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Clinical Usefulness of Bronchoalveolar Lavage in the Management of Pulmonary Infiltrates in Adults with Hematological Malignancies and Stem Cell Transplantation.

IntroductionPulmonary complications are frequent in patients with hematologic malignancies and stem cell transplantation. Regardless of the microbiological usefulness of bronchoalveolar lavage (BAL), little information exists on both its benefits as a guide for therapeutic decisions and its impact on patients' clinical outcome.MethodsA prospective observational single-center study was performed between July 2011 and July 2016. Consecutive episodes of pulmonary infiltrates were analyzed in subjects over 18 years of age who presented hematologic malignancies and underwent chemotherapy or stem ce

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… RSV, human metapneumovirus, adenovirus, rhinovirus, and Influenza A detection by real-time PCR: nucleic acid was extracted by total nucleic acids from 200 ul of the original sample using the automated MagNA Pure LC 2.0 with the MagNA Pure Compact Nucleic Acid Isolation Kit I extraction kit from Roche … Real-time PCR was performed with 5ul of nucleic acid eluate using for Influenza A/H1N1, adenovirus, and human metapneumovirus commercial assay set (TibMolbiol, Roche) and the enzyme LightCycler Multiplex RNA Master Virus in the Light Cycler 2.0 device as manufacturer’s instruction. …

Viral Respiratory Tract Infections in Allogeneic Hematopoietic Stem Cell Transplantation Recipients in the Era of Molecular Testing.

Viral respiratory tract infection (vRTI) is a significant cause of morbidity and mortality in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). This study aimed to assess the epidemiologic characteristics, risk factors, and outcomes of vRTI occurring in the period from conditioning to 100 days after allo-HSCT in the era of molecular testing. This study was a retrospective record review of patients who underwent allo-HSCT at Royal Melbourne Hospital between January 2010 and December 2015. Symptomatic patients were tested using respiratory multiplex polymerase c

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… Introduction Background Respiratory viruses (RVs), including influenza virus, parainfluenza virus, respiratory syncytial virus (RSV), rhinovirus, coronavirus, adenovirus, and human metapneumovirus (hMPV), are common causes of viral respiratory tract infection (vRTI) 1 , 2 , 3 . … Fourth European Conference on Infections in Leukaemia (ECIL-4): guidelines for diagnosis and treatment of human respiratory syncytial virus, parainfluenza virus, metapneumovirus, rhinovirus, and coronavirus. Clin Infect Dis. 2013;56:258–266. doi: 10.1093/cid/cis844. 15. …

За пределами границы - это осложнение импортного японского энцефалита: отчет о деле.

Японский энцефалит (JE) — инфекция, эндемичная во многих странах Азии и западной части Тихого океана. Хотя большинство инфекций носит асимптомический характер, они меньше 1% Клинические заболевания, как правило, вызывают острый энцефалит. Коэффициент смертности колеблется от 20 в адрес 30%, и до половины выживших развивают долгосрочные неврологические или психиатрические сиквелы. Несмотря на то, что среди путешественников из неэпидемиологических районов редкость, риск возрастает в результате продолжительного воздействия на сельские районы или отсутствия вакцинации. Иммунокомпромированные люди,

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… 2.0 Lactate (mmol/L) 1.2 0.5–2.0 Oxyhemoglobin (%) 89 95.0–98.0 Carboxyhemoglobin (%) 3.4 0.5–1.5 Methemoglobin (%) 0.7 0.0–1.5 Table 3 Cytology and serology Tests Results Microbiology/serology panel COVID-19/SARS-COV-2 PCR Negative Influenza A Negative Influenza B Negative Adenovirus Negative Human metapneumovirus … reaction, CSF cerebrospinal fluid, RBC red blood cells, WBC white blood cells, NMO neuromyelitis optica, IgG immunoglobulin g, IgM immunoglobulin m Tests | Results Microbiology/serology panel COVID-19/SARS-COV-2 PCR | Negative Influenza A | Negative Influenza B | Negative Adenovirus | Negative Human metapneumovirus …

Viruses

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… Adenovirus, influenza, parainfluenza, respiratory syncytial virus (RSV), the other less studied or less clinically significant infections such as rhinovirus, coronavirus, and the relatively newly described metapneumovirus are included in this section. …

Hemato- Oncology Care in COVID-19 Pandemic: Crisis within a Crisis.

