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Conservative Treatment Versus Ultrasound-Guided Injection in the Management of Meralgia Paresthetica: A Randomized Controlled Trial.

BACKGROUND: Meralgia paresthetica (MP) is an entrapment mononeuropathy of the lateral femoral cutaneous nerve (LFCN), in which conservative treatment options are not always sufficient. OBJECTIVES: The aim of this study was to evaluate the efficacy of ultrasound (US)-guided LFCN injection in the management of MP by comparing with transcutaneous electrical nerve stimulation (TENS) therapy and sham TENS therapy. STUDY DESIGN: A prospective, randomized, sham-controlled study. SETTING: Health Sciences University Training and Research Hospital in Turkey. METHODS: Patients diagnosed with LFCN com

Cost of peripheral neuropathy in patients receiving treatment for multiple myeloma: a US administrative claims analysis.

BackgroundPeripheral neuropathy (PN) is a common consequence of multiple myeloma (MM) among those commonly treated with older-generation proteasome inhibitors (PIs). In this study, we evaluated the economic burden attributable to PN among MM patients in real-world practice settings in the US.MethodsAdults diagnosed with MM and first treated (index event) between 1 July 2006 and 28 February 2017 were identified from MarketScan® Commercial and Medicare claim databases. Continuous enrollment for at least 12 months without treatment and PN diagnoses were required pre-index. Patients were followed

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… E0941 | Drug or chemical-induced diabetes mellitus with neurological complications with diabetic mononeuropathy E1041 | Type 1 diabetes mellitus with diabetic mononeuropathy E1141 | Type 2 diabetes mellitus with diabetic mononeuropathy E1341 | Other specified diabetes mellitus with diabetic mononeuropathy … mononeuropathies of right lower limb G5782 | Other specified mononeuropathies of left lower limb G5783 | Other specified mononeuropathies of bilateral lower limbs G588 | Other specified mononeuropathies G589 | Mononeuropathy, unspecified G64 | Other disorders of peripheral nervous system G610 | Guillain–Barré …

Sensitivity and specificity of single and combined clouds analyses compared with quantitative motor unit potential analysis.

INTRODUCTION: Turns-amplitude, number of small segments (NSS)-activity, and envelope-activity clouds are three methods of electromyography (EMG) interference pattern analysis. Our objective was to evaluate the sensitivity and specificity of each individual cloud analysis and combined clouds analysis to compare with that of quantitative motor unit potential (QMUP) analysis. METHODS: A total of 379 muscles from 100 patients were analyzed by both QMUP and clouds analyses. Calculation of sensitivity and specificity was based on the clinical diagnosis as the "gold standard." RESULTS: For discrimi

The role of spinal neuroimmune activation in morphine tolerance/hyperalgesia in neuropathic and sham-operated rats.

Hypersensitivity resulting from nerve injury or morphine tolerance/hyperalgesia is predicted to involve similar cellular and molecular mechanisms. One expected but incompletely explored mechanism is the activation of central neuroimmune responses associated with these conditions. To begin to address this, we undertook three separate studies: First, we determined the acute antinociceptive action of morphine, the rate of development of opioid tolerance, and withdrawal-induced hyperalgesia/allodynia in nerve-injured and sham-operated rats using noxious (thermal and mechanical) and non-noxious (me

Сочетание физического объема и риска заболеваний нервной системы: ретроспективное когортное исследование.

ОКРУЖАЮЩАЯ СРЕДА: Объем физической активности (ПАВ) связан с широким спектром последствий для здоровья; однако его связь с случайными заболеваниями нервной системы по-прежнему не до конца изучена. В этом исследовании были изучены их взаимоотношения с использованием данных из UK Biobank. МЕТОДЫ: Было проведено ретроспективное когортное исследование, охватывающее 278,306 - участники из Биобанка Соединенного Королевства. ПАВ была определена как метаболический эквивалент задач (МЕТ) минут в неделю на основе саморегистрируемых уровней физической активности и классифицирована по категориям: three гр

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… It shown that the top five death ratio of nervous system diseases are Mononeuropathies of upper limb, Sleep disorders, Nerve root and plexus compressions in diseases classified elsewhere, Transient cerebral ischaemic attacks and related syndromes, and Other extrapyramidal and movement disorders. … system; G23, Other degenerative diseases of basal ganglia; G25, Other extrapyramidal and movement disorders; G35, Multiple sclerosis; G45, Transient cerebral ischaemic attacks and related syndromes; G47, Sleep disorders; G55, Nerve root and plexus compressions in diseases classified elsewhere; G56, Mononeuropathies …

Каталоги оценок показателей качества жизни, связанных с здоровьем, по шкале EQ-5D-3L для 199 хронических заболеваний и рисков здоровья для использования в Великобритании и США.

