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Bioactivity of the Genus Turnera: A Review of the Last 10 Years.

Turnera is a genus of plants whose biological activity has been widely studied. The importance of this genus, particularly Turnera diffusa, as a source of treatment for various conditions is evidenced by the large number of new studies that have evaluated its biological activity. Accordingly, the objective of this review was to compile the information published in the last ten years concerning the biological activities reported for Turnera spp. The present work includes 92 publications that evaluate 29 bioactivities and toxicological and genotoxic information on five species of this genus. Amo

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… However, these results were statistically inferior to the positive control nystatin [ 95 ]. … Sri et al. reported that the ethanolic extract of the T. subulata flower presented a growth IZ of 12 mm against C. albicans and A. niger ; however, this value was much lower than that of the nystatin positive control (35 mm) [ 99 ]. …

Cabozantinib Cutaneous Toxicity-Comprehensive Review.

BackgroundIn the context of modern cancer therapy, the management of adverse effects of systemic therapies can lead to the avoidance of underdosing and withdrawal and increases in the quality of the therapeutic act and the quality of life. This review offers an overview of the skin-related toxicities associated with Cabozantinib, a multikinase inhibitor (MKI) that is approved for treating advanced kidney cancer, hepatocellular carcinoma, and medullary thyroid cancer. It covers the most common dermatological side effects, such as palmar-plantar erythrodysesthesia, stomatitis, hair alterations,

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… Grade 1 or 2 | Medicated mouthwash to treat oral mucositis, which may include nystatin, diphenhydramine, viscous lidocaine, dyclonine, aluminum hydroxide, or magnesium hydroxide, and occasionally corticosteroids, or mouth rinses with 0.9% saline or 0.9% sodium bicarbonate. …

Stevens–Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) : Immunologic Reactions

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… can cause SJS and TEN include vancomycin, valproate, levofloxacin, etravirine, isotretinoin, quinolones, diclofenac, fluconazole, sitagliptin, oseltamivir, penicillins, barbiturates,sulfonamides, azithromycin, oxcarbazepine, zonisamide, modafinil, pyrimethamine, ethosuximide, bupropion, telaprevir, nystatin …

Перспективы Талкетамаба и его полезности в лечении множественной миеломы: безопасность, эффективность и место в терапии.

Несмотря на недавние достижения, большинство пациентов с множественной миэломой в конечном итоге развивают сопротивление имеющимся методам лечения, подчеркивая необходимость новых терапевтических стратегий. G Класс рецептора с протеиновыми соединениями C 5 Член D (GPRC5D) стал жизнеспособной новой терапевтической целью для клеток миэломы, которая привела к клиническому развитию талькетамаба, первого GPRC5D-directed bi специфичный Т-активист (TCE). В августе Талкетамаб получил ускоренное утверждение 2023 Управление по контролю за продуктами питания и лекарствами. Помимо ожидаемой краткосрочной

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… The most common medications used for management of dysgeusia included dexamethasone, triamcinolone and nystatin. Other strategies such as mineral and vitamin supplementation with zinc and biotin, salivary stimulants, and oral hydration have been used. …

Infectious Diseases

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Epidemiology and source of infection in cancer patients with febrile neutropenia: an experience from a developing country.

BackgroundFebrile neutropenia (FN) is a life-threatening complication that predisposes cancer patients to serious infections. This study aims to describe the epidemiology and source of infection in cancer patients with FN in a tertiary care hospital.MethodsA hospital-based retrospective study was conducted in a large tertiary care hospital from January 2020 to December 2021. Data on cancer patients with FN were collected from the hospital information system.Results150 cancer patients with FN were identified during the study period. Most patients were males (98; 65.3%), and the mean age of part

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… Other regimens that were mentioned in another study were gentamicin, vancomycin, and nystatin [ 35 ]. …

Is photobiomodulation an effective preventive strategy for oral mucositis in patients with hematologic diseases undergoing chemotherapy?: A systematic review of randomized controlled trials.

