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Unveiling muscle fatigue: identifying key gene biomarkers and therapeutic targets.

Muscle fatigue, a potential risk factor for athlete injuries, lacks specific therapeutic targets and diagnostic biomarkers. This study aimed to identify biomarkers or targets for muscle fatigue to develop new diagnostic and treatment approaches. We utilized skeletal muscle and blood expression Quantitative Trait Loci data, employing the methods of Summary-data-based Mendelian Randomization (SMR) and Bayesian colocalization to identify genes that exhibit significant association with fatigue. DSigDB database and molecular docking method were used to predict potential drug candidates for the iden…

Fatigue-Resistant Dithienylarene Photoswitches with Acid-Regulated Thermal Ring Opening.

Dithienylarene photoswitches are an emerging class of diarylethenes, in which photochemical ring closure is accompanied by pronounced change … isomer from 2.9 h to 15 s in EtOH at 25 °C but, crucially, without significantly deteriorating the fatigue resistance upon repeated isomerization cycles. The parent BPPyr form with its original properties could be recovered via deprotonation; furthermore, N-methylation of BPPyr produced a water-soluble, ionic compound ([BPPyr-Me2]2+ ) switchable by visib …

Fatigue Among Adults Age 18 and Older: United States, 2024.

OBJECTIVE: This report describes fatigue symptoms among adults by sociodemographic characteristics, as well as co-occurrence with functioning difficulties and limitations in work and social activities. METHODS: Data from the 2024 National Health Interview Survey were used to estimate fatigue symptoms among adults age 18 and older. Fatigue is based on reported frequency of fatigue in the past 3 months, with frequent fatigue defined as experiencing fatigue symptoms most days or every day during the 3-month period. Estimates are presented by sex, age, race and Hispanic origin, family income, reg…

Fatigue after Thyroidectomy: A Qualitative Exploration of Patients' Lived Experiences.

INTRODUCTION: Fatigue is a common, yet understudied, patient-reported symptom after thyroidectomy. This study sought to explore patients' lived experience of fatigue post-thyroidectomy. METHODS: Semi-structured interviews were conducted with adult patients who underwent thyroidectomy for benign and malignant thyroid disease between January 2021 and January 2024. Data were analyzed by qualitative content analysis. RESULTS: Participants (n = 20) were a median of 44 years (range 21-73). The majority were female (90%), White (75%), diagnosed with thyroid cancer (45%), and had undergone a total t…

Stress-Controlled Torsional Fatigue Assessment of Selected Contemporary Endodontic Instruments.

OBJECTIVES: To compare stress-controlled torsional fatigue resistance of TruNatomy (TN), ProTaper Next (PTN), and ProTaper Ultimate (PTUL) instruments of comparable sizes at both room and body temperature. MATERIALS AND METHODS: Torsional strength and related twist angles were determined at both temperatures in a torque testing fixture. Stress-controlled torsional fatigue resistance (TFR) was determined by cycling instruments in a custom fixture to pre-set twist angles corresponding to 90% torsional strength until fracture. Data were analyzed using two-way ANOVA and Tukey post-hoc tests with t…

TiNbSn alloy spine rods resistant to fatigue fracture and flattening.

The critical issues of fatigue fracture and flattening in the Ti-6Al-4V and CoCrMo spine rods for spine deformity correction surgery remain unresolved. To address them we propose a hypothesis that fatigue fracture stems from crystal defects and residual stresses, and flattening originates from the Bauschinger effect. To test the hypothesis, TiNbSn alloy spine rods with an apex radius of 120 mm (R120) were prepared by heating an as-swaged TiNbSn rod at 400°C for 5 h ("warm-contoured") using a rod fixing device designed to shape the rod while minimizing plastic deformation to reduce crystal defe…

COVID-19-Induced GI Vascular Abnormalities: Beyond Fatigue and Lungs.

