Результаты поиска

Demonstration and distribution of tau-positive glial coiled body-like structures in white matter and white matter threads in early onset Alzheimer's disease.

The present report concerns the demonstration and distribution of tau-positive structures in the frontal and temporal white matter of five autopsy cases of early onset Alzheimer's disease (AD). The relationship between white matter lesions and tau positive structures was also investigated. Five early onset AD brains, which had not only unambiguous white matter lesions, but also no or rare atherosclerosis and minimal amyloid angiopathy, were examined. There were several tau-positive coiled body-like structures and many thread-like structures in the white matter, although previous reports showed…

Maternal blood C-reactive protein, white blood cell count, and temperature in preterm labor: a comparison with amniotic fluid white blood cell count.

OBJECTIVE: To compare the diagnostic and prognostic performance of maternal blood C-reactive protein, white blood cell count (WBC), and temperature with that of amniotic fluid (AF) WBC in preterm labor. METHODS: One hundred two women with preterm labor and intact membranes were studied. Maternal blood was collected to measure C-reactive protein concentration and WBC, and maternal temperature was also measured. Amniotic fluid obtained by amniocentesis was cultured and WBC determined. Receiver operating characteristic curve, logistic regression, and survival techniques were used for analysis. …

Novel Dolphin Tupavirus из Stranded Atlantic White-Sidd Dolphin с острым энцефалитом, Канада, 2024 год.

Мы секвенировали новый рхабдовирус Тупавирус дельфини (dolphin tupavirus) из мозга мертвого атлантического белого дельфина с сильным энцефалитом в Канаде. Гибридизация на месте связывает присутствие вируса с патологией мозга и смертью животного. Наши выводы подчеркивают важность мониторинга морских млекопитающих в случае неожиданных патогенов.

Совпадение в аннотации оригинала
We sequenced a novel rhabdovirus, Tupavirus delphini (dolphin tupavirus), from the brain of a stranded dead Atlantic white-sided dolphin with severe encephalitis in Canada. In situ hybridization linked presence of the virus to the animal's brain pathology and death. Our findings underscore the importance of monitoring marine mammals for unexpected pathogens.

A case of CD36 deficiency with multiple white matter lesions.

BACKGROUND: CD36 deficiency is associated with abnormal fatty acid metabolism, which may increase the risk of developing atherosclerosis. However, there are few reports on a possible link between CD36 deficiency and cerebral white matter lesions. CASE REPORT: We present the case of a 44-year-old woman with heart failure due to CD36 deficiency and multiple white matter lesions. Her comprehensive examination for heart failure, including a single-photon emission computed tomography (SPECT) with 201thallium and 123I-β-methyl-p-iodophenyl pentadecanoic acid, revealed a fatty acid metabolism disord…

Contexts of drinking and cannabis use by Whites and Hispanics in California.

This study examines the contexts in which alcohol and cannabis are used among White and Hispanic co-users in 40 selected cities in California. Data were obtained from a household sample of 1,069 adults aged 21 to 49, collected via an online standardized questionnaire. Alcohol and cannabis use occurred mostly in two primary settings: at home alone or with family and at home with friends. Controlled analyses identified distinct correlates associated with each consumption context. However, race/ethnicity and co-use status (concurrent vs. simultaneous use) did not have statistically significant ef…

The ecological dynamics and consequences of phytoplasma infection in white trillium.

BACKGROUND AND AIMS: Ecologists have long sought to link within-population dynamics to patterns of species occurrence and persistence across the range. Theoretical models suggest pathogens have important implications for plant populations and perhaps even limit plant distributions, though more empirical evidence is needed, especially in wild plant populations. METHODS: In the field, we characterized the infection dynamics of phytoplasma, a vectored and sterilizing bacterial pathogen, in wild populations of white trillium. We identified the highest molecular matches for the local bacterial str…

Histological and transcriptomic analysis of the white hepatopancreas in Amphioctopus fangsiao.

Ink production and release is one of the most important defense strategies in cephalopods. Previous studies have shown that ink production and release are closely associated with the hepatopancreas. In octopuses, the ink sac is embedded within the hepatopancreas, and the surrounding hepatopancreatic tissue appears white. To explore the differences between the white hepatopancreas and normal hepatopancreas, as well as the potential function of the white hepatopancreas, this study took Amphioctopus fangsiao as the research object and conducted histological and transcriptomic studies on white hep…

Predictors and prevalence of support for white nationalism in the United States.

White nationalism has become increasingly visible in American public life1-10. Yet we lack knowledge of the predictors and prevalence of explicit support for this ideology, as survey research has treated it as a latent construct captured through indirect indicators11-15. We introduce and validate a measure that informs respondents of the core tenets of the white nationalist movement and then asks whether they support the movement. Expressed support is distinct from organizational affiliation with the movement, which we do not measure. Here we show with three national surveys of non-Hispanic wh…

Fluorination of White Phosphorus with Fluoride Salts and Quinone Oxidants.

We report the synthesis of hexafluorophosphate (PF6-) salts directly from white phosphorus (P4) and simple fluorides MF (M = Li, Na, K, Cs, NMe4) in a single step. The utilization of p-quinones, such as 2,3-dichloro-4,5-dicyano-1,4-benzoquinone (DDQ) offers a selective fluorination pathway, which affords MPF6 salts in up to 95% yield in acetonitrile (MeCN). NMR investigations of the DDQ-mediated P4 fluorination reaction revealed the formation of PF3 and PF5·MeCN as key reaction intermediates. Donor-acceptor interactions between DDQ and fluoride are critical, effectively increasing the fluoride…

Respiratory morbidity and mortality in Black and White preterm infants.