СВОДНАЯ ИНФОРМАЦИЯ: В экономической оценке важное значение имеют связанные со здоровьем показатели качества жизни (HRQOL), однако в некоторых случаях отсутствуют первичные источники и требуется информация из вторичных источников. Существующие каталоги HRQOL Соединенного Королевства/США основаны, в частности, на предыдущих системах классификации диагнозов. Недавно опубликованный датский каталог объединился EQ-5D-3L Данные национальных обследований в области здравоохранения с использованием национальных регистров, содержащих информацию о пациентах ICD-10 - диагностика, медицинское обслуживание и

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… of upper limb G56 1460 57.4 5.0 0.1029 0.715 0.0088 0.689 0.796 0.883 0.789 0.0060 0.767 0.827 0.860 49 Mononeuropathies of lower limb, other mononeuropathies and mononeuropathy in diseases classified elsewhere G57–G59 193 56.9 4.9 0.2683 0.685 0.0257 0.620 0.727 0.85 0.768 0.0178 0.706 0.810 0.854 … of upper limb | G56 | 1460 | 57.4 | 5.0 | 0.1029 | 0.715 | 0.0088 | 0.689 | 0.796 | 0.883 | 0.789 | 0.0060 | 0.767 | 0.827 | 0.860 49 | Mononeuropathies of lower limb, other mononeuropathies and mononeuropathy in diseases classified elsewhere | G57–G59 | 193 | 56.9 | 4.9 | 0.2683 | 0.685 | 0.0257 | …

Acute Foot Drop in the Initial Presentation of Systemic Lupus Erythematosus.

The case of a 20-year-old woman with newly diagnosed systemic lupus erythematosus (SLE) who developed acute foot drop secondary to mononeuritis multiplex is presented. Peripheral neuropathy etiology is broad, but in the setting of SLE, it should raise concern for vasculitis, as seen in this case with mononeuritis multiplex. Diagnosis requires an understanding of SLE pathology as seen with muscle and nerve biopsy. Prompt diagnosis and high-dose corticosteroids are critical, but pain may persist despite immunosuppression. Cite this article as: Gabriel M, Chavez X. Acute foot drop in the initial

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… inflammation and damage, classically to the skin, joints, kidneys, hematologic system, and central nervous system (CNS). 1 , 2 However, SLE has also been associated with peripheral nervous system involvement, causing peripheral neuropathy presenting as motor, sensory, or mixed fiber polyneuropathy, isolated mononeuropathy … Findings in peroneal-innervated muscles raised concern for superimposed tibial and peroneal mononeuropathies versus sciatic neuropathy, though technical limitations may have affected interpretation. …

Various neurological symptoms by neurolymphomatosis as the initial presentation of primary testicular lymphoma.

Neurological symptoms induced by the infiltration of malignant lymphoma into the nervous systems are subsumed under the term neurolymphomatosis (NL). Here, we report the case of a 30-year-old Japanese man with primary testicular lymphoma complicated, as seen in various neurological findings, by secondary NL prior to testicular swelling. Painless right scrotal enlargement was noticed more than 1 month after the appearance of neurological complications such as right upper extremity numbness, dysarthria, facial palsy, and diplopia. Proactive investigation and biopsies of extranodal sites at high

Nuances in the treatment of malignant tumors of the clival and petroclival region.

Introduction Malignancies of the clivus and petroclival region are mainly chordomas and chondrosarcomas. Although a spectrum of malignancies may present in this area, a finite group of commonly encountered malignant pathologies will be the focus of this review, as they are recognized to be formidable pathologies due to adjacent critical neurovascular structures and challenging surgical approaches. Objectives The objective is to review the literature regarding medical and surgical management of malignant tumors of the clival and petroclival region with a focus on clinical presentation, diagnost

Hereditary transthyretin amyloidosis presenting with carpal tunnel syndrome.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Utilization of medications for neuropathic pain in patients with and without knee and hip osteoarthritis in Sweden: A population-based cohort study.

