Результаты поиска

Musculoskeletal and skin considerations in children with medical complexity: Common themes and approaches to management.

The term "children with medical complexity" (CMC) describes a population of heterogeneous genetic and metabolic disorders with multi-system involvement, with shared common abnormalities within the musculoskeletal system. Disorders that affect the central nervous system (CNS) result in abnormal muscular tone, ranging from dystonia and spasticity, to hypotonia, to combinations of both (axial hypotonia with appendicular hypertonia). Abnormal tone can impair movement and function and contribute to development of contractures, progressive scoliosis and hip dislocation. Impaired mobility, chronic il…

A group of patients with Marfan's syndrome, who have finger and toe contractures, displays tendons' alterations upon an ultrasound examination: are these features common among classical Marfan patients?

The involvement of the musculoskeletal system with other mild pleiotropic manifestations represents a clinical criterion, called "systemic features," to d iagnose Marfan's syndrome. We aimed to investigate the features of the hands and feet redressable contractures present in a group of Marfan patients. In 13 patients with previously diagnosed Marfan's syndrome, an accurate clinical examination was performed. In particular the characterization of the musculoskeletal system by visual analogic scale to measure muscle pain (VAS) and muscle strength (MRC system) was carried out; the Beighton scale…

Primary biliary cirrhosis in The Netherlands. An analysis of associated diseases, cardiovascular risk, and malignancies on the basis of mortality figures.

BACKGROUND/METHODS: In 1979 death rate registration for primary biliary cirrhosis (PBC) became available in The Netherlands. In the 14-year … s (P < 0.05). In patients with PBC the frequency of HCC (SMR, 25.5; P < 0.0001) and diseases of the musculoskeletal system/connective tissue (SMR, 5.1; P < 0.0001) was higher than in the general population. Malignancies in general (SMR, 0.7), pancreatic carcinoma (SMR, 2.5), breast cancer (SMR, 0.1) and diseases of the circulatory system (SMR, 0.8) differed but not sign …

Expert-based recommendations on acetaminophen for musculoskeletal pain: insights from the Italian MOST pain panel.

INTRODUCTION: Musculoskeletal (MSK) pain remains a prevalent cause of disability and healthcare burden. Acetaminophen is widely used for its safety and accessibility, but its positioning within multimodal pain strategies varies across healthcare systems. AREAS COVERED: This expert-based position paper aims to offer practical reflections on the role of acetaminophen in managing acute MSK pain, based on the experience of a multidisciplinary panel of Italian clinicians. The manuscript addresses current prescribing practices, organizational barriers, and opportunities for optimizing acetaminophen

The bone-muscle connection in breast cancer: implications and therapeutic strategies to preserve musculoskeletal health.

Breast cancer and its therapies frequently result in significant musculoskeletal morbidity. Skeletal complications include bone metastases, pain, bone loss, osteoporosis, and fracture. In addition, muscle loss or weakness occurring in both the metastatic and curative setting is becoming increasingly recognized as systemic complications of disease and treatment, impacting quality of life, responsiveness to therapy, and survival. While the anatomical relationship between bone and muscle is well established, emerging research has led to new insights into the biochemical and molecular crosstalk be

Совпадение в полном тексте источника
… In aging and several chronic conditions, lower bone density and lean muscle mass have been observed to be interrelated and coexistent [ 36 ], supporting the concept of a cohesive musculoskeletal system. … Despite the known benefits of exercise, physical activity decreases after breast cancer diagnosis and treatment, exacerbating insult to the musculoskeletal system. …

Magnetic resonance imaging in oncology: an overview.

This review discusses a growing area of imaging in oncology. Traditionally, the primary role of magnetic resonance imaging (MRI) has been in the investigation of neurological diseases and in the diagnosis of musculoskeletal abnormalities. With the increasing availability of MRI systems and with the advances in technology, the role of this modality out with these areas is rapidly expanding. This review outlines the areas where MRI has a specific role in the imaging of patients with cancer. In particular, emphasis is placed on areas outside of the central nervous and musculoskeletal systems. Thi…

A review of the measurement properties of disability measures used in children and adolescents with musculoskeletal pain: a clinimetric review.

