Результаты поиска

ZBP1 deficiency ameliorates the motor dysfunction following brachial plexus root avulsion in mice.

Brachial plexus root avulsion (BPRA) is a devastating peripheral nerve injury that results in irreversible forelimb motor dysfunction, large … 1 deficiency significantly improved forelimb motor function, increased MN survival, enhanced axonal remyelination, and attenuated biceps brachii muscle atrophy after BPRA. These beneficial effects were associated with reduced expression of pyroptosis-related and pro-inflammatory genes in the spinal ventral horn, suggesting an alleviation of the neuroinflammator …

Plasticity, injury-induced reprogramming, and translational applications of Schwann cells in neural regeneration.

Schwann cells (SCs), the predominant glial cell population in the peripheral nervous system (PNS), have undergone a paradigm shift from hist … lesioned central nervous system (CNS), including spinal cord injury sites, where they contribute to remyelination, modulation of glial scar formation, and partial restoration of electrophysiological connectivity and behavioral function. These attributes collectively establish SCs as phenotypically adaptable cellular mediators capable of facilitating neural repa …

A Multidimensional Engineering Strategy Reprograms Microglia via Targeted and Sustained-Release Extracellular Vesicles for Spinal Cord Injury Repair.

Spinal cord injury (SCI) induces neuroinflammation predominantly mediated by microglia, thereby establishing a detrimental milieu that imped … at enhanced myelin debris clearance and quelled inflammation. Consequently, axonal regeneration and remyelination were markedly improved, driving significant motor recovery in SCI mice. By integrating preconditioning, active targeting, and stimuli-responsive biomaterials, this strategy provides an elegant blueprint for engineering EV-based therapies to repair t …

Receptor-interacting protein kinase 1 regulates microglial polarization via the Csf3-JAK2/STAT3 axis in lipopolysaccharide-induced inflammation and lysolecithin-induced demyelination.

In numerous demyelinating diseases, brain tissue exhibits excessive inflammatory responses that promote the activation of immune cells, thereby exacerbating cellular damage and amplifying inflammatory cascades. Emerging evidence highlights receptor-interacting protein kinase 1 (RIPK1) is a pivotal regulator of neuroinflammation, and its dysregulation contributes to the pathogenesis of various central nervous system (CNS) disorders. While our previous work established that RIPK1 kinase inhibition promotes remyelination in acute demyelinating models, however, the precise mechanisms of RIPK1 in m…

Case Report and Literature Review of Spinal Anesthesia-Related Peroneal Nerve Injury Complicated with Diabetic Foot Peripheral Neuropathy.

Perioperative peripheral nerve injury (PPNI) is rare but potentially disabling. In patients with diabetic peripheral neuropathy (DPN), the t … recovery: dorsiflexion improved from 0/5 to 4/5 by 3 months, with electrophysiological evidence of remyelination. This case underscores the need for a stratified diagnostic approach (rule out central, then clarify peripheral) and highlights that functional nerve injury can occur without compressive findings on imaging. Early multimodal intervention enables fav …

Multimodal electroconductive PLGA-based scaffold orchestrates neuroprotection and regeneration following severe spinal cord injury.

Spinal cord injury (SCI) is a devastating neurological condition that has limited therapeutic options; thus, developing innovative regenerat … ery and reduces neuropathic pain. Histological analyses show reduced glial scar formation, enhanced remyelination, and robust axonal regeneration. Molecular studies further confirm the upregulation of anti-inflammatory cytokines and neurotrophic factors, thereby demonstrating the ability of the scaffold to reprogram the injury microenvironment for regeneration. …

Adjunctive strategies in multiple sclerosis treatment: non-pharmacological approaches and their potential clinical implications.

BACKGROUND: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease affecting the central nervous system (CNS), and represen … anisms, such as modulation of neuroinflammation, suppression of glial cell activation, promotion of remyelination, and enhancement of neuroprotective processes. By integrating preclinical experimental data from animals with clinical evidence from MS patients, we also illustrate how various non-pharmacological strategies can dynamically modulate the disease micr …

Fasciola hepatica excretory-secretory products attenuate demyelination and reduce neuroinflammation in the Cuprizone -induced multiple sclerosis model.