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… Fourth European Conference on Infections in Leukaemia (ECIL-4): guidelines for diagnosis and treatment of human respiratory syncytial virus, parainfluenza virus, metapneumovirus, rhinovirus, and coronavirus. Clin Infect Dis. 2013;56:258–66. doi: 10.1093/cid/cis844. …

Respiratory Tract Infections: Sinusitis, Bronchitis, and Pneumonia

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… These include influenza A and B, adenovirus, rhinovirus, coronavirus, parainfluenza, RSV, and human metapneumovirus [ 37 – 40 ]. … Human metapneumovirus (hMPV) is also recognized as a serious pulmonary pathogen in this population. The spectrum of hMPV disease may range from mild upper respiratory tract infection to serious disseminated infection leading to respiratory failure and encephalitis. …

Epidemiologic and Clinical Characteristics of Coronavirus and Bocavirus Respiratory Infections after Allogeneic Stem Cell Transplantation: A Prospective Single-Center Study.

Epidemiologic data about coronaviruses (CoVs) and human bocavirus (HBoV) in the setting of allogeneic hematopoietic stem cell transplantation (allo-HSCT) are scarce. We conducted a prospective longitudinal study on respiratory viral infections (RVIs) in allo-HSCT recipients with respiratory symptoms from December 2013 until June 2016. Respiratory virus in upper and/or lower respiratory tract (URT and LRT) specimens were tested using Luminex xTAG RVP Fast v1 assay. Seventy-nine consecutive allo-HSCT recipients developed a total of 192 virologically documented RVI episodes over 30 months. The me

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… Introduction There is an important amount of data concerning the most frequent community-acquired respiratory viruses (CARVs) such respiratory syncytial virus (RSV), human parainfluenza virus (HPiV), human influenza virus, human metapneumovirus (HMPV), or human rhinovirus in the setting of allogeneic … Fourth European Conference on Infections in Leukaemia (ECIL-4): guidelines for diagnosis and treatment of human respiratory syncytial virus, parainfluenza virus, metapneumovirus, rhinovirus, and coronavirus. Clin Infect Dis. 2013;56:258–266. doi: 10.1093/cid/cis844. 25. …

Infections After High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantation

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… pneumoniae , Enterobacter spp; b Most frequent: Acinetobacter spp., Stenotrophomonas maltophilia ; c Most frequent: C. albicans , C. glabrata , C. tropicalis , C. parapsilosis ; d Most frequent: A. fumigatus (~90 %), A. flavus , A. terreus , A. niger ; e Most frequent: Respiratory syncytial virus, metapneumovirus … Viral infections in the early post-transplant period are limited to reactivation of herpes simplex virus (HSV) and respiratory viral infections (Influenza A and B, parainfluenza 1–3, respiratory syncytial virus [RSV], metapneumovirus, and adenovirus). …

Respiratory syncytial virus in hematopoietic cell transplant recipients and patients with hematologic malignancies.

In the USA and other western nations, respiratory syncytial virus is one of the most commonly encountered respiratory viruses among patients who have been diagnosed with a hematologic malignancy or who have undergone a stem cell transplant. Multiple studies have been performed to evaluate the complications associated with respiratory syncytial virus infections. Other studies have evaluated therapeutic agents and strategies in which these agents can be used. There have also been numerous reports of outbreaks in bone marrow transplant units and oncology wards, where infection control measures ha

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… One of the most common community respiratory viruses that may lead to the death of HCT recipients and HM patients is respiratory syncytial virus (RSV), 4 – 10 whose incidence is second only to that of influenza according to prior reports; 4 , 5 , 8 , 11 , 12 other viruses include parainfluenza virus, metapneumovirus … Mortality rates of human metapneumovirus and respiratory syncytial virus lower respiratory tract infections in hematopoietic cell transplantation recipients. Biol Blood Marrow Transplant. 2013;19(8):1220–1226. 48. Mendes ET, Ramos J, Peixoto D, et al. …

Incidence, significance, and persistence of human coronavirus infection in hematopoietic stem cell transplant recipients.