Purpose to conduct a systematic review to assess whether photobiomodulation is effective in preventing oral mucositis in patients with hematologic diseases undergoing chemotherapy. Methods: A systematic search was conducted in the Embase, Medline/PubMed, Cochrane, Scopus, Web of Science and LILACS databases. The strategy included selected randomized clinical trials that evaluated the prevention of oral mucositis, directly comparing the use of photobiomodulation for chemotherapy-induced oral mucositis in patients with hematologic diseases with alternative non-laser therapies. The risk of bias i

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… In the conventional therapy group, the “mucositis formula” consisted of 0.15 g of benzydamine, 1.13 g of nystatin, 2 g of neotutocaine, and 10 mL of distilled water. …

Ведомые АПРЕЛЬ БКМА/ТАКИ двойные целевые лиганды-наркотики для селективной и мощной терапии множественной миеломы.

Антиген созревания клеток B (BCMA) в значительной степени проявляется в злокачественных плазменных клетках и является идеальной терапевтической целью в множестве миеломы (MM). Однако эффективность лечения, ориентированного на BCMA, часто ограничивается регулированием деградации антигенов и выходом из опухоли. В этой связи мы представляем информацию о разработке двухцелевого лиганда-наркотика (НРС), использующего подпитывающий распространение лиган (АПРИЛ), естественного лиганда как для BCMA, так и для трансмембранового активатора, а также кальция-модулятора и циклофилина лиганда (TACI). Такая

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… In contrast, inhibitors targeting lipid raft (methyl- β -cyclodextrin) and caveolae (nystatin) had minimal effects on both cell types. …

Treatment of Stage 2 Medication-Induced Osteonecrosis of the Jaw: A Case Series.

Medication-induced jaw osteonecrosis (MRONJ) is a rare and serious disease with a negative impact on patients' quality of life, whose exact cause remains unclear and which may have a multifactorial origin. Although there are different therapeutic protocols, there is still no consensus. This case series evaluated three patients diagnosed with staged 2 MRONJ treated at the University of Murcia dental clinic according to the protocols described by the Spanish Society of Oral and Maxillofacial Surgery and the American Association of Oral and Maxillofacial Surgeons. Within 12 months of the applicat

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… If mycosis associated with osteonecrosis is suspected, nystatin or fluconazole should be used. Some studies also prescribed penicillin G + IV metronidazole [ 44 ], levofloxacin + metronidazole [ 45 ], piperacillin + tazobactam or imipenem + cilastatin [ 46 , 47 ], with favorable results. …

Infectious Diseases

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Growth inhibition of head and neck squamous cell carcinoma cells by sgRNA targeting the cyclin D1 mRNA based on TRUE gene silencing.

Head and neck squamous cell carcinoma (HNSCC) exhibits increased expression of cyclin D1 (CCND1). Previous studies have shown a correlation between poor prognosis of HNSCC and cyclin D1 overexpression. tRNase ZL-utilizing efficacious gene silencing (TRUE gene silencing) is one of the RNA-mediated gene expression control technologies that have therapeutic potential. This technology is based on a unique enzymatic property of mammalian tRNase ZL, which is that it can cleave any target RNA at any desired site by recognizing a pre-tRNA-like complex formed between the target RNA and an artificial sm

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… Several endocytosis inhibitors including chlorpromazine, nystatin or methyl-β-cyclodextrin were unable to diminish the apoptosis-inducing or target mRNA-reducing effects induced by naked sgRNA (Tamura et al., unpublished data), suggesting that functional uptake by cells in culture does not appear to …

Modulation of Oxidative Stress by Ozone Therapy in the Prevention and Treatment of Chemotherapy-Induced Toxicity: Review and Prospects.

