Результаты поиска

[MOTIVATION TO HAVE A CHILD AMONG CHILDLESS WOMEN OF REPRODUCTIVE AGE, DEPENDING ON THEIR MARITAL STATUS].

SIGNIFICANCE: Effectiveness of demographic and family policies depends on considering as many factors that influence the population reproduc … ermining a high motivation to have a child was based on the analysis of characteristics of women in Moscow who sought treatment for infertility at the Center for Reproduction and Family Planning. RESULTS: The health status of childless women in partnership was better and the share of those who still can have children among such women was higher compared …

Oral health, mouthwashes and cancer--what is the story?

DESIGN: Two hospital-based case-control studies were conducted in central and eastern Europe and Latin America. CASE / CONTROL SELECTION: Cases and controls were recruited in Moscow (Russia), Bucharest (Romania) and Lodz and Warsaw (Poland) from 1998 to 2002, and from 1998 to 2003 in Buenos Aires (Argentina), La Habana (Cuba) and the Brazilian towns Rio de Janeiro, São Paulo, Pelotas, Porto Alegre and Goiânia. Incident cases of squamous cell carcinoma of the head and neck (oral cavity, pharynx, larynx) and oesophagus, as well as age- (in quinquennia) and sex frequency-matched controls, were en…

[The role of hormone analysis in the nosologic diagnosis and in the control of treatment of congenital primary hypothyroidism].

A total of 125 children and teenagers, aged 1 to 15 (including 74 patients with primary congenital hypothyroidism--CH--and 51 healthy children), were investigated in the city of Moscow for the purpose of elaborating new approaches towards the differentiated diagnostics of CH and of optimizing the assessment of the adequacy of its substitutive hormonal therapy (SHT). The concentrations of the thyrotropic hormone (TTH), free fractions of triiodothyronine and thyroxin (cT3 and cT4), thyreoglobulin (Tg) and of thyreoid peroxidase (hard-phase test-tube method, electro-chemiluminescent reaction, i.e…

[Long-term results of surgical treatment of patients with aortic valve disease and functional mitral insufficiency].

AIM: To analyze long-term surgical results in patients with aortic valve disease and concomitant mitral regurgitation (MR) depending on volume of valve surgery. MATERIAL AND METHODS: It was studied 5-year results in 71 patients with aortic valve disease and different degree of mitral regurgitation. Patients were divided into 3 groups. Control group included 40 patients after aortic valve replacement (AVR) and no mitral insufficiency. The 2nd group consisted of 16 patients after AVR and concomitant mitral regurgitation degree 2-3. The 3rd group - 15 patients after aortic and mitral valve repla

Genetic variations in the pancreatic ATP-sensitive potassium channel, beta-cell dysfunction, and susceptibility to type 2 diabetes.

The KCNJ11 and ABCC8 genes encode the components of the pancreatic ATP-sensitive potassium (KATP) channel, which regulates insulin secretion by beta-cells and hence could be involved in the pathogenesis of type 2 diabetes (T2D). The KCNJ11 E23K and ABCC8 exon 31 variants have been studied in 127 Russian T2D patients and 117 controls using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) approach. The KCNJ11 E23 variant and the ABCC8 exon 31 allele A were associated with higher risk of T2D [Odds ratio (OR) of 1.53 (P=0.023) and 2.41 (P=1.95 x 10(-5))], respectiv

Age-Associated Plasma Protein Signatures and Proteomic Age Estimation by Data-Independent Acquisition Mass Spectrometry in a Russian Cross-Sectional Cohort.

Chronological age can be estimated from molecular profiles; however, predictive accuracy alone does not establish a biologically validated ageing clock. We therefore evaluated whether plasma protein intensities measured by data-independent acquisition mass spectrometry (DIA-MS) support chronological-age estimation in a cross-sectional cohort from Moscow, Russia, while explicitly examining acquisition-order and MS-batch confounding. Plasma samples from 350 adult participants aged 19.8 to 99.1 years were analyzed as single-shot, single-injection DIA-MS acquisitions on a Q Exactive HFX platform. …

[Immune status of patients with cardiac arrhythmias: idiopathic and in primary heart disease].

