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Methodological Aspects of the Phase II Study AFF006 Evaluating Amyloid-beta -Targeting Vaccine AFFITOPE® AD02 in Early Alzheimer's Disease - Prospective Use of Novel Composite Scales.

BACKGROUND: Optimized scales and composite outcomes have been proposed as a way to more accurately measure Alzheimer's disease related decline. AFFITOPE® AD02, is an amyloid-beta (Aβ)-targeting vaccine to elicit anti-Aβ antibodies. IMM-AD04, commonly known as Alum, originally designated as a control agent, appeared to have disease-modifying activity in a multicenter, parallel group phase II study in early AD patients. OBJECTIVES: To develop adapted outcomes for cognition, function and a composite scale with improved sensitivity to decline and treatment effects in early AD (mild plus prodromal

AGA Clinical Practice Update on the Epidemiology, Evaluation, and Management of Exocrine Pancreatic Insufficiency: Expert Review.

DESCRIPTION: Exocrine pancreatic insufficiency (EPI) is a disorder caused by the failure of the pancreas to deliver a minimum/threshold leve … eatment of at least 40,000 USP units of lipase during each meal in adults and one-half of that with snacks. The subsequent dosage can be adjusted based on the meal size and fat content. BEST PRACTICE ADVICE 13: Routine supplementation and monitoring of fat-soluble vitamin levels are appropriate. Dietary modifications include a low-moderate fat diet with …

Therapeutic Uses and Pharmacological Properties of Shallot (Allium ascalonicum): A Systematic Review.

BackgroundShallot (Allium ascalonicum L.) is a traditional plant species used throughout the world both for culinary purposes and as a folk remedy. To date (i.e., April 2022), there is no report on the main pharmacological activities exerted by shallot preparations and/or extracts.Scope and approachThe aim of this study was to comprehensively review the pharmacological activities exerted by shallot, with rigorous inclusion and exclusion criteria based on the scientific rigor of studies. Prisma guidelines were followed to perform the literature search.Key findings and conclusionsThe literature

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… P : bulb | ( 64 ) | E : 1.42 mg/g fw | E (Water; 1:2) | Mendoza, Argentina | PN : shallot P : bulb | ( 60 ) | Snack : 86.70 mg QE/L | D ( 40°C; 96 h) >> M (60 mm mesh sieve) >> snack (25%) | Shasha market, Akure, Ondo State, Nigeria | PN : Shallot BN : A. ascalonicum P : bulb | ( 65 ) DPPH | E (MAC … A more recent study analyzed the ability of shallot-enriched amaranth-based extruded snacks to modulate carbohydrate hydrolyzing enzymes in streptozotocin-induced diabetic rats. …

Использование каннабиса и риск возникновения периодонтита и негативных последствий для здоровья полости рта: систематический анализ литературы.

Каннабис широко употребляется во всем мире. К числу общих методов потребления относятся курение, оплодотворение и потребление съедобных веществ. Несмотря на все более широкое использование каннабиса, его воздействие на лечение и лечение расстройств, связанных с оральным здоровьем, по-прежнему недостаточно изучено. Каннабис ассоциируется с негативными оральными последствиями, такими, как периодонтит, ксеростомия, кариес и ингивит. Эти отрицательные оральные эффекты осложняют стоматологическую помощь. Был проведен систематический обзор литературы с целью поиска баз данных PubMed, EMBASE и Cochra

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… Le A et al. reported that 46.7% of cannabis users frequently consumed sugary beverages or snacks compared to 26.3% of non-users (adjusted prevalence ratio 1.26; 95% CI 1.07-1.48) [ 20 ]. … The "munchies" (frequent consumption of sugary beverages and snacks) appears to be a primary driver; one study noted that 46.7% of cannabis users frequently consumed sugary snacks compared to 26.3% of non-users [ 20 ]. …

Diet-driven microbiome changes and physical activity in cancer patients.

Exploring the role of the gut microbiome in oncology is gaining more attention, mainly due to its ability to shape the immune system in cancer patients. A well-balanced microbial composition forms a symbiotic relationship with the host organism. Mounting evidence supports the potential of modifiable lifestyle factors, such as diet and physical activity, in restoring intestinal dysbiosis related to cancer development and treatment. In this Minireview, we describe the host-microbiome interplay following different dietary patterns, including a high-fat diet, fiber-rich diet, diet rich in rice and

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… Differences in a stool metabolome linked to gut microbial metabolism were observed between overweight and obese colorectal survivors supplemented with 35 g of cooked navy bean and navy bean-free snacks ( 64 ). … Individual nutritional plans for patients contained measures such as oral nutritional supplements, snacks rich in proteins, and snacks rich in energy. Medical history such as anti-cancer therapy, drugs, and blood parameters was documented by the dietician. …

Associations of patient-generated subjective global assessment (PG-SGA) and NUTRISCORE with survival in gastric cancer patients: timing matters, a retrospective cohort study.

