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Pediatric kidney diseases in an African country: prevalence, spectrum and outcome.

Insufficient data to guide the authorities responsible for resource allocation and a focus on communicable diseases increase the challenges of care of children with kidney disease in resource-constrained settings like ours. This study was performed with the aim to describe the current spectrum of pediatric nephrology disease in a tertiary hospital in Sub-Saharan Africa and highlight the challenges encountered in their care. A 4-year retrospective review of pediatric renal admissions was carried out and the overall prevalence, disease-specific prevalence and mortality rates were determined. Res…

Diagnostic performance of combined specific urinary proteins and urinary flow cytometry in urinary tract pathology.

BACKGROUND: Urinalysis comprises three techniques: urinary flow cytometry, test strip analysis and determination of specific urinary proteins. We investigated the diagnostic possibilities of combining these methods for a cohort of patients with a variety of well-documented urological and nephrological pathology. METHODS: Urinary samples from 407 in- and out-patients with nephrological or urological pathology were retrospectively included in our study. Test strip analysis (URISYS 2400), urinary flow cytometry (UF-100) and urinary protein analysis [albumin, total protein, alpha1-microglobulin (

Cardiovascular-Kidney-Metabolic Syndrome: Models of Care.

Cardiovascular-kidney-metabolic (CKM) syndrome represents the complex interplay between cardiovascular disease (CVD), chronic kidney disease (CKD), and metabolic disorders such as type 2 diabetes and obesity. These conditions share overlapping risk factors, pathophysiological mechanisms, and clinical outcomes, leading to progressive organ dysfunction, as well as increased morbidity and mortality. Traditional disease-specific care models, in which cardiology, nephrology, and endocrinology operate in separate clinics, are increasingly inadequate for addressing the integrated nature of CKM syndro…

Hemodiafiltration: balancing clinical efficacy with planetary health.

PURPOSE OF REVIEW: The 2023 CONVINCE trial demonstrated improved survival with high-dose hemodiafiltration (HDF), prompting discussions about widespread adoption. However, this clinical advancement occurs amid growing awareness of healthcare's environmental impact, particularly dialysis treatments that consume extensive water and energy resources. This review examines the environmental implications of HDF adoption, synthesizing recent evidence on resource consumption and emerging sustainability solutions in the context of the climate crisis facing nephrology. RECENT FINDINGS: Life cycle asses…

Sleep Quality, Daytime Sleepiness, and Circadian Rhythm Characteristics in Chronic Kidney Disease: A Cross-Sectional Study Across Disease Stages.

ObjectiveTo compare sleep quality, daytime sleepiness, and circadian rhythm characteristics across clinically defined chronic kidney disease (CKD) groups and to examine their relative contribution to global subjective sleep quality.MethodThis two-center, cross-sectional study enrolled 344 adults with CKD (response rate: 96.6%) from nephrology settings in Turkey. Participants were classified into three groups: mild-to-moderate CKD (KDIGO stages 2-3; n = 133), advanced CKD without dialysis (stages 4-5; n = 37), and dialysis-dependent CKD (stage 5D; n = 174). Sleep quality, daytime sleepiness, an…

Epidemiology, Risk Factors and Outcomes of AKI and CRRT in Patients on ECMO: Workgroup Statements from the Joint Acute Disease Quality Initiative (ADQI) and Extracorporeal Life Support Organization (ELSO) Consensus Conference on ECMO, AKI, fluid management and CRRT.

Extracorporeal life support (ECLS), most commonly delivered as extracorporeal membrane oxygenation (ECMO), is a lifesaving therapy for refra … Disease Quality Initiative (ADQI XXXVI) consensus conference, during which international experts in nephrology, critical care, cardiology, perfusion, and extracorporeal support convened to evaluate current evidence and generate consensus statements regarding the epidemiology, prevention, and management of AKI in patients receiving ECLS. The conference emphas …

Evaluation of oral hygiene and gingival parameters in pediatric nephrotic syndrome within an interdisciplinary care model.

