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Babesia microti-induced fulminant sepsis in an immunocompromised host: A case report and the case-specific literature review.

Babesia microti is an obligate intra-erythrocytic parasite transmitted by infected ticks. B. microti is a eukaryote much larger than prokaryotic microbes and more similar to human hosts in their biochemistry and metabolism. Moreover, Babesia spp. possess various immune evasion mechanisms leading to persistent and sometimes life-threatening diseases in immunocompromised hosts. Chronic lymphocytic leukemia (CLL) is the most prevalent adult B-cell malignancy, and a small percentage of CLL transforms into aggressive lymphomas. CLL also causes immune dysfunction due to the over-expansion of immatur

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… Tests for Ehrlichia muris-like, Ehrlichia ewingii/canis, Ehrlichia chaffeensis, Anaplasma phagocytophilum, Streptococcus pneumoniae, Legionella, and Lyme antibody were all negative. …

Delayed Presentation of Thymoma-Related Aplastic Anemia: An Unusual Presentation of a Rare Complication.

A 68-year-old Caucasian man presented with gross hematuria and oral mucosal bleeding. The patient was known to have an anterior mediastinal mass, highly suspicious for thymoma, which was incidentally identified on imaging, 8 years prior. The patient then declined treatment and was lost to follow-up. On presentation, imaging re-demonstrated the anterior mediastinal mass and the patient was found to have profound pancytopenia. Bone marrow biopsy confirmed the diagnosis of aplastic anemia (AA). Despite optimal treatment, the patient expired on day 9 of admission. In this case we report an unusual

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… Given that the patient had a recent history of hiking in a tick-infested area, Lyme disease and Ehrlichia chaffeensis were suspected; however, antibodies screening resulted negative. …

Dengue-Related Hemophagocytic Lymphohistiocytosis in an Adult: A Case Report and Brief Update.

Dengue virus is an arbovirus transmitted through the bite of infected Aedes mosquitoes. Many unusual clinical features are being reported in dengue. Dengue complicated with hemophagocytic lymphohistiocytosis (HLH) is a rare but potentially fatal condition. Here, we report an 18-year-old otherwise healthy female with dengue fever complicated with HLH. The diagnosis was made by fulfilling the clinical and laboratory criteria of HLH. She was managed successfully with a methylprednisolone pulse regimen. Our case highlights the importance of early recognition of complications and prompt treatment f

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… parechovirus, enterovirus, H1N1 influenza virus, and recently severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) Bacterial infections | Staphylococcus aureus, Campylobacter spp., Fusobacterium spp., Mycoplasma spp., Chlamydia spp., Legionella spp., Salmonella typhi, Rickettsia spp., Brucella spp., Ehrlichia …

Disorders of the Gastrointestinal System

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Advanced Diagnostic Techniques

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Vacuoles, E1 Enzyme, X-linked, Autoinflammatory, and Somatic (VEXAS) Syndrome: A Case Report.

VEXAS is an acronym that stands for the technical terms of key descriptors of the condition: vacuoles, E1 enzyme, X-linked, autoinflammatory, and somatic (VEXAS) syndrome, which is a recently identified autoinflammatory disorder primarily affecting men older than 50 years of age. It is commonly associated with a somatic mutation in the X-linked ubiquitin-activating enzyme-encoding UBA1 gene. This condition manifests in a range of hematologic and systemic inflammatory symptoms, such as cytopenias, recurrent fevers, and an elevated risk for hematologic malignancies like myelodysplastic syndrome

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… Our infectious evaluation yielded unremarkable results, with negative tests for ehrlichia, anaplasma, babesia, lyme, coxiella, bartonella, brucellosis, mycoplasma, tuberculosis, endemic mycoses, human immunodeficiency virus (HIV), hepatitis B/C, syphilis via rapid plasma reagin (RPR), Epstein-barr virus …

Infectious Diseases

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… Treat with doxycycline or chloramphenicol ehrlichia — E. chaffeensis (human monocytic ehrlichiosis) transmitted by lone star tick. Peaks in May to July. Infects lymphocytes, monocytes, and neutrophils intracellularly. … Human granulocytic anaplasmosis is caused by a related Ehrlichia and produces similar illness without rash. Transmitted by Ixodes tick and co-infection with Lyme disease possible. …

Pericardial effusion secondary to epicardial undifferentiated pleomorphic sarcoma in a young cat.