AIM: A detailed description of immune status abnormalities of adult patients with heart arrhythmia either idiopathic or in combination with primary heart disease such as chronic myocarditis and dilated cardiomyopathy (DCMP). MATERIAL AND METHODS: Eighty two consecutive patients aged 16-57 years admitted to the L.A. Myasnikov Institute of Clinical Cardiology (Moscow) for heart arrhythmia were studied. Among them 35 patients had idiopathic heart arrhythmia (IHA, group 1) with no evidence of any primary heart disease, while other 47 patients (group 2) had heart arrhythmia combined with primary h…

[Endovascular embolization as a stage of preoperative preparation for improving surgical treatment of patients with inverted papilloma - a retrospective case series analysis. A clinical example of simultaneous endovascular embolization using navigation under the control of flat-detector computed tomography on a robotic angiographic complex and removal of an inverted papilloma in a hybrid operating room].

UNLABELLED: Inverted papilloma (IP) is a sinonasal epithelial tumor that originates from Schneiderian membrane. A number of cellular factors … ment with preliminary embolization of the vessels feeding the tumor in the ENT department of Botkin Moscow Multidisciplinary Scientific and Clinical Center from the beginning of 2020 to December 2024. The demographic and clinical data of patients, as well as the main aspects of endovascular interventions and characteristics of the surgical stage of sinon …

The abortion and contraceptive behavior: results of the all-Russian Research.

The problem of abortion is actual in all spheres of public life. Despite the fact that in Russia, according to the Ministry of Health, the n … uestionnaire survey in late 2019 - early 2020 carried out in 10 Subjects of the Russian Federation: Moscow, Republic of Bashkortostan, Republic of Tatarstan, Vologda Oblast, Volgograd Oblast, Ivanovo Oblast, etc. The total sampling consisted of 5 616 respondents. The study implemented such scientific research methods as: analysis, synthesis, generalizati …

[Comparative evaluation of results of laboratory researches of milk in Kuzbass while carrying out control and surveillance measures for identifying false].

Milk is one of the main products of the consumer basket, a source of nutrients, and has specific characteristics due to its chemical and mic … king pasteurized milk with various fat content, manufactured by enterprises of the Kemerovo Region, Moscow Region, Kazakhstan, Altai Territory. Results and discussion. In total, for 2017-2019, 258 samples of pasteurized drinking milk were studied, of which 11 samples did not meet the requirements of regulatory documents on physical-chemical and organolep …

; RESULTS OF RESECTION METHODS OF TREATMENT IN PATIENTS WITH GIANT PYLORODUODENAL ULCERS COMPLICATED BY PERFORATION AND BLEEDING.

We studied the immediate and long-term results of various methods of gastric resection in 35 patients operated at the S.S. Yudin State Medical Center in Moscow from 2000 to 2019. 20 (57.1%) patients were operated on for perforation, and 15 (42.6%) patients underwent surgery for ulcerative bleeding. There were 27 (77.2%) males and 8 (22.8%) females. The average age of patients was 48.3±2.3 years. The diagnosis of peptic ulcer disease was previously made in 24 (68.6%) patients, the duration of the disease was 7.7±2.7 years. Of the 35 patients, 29 (82.8%) underwent standard gastric resection with…

Alterations in plasma non-esterified fatty acid (NEFA) kinetics and relationship with insulin resistance in polycystic ovary syndrome.

STUDY QUESTION: Are non-esterified fatty acid (NEFA) kinetics altered in women with polycystic ovary syndrome (PCOS)? SUMMARY ANSWER: Women … NIH grants R01-DK073632 and R01-HD29364 to R.A.; a Career Development Award from MD Medical Group, Moscow, RF, to D.L. and Augusta University funds to Y.-H.C. RA serves as consultant to Ansh Labs, Medtronics, Spruce Biosciences and Latitude Capital. U.E., Z.A., D.L., R.M., Y.-H.C., R.C.B. and Y.D.I.C. have no competing interests to declare. TRIAL REGIS …

A biochemical approach to the problem of aging: "megaproject" on membrane-penetrating ions. The first results and prospects.

Antioxidants specifically addressed to mitochondria have been studied for their ability to decelerate aging of organisms. For this purpose, a project has been established with participation of several research groups from Belozersky Institute of Physico-Chemical Biology and some other Russian research institutes as well as two groups from the USA and Sweden, with support by the "Mitotechnology" company founded by "RAInKo" company (O. V. Deripaska and Moscow State University). This paper summarizes the first results of the project and estimates its prospects. Within the framework of the project…

COVID-19 pandemic in Saint Petersburg, Russia: Combining population-based serological study and surveillance data.

BACKGROUND: The COVID-19 pandemic in Russia has already resulted in 500,000 excess deaths, with more than 5.6 million cases registered offic … esponse. We have used enzyme-linked immunosorbent assay CoronaPass total antibodies test (Genetico, Moscow, Russia) to report seroprevalence. We corrected the estimates for non-response using the bivariate probit model and also accounted the test performance characteristics, obtained from independent assay evaluation. In addition, we have summarised the …

[Quantitative phase imaging (QPI) of peripheral blood platelets for evaluation of thrombotic and hemorrhagic complications in patients with staghorn kidney stones after PCNL].