OBJECTIVES: To evaluate the association between parental ethnicity and respiratory outcomes in infants born before 34 weeks of gestation. METHODS: Retrospective matched case-comparison study of inborn infants admitted to two London tertiary neonatal units between September 2022 and September 2025. Infants were included if both parents self-identified as Black (African or Caribbean) or White (British, Irish or Other) ethnicity. Clinical data were collected from electronic records. The primary outcome was the rate of bronchopulmonary dysplasia (BPD). RESULTS: 394 infants (197 Black, 197 White)…

Effect of Propofol and Sevoflurane on Vanishing White Matter Models.

BACKGROUND: The leukodystrophy vanishing white matter (VWM) most often has its onset in childhood and is characterized by chronic decline and additionally stress-provoked acute neurological deterioration. Anesthesia is a stressor that can trigger this acute decline. The commonly used inhalational anesthetic sevoflurane has been reported to activate the integrated stress response (ISR), whereas the intravenous anesthetic propofol has not. We aimed to assess the differential effects of these anesthetics in models of VWM. METHODS: We investigated the molecular effects of sevoflurane and propofol…

The White Matter Connectome Supporting Speech and Language in the Human.

The neurobiology of language has moved beyond the classical dorsal-ventral dichotomy to embrace a more complex, distributed, and dynamic white matter connectome. This special issue, The White Matter Connectome Supporting Speech and Language in the Human, presents 10 empirical studies that leverage traditional and advanced diffusion modeling and analyses-including Restriction Spectrum Imaging, fixel-based analysis, and network control theory-to map this complexity. The contributions are organized into three themes: developmental plasticity, lateralization, and clinical resilience. Findings rang…

Роль коллагена типа I в травме белой материи.

Увечье белой материи - патология мозга, отмеченная потерей олигодендроцитов и результирующим демиэлированием. Различные механизмы вызывают травму белой материи, включая ишемический инсульт и множественный склероз. Олигодендроциты регенерируют белую материю в центральной нервной системе в процессе, называемом ремиелинацией, волшебным демиелином аксонов с новым миелином. Несмотря на то, что сбой в ремии можно наблюдать при постепенном множественном склерозе и после ишемического инсульта, механизмы регенерации поврежденной белой материи остаются неясными. В этом обзоре мы в первую очередь концент

Совпадение в аннотации оригинала
White matter injury is a cerebral pathology marked by the loss of oligodendrocytes and the resultant demyelination. Various mechanisms induce white matter injury, including ischemic stroke and multiple sclerosis. Oligodendrocytes regenerate white matter in the central nervous system in a process called remyelination, ensheathing demyelinated axons with new m…

Белая материя в кризисе: Олигодендроциты и патофизиология множественного склероза.

Множественный склероз — это хроническое нервно-дегенеративное расстройство центральной нервной системы с иммунной подоплекой, характеризующееся широко распространенным обезвоживанием, аксонной травмой и прогрессивным неврологическим расстройством. Патофизиология множественного склероза включает сложные взаимодействия между иммунными клетками и постоянными клетками центральной нервной системы, при этом олигодендроциты (милиновые глиальные клетки) играют центральную роль как в наступлении, так и в развитии болезни. Дисфункция олигодендроцитов, включая снижение регенеративной способности, повышен

Physiopathological Roles of White Adiposity and Gut Functions in Neuroinflammation.

White adipose tissue (WAT) and the gut are involved in the development of neuroinflammation when an organism detects any kind of injury, thereby triggering metainflammation. In fact, the autonomous nervous system innervates both tissues, although the complex role played by the integrated sympathetic, parasympathetic, and enteric nervous system functions have not been fully elucidated. Our aims were to investigate the participation of inflamed WAT and the gut in neuroinflammation. Firstly, we conducted an analysis into how inflamed peripheral WAT plays a key role in the triggering of metainflam…

The Hidden Hand in White Matter: Pericytes and the Puzzle of Demyelination.

Disruption of myelin, the fatty sheath-insulating nerve fibers in the white matter, blocks or slows the rapid transmission of electrical signals along nerve cells and contributes to several neurodegenerative diseases such as multiple sclerosis. Traditionally, research has focused on neuronal dysfunction as the primary factor, including autoimmunity, infections, inflammation, and genetic disorders causing demyelination. However, recent insights emphasize the critical role of pericytes, non-neuronal cells that regulate blood flow and maintain the health of blood vessels within white matter. This…

Comparison of Patch Testing Results of White and Black Patients.

Patch testing is the standard diagnostic test used for patients presenting with symptoms of allergic contact dermatitis. The grading of patch test results classically varies from 1 to 3. The assessment of these results begins with a visual inspection of the presence of erythema, vesiculation, and induration. This leads to a subjectivity in visual evaluation of a patch test. Positive patch testing results can present differently in patients with darker skin tones. A greater variety of images of allergic contact dermatitis in patients with darker skin phototypes can better guide the diagnosis of

A case of Williams syndrome with Wolff-Parkinson-White syndrome.

INTRODUCTION: Williams syndrome (WS) cases have been reported to have with 25-100 times greater increased risk of sudden cardiac death (SCD). SCD has been reported in cases without any evidence of structural cardiovascular anomalies. Wolff-Parkinson-White (WPW) syndrome is characterized by short PR interval and delta wave. Ventricular preexcitations can develop paroxysmal reentrant tachycardia through Kent bundle or less frequent atrial fibrillation and in some cases with accessory pathway effective refractory period (APERP) under 250 ms considered as risky and may lead to SCD. WS associated w…