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Microstructural alterations of the human fornix in trigeminal neuralgia.

Trigeminal neuralgia (TN), a severe chronic neuropathic pain disorder, has been associated with abnormalities in limbic structures, particularly the hippocampus. The fornix, the hippocampus's primary efferent pathway, is integral to limbic-cognitive networks and exhibits microstructural changes across the adult lifespan. Fornix white matter (WM) integrity abnormalities in TN, and potential modifications following surgical pain relief have not been previously characterized. We examined whether TN is associated with alterations in fornix microstructure and what happens to these abnormalities fol…