Multiple sclerosis (MS) is characterized by chronic neuroinflammation and progressive demyelination, with current therapies failing to adequately address both processes simultaneously. Helminth-derived excretory-secretory products (ESP) are immunomodulatory molecules that suppress host inflammation and are promising candidates for MS treatment. However, their capacity to promote remyelination remains poorly understood. This study investigated the effects of Fasciola hepatica ESP in the cuprizone-induced demyelination model. Male C57BL/6 mice were divided into four groups: control (CON), contro…

What Is New in Spinal Cord Injury Management: A Narrative Review on the Emerging Role of Nanotechnology.

Traumatic injuries to the brain and spinal cord remain among the most challenging conditions in clinical neuroscience due to the complexity … uctured scaffolds designed to modulate the injured microenvironment and support axonal regrowth and remyelination. Emerging evidence indicates that nanotechnology enables real-time, minimally invasive detection of inflammation, oxidative stress, and cellular damage, while improving therapeutic efficacy and reducing systemic side effects through targeted deliver …

Single-Cell Multi-omics Assessment of Spinal Cord Injury Blocking via Cerium-doped Upconversion Antioxidant Nanoenzymes.

Spinal cord injury (SCI) impairs the central nervous system and induces the myelin-sheath-deterioration because of reactive oxygen species ( … expression of myelination-related genes, and the study also reveals the gene regulatory dynamics of remyelination after treatment. Besides, the ETLSA strategy synergistically boosts ROS consumption through the superoxide dismutase (SOD)-related pathways after SOD-siRNA treatment. In conclusion, this SETLSA strategy with simultaneously blocking and dynamic monit …

Smooth muscle extracellular matrix modified small intestinal submucosa conduits promote peripheral nerve repair.

Challenges still exist to develop an ideal cell-free nerve guidance conduit (NGC) providing a favorable microenvironment for rapid and succe … omoting angiogenesis, proliferation and migration of Schwann cells and neuron, axonal regeneration, remyelination, and neurological functional recovery.

Applicability of regenerative oligodendrocyte precursor cell optic nerve transplantation in rat model of demyelinating disease.

Cell-based therapies, particularly transplanted human oligodendrocyte progenitor cells (OPCs), are being explored for neuroprotection and remyelination in demyelinating diseases of the central nervous system (CNS). In this study, we investigated the potential of OPC transplantation into the optic nerve of dark agouti (DA) rats with experimental autoimmune encephalomyelitis (EAE). Human OPCs were transplanted 30 days after EAE induction in one optic nerve, while the contralateral nerve was injected with a vehicle. FTY720 (fingolimod) was administered starting from day 25 post-EAE to prevent gra…

Бифункциональные нанокарьеры на основе читоза как перспективный терапевтический подход к лечению заболеваний головного мозга: критический обзор с упором на множественный склероз по сравнению с новыми стратегиями, технологиями и видами применения.

Chitosan (CS) появился в качестве перспективного кандидата на лечение заболевания мозга (BD) (таких, как болезнь Альцгеймера, Паркинсона и Множественный склероз (MS)) из-за его противовоспалительных, антиоксидативных и нейрозащитных свойств. Способность CS взаимодействовать с барьером для мозга крови (BBB) повышает проницаемость наркотиков в центральной нервной системе (CNS) и открывает новые возможности для эффективных стратегий лечения, направленных на преодоление ограничений традиционной терапии. Кроме того, роль CS в регенеративной медицине выходит за рамки доставки наркотиков, поскольку о

Совпадение в аннотации оригинала
Chitosan (CS) has appeared as a promising candidate in brain disease (BD) (such as Alzheimer's, Parkinson's, and Multiple sclerosis (MS)) th … shown that CS-based scaffolds, when combined with neurotrophic factors and stem cells, can enhance remyelination and neuroprotection in BD models. The immunomodulatory effects of CS further contribute to reducing neuroinflammation by shifting immune responses toward an anti-inflammatory phenotype, thereby mitigating the progression of BD-associated damage. Thi …

Short and mid-term research priorities for Veterans with multiple sclerosis: A modified Delphi process engaging Veterans, researchers, and operational partners.