COVID-19 infection is associated with multi-system complications other than primary pulmonary disease. It is well-documented that it causes an inflammatory response, which in severe cases can lead to pathologies in other organ systems. Gastrointestinal (GI) manifestations are common and includes anorexia, diarrhoea, nausea, vomiting, and abdominal pain. An uncommon GI manifestation in COVID-19 infection is GI bleeding (GIB). Angioectasia is one of the rare causes of GIB, not very common, reasonably straightforward to diagnose, but difficult to treat, with no consensus in the literature on the

Endurance Athletes Are More Resistant to Mental Fatigue Than Nonathletes.

Acute mental fatigue refers to a temporary decline in cognitive function resulting from prolonged mental effort pertaining to a cognitively demanding task. Previous studies have indicated that acute mental fatigue decreases performance on subsequent physical effortful tasks as well as the capacity and/or motivation to invest mental effort. Scholars have recently suggested that aerobic training can enhance willpower. We hypothesized that endurance athletes are less responsive to the detrimental effects of acute mental fatigue than are nonathletes. Two groups of participants (50 athletes vs. 50 …

Cancer fatigue and hair loss experiences among American Indian men.

Background: Little is known about the cancer symptom experiences of Indigenous populations, particularly concerning fatigue and hair loss. Hair loss can have many detrimental effects given the significant cultural importance of hair in Indigenous communities. Gaining a better understanding of the unique perspectives of American Indian male cancer survivors as they manage these two distinct symptoms is essential for improving symptom management and quality of life measures in this underserved population. Methods: A multi-pronged study explored the barriers, facilitators, and cultural constructs…

Jitter and muscle fiber conduction velocity in long COVID fatigue.

BACKGROUND: Long coronavirus disease (long COVID, LC) is defined as the continuation or development of new symptoms 3 months after the acute stage of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In LC, the rate of fatigue/postexertional malaise (F-PEM) has been described to be as high as 70%, regardless of age or severity of the acute symptoms. OBJECTIVE: To evaluate the neuromuscular junction (NMJ) function and the isolated muscle fiber conduction velocity (MFCV) in situ in LC cases and controls. METHODS: We studied 37 subjects without SARS-CoV-2 (controls) and 32…

Can exercise reduce fatigue in people living with kidney disease?

PURPOSE OF REVIEW: In people living with kidney disease (KD) Fatigue is a whole-body tiredness that is not related to activity or exertion. Often self-reported, fatigue is a common and highly burdensome symptom, yet poorly defined and understood. While its mechanisms are complex, many fatigue-related factors may be altered by exercise and physical activity intervention. Thus, this review aims to review the latest research on exercise in reducing fatigue in people living with KD. RECENT FINDINGS: The benefits of exercise in KD are well known, yet recent data from clinical trials on fatigue are…

Imposed expiratory resistance, dynamic hyperinflation and locomotor power and fatigue.

Expiratory flow limitation results in dynamic hyperinflation, dyspnoea and premature exercise intolerance. We aimed to measure whether expiratory resistance reduces locomotor power via limiting maximal voluntary motor activity, exacerbating muscle fatigue, or both. Healthy volunteers (n = 14; 23 (3) years) performed a series of very heavy-domain constant power cycling exercise tests with and without an imposed expiratory flow resistance (7 cmH2O/L/s). The decline in maximal evocable isokinetic power at intolerance during each experimental condition was apportioned to: (1) the power equivalent …

Research on driver's wrist motion pattern and fatigue characterization methods.

OBJECTIVES: Studies have shown that driving fatigue leads to changes in driving behavior. The aim of this study was to analyze the effects of sleep deprivation and prolonged driving time on drivers' wrist motion characteristics. METHODS: Seventeen participants were recruited to participate in a 90-min simulated driving experiment after normal sleep and sleep deprivation, and wrist-worn wearable sensors were used to record the acceleration of the driver's wrist and to characterize it in the time domain, frequency domain and entropy. PERCLOS was used as the standard to clarify the wrist motion …

Fatigue failure of constrained total knee replacement: A case report.

Hinged implants for total knee arthroplasty (TKA) improve stability and joint function in a ligamentously compromised knee, but potentially at the cost of reduced implant longevity due to increased mechanical stress on the construct. This report details the case of an 83-year-old woman who underwent a revision total knee arthroplasty for a chronically dislocated hinged knee prosthesis in August 2024 at our institution. The patient presented with a several month history of pain and instability with reported self-reduction of the prosthesis to aid in ambulation. The revision surgery revealed tha

Усталые умы, нормальные оценки: переосмысление когнитивной усталости при множественном склерозе.