This study aimed to evaluate oral hygiene, gingival condition, and the presence of selected periodontal pathogens in children with nephrotic … key periodontal pathogens. These findings suggest that systematic dental follow-up integrated with nephrology care may have a protective effect on oral health and help prevent inflammation-associated complications.Implementing regular dental screening within pediatric nephrology care can enhance early intervention, reduce oral disease burden, and support sy …

Цель CD20 для разрушения клеток B в аутоиммунной почечной болезни: следующее поколение.

АнтиCD20 моноколональные антитела приобретают клиническое значение в нефрологическом сообществе благодаря их продемонстрированной эффективности и благоприятным характеристикам безопасности в краткосрочной, среднесрочной и долгосрочной перспективе. В настоящее время в рамках более широкого спектра аутоиммунных заболеваний, включая гломерулопатии, как с сопутствующей, так и без сопутствующей подоцитопатией, изучается лечение истощения клеток В. Последние достижения привели к разработке новых антиCD20 агентов, которые используются не только в качестве потенциальных альтернатив кортикостероидам, н

Совпадение в аннотации оригинала
Anti-CD20 monoclonal antibodies are gaining clinical relevance in the nephrology community due to their demonstrated efficacy and favorable safety profiles across short-, medium-, and long-term use. Initially developed for hematologic malignancies and multiple sclerosis, B-cell depletion therapies are now being investigated across a broader spectrum of autoi…

Rationale and design of the Nephrotic Syndrome Study Network (NEPTUNE) Match in glomerular diseases: designing the right trial for the right patient, today.

Glomerular diseases are classified using a descriptive taxonomy that is not reflective of the heterogeneous underlying molecular drivers. Th … ical trials. Noninvasive biomarkers have been developed for real-time pathway analyses. A Molecular Nephrology Board reviews the pathway maps together with clinical, laboratory, and histopathologic data assembled for each patient to compile a Match report that estimates the fit between the specific molecular disease pathway(s) identified in an individual pat …

Long-term outcomes and associated prognostic risk factors of childhood-onset lupus nephritis.

BACKGROUND: This study investigated the clinical characteristics and kidney outcomes of childhood-onset lupus nephritis (LN), and risk factors associated with prognosis. METHODS: We enrolled 216 patients with histologically diagnosed LN during childhood. The Korean Society of Pediatric Nephrology organized a retrospective cohort study of childhood-onset LN in 13 major pediatric nephrology centers in South Korea. RESULTS: The mean age at kidney biopsy was 13.2 ± 3.22 years. The main forms of presentation were nephrotic syndrome and/or hematuria in 152 patients (70.4%), and the most common his…

Cystic Kidney Diseases From the Adult Nephrologist's Point of View.

Cystic kidney diseases affect patients of all age groups with the onset spanning from prenatal disease to late adulthood. Autosomal-dominant … ecessive polycystic kidney disease-are often being viewed as a disorder only important in pediatric nephrology. However, more recent data has revealed that, despite clear age peaks of onset for each disorder, all of them can also show highly variable phenotypes with classical adult onset genetic diseases being of importance in pediatrics and vice versa. Furt …

Kidney Disease Profile of Syrian Refugee Children.

INTRODUCTION: Although preventative nephrology is the effective management of childhood kidney diseases, it is hard to provide it in this undesirable conditions. In this study, we aimed to document the kidney disease profile of Syrian refugee children admitted to our hospital. MATERIALS AND METHODS: One hundred and thirty Syrian refugee children were admitted to the Pediatric Nephrology Department of the University of Gaziantep from September 2012 to January 2015. Demographic data, history, symptoms, physical examination findings, laboratory investigations, diagnosis, disease outcome, and the…

Microscopic polyangiitis: a large single-center series.