(1) Background: Cancer is one of the leading causes of mortality worldwide. Radiotherapy and chemotherapy attempt to kill tumor cells by different mechanisms mediated by an intracellular increase of free radicals. However, free radicals can also increase in healthy cells and lead to oxidative stress, resulting in further damage to healthy tissues. Approaches to prevent or treat many of these side effects are limited. Ozone therapy can induce a controlled oxidative stress able to stimulate an adaptive antioxidant response in healthy tissue. This review describes the studies using ozone therapy

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… In 2008, a randomized study in children with chemo-induced mucositis showed that topical ozonated sunflower (Oleozon ® , Centro Nacional de Investigaciones Científicas, La Habana, Cuba) leads to higher and faster mucositis recovery than conventional treatment with “Chlorhexidine + Nystatin” [ 63 ]. …

Всеобъемлющая оценка неблагоприятных профилей, связанных с биконкретными антителами в множестве миеломы.

Биотечные антитела (BSAbs) сулили большие надежды в борьбе с повторной/охлажденной множественной миеломой (MM). Несмотря на свою эффективность, этот класс наркотиков связан со значительными токсичными свойствами. В этом исследовании мы провели совместный анализ имеющихся клинических испытаний БСАБ для лечения ММ, включая полные публикации и резюме до апреля 2025. BsAb были отнесены к категории two группы: антигены созревания клеток B (BCMA) и GPRC5D/FcRH5 BsAbs. Тест Welch был проведен для сравнения характеристик безопасности каждого агента. Для кластеризации мы использовали анализ основных ко

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… Regarding dysgeusia, we did not identify any successful approaches in our pooled analysis to mitigate these side effects, however, real-world data suggest decreasing the frequency of talquetamab to q4w and prophylactic use of dexamethasone mouth rinses and nystatin mouthwash or zinc and vitamin B complex …

Pharmacological treatment options for mast cell activation disease.

Mast cell activation disease (MCAD) is a term referring to a heterogeneous group of disorders characterized by aberrant release of variable subsets of mast cell (MC) mediators together with accumulation of either morphologically altered and immunohistochemically identifiable mutated MCs due to MC proliferation (systemic mastocytosis [SM] and MC leukemia [MCL]) or morphologically ordinary MCs due to decreased apoptosis (MC activation syndrome [MCAS] and well-differentiated SM). Clinical signs and symptoms in MCAD vary depending on disease subtype and result from excessive mediator release by MC

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… protein, and baker’s yeast should be omitted from the diet for 3–4 weeks R review article (further references therein) Table 6 Symptomatic treatment (orally as needed) in MCAD (modified from Molderings et al. 2014 ) Colitis ⇒ budesonide; for some days, prednisone >20 mg/day Diarrhea ⇒ c(h)olestyramine; nystatin … histidine decarboxylase | | X | X | Hagel et al. 2013 Johnston et al. 1992 Uchida et al. 1989 Chatterjee et al. 1975 Table 6 Symptomatic treatment (orally as needed) in MCAD (modified from Molderings et al. 2014 ) Colitis ⇒ budesonide; for some days, prednisone >20 mg/day Diarrhea ⇒ c(h)olestyramine; nystatin …

Prophylaxis and Empirical Therapy of Infection in Cancer Patients

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… Oral gentamicin, vancomycin, and nystatin were used. Subsequently, absorbable drugs—first, trimethoprim-sulfamethoxazole (TMP-SMX), usually given in combination with oral nystatin or amphotericin B—and then fluoroquinolones, were introduced. …

Primary Aggressive Oral Lymphomas (PAOL): A Narrative Review of Diagnosis, Molecular Features, Therapeutic Approaches, and the Integrated Role of Dentists and Hematologists.