BackgroundThe timing of nutritional assessment may be important to treat cancer patients and predict their prognosis. This study examined whether Patient-Generated Subjective Global Assessment (PG-SGA) and NUTRISCORE scores were associated with survival among gastric cancer patients who underwent surgery and chemotherapy and whether the timing of the assessment after surgery mattered.MethodsA total of 952 gastric cancer patients (622 men and 330 women) were included in this retrospective cohort study. The PG-SGA and NUTRISCORE scores were calculated at 1 month (n = 952), 2 months (n = 657), an

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… Information on weight loss, the number of meals and snacks, eating speed, and digestive symptoms were collected through face-to-face interviews by registered dietitians during nutritional consultation. Energy and protein intake was assessed by registered dietitians using a one-time 24h recall. … ± 17.2 Protein intake relative to requirement (%) b | 81.3 ± 24.1 | 78.1 ± 23.5 | 70.3 ± 24.5 | 62.4 ± 24.0 | 92.2 ± 19.6 | 79.1 ± 24.4 | 64.7 ± 22.3 | 56.2 ± 20.0 Number of meals (times/day) b | 3.4 ± 0.9 | 3.5 ± 1.0 | 3.5 ± 0.9 | 3.4 ± 0.9 | 3.7 ± 1.1 | 3.5 ± 1.0 | 3.4 ± 0.9 | 3.3 ± 0.8 Number of snacks …

A geriatrician's approach to managing the complex older adult with obesity.

The prevalence of obesity in older adults is rapidly increasing due to the demographic shift occurring globally. Older adults with obesity face health care challenges due to multimorbidity, functional dependency, and disability. This population often has prior history of struggles through weight-loss attempts during the middle years of life. Therefore, weight-loss intervention needs a personalized approach, taking into consideration weight-loss attempts, relapse, and life events, including bariatric surgery, functional limitations, psychosocial status, and current residential environment. Raci

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… Ensuring an intake of 20 to 30 g of protein with each meal along with a protein snack following exercise can help cut down elevated unhealthy caloric needs during those times [ 95 ]. … Educational handouts on protein‐ and fiber‐rich foods and emphasis on intake of 20 to 30 g of protein while highlighting the limitation of ultraprocessed snacks and meals would help guide patients of varying nutritional backgrounds and enhance adherence. …

The 11th NORDIC NUTRITION CONFERENCE NNC2016.

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Mindfulness-Based Group Medical Visits: Strategies to Improve Equitable Access and Inclusion for Diverse Patients in Cancer Treatment.

BackgroundMindfulness-based interventions (MBIs) are supported by clinical practice guidelines as effective non-pharmacologic interventions for common symptoms experienced by cancer patients, including anxiety, depression, and fatigue. However, the evidence predominately derives from White breast cancer survivors. Racial and ethnic minority patients have less access to integrative oncology care and worse cancer outcomes. To address these gaps, we designed and piloted a series of mindfulness-based group medical visits (MB-GMVs), embedded into comprehensive cancer care, for racially and ethnical

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… Lovingkindness meditation Attitudes: Generosity, gratitude Micro-practice: 4-7-8 breath, box breathing, abdominal breathing Evidence base: NCCN, SIO-ASCO Creative expression: Drawing (challenges and supports) Prescriptions: Daily meditation, gratitude journal Naming practice, “mind-body snacks” d 2. … In addition to prescribing daily meditation practice, we focused on micro-practices or “MBM snacks” 39 (eg, brief breathing techniques) for times of acute stress and mindful awareness in activities of daily life for when patients were short on energy or time. …

Расширение повседневной памяти и участие в многочисленных склерозах: экспериментальное исследование метакогнитивной стратегии вмешательства.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Когнитивная дисфункция у лиц с множественным склерозом (МС) связана с ограничениями в повседневной деятельности и ограниченным участием. Существующие меры по устранению когнитивной дисфункции часто свидетельствуют о непоследовательном переходе на повседневную деятельность и, как правило, требуют частых посещений клиник, что может быть сопряжено с трудностями для пациентов с НР из-за проблем с мобильностью. Для преодоления этого барьера мы разработали систему когнитивного вмешательства на основе телемедицины, которая основана на подготовке по вопросам метакогнитивной стра

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… Review of journal entry 8 Weekly errands Finding brunch items on a menu 9 Finding restaurant business cards Finding personal business cards 10 Comparing items on two menus Remembering names 11 Shopping on a budget for a social night: Different games Snacks 12 Shopping home decor on a … Review of journal entry Weekly errands Finding brunch items on a menu Finding restaurant business cards Finding personal business cards Comparing items on two menus Remembering names