Когнитивная усталость относится к числу наиболее распространенных и нетрудоспособных симптомов, с которыми сталкиваются лица с множественным склерозом (МС), однако она по-прежнему недостаточно признается и недостаточно лечится как в научных исследованиях, так и в клинических условиях. Несмотря на распространенность этого явления, когнитивная усталость часто путается с общей усталостью или упускается из виду в стандартных нейропсихологических оценках, основанных на кратких, дезтекстуализированных показателях эффективности. Эта точка зрения свидетельствует об изменении парадигмы в том, как конце

Совпадение в аннотации оригинала
Cognitive fatigue is among the most pervasive and disabling symptoms experienced by individuals with multiple sclerosis (MS), yet it remains underrecognized and undertreated in both research and clinical settings. Despite its prevalence, cognitive fatigue is often confused with general fatigue or overlooked in standard neuropsychological assessments that rel…

Рефлексология ног в случае утомления, связанного с множественным склерозом: систематический обзор.

Усталость, широко распространенный и серьезный симптом у пациентов с множественным склерозом, негативно сказывается на повседневной жизни пациентов и их качестве жизни. Хотя в последние годы рефлексология ног широко использовалась в борьбе с усталостью, ее воздействие на многих пациентов, страдающих от усталости, связанной со склерозом, остается неясным. ЦЕЛЬ ПРИМЕНИТЕЛЬНОГО ИССЛЕДОВАНИЯ: Цель этого систематического обзора заключалась в изучении воздействия рефлексологии ног на многократную усталость, связанную со склерозом. МЕТОДЫ/ДЕСИГН: Протокол систематического обзора и подготовка статей о

Совпадение в аннотации оригинала
BACKGROUND: Fatigue, a common and serious symptom in multiple sclerosis patients, negatively affects patients' activities of daily living and their quality of life. While foot reflexology has been widely used in fatigue management in recent years, its effect on multiple sclerosis-related fatigue patients remains unclear. PRIMARY STUDY OBJECTIVE: This system…

Meta-analysis of visual fatigue based on visual display terminals.

BACKGROUND: This study aims to explore the impact of using visual display terminal (VDT) on the visual fatigue of operators through meta-analysis. METHODS: The terms "VDT", "visual fatigue", "eyestrain", and "viewing distance" were selected from the Wangfang, China National Knowledge Infrastructure (CNKI), Web of Science, Springer, and Science Direct online databases. The retrieval time was from the establishment of the database to the present. All clinical studies related to the analysis of the effects of VDT use on visual fatigue were available. The included studies were screened, and after…

Multifactorial Nature of Fatigue in North Indian Rheumatoid Arthritis Patients.

INTRODUCTION: Fatigue is a common, disabling, and poorly understood aspect of Rheumatoid arthritis (RA) treatment. Better understanding of fatigue is required for holistic treatment of RA. The present study was conducted to evaluate factors (disease activity, pain, sleep quality, and vitamin D) contributing to fatigue in RA. METHOD: A cross-sectional study was conducted on 204 patients of RA. Fatigue was measured using CFQ-11 scale, pain and sleep impairment were assessed on visual analogue scale, disease activity by DAS 28 ESR, and vitamin D levels by enzyme chemiluminescence immunoassay. Un…

Degradation and Fatigue Behavior of 3D-Printed Bioresorbable Tracheal Splints.

Severe infantile tracheobronchomalacia (TBM) is often treated with invasive surgery and fixed-size implants to support the trachea during respiration. A novel 3D-printed extra-luminal splint has been developed as a flexible and bioresorbable alternative. Therefore, the goal of the present study was to use an in vitro breathing simulator model to comprehensively evaluate the structural stiffness and failure modes of two sizes of a novel bioresorbable 3D-printed splint design under a range of physiological degradation conditions. Two thicknesses, 2 mm and 3 mm, of a novel 3D-printed bioresorbabl