CASE SUMMARY: A 6.4 kg 3-year-old male neutered indoor-outdoor domestic shorthair cat was referred for further evaluation of non-resolving lethargy and hyporexia of 4 days' duration. Physical examination identified tachypnea with mild respiratory effort and muffled lung sounds bilaterally. Point-of-care ultrasound revealed a large volume of pleural and pericardial effusion (PCE), which was confirmed by thoracic radiography. Echocardiogram indicated normal cardiac function but revealed a mass-like structure along the left epicardium within the pericardial space. After 72 hours in hospital, re-e

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… A vector-borne panel was submitted to the North Carolina State University Vector Borne Disease Lab, including PCR assays for Anaplasma species, Babesia species, Bartonella species, Cytauxzoon species, Ehrlichia species, hemotropic Mycoplasma species, Rickettsia species and immunofluorescence assays for …

Infectious Diseases

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… Treat with doxycycline or chloramphenicol ehrlichia — E. chaffeensis (human monocytic ehrlichiosis) transmitted by lone star tick. Peaks in May to July. Infects lymphocytes, monocytes, and neutrophils intracellularly. … Human granulocytic anaplasmosis is caused by a related Ehrlichia and produces similar illness without rash. Transmitted by Ixodes tick and co-infection with Lyme disease possible. …

Application of NMR-based metabolomics and machine learning for non-invasive disease screening in dogs.

BackgroundBlood-based metabolomics is increasingly recognised as a powerful tool for disease detection in human medicine. However, its application in veterinary science remains limited.ObjectiveTo evaluate the ability of an NMR-based metabolomics platform combined with machine learning to screen dogs for cancer, cardiovascular disease (CVD), and overall health status.AnimalsClient-owned dogs were recruited from two sites. Of 156 animals enrolled, 139 remained after exclusions and were used for training and cross-validation of classification models.MethodsBlood samples were obtained from clinic

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… Screening included a rapid enzyme-linked immunosorbent assay (ELISA)-based test (SNAP ® 4Dx ® Plus Test, IDEXX Laboratories Italia S.r.l., Milan, Italy) for Dirofilaria immitis antigen and antibodies against Borrelia burgdorferi C6 peptide, Ehrlichia canis/Ehrlichia ewingii , and Anaplasma phagocytophilum …

Prognostic factors and long-term outcome in dogs diagnosed with primary and secondary immune thrombocytopenia in Ireland.

OBJECTIVES: The objectives of this study were to describe the outcome and prognostic factors in dogs diagnosed with primary and secondary immune thrombocytopenia (ITP). MATERIALS AND METHODS: Medical records of dogs diagnosed with primary and secondary ITP in a referral hospital in Ireland were retrospectively evaluated. Short- and long-term survivals were analysed using Cox proportional-hazards regression models. RESULTS: Medical records from 49 dogs were included. Primary and secondary ITP were diagnosed in 81.25% and 18.75% of dogs, respectively. The survival rate was 69% at 2 weeks (95%

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… Infectious disease screening was performed for common canine vector‐borne diseases including Echrlichia canis, Ehrlichia ewingii, Anaplasma phagocytophilum, Anaplasma platys, Borrelia burgdorferi and Dirofilaria immitis , using a commercially available test (SNAP® 4DX, IDEXX). …

Advanced Diagnostic Techniques

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Magnetic Resonance Imaging Findings in 13 Neurologic Pot-Bellied Pigs.