Hematopoietic stem cell transplant (HSCT) recipients are at increased risk of respiratory viral infections and their associated complications. Unlike other respiratory viruses, little is known about the clinical significance of human coronavirus infection (HCoV) in this population. We retrospectively identified all HSCT recipients who were transplanted between May 2013 and June 2017 at our institution and characterized the cumulative incidence of post-transplant HCoV infection. Of 678 patients who underwent HSCT during the study period, 112 (17%) developed HCoV infection, making HCoV the fourt

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… HCoV was the fourth most common respiratory viral infection in this population, more common than adenovirus (4%), human metapneumovirus (6%), and RSV (13%), but less common than rhinovirus/enterovirus (29%), parainfluenza (26%), and influenza (20%; Fig. 1a ). … Hirsch HH Martino R Ward KN Boeckh M Einsele H Ljungman P Fourth European Conference on Infections in Leukaemia (ECIL-4): guidelines for diagnosis and treatment of human respiratory syncytial virus, parinfleunza virus, metapneumovirus, rhinovirus and coronavirus Clin Infect Dis 2013 56 258 66 10.1093 …

Extrinsic airway compression: an unusual presentation of thoracic vertebral osteophytes from osteoarthritis.

Extrinsic airway compression secondary to vertebral osteophytes is a rare clinical entity. We report a case of an elderly patient presenting with pneumonia where a subsequent chest CT scan showed right main bronchus compression caused by lower thoracic vertebral osteoarthritis-related osteophytes. There were additional incidental findings of sclerotic skeletal lesions prompting a new diagnosis of metastatic prostate cancer. The pneumonia improved with antibiotic therapy. Interventional management of airway compression was not pursued in this patient given his poor functional state and advanced

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… *Respiratory viral panel includes for influenza A and B, human parainfluenza viruses, enterovirus, adenovirus, human metapneumovirus, Bordetella pertussis and SARS-CoV-2. His admission chest X-ray (CXR) showed only minimal blunting of the right costophrenic angle ( figure 1 ). …

Pneumonia in the Cancer Patient

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… Human metapneumovirus (hMPV) has been recently recognized as a serious pulmonary pathogen. The spectrum of hMPV disease may range from mild upper respiratory tract infection to serious disseminated infection leading to respiratory failure and encephalitis. … Safdar A Immune modulatory activity of ribavirin for serious human metapneumovirus disease: early i.v. therapy may improve outcomes in immunosuppressed SCT recipients Bone Marrow Transplant 2008 41 8 707 8 10.1038/bmt.2008.80 18347567 41. …

Intestinal/Multivisceral Transplantation

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… Table 30.2 Common viral pathogens isolated in transplanted children with lower respiratory tract infection Rhinovirus Influenza Parainfluenza Respiratory syncytial virus Adenovirus Metapneumovirus Table 30.2 Common viral pathogens isolated in transplanted children with lower respiratory tract infection … Rhinovirus Influenza Parainfluenza Respiratory syncytial virus Adenovirus Metapneumovirus Respiratory failure in intestinal/multivisceral transplant recipients should be managed as it is in other critically ill populations with a few caveats. …

Belantamab mafodotin, carfilzomib, lenalidomide и дексаметазон для рецидива или рефракта множественной миеломы.