INTRODUCTION: An evaluation and prognosis of complications of different treatment options in patients with staghorn stones are necessary to … eripheral blood platelets on the domestic microscopic phase interference device MIM-320 ("Amphora", Moscow, Russia). Particular functional activity of 4 morphologic types of living cells based on a degree of activity was evaluated. RESULTS AND DISCUSSION: In patients with staghorn stones, significant morpho-functional changes in the platelets were obser …

Effect of Lactobacillus reuteri NCIMB 30351 drops on symptoms of infantile functional gastrointestinal disorders and gut microbiota in early infants: Results from a randomized, placebo-controlled clinical trial.

Infantile functional gastrointestinal disorders, such as colic, constipation, diarrhea, and gastroesophageal reflux (regurgitation), often o … t-marketing clinical study was conducted in two clinical units-Children's City Clinical Hospital of Moscow and Medical Center "St. Andrew's Hospitals-NEBOLIT" from March 2020 to May 2022 in 90 infants aged from 1 to 4 months (mean age (± SD) 12.3 ± 5.09 weeks; 53.3% females, 46.7% males). Patients with colic, regurgitation (single symptom or combination …

Efficacy of Micronized Purified Flavonoid Fraction in the Posthemorrhoidectomy Period Trial: Open-Label Randomized Controlled Trial.

BACKGROUND: Frequent early postoperative complications of hemorrhoidectomy are thrombosis and edema of mucocutaneous "bridges." OBJECTIVE: This study aimed to investigate the efficacy of micronized purified flavonoid fraction in preventing complications after elective hemorrhoidectomy. DESIGN: Prospective unicentral open-label randomized controlled trial. SETTINGS: 2021-2022 at the Clinic of Colorectal and Minimally Invasive Surgery at Sechenov University (Moscow, Russia). PATIENTS: Patients who underwent hemorrhoidectomy for grade III and IV hemorrhoids. INTERVENTIONS: After hemorrhoidec…

Epoetin Theta with a New Dosing Schedule in Anaemic Cancer Patients Receiving Nonplatinum-Based Chemotherapy: A Randomised Controlled Trial.

INTRODUCTION: Recombinant human erythropoietin (r-HuEPO) is used to treat symptomatic anaemia due to chemotherapy. A new r-HuEPO, Epoetin theta (Eporatio®), was investigated and compared to placebo in a randomised, double-blind clinical trial in adult cancer patients receiving nonplatinum-based chemotherapy. The primary efficacy endpoint was the responder rate (complete haemoglobin (Hb) response, i.e., Hb increase ≥2 g/dl) without the benefit of a transfusion within the previous 4 weeks. RESEARCH DESIGN AND METHODS: 186 patients were randomised to s.c. treatment for 12 weeks with either Epoeti

Совпадение в полном тексте источника
… Korman Moscow, E. Voznyi Moscow, V. Ivanova Moscow, L. Neluybina Moscow, O. Rukavitsin Moscow, I. Zyuzgin Saint Petersburg, B. Afanasyev Saint Petersburg, E. Osmanov Moscow, V. Pavlov Obninsk, I. Lisukov Novosibirsk, D. Viushkov Omsk, S. Tjulandin Moscow, A. Agamov Yaroslavl, A. Bakirov Ufa, O. …

Ten-year retrospect of the investigation of proximal limbs metastasis in cancer: a multi-center study on survival outcome, limb function status and surgical procedures analysis.

BACKGROUND: The aim of study was to evaluate survival outcome and limb function in cancer patients with proximal limbs metastasis. Associated factors on survival outcome and limb function were identified. The comparative analysis between intramedullary nailing and prosthesis surgery in cancer patients with proximal limb metastasis was performed. METHODS: In this five-center retrospective study, patients diagnosed with limbs metastasis were collected. Descriptive statistics was used and log-rank test was performed to analyze the survival in subgroups. The Cox proportional hazards regression an

Совпадение в полном тексте источника
… Herzen Moscow Oncology Research Institute, Branch, National Medical Radiology Research Center, Ministry of Health Russia, Moscow, Russia; (4) MRNC named after A.F. … Hertsen Moscow Oncology Research Center (CT3772Y4J). The present study preliminarily included patients who were diagnosed with bone metastasis to proximal limbs (humerus or femur). …