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Mononeuritis multiplex caused by Coxiella burnetii infection (Q fever).

After 1 week of flu-like illness, a 64-year-old man developed rapidly progressive mononeuritis multiplex involving the right arm and both legs. Serologic studies identified Coxiella burnetii as the cause of the febrile disease (Q fever). Fourteen days doxycycline treatment (200 mg daily) induced rapid and complete recovery. After 6 months, flu-like symptoms, weakness and hypalgesia of the right leg reappeared. Antibody titers again identified Q fever. Doxycycline was re-established and induced prompt recovery. Q fever has been associated with various neurologic complications such as meningoenc…

Q fever--still a query and underestimated infectious disease.

Coxiella burnetii (C.b.) is a strictly intracellular, Gram-negative bacterium. It causes Q fever in humans and animals worldwide. The animal Q fever is sometimes designated "coxiellosis". This infection has many different reservoirs including arthropods, birds and mammals. Domestic animals and pets, are the most frequent source of human infections. Q fever may appear basically in two forms, acute and chronic (persistent). The latter form of Q fever in animals is characteristic by shedding C.b. into the environment during parturition or abortion. Human Q fever results usually from inhalation of…

Seroepidemiological survey of Q fever in León province, Spain.

A seroepidemiological survey, using an indirect immunofluorescence test against Coxiella burnetii (antigenic phase II), was carried out in L … was encountered among males and females older than 64 years. In the same way, a significant higher Q fever prevalence was observed among individuals having occupations related to agriculture and among those having close relationship with animals.

[Q fever-induced endocarditis. An analysis of 6 cases].

Endocarditis by Q fever is a diagnostic and therapeutic challenge given the diagnostic delay and elevated morbidity and mortality it carries. Six cases of endocarditis by Q fever attended over the last 7 years were retrospectively studied. Five patients had been previously diagnosed of valvular involvement and three had prosthesis. Five patients presented a febrile syndrome of prolonged duration with negative hemocultures and progressive valvular changes. One patient presented acute valvular failure requiring emergency surgery. The most significant laboratory data were anemia, thrombocytopenia…

[Q fever and fetal death in utero. Two cases].

Some cases of late abortion occurring after a Coxiella burneti infection, more often with a chronic evolution, have already been mentioned in the literature. We reported here two cases of early abortion, contemporaneous of an acute infection due to C. burneti. Two patients, after a contact, before and at the beginning of the pregnancy, with an animal susceptible to contaminate human beings by C. burneti, presented no clinical symptom characteristic of Q fever. The fetal death for the two cases was found out at the 17th week of amenorrhoea. All the investigations in order to search for an abort…

Q fever: an emerging public health concern in Canada.

Q fever in humans and coxiellosis in livestock are on the increase in Canada. The progressive spread of Coxiella burnetii takes place in the animal reservoirs of the rickettsia, mainly domestic ruminants. Human Q fever is a reverberation of the coxiellosis situation on our farms. Increasing animal concentration resulting from the industrialization of agriculture and oversight of the infection in livestock permitted the extension of the zoonotic problem on the farms. Initiative for control of coxiellosis, however, is called for by public health interests at the present time to assure occupation…

[Unusual manifestations of Q fever disclosing hairy cell leukemia].

An unusual case of Q fever in a 62-year-old female is described. The patient presented with severe pneumonia and developed renal failure, disseminated intravascular coagulation and pancytopenia which recurred after antibiotics were discontinued. Subsequently hairy cell leukemia was diagnosed and evolved favorably under treatment with doxycycline and alpha-interferon. A review of the literature confirms that renal failure and disseminated intravascular coagulation do not appear to be associated with Coxiella burnetti infections, nor has the association of Q fever and hairy cell leukemia been pr…

Q fever pneumonia presenting as an eosinophilic pleural effusion.

A patient with an eosinophilic pleural effusion due to Q fever is described.

Q fever vaccines: present status and application in man.

Of three Q fever vaccine candidates available at present, i.e., phase I corpuscular untreated, soluble, and phase I corpuscular chloroform-methanol treated vaccines, the first two were tested on hundreds of subjects exposed to Q fever. Based on their sufficient immunogenicity (which depends also on the tests employed) and low reactogenicity (providing that subjects with previous contact with Coxiella (C.) burnetii are excluded from vaccination) these two vaccines can be recommended for vaccination of humans at risk. Further studies are required, however, to answer definitively which vaccine ty…

Q fever pneumonia associated with exposure to wild rabbits.

4 patients with atypical pneumonia and a history of exposure to wild rabbits were found to have antibodies to Coxiella burnetii but not to the other organisms also commonly associated with atypical pneumonia. 10 (45%) of 22 snowshoe hares caught in the area where 1 of the patients snared his rabbits had antibodies to Coxiella burnetii. Q fever ought to be included in the differential diagnosis of pneumonia acquired following exposure to wild rabbits.

Chronic Q fever endocarditis with massive splenomegaly in childhood.

Two children with congenital heart disease developed persistent fever, anemia, and hepatosplenomegaly. Both were shown to have intracardiac vegetations and evidence of infection with Coxiella burnetti. Thus, the same clinical manifestations of Q fever may develop in both children and adults.

Фосфорилирование-дефосфорилирование ядерных белков во время инфекции (Q лихорадка).

Предложение о том, что выражение гена может регулироваться фосфорилацией нехистонных хроматиновых белков, было испытано путем изучения увеличения транскрипции в результате лихорадки Q. Некоторые виды деятельности, связанные с ядерным фосфопротеином печени и фосфатазной деятельностью, были изменены после того, как свиньи-морозки были заражены ожогом Коксиеллы. Протеины нонхистоунового хроматина увеличили активность фосфопротеиновых киназ и дифференцировали фосфорилаты. Добавление сперматозоида также стимулировало ядерные фосфопротеиновые киназы неинфекционной и зараженной печени. Заражение сопр

Совпадение в аннотации оригинала
The proposal that gene expression may be regulated by phosphorylation of nonhistone chromatin proteins was tested by studying increased transcription resulting from Q fever. Certain liver nuclear phosphoprotein kinase and phosphatase activities were altered after guinea pigs were infected with Coxiella burnetii. Nonhistone chromatin proteins had increased ph…