Primary aggressive oral lymphomas (PAOL) are a rare subset of extranodal non-Hodgkin lymphomas arising in the oral cavity without evidence of other systemic involvement at diagnosis. PAOL accounts for only about 2-3% of all lymphomas. They most commonly belong to aggressive B-cell subtypes such as Diffuse large B-cell lymphoma (DLBCL) and plasmablastic lymphoma (PBL), with occasional cases of Burkitt lymphoma and T-cell/NK-cell lymphomas. Clinically, these malignancies often present with non-specific symptoms (e.g., swelling, pain, ulceration, tooth mobility) that mimic benign dental condition

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… The care team often prescribes prophylactic antifungals (e.g., nystatin or fluconazole) to prevent thrush and antiviral prophylaxis (e.g., acyclovir) in patients with prior herpes to prevent reactivation. …

Инфекционные токсичные вещества, связанные с биконкретными антителами и клетками CAR-T в множестве миеломы: систематический обзор.

Лечение с перенацеливанием клеток изменило лечение повторной/охлажденной множественной миэломы (RRMM), но связано со значительным риском инфицирования. Мы систематически анализировали инфекционные заболевания после терапии Т-клеток CAR и биконкретных антител (BSAbs) с уделением особого внимания частотности, времени, патогенам, факторам риска и профилактике. Следуя руководящим принципам PRISMA, мы обыскали Паббмеда до мая. 22, 2026, и включает исследования, содержащие информацию о инфекционных результатах у пациентов, проходящих курс лечения с помощью клеток CAR-T или BsAbs. Всего 123 Был прове

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… Local care measures involving cortisone and nystatin are being considered as a way of preventing local inflammation [ 47 ]. Haematotoxicity (36–67%) was rarely severe [ 43 – 46 ]. …

Mucositis and Infection in Hematology Patients.

Survival in patients with hematological malignancies has improved over the years, both due to major developments in anticancer treatment, as well as in supportive care. Nevertheless, important and debilitating complications of intensive treatment regimens still frequently occur, including mucositis, fever and bloodstream infections. Exploring potential interacting mechanisms and directed therapies to counteract mucosal barrier injury is of the utmost importance if we are to continue to improve care for this increasingly growing patient population. In this perspective, I highlight recent advanc

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… Efficacy of chlorhexidine and nystatin rinses in prevention of oral complications in leukemia and bone marrow transplantation Oral Surg. Oral Med. Oral Pathol. 1992 73 682 689 10.1016/0030-4220(92)90009-F 1437036 21. Dodd M.J. Larson P.J. Dibble S.L. Miaskowski C. Greenspan D. MacPhail L. …

Medication-Related Osteonecrosis of the Jaw: A Systematic Review of Case Reports and Case Series.

Medication-related osteonecrosis of the jaw (MRONJ) is a rare condition, typically seen in patients receiving antiresorptive or antiangiogenic drugs. This study aims to synthesize reports and case series of MRONJ regarding sociodemographic and clinical characteristics and to evaluate the effectiveness of the treatments applied. Following PRISMA guidelines, a search for case reports and case series was carried out in the PubMed-Medline database until March 2024. A total of 88 articles were included in this review, in a total of 151 cases. The key findings reveal that females were the most affec

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… In turn, 0.2% chlorhexidine was administered together with a nystatin solution, of unknown concentration, in 1% of cases ( n = 1) ( Figure 11 ). Figure 11 Distribution of the population by mouthwash administered—relative frequency and absolute frequency (unk. % = unknown concentration). 3.11. …

Is Camphor the Future in Supporting Therapy for Skin Infections?

The aim of this review is to present the potential application of camphor-a bicyclic monoterpene ketone-in the prevention of skin infections. Skin diseases represent a heterogeneous group of disorders characterized by prolonged symptoms that significantly diminish the quality of life. They affect the dermis, the epidermis, and even subcutaneous tissue. They very often have a bacterial or fungal background. Therapy for dermatological skin disorders is difficult and long-term. Therefore, it is important to find a compound, preferably of natural origin, that (i) prevents the initiation of this in

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… AMB—amphotericin B; CLT—clotrimazole; COM—ciclopirox olamine; ECC—econazole; FLC—fluconazole; ITC—itraconazole; KTC—ketoconazole; MIC—miconazole; NYT—nystatin; 5FC—flucytosine; ND—not defined. …