This study reports the magnetic resonance imaging (MRI) findings in 13 pot-bellied pigs presented to our institution with neurological deficits. Nine pigs had abnormal MRI findings (7 with spinal cord localization and 2 with brain localization), with three of them having histopathological confirmation of the diagnoses. MRI diagnoses included a myopathy suspected to be secondary to Erysipelothrix rhusiopathiae, a round cell neoplasia involving the vertebral canal, myelomalacia, a cervical cyst like extradural lesion, pelvic fracture with secondary cauda equina involvement, two cases of fibrocar

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… Differential diagnoses included otitis media interna with intracranial extension, a meningoencephalitis from a viral source (pseudorabies, Teschen disease, and rabies), or vector-borne diseases (ehrlichia, rickettsia). …

Изучение цереброваскулярных проявлений нейроборлиоза: обзор.

Заболевание Lyme - это зоонотическая инфекция, передающаяся Боррелией Бурдорфери, и, если ее не диагностировать, она может появиться на более поздних этапах с неврологическими проявлениями. Цель этого обзора заключается в обобщении данных о инсультовом или аналогичном цереброваскулярном исходе нейроборрелиоза Лайма (НБ) для содействия раннему распознаванию и лечению. 90 - пациенты, отвечающие критериям Европейской федерации неврологических обществ/Американской академии неврологических заболеваний/Американской школы ревматологии (EFNS/IDSA/AAN/ACR) для ЛНБ с радиологически или серологически под

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… During tick-endemic seasons (i.e. summer, when people do tend to do more outdoor activities), most clinicians should try to include a tick profile: anything an Ixodes tick can transmit (identifying for Borrelia , Anaplasma , Babesia , and Ehrlichia ). …

Research Hotspots and Trends in Global Cancer immunometabolism:A Bibliometric Analysis from 2000 to 2023.

BackgroundCancer poses a major global health challenge, and immunotherapy, known as the third revolution in cancer treatment, has brought new hope to patients. The emerging field of immunometabolism has further enhanced the safety and efficacy of immunotherapy. Over the past two decades, this field has rapidly evolved in oncology, leading to numerous significant findings. This review systematically examines the literature on immunometabolism in cancer, visualizing research trends and identifying future directions.MethodsA comprehensive literature search was conducted in the Web of Science, Pub

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… M1 and M2 macrophages polarization via mTORC1 influences innate immunity and outcome of Ehrlichia infection . J Cell Immunol . 2020 ; 2 ( 3 ): 108 – 115 . doi: 10.33696/immunology.2.029 32719831 PMC7384756 46. Zhao J , Huang H , Zhao J , et al. …

RESEARCH COMMUNICATIONS OF THE 34th ECVIM-CA CONGRESS.

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… ISCAID‐P‐6 | Dominguez | Exploring the Impact of Initial Treatment on Clinical Outcomes in Canine Leishmaniosis: A Retrospective Analysis over 20 years (2000‐2020) ISCAID‐P‐7 | Cloete | Prevalence of co‐infections with Ehrlichia spp. or Theileria spp. in dogs naturally infected with babesiosis in the …

Disorders of the Spinal Cord

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… Rickettsial causes include Rickettsia rickettsii (Rocky Mountain spotted fever [RMSF]) and Ehrlichia canis . Fungal causes include Cryptococcus neoformans , Blastomyces dermatitidis , Histoplasma capsulatum , and Coccidioides immitis . …

Feline Coronavirus Infection

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… Microbiologic Testing FeLV antigen and FIV antibody serology: negative Serology (IFA) and blood culture for Bartonella clarridgeiae and Bartonella henselae : negative Serology (IFA) for vector-borne diseases: negative for antibodies to Ehrlichia canis , Neorickettsia risticii , Anaplasma spp., and Rickettsia …

Proceedings 27th Symposium ESVN‐ECVN

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Plasma Cell Disorders

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… Microscopic and clinical evidence for Anaplasma (Ehrlichia) phagocytophilum infection in Italian cats. Vet Rec. 2005;156(24):772–774. doi: 10.1136/vr.156.24.772. 95. Bida JP, Kyle RA, Therneau TM. …