Резюме Belantamab mafodotin (Belamaf), антитела-наркотики, направленные против антигена ячеек B-клеток, продемонстрировало активность одного агента в повторной/охлажденной миеломе (RRMM), но связано с окулярной токсичностью. Это фазы 1/2 в ходе исследования была проведена оценка безопасности и предварительной эффективности использования беналафа 8 Недели в сочетании с карфилзомидом, линалидомидом и дексаметасоном (KRd-b) у пациентов с RRMM. Пациенты, имеющие право на получение помощи, по крайней мере, 1 :: предыдущая терапия и не продвинулась по полной дозе леналидомида. На стадии " доза-

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… . † COVID-19, metapneumovirus, and necrotizing fasciitis. ‡ Hypogammaglobulinemia, seasonal allergies, chest congestion, immune thrombocytopenia, and immunoglobulin deficiency. § Petechiae, painless bumps on inside of lips, skin peeling on hands, rosacea, and skin graft for cellulitis. … includes eye disorders, infections, hematologic events, stroke, and other nonhematologic events that occurred in at least 10% of patients. ∗ Double vision, cloudy vision, ocular pruritus, bilateral crusting, redness, stye, moderate corneal striae and edema, Fuchs dystrophy, and epitheliopathy. † COVID-19, metapneumovirus …

Инфекции и параметры юморального иммунитета талькетамабом в реанимированном/охотничьем миеломе MonumenTAL-1.

" Резюме " является первым утвержденным документом GPRC5D-targeting bi специфическая антитела для лечения повторной/рефрактной множественной миеломы (RRMM) на основе результатов фазы 1/2 MonumenTAL-1 Учёба. Мы сообщаем о характеристике инфекции среди пациентов, лечившихся талькетамабом. MonumenTAL-1. Пациенты с тройным классом, подвергшиеся воздействию RRM, получают подкожный талькутамаб 0.4 мг/кг еженедельно или 0.8 мг/кг каждые две недели (EOW). Пациенты, прошедшие терапию перенаправления Т-клеток, были включены в отдельную группу и получили любой из графиков. Инфекции (классифицир

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… 0 0 1 (2.0) Fungal sepsis 1 (0.7) 0 0 Gastroenteritis, Escherichia coli 1 (0.7) 0 0 Herpes zoster 1 (0.7) 0 0 Human ehrlichiosis 1 (0.7) 0 0 Implant site infection 1 (0.7) 0 0 Influenza 1 (0.7) 0 0 Klebsiella bacteremia 1 (0.7) 0 0 Klebsiella sepsis 0 1 (0.7) 0 Large intestine infection 0 1 (0.7) 0 Metapneumovirus … Gastroenteritis, Escherichia coli | 1 (0.7) | 0 | 0 Herpes zoster | 1 (0.7) | 0 | 0 Human ehrlichiosis | 1 (0.7) | 0 | 0 Implant site infection | 1 (0.7) | 0 | 0 Influenza | 1 (0.7) | 0 | 0 Klebsiella bacteremia | 1 (0.7) | 0 | 0 Klebsiella sepsis | 0 | 1 (0.7) | 0 Large intestine infection | 0 | 1 (0.7) | 0 Metapneumovirus …

Intestinal Coccidian Infections in Cancer Patients: A Case Series.

Introduction Coccidian protozoa and microsporidian fungi are opportunistic pathogens increasingly implicated in infections in immunosuppressed individuals. These parasites typically infect the intestinal epithelium, resulting in secretory diarrhea and malabsorption. The disease burden and timeline are both greater and longer among immunosuppressed patients. Therapeutic options for immunocompromised individuals are limited. As a result, we wanted to better characterize the disease course and treatment efficacy of these parasitic gastrointestinal infections. Methods We performed a single-center,

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… ) were immunocompromised. 75% (3/4) of patients infected with Cyclospora had a history of allogeneic hematopoietic stem cell transplant; none had GVHD. 50% (2/4) of these cases had a co-pathogen isolated, in which one patient had varicella-zoster virus present in their stool sample, and another had metapneumovirus …

Outcomes of hematopoietic SCT recipients with rhinovirus infection: a matched, case-control study.