BACKGROUND: Musculoskeletal pain is common in children and adolescents and is associated with disability. Although multiple Patient-Reported Outcome Measures (PROMs) are used to assess disability, no previous review has evaluated both risk of bias and certainty of the evidence. This study aimed to appraise and summarise the evidence on PROMs for disability in children with musculoskeletal pain. METHODS: We conducted a systematic review following the COnsensus-based Standards for the selection of health status Measurement INstruments (COSMIN). We included studies of measurement properties of d

Suppressed prefrontal cortex oscillations associate with clinical pain in fibrodysplasia ossificans progressiva.

BACKGROUND: Pain is a highly prevalent symptom experienced by patients across numerous rare musculoskeletal conditions. Much remains unknown regarding the central, neurobiological processes associated with clinical pain in musculoskeletal disease states. Fibrodysplasia ossificans progressiva (FOP) is an inherited condition characterized by substantial physical disability and pain. FOP arises from mutations of the bone morphogenetic protein (BMP) receptor Activin A receptor type 1 (ACVR1) causing patients to undergo painful flare-ups as well as heterotopic ossification (HO) of skeletal muscles,

Infantile Pompe disease on ERT: update on clinical presentation, musculoskeletal management, and exercise considerations.

Enzyme replacement therapy (ERT) with alglucosidase alpha, approved by the FDA in 2006, has expanded possibilities for individuals with Pomp … in children now surviving longer with residual weakness impacting development and integrity of the musculoskeletal system; and the potential impact and role of exercise in infantile Pompe survivors treated with ERT.

Employment and occupational outcomes of workers with musculoskeletal pain in a French region.

OBJECTIVES: To study the employment and occupational outcomes of workers who were diagnosed with upper limb musculoskeletal disorders (UL-MSDs) or had complained of upper limb musculoskeletal pain a few years before compared with workers who had no upper limb pain. METHODS: In 2002-2005, an epidemiological surveillance system was set up. Occupational physicians examined 3710 randomly selected workers. It focused on six UL-MSDs: rotator cuff syndrome, lateral epicondylitis, flexor-extensor peritendinitis of the hands and fingers, de Quervain's disease, carpal tunnel syndrome and ulnar tunnel s

Modeling Huntington disease in yeast: perspectives and future directions.

OBJECTIVES: To perform a systematic literature review (SLR) on the association of common variable immunodeficiency (CVID) and rare and complex connective tissue and musculoskeletal diseases, namely systemic lupus erythematosus (SLE), Sjögren's syndrome (SS), idiopathic inflammatory myopathies (IIM), systemic sclerosis (SSc), relapsing polychondritis, antiphospholipid syndrome, immunoglobulin (Ig) G4-related disease, as well as undifferentiated and mixed connective tissue disease. METHODS: An SLR on studies and cases about the association of CVID and rare and complex connective tissue and musc

[Erdheim-Chester disease].

HISTORY AND CLINICAL FINDINGS: A 55-year-old female was admitted complaining of musculoskeletal pain and weakness of both lower extremities for a number of years. Due to a hypothalamic mass of unknown aetiology a diabetes insipidus, a gonadotrophic, somatotrophic and a partially corticotrophic insufficiency had developed. INVESTIGATIONS: Laboratory investigations yielded elevated levels of several inflammatory parameters (C-reactive protein, blood sedimentation rate, fibrinogen and thrombocytes). Serological parameters indicating a systemic rheumatic disorder were absent. X-ray examination re

Vincristine impairs musculoskeletal development in pediatric mice.

BACKGROUND: Over 85% of children diagnosed with cancer now survive their disease, yet cancer and chemotherapy frequently associate with long-term health complications, including impaired musculoskeletal development. Despite high survival rates, there is limited research on how pediatric chemotherapy affects muscle and bone physiology. Vincristine, a vinca alkaloid chemotherapeutic, is widely used in pediatric oncology, but its systemic effects on the developing musculoskeletal system remain poorly understood. This study aimed to investigate the musculoskeletal consequences of vincristine in a …

Evaluating the Impact of Active Footwear Systems on Vascular Health and Static Balance: An Exploratory Study.