ObjectiveUse of neuropathic pain medications is increasing in OA patients, but it is unclear if this is driven by OA-specific use or presence of comorbidities. We aimed to investigate the use of neuropathic pain medications attributable to knee and hip OA pain.DesignWe included all residents aged ≥35 years of the Skåne region, Sweden, in 2018. After exclusions, 645,991 individuals remained, where 81,606 had diagnosed knee and/or hip OA. We compared prevalence of dispensed neuropathic pain medications between those with and without OA using logistic regression (odds ratios approximated risk rat

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… bifida (split spine) Q05 Gait disturbances and movement disorders R26 Neuropathies∗ Other spirochetal infections A69 Shingles B02 Diseases of the trigeminus nerve G50 Diseases of other cerebral nerves G52 Changes in cranial nerves in diseases classified elsewhere G53 Diseases in brachial plexus G54 Mononeuropathies … of the upper extremity G56 Mononeuropathies of the lower extremity G57 Other mononeuropathies G58 Hereditary and idiopathic neuropathy G60 Inflammatory polyneuropathy G61 Other polyneuropathies G62 Polyneuropathy in diseases classified elsewhere G63 Other diseases of the peripheral nervous system G64 …

Transferability of a US claims-based machine learning model for ATTRwt-CM identification: a retrospective evaluation in a German setting.

Cardiac amyloidosis (CA), a fatal and progressive cardiomyopathy is characterized by amyloid deposition within the myocardium. The main forms of CA include transthyretin amyloidosis (ATTR-CM; distinguished into a hereditary and wildtype form [ATTRv and ATTRwt]) and light-chain amyloidosis (AL). Transthyretin amyloidosis with cardiomyopathy (ATTR-CM) is increasingly recognized among heart failure (HF) patients, despite its underestimated prevalence as a rare disease. ATTR-CM is challenging to diagnose due to its broad phenotypic overlap with HF, yet a timely differentiation of CA is crucial, as

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… The features in yellow are captured within the ACCB only (relating to HF), whereas the one presented in blue (mononeuropathies of the upper limbs) indicates a presence in both ACCB and SAVER. … The features in yellow are captured within the ACCB only (relating to HF), whereas the one presented in blue (mononeuropathies of the upper limbs) indicates a presence in both ACCB and SAVER. …

Neuropathic cancer pain: What we are dealing with? How to manage it?

Cancer pain is a serious health problem, and imposes a great burden on the lives of patients and their families. Pain can be associated with delay in treatment, denial of treatment, or failure of treatment. If the pain is not treated properly it may impair the quality of life. Neuropathic cancer pain (NCP) is one of the most complex phenomena among cancer pain syndromes. NCP may result from direct damage to nerves due to acute diagnostic/therapeutic interventions. Chronic NCP is the result of treatment complications or malignancy itself. Although the reason for pain is different in NCP and non

Burden, Outcome, and Comorbidities of Extrahepatic Manifestations in Hepatitis B Virus Infections.

Hepatitis B virus (HBV) infections affect approximately 296 million people around the world, and the prevalence of any past or present HBV infection during the years 2015-2018 was as high as 4.3%. Acute HBV infection often presents with nonspecific symptoms and is usually self-limited, but 5% of patients can have persistent infections leading to chronic HBV infection and the risk of turning into chronic HBV infection is significantly higher in babies with vertical transmission (95%). Patients with chronic HBV infection are usually asymptomatic, but 15 to 40% of chronic HBV carriers develop cir

From Biology to Treatment of Monoclonal Gammopathies of Neurological Significance.

Monoclonal gammopathy and peripheral neuropathy are common diseases of elderly patients, and almost 10% of patients with neuropathy of unknown cause have paraprotein. However, growing evidence suggests that several hematological malignancies synthesize and release monoclonal proteins that damage the peripheral nervous system through different mechanisms. The spectrum of the disease varies from mild to rapidly progressive symptoms, sometimes affecting not only sensory nerve fibers, but also motor and autonomic fibers. Therefore, a multidisciplinary approach, mainly between hematologists and neu

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… Fifteen out of the nineteen patients had a sensory or sensorimotor axonal neuropathy, one had a multiple mononeuropathy, and three fulfilled the clinical and neurophysiological criteria of chronic inflammatory polyradiculoneuropathy (CIDP) [ 94 ]. … PNS involvement is not common in IVL, but neuropathies with sensory and motor deficits may be present, ranging from acute polyradiculoneuropathy [ 100 ] and multiple mononeuropathies [ 101 ] to demyelinating polyneuropathy [ 102 ]. …

Радиоактивно изолированный синдром, сопровождающий наследственную нейропатию с ответственностью перед прицелом: сообщение о новом фенотипе демиелина.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… Hereditary neuropathy with liability to pressure palsies (HNPP) is an autosomal dominant disorder caused by peripheral myelin protein 22 (PMP22) gene deletion on chromosome 17p11.2-p12. 1 It leads to peripheral nerve susceptibility to mechanical stress, typically presenting as recurrent mononeuropathies …

Integrated Medicine for Chemotherapy-Induced Peripheral Neuropathy.

Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of typical chemotherapeutics among cancer survivors. Despite the recent progress, the effective prevention and treatment strategies for CIPN remain limited. Better understanding of the pathogenesis of CIPN may provide new niches for developing a new ideal therapeutic strategy. This review summarizes the current understanding of CIPN and current recommendations along with completed/active clinical trials and aims to foster translational research to improve the development of effective strategies for managing CIPN.

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… Taxanes | Docetaxel Paclitaxel Nab-paclitaxel Cabazitaxel Ixabepilone | Stabilization of microtubule polymers | Docetaxel ~400 mg/m 2 Paclitaxel ~1000 mg/m 2 ; doses of ≥250 mg/m 2 may be needed after the first dose | 48.2% | Taste impairment | Sensorimotor neuropathy | Occasionally cranial nerves, mononeuropathies … , autonomic features, “coasting” Vinca alkaloids | Vincristine Vinblastine Vinorelbine Vindesine | Destabilization of microtubule polymers | Vincristine >4 mg/m 2 may be needed after the first dose | 20%; Vincristine 30–40% | Taste impairment | Sensorimotor neuropathy | Occasionally cranial nerves, mononeuropathies …

Current and future applications of ultrasound imaging in peripheral nerve disorders.

Neuromuscular ultrasound (NMUS) is a rapidly evolving technique used in neuromuscular medicine to provide complimentary information to standard electrodiagnostic studies. NMUS provides a dynamic, real time assessment of anatomy which can alter both diagnostic and management pathways in peripheral nerve disorders. This review describes the current and future techniques used in NMUS and details the applications and developments in the diagnosis and monitoring of compressive, hereditary, immune-mediated and axonal peripheral nerve disorders, and motor neuron diseases. Technological advances have

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… In one study of mononeuropathies, the diagnostic or management trajectory was altered by peripheral nerve US in over 42% of cases[ 67 ]. … Once equipped, NMUS in mononeuropathy cohorts is reported to improve quality of life outcomes, with only modest outlays on cost-effectiveness analyses[ 267 , 268 ]. …

Brazilian consensus for diagnosis, management and treatment of hereditary transthyretin amyloidosis with peripheral neuropathy: second edition.

Hereditary transthyretin amyloidosis with peripheral neuropathy (ATTRv-PN) is an autosomal dominant inherited sensorimotor and autonomic polyneuropathy with over 130 pathogenic variants identified in the TTR gene. Hereditary transthyretin amyloidosis with peripheral neuropathy is a disabling, progressive and life-threatening genetic condition that leads to death in ∼ 10 years if untreated. The prospects for ATTRv-PN have changed in the last decades, as it has become a treatable neuropathy. In addition to liver transplantation, initiated in 1990, there are now at least 3 drugs approved in many

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… , early motor involvement, mild autonomic features, severe cardiac involvement, and no family history. 27 41 42 49 This latter phenotype predominates in patients from nonendemic areas. 29 44 50 51 Also, ATTRv may have uncommon phenotypes, including ataxic neuropathy, upper-limb predominant multiple mononeuropathies … Differential diagnosis | Clues for the differential diagnosis Diabetic neuropathy | Poor glycemic control and mild motor involvement CIDP | Proximal and distal weakness and non-uniform demyelination on NCS Leprosy | Multiple mononeuropathies/asymmetric neuropathy, typical skin lesions Toxic neuropathies …

A Small Number of Surgeons Perform the Large Majority of Uncommon Nerve Decompression Procedures.

BACKGROUND: Notable surgeon-to-surgeon variation in rates of uncommon surgery can reflect appropriate concentration of expertise with technically difficult or risky procedures that address problematic impairment due to objective pathophysiology. Examples include vascularized tissue transfer or transplantation to address complex tissue loss and release of bony elbow ankylosis. Perhaps more problematic is notable variation in straightforward, discretionary surgeries intended to alleviate pain, offered in the absence of objectively measurable pathophysiology, and without experimental evidence of