The impact of rhinovirus in hematopoietic SCT (HSCT) recipients is not well defined. A retrospective, matched, case-control study of HSCT recipients with rhinovirus was conducted between 2009 and 2011. Controls were matched for timing relative to transplant, malignancy, and stem cell source. There were 47 cases and 94 controls. The cases and controls did not differ with respect to age, gender, ethnicity, donor source, malignancy, conditioning regimen, immunosuppression, antimicrobial prophylaxis or significant comorbidities. There were no differences in need for intensive care unit care, 100 d

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… Fourth European Conference on Infections in Leukaemia (ECIL-4): guidelines for diagnosis and treatment of human respiratory syncytial virus, parainfluenza virus, metapneumovirus, rhinovirus, and coronavirus. Clin Infect Dis. 2013;56:258–266. doi: 10.1093/cid/cis844. 3. Bowden RA. …

Prophylaxis and Empirical Therapy of Infection in Cancer Patients

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Мультиорганическая неисправность 5 Синдром цитокина у пациента с множественной миеломой после вливания карфилзомиба: доклад о деле.

Фон: Синдром высвобождения цитокина (CRS) представляет собой опасное для жизни системное воспалительное состояние, характеризующееся чрезмерным производством цитокина, что ведет к многоорганической дисфункции. Она обычно связана с Т-комплексными терапиями, такими, как химериковые антигенные рецепторы (CAR) Т клетки, Т-клекторные двуэлементные молекулы и моноклонные антитела. Известно, что карфилзомиб, протеиновый ингибитор, вызывает целый ряд негативных последствий, в первую очередь гематологическое и сердечно-сосудистое. Тем не менее, многоорганический уровень отказа 5 (Смертельная), аналогич

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… Negative Tests Done from Sputum Obtained Through Bronchoalveolar Lavage Pathogen/Test | Result Pneumocystis jiroveci PCR | Negative Adenovirus | Negative Coronavirus 229E | Negative Coronavirus HKU1 | Negative Coronavirus NL63 | Negative Coronavirus OC43 | Negative SARS Coronavirus-2 | Negative Human Metapneumovirus …

GvHD prophylaxis with tacrolimus, sirolimus, and mycophenolate mofetil after reduced intensity conditioning hematopoietic stem cell allogeneic transplantation.

We present the largest prospective real-world experience in 159 patients who received the triple combination of tacrolimus/sirolimus/mycophenolate mofetil after reduced intensity conditioning allogeneic hematopoietic stem cell transplantation (RIC-alloHSCT) from matched-related (MRD), matched-unrelated (MUD) or mismatched-unrelated donors (MMURD). Despite the high-risk and elderly population, non-relapse mortality (NRM) at day +100 and 1 year was 5.1% and 8.6%. Grades 2-4 and 3-4 acute Graft-versus-host disease (GvHD) at day +180 was 30.3% and 13%, respectively. Chronic GvHD at 1 and 3 years w

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… disease) 3 (1.3) EBV DNA-emia 1 (0.6) EBV-associated lymphoproliferative disease 0 Adenovirus DNA-emia 1 (0.6) Varicella Zoster virus reactivation 4 (1.3) Hepatitis B virus reactivation 1 (0.6) Respiratory viruses (grade 3) 9 (5.6) Respiratory syncitial 3 (1.9) Influenza 2 (1.3) Parainfluenza 1 (0.6) Metapneumovirus … DNA-emia | 1 (0.6) EBV-associated lymphoproliferative disease | 0 Adenovirus DNA-emia | 1 (0.6) Varicella Zoster virus reactivation | 4 (1.3) Hepatitis B virus reactivation | 1 (0.6) Respiratory viruses (grade 3) | 9 (5.6) Respiratory syncitial | 3 (1.9) Influenza | 2 (1.3) Parainfluenza | 1 (0.6) Metapneumovirus …