OBJECTIVE: Microscopic polyangiitis (MPA) is a rare systemic vasculitis, antineutrophil cytoplasmic antibody associated, characterized by necrotizing small vessel involvement with few or no immune complex deposits. Necrotizing glomerulonephritis is common. Pulmonary capillaritis causing alveolar hemorrhage and hemoptysis is well recognized, but most case series are reported in the nephrology literature and emphasize renal considerations. We present a single-center 10-year retrospective review of 40 patients meeting the 2012 Revised Chapel Hill Nomenclature of MPA, with specific p-antineutrophi…

The kidney, a victim and culprit of autoimmune and alloimmune responses.

The Working Group of the European Renal Association-European Nephrology and Dialysis Association (ERA-EDTA) dedicated to immune system involvement in renal disease (Immunonephrology Working Group) was established in 2009 to facilitate exchanges of ideas on basic science research and new treatment protocols among European nephrologists. A section of the ERA-EDTA website describes activities and is open for new applications and proposals. In 2010, the first meeting of this Working Group focused on aspects of immune-mediated renal damage shared by kidney during glomerulonephritides or after kidne…

Prediction of presence of kidney disease in patients undergoing intravenous iodinated contrast enhanced computed tomography: a validation study.

OBJECTIVES: To validate two previously presented models containing risk factors to identify patients with estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m2 or eGFR <45 ml/min/1.73 m2. METHODS: In random patients undergoing intravenous contrast-enhanced computed tomography (CECT) the following risk factors were assessed: history of urological/nephrological disease, hypertension, diabetes mellitus, anaemia, congestive heart failure, other cardiovascular disease or multiple myeloma or Waldenström disease. Data on kidney function, age, gender and type and indication of CECT were also

Bilateral renal and bladder agenesis with exceptional survival without prenatal intervention: a case report.

Bilateral renal agenesis (BRA) is typically considered a lethal condition due to severe pulmonary hypoplasia caused by early-onset anhydramnios. We report the case of a male infant who survived without prenatal intervention, underwent complex postnatal nephrological and surgical management, and ultimately received a successful renal transplant. This case highlights the exceptional possibility of survival of a patient with BRA and underscores the importance of multidisciplinary care.

Citrate, a green alternative to heparin.

An alternative to systemic heparin anticoagulation for HD is citrate dialysate (CD) which contains a small amount of citric acid. The nephrology community demands an environmentally sustainable kidney care and among others, heparin is a threat to planetary health. Citrate is the green alternative to heparin in HD and it is most likely better for the internal enviromment since it simultaneously provokes increased hemoglobin with a fixed dose of erythropoietin and reduced iron administration.

Unintentional puncture of thyroid cyst during insertion of dialysis catheter.

Central venous catheter (CVC) for hemodialysis are frequently implanted to the internal jugular vein. Thyroid cysts are commonly shown in ultrasound examination and their recognition should not pose a problem. Herby we present an uncommon case of the thyroid cyst unintended puncture, during an attempt of CVC insertion. No further clinical consequences were observed. For all practitioners, involved in interventional nephrology, such complication may be of the utmost importance.

Brazilian nephrologist's knowledge of intradialytic exercise: a national survey.

INTRODUCTION: Nephrologists' lack of knowledge regarding the benefits of intradialytic exercise (IE) may result in patients not being adequately instructed to participate in exercise programs and to become more active. PURPOSE: To evaluate the knowledge of Brazilian nephrologists regarding guidance and importance of IE for patients with chronic kidney disease. METHODS: This was a cross-sectional survey of 16 items administered to Brazilian nephrologists actively registered with the Brazilian Nephrology Society. RESULTS: A total of 262 nephrologists participated in the study. Most of the par…

Primary hyperoxaluria type 1 diagnosis in adult dialysis patients: prediction model assessment in a group of Italian patients.

BACKGROUND: To increase the diagnostic rate of primary hyperoxaluria type 1 (PH1) in the adult dialysis setting, a prediction model based on five readily available clinical parameters was recently developed and validated in an adult hemodialysis population. To further test the prediction model in clinical practice, this case series describes the retrospective application of the diagnostic algorithm in a group of adult dialysis patients with PH1 treated at different Italian nephrology centers. METHODS: Between January and May 2023, adult patients (≥ 18 years) undergoing chronic hemodialysis wi…