Work-related musculoskeletal disorders are prevalent in occupations requiring prolonged standing and repetitive movements, often leading to vascular issues and reduced static balance. Innovations in wearable technology, such as smart footwear integrating active systems, aim to mitigate these challenges. This exploratory study assessed the effects of a novel active footwear system, incorporating compression and vibration, on vascular blood flow and static balance in healthy adults. Sixteen healthy participants (seven men and nine women) were randomized into active and placebo phases, each invol

The impact of Drew Noden's work on our understanding of craniofacial musculoskeletal integration.

The classical anatomist Drew Noden spearheaded craniofacial research, laying the foundation for our modern molecular understanding of development, evolution, and disorders of the craniofacial skeleton. His work revealed the origin of cephalic musculature and the role of cranial neural crest (CNC) in early formation and patterning of the head musculoskeletal structures. Much of modern cranial tendon research advances a foundation of knowledge that Noden built using classical quail-chick transplantation experiments. This elegant avian chimeric system involves grafting of donor quail cells into h

Customized device for individuals with limited range of motion to insert and remove dentures.

AIM: To develop a device to aid in insertion and removal of dentures in patients with limited range of motion. CASE REPORT: A 62-year-old male with congenital musculoskeletal system anomaly, severe scoliosis, missing teeth, and poor dentition presented for comprehensive dental care. Patient had significant range of motion limitations resulting in an inability to reach his mouth. A device allowing for independent insertion, removal, and cleaning of dentures was made for patient. Dentures were fabricated and scanned using an intraoral scanner, traditional surgical guide for implant placement wa…

Monitoring Methods of Human Body Joints: State-of-the-Art and Research Challenges.

The world's population is aging: the expansion of the older adult population with multiple physical and health issues is now a huge socio-economic concern worldwide. Among these issues, the loss of mobility among older adults due to musculoskeletal disorders is especially serious as it has severe social, mental and physical consequences. Human body joint monitoring and early diagnosis of these disorders will be a strong and effective solution to this problem. A smart joint monitoring system can identify and record important musculoskeletal-related parameters. Such devices can be utilized for c

Vibration stimuli and the differentiation of musculoskeletal progenitor cells: Review of results in vitro and in vivo.

Due to the increasing burden on healthcare budgets of musculoskeletal system disease and injury, there is a growing need for safe, effective and simple therapies. Conditions such as osteoporosis severely impact on quality of life and result in hundreds of hours of hospital time and resources. There is growing interest in the use of low magnitude, high frequency vibration (LMHFV) to improve bone structure and muscle performance in a variety of different patient groups. The technique has shown promise in a number of different diseases, but is poorly understood in terms of the mechanism of action…

[Current opinions on gout, its diagnosis and treatment].

Gout is a heterogenous group of metabolic diseases characterized by formation and deposition of sodium urate crystals in various tissues. Gouty arthritis is a rheumatic syndrome occurring in individuals with hyperuricaemia; this is an inflammatory disease of the musculoskeletal system with a presence of sodium urate crystals. Hyperuricaemia, i.e. pathologically increased levels of uric acid in the serum, represents the most important risk factor for the development of gouty arthritis. The causes of hyperuricaemia may include an increased production of uric acid and/or its reduced elimination f…

Surgical management of spasticity in persons with cerebral palsy.

Cerebral palsy is a disorder that primarily affects the neurologic system but secondarily affects the musculoskeletal system through the effects of spasticity, dystonia, and other movement disorders. The treatment of cerebral palsy requires a multidisciplinary approach with treatment aimed at modulating the movement disorder through oral medication, injectable drugs (phenol, botulinum toxin), and physical and occupational therapy. Treatment of the neurologic effects of the central movement disorders include selective dorsal rhizotomy, intrathecal baclofen pump placement, and potentially deep b…