BACKGROUND/OBJECTIVE: Identifying research priorities of Veterans, MS researchers, and key stakeholders is critical to advance high-quality, … ine research questions focused on advancing research in several thematic areas: neuroprotection and remyelination, alleviating MS symptoms, epidemiology, and exercise. CONCLUSION: Engaging multiple methods and Veterans at every stage of priority setting enables a representative and nuanced description of the most important VA-centric MS research questions. MS …

Расположение RNA на основе RiboTag обнаруживает олигодендроглиевую воспаление в аутоиммунном энцефаломиелите: последствия для патогенеза.

Клетки олигодендроглиевой линии (ООК) необходимы для миелинирования, ремиелиции и нейронной метаболической поддержки, но недавние данные указывают на то, что они также играют активную роль в нейроинфламмации. Цель этого исследования состояла в том, чтобы выявить подстрекательский транслатом ОРЦ в начале экспериментального аутоиммунного энцефаломиэлита (EAE) - широко используемой модели множественного склероза (MS) с использованием последовательности РНК на основе RNA, основанной на RiboTag. Мы пересекли мышей Риботага Olig2-Cre Мыши для получения экспресс-выражения реберосомного белка HA-тагон

Совпадение в аннотации оригинала
Oligodendroglial lineage cells (OLCs) are essential for myelination, remyelination and neuronal metabolic support, but recent evidence suggests they also play active roles in neuroinflammation. This study aimed to identify the inflammatory translatome of OLCs during the onset of experimental autoimmune encephalomyelitis (EAE), a widely used model for Multipl…

Remodeling of the Intra-Conduit Inflammatory Microenvironment to Improve Peripheral Nerve Regeneration with a Neuromechanical Matching Protein-Based Conduit.

Peripheral nerve injury (PNI) remains a challenging area in regenerative medicine. Nerve guide conduit (NGC) transplantation is a common tre … e and resulting in functional recovery of neurons. In a rat sciatic nerve crush model, NGC promoted remyelination and functional and structural regeneration. Generally, the DMF/RSF/P:P conduit provides a new potential therapeutic approach to promote nerve repair in future clinical treatments.

IPSC-Derived Sensory Neurons Directing Fate Commitment of Human BMSC-Derived Schwann Cells: Applications in Traumatic Neural Injuries.

The in vitro derivation of Schwann cells from human bone marrow stromal cells (hBMSCs) opens avenues for autologous transplantation to achieve remyelination therapy for post-traumatic neural regeneration. Towards this end, we exploited human induced pluripotent stem-cell-derived sensory neurons to direct Schwann-cell-like cells derived from among the hBMSC-neurosphere cells into lineage-committed Schwann cells (hBMSC-dSCs). These cells were seeded into synthetic conduits for bridging critical gaps in a rat model of sciatic nerve injury. With improvement in gait by 12-week post-bridging, evoked…

Bredigite-Based Bioactive Nerve Guidance Conduit for Pro-Healing Macrophage Polarization and Peripheral Nerve Regeneration.

Structural and functional healing of peripheral nerves damaged by trauma or chronic disease remain major clinical challenges, requiring the … lation. More importantly, the macrophages activated by BRT in turn promote RSC96 cell migration and remyelination. In a rat sciatic nerve defect model, improved electrophysiological performance and alleviated gastrocnemius muscle atrophy are observed at 12 weeks post-implantation. Further experiments verify that BRT-loaded NGC facilitates axonal regrowth and re …

Emerging therapeutic targets for neuromyelitis optica spectrum disorder.

Introduction: Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory demyelinating disease of the central nervous system affectin … nd their binding to AQP4, complement-dependent and cell-mediated cytotoxicity, blood-brain barrier, remyelination and immune effector and regulatory cells, with treatment modalities including small molecules, biologics, and cells.Expert opinion: Though newer NMOSD therapies appear to have increased efficacy in reducing relapse rate and neurological deficit, inc …

Differential Expression of miRNAs and Behavioral Change in the Cuprizone-Induced Demyelination Mouse Model.

The demyelinating diseases of the central nervous system involve myelin abnormalities, oligodendrocyte damage, and consequent glia activatio … uggesting that differences in miRNA expression in vivo may be new potential therapeutic targets for remyelination.