures included external gamma radiation and to a lesser extent plutonium-238, tritium and neutrons. Vital status and cause of death was determined through 2009. Standardized mortality …

AlF4- reversibly inhibits 'P'-type cation-transport ATPases, possibly by interacting with the phosphate-binding site of the ATPase.

The only known cellular action of AlF4- is to stimulate the G-proteins. The aim of the present work is to demonstrate that AlF4- also inhibits 'P'-type cation-transport ATPases. NaF plus AlCl3 completely and reversibly inhibits the activity of the purified (Na+ + K+)-ATPase (Na+- and K+-activated ATPase) and of the purified plasmalemmal (Ca2+ + Mg2+)-ATPase (Ca2+-stimulated and Mg2+-dependent ATPase). It partially inhibits the activity of the sarcoplasmic-reticulum (Ca2+ + Mg2+)-ATPase, whereas it does not affect the mitochondrial H+-transporting ATPase. The inhibitory substances are neither F

15th Report on Carcinogens.

BACKGROUND: The Report on Carcinogens (RoC) is a congressionally mandated, science-based public health document that the National Toxicology … 15 Listings); Benzo[a]pyrene (see Polycyclic Aromatic Hydrocarbons: 15 Listings); Benzotrichloride; Beryllium and Beryllium Compounds; 2,2-Bis(bromomethyl)-1,3-propanediol (Technical Grade); Bis(chloroethyl) Nitrosourea (see Nitrosourea Chemotherapeutic Agents); Bis(chloromethyl) Ether and Technical-Grade Chloromethyl Methyl Ether; Bromochloroacetic Acid (s …

YbiV from Escherichia coli K12 is a HAD phosphatase.

The protein YbiV from Escherichia coli K12 MG1655 is a hypothetical protein with sequence homology to the haloacid dehalogenase (HAD) superfamily of proteins. Although numerous members of this family have been identified, the functions of few are known. Using the crystal structure, sequence analysis, and biochemical assays, we have characterized YbiV as a HAD phosphatase. The crystal structure of YbiV reveals a two-domain protein, one with the characteristic HAD hydrolase fold, the other an inserted alpha/beta fold. In an effort to understand the mechanism, we also solved and report the struct

Metabolism and possible health effects of aluminum.

Literature regarding the biochemistry of aluminum and eight similar ions is reviewed. Close and hitherto unknown similarities were found. A hypothetical model is presented for the metabolism, based on documented direct observations of Al3+ and analogies from other ions. Main characteristics are low intestinal absorption, rapid urinary excretion, and slow tissue uptake, mostly in skeleton and reticuloendothelial cells. Intracellular Al3+ is probably first confined in the lysosomes but then slowly accumulates in the cell nucleus and chromatin. Large, long-lived cells, e.g., neurons, may be the m

Sarcoidosis and autoimmunity: In the depth of a complex relationship.

Sarcoidosis is a chronic granulomatous disease that can virtually affect any organ. Its etiology is unknown, although it has been proposed that environmental or biological agents can act as triggers, ultimately leading to chronic inflammation in genetically predisposed individuals. The main component of sarcoid inflammation is represented by an exaggerated T- lymphocytic cellular response to a putative antigen that could not be efficiently cleared in the patient. However, several clinical and immunological observations, such as the association of sarcoidosis to autoimmune diseases or the prese

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… triggered in genetically predisposed individuals by the exposure to hypothesized antigens: infectious agents such as Mycobacterium tuberculosis , atypical mycobacteria, mycoplasma species and Propionibacterium acnes , several fungal and viral agents; inorganic agents (aluminum, zirconium, titanium, beryllium …

Air toxics exposure from vehicle emissions at a U.S. border crossing: Buffalo Peace Bridge Study.

The Peace Bridge in Buffalo, New York, which spans the Niagara River at the east end of Lake Erie, is one of the busiest U.S. border crossin … adjacent to the plaza as they were at the upwind GLC site on lake-wind sampling days. Other metals (beryllium, sodium, magnesium, potassium, titanium, manganese, cobalt, strontium, tin, cesium, and lanthanum) showed significant increases downwind as well. Sulfur, arsenic, selenium, and a few other elements appeared to be markers for regional transport as th …

Multisystemic sarcoidosis-important lessons learnt from one of the great imitators.

We report a case of a woman who was admitted with a suspicion of metastatic malignancy of unknown primary origin. A few months prior to her admission, she presented to a rheumatologist with acute anterior uveitis, psoriasiform rashes and polyarthritis. A diagnosis of psoriatic arthropathy was made and she was treated accordingly. Soon after she presented with persistent back and right upper quadrant abdominal pain for which she had a CT scan done with evidence of hilar lymphadenopathy, liver hypodensities and lytic-sclerotic bone lesions. She was referred to our hospital for further investigat

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… erythematosus Primary biliary cirrhosis Crohn’s disease Rheumatoid arthritis Idiopathic Sarcoidosis Neoplastic Haematologic malignancy Lymphoma—in particular Hodgkin’s lymphoma Intra-abdominal neoplasms Others Drugs Allopurinol Carbamazepine Isoniazid Phenylbutazone Reaction to foreign bodies/others Beryllium …

Cancer burden and risk in the Chinese population aged 55 years and above: A systematic analysis and comparison with the USA and Western Europe.

BackgroundWe analysed the cancer burden among elderly Chinese people over the age of 55 years and compared them to USA and Western Europe to explore the cancer model in China.MethodsWe retrieved data on 29 cancers with 34 risk factors from the 2019 Global Burden of Disease database to evaluate the cancer burden in Chinese elderly individuals aged 55 years and older. We then used the age-standardised incidence rate (ASIR), age-standardised death rate (ASDR), age-standardised disability-adjusted life year (DALY) rate, and average annual percentage change (AAPC) to compare the characteristics and

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… Occupational exposure to arsenic, asbestos, benzene, beryllium, cadmium, chromium, diesel engine exhaust, formaldehyde, nickel, polycyclic aromatic hydrocarbons, silica, sulfuric acid, and trichloroethylene were considered occupational carcinogens. …

Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.

BACKGROUND: The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of risk factor exposure and attributable burden of disease. By providing estimates over a long time series, this study can monitor risk exposure trends critical to health surveillance and inform policy debates on the importance of addressing risks in context. METHODS: We used the comparative risk assessment framework developed for previous iterations of GBD to estimate levels and trends in exposure, attributable deaths, and attributable disability-adjusted life-years

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… 5 | 0 | ·· | ·· | Yes | ·· | Yes | Yes 4 | Occupational exposure to arsenic | Tracheal, bronchus, and lung cancer | 0 | ·· | ·· | 9 | 0 | ·· | ·· | No | ·· | Yes | No 4 | Occupational exposure to benzene | Leukaemia | 0 | ·· | ·· | 12 | 0 | ·· | ·· | Yes | ·· | Yes | No 4 | Occupational exposure to beryllium … | Proportion of the population ever exposed to beryllium at work or through their occupation | No occupational exposure to beryllium | 82·6% | 74·9% | 87·2% 4 | Occupational exposure to cadmium | Proportion of the population ever exposed to cadmium at work or through their occupation | No occupational …

Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.

BACKGROUND: The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 comparative risk assessment (CRA) is a comprehensive approach to risk factor quantification that offers a useful tool for synthesising evidence on risks and risk-outcome associations. With each annual GBD study, we update the GBD CRA to incorporate improved methods, new risks and risk-outcome pairs, and new data on risk exposure levels and risk-outcome associations. METHODS: We used the CRA framework developed for previous iterations of GBD to estimate levels and trends in exposure, attributable deaths, and

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… | No occupational exposure to arsenic | 100·0% | 100·0% | 100·0% 4 | | | Occupational exposure to benzene | Proportion of the population ever exposed to benzene at work or through their occupation | No occupational exposure to benzene | 100·0% | 100·0% | 100·0% 4 | | | Occupational exposure to beryllium … | Proportion of the population ever exposed to beryllium at work or through their occupation | No occupational exposure to beryllium | 100·0% | 100·0% | 100·0% 4 | | | Occupational exposure to cadmium | Proportion of the population ever exposed to cadmium at work or through their occupation | No occupational …

Exposome and unhealthy aging: environmental drivers from air pollution to occupational exposures.

The aging population worldwide is facing a significant increase in age-related non-communicable diseases, including cardiovascular and brain pathologies. This comprehensive review paper delves into the impact of the exposome, which encompasses the totality of environmental exposures, on unhealthy aging. It explores how environmental factors contribute to the acceleration of aging processes, increase biological age, and facilitate the development and progression of a wide range of age-associated diseases. The impact of environmental factors on cognitive health and the development of chronic age

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… Asbestos, silica, diesel exhaust, uranium, arsenic, beryllium, cadmium, silica, vinyl chloride, nickel compounds, chromium compounds, coal products, mustard gas, and chloromethyl ethers are significant risk factors for lung cancer [ 281 – 291 ]. …

Rapid health transition in China, 1990-2010: findings from the Global Burden of Disease Study 2010.

BACKGROUND: China has undergone rapid demographic and epidemiological changes in the past few decades, including striking declines in fertility and child mortality and increases in life expectancy at birth. Popular discontent with the health system has led to major reforms. To help inform these reforms, we did a comprehensive assessment of disease burden in China, how it changed between 1990 and 2010, and how China's health burden compares with other nations. METHODS: We used results of the Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010) for 1990 and 2010 for China

Chest and Mediastinum

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Премии победителей и резюме 32nd Ежегодный симпозиум Общества протеинов; Бостон, ОЭТ, июль 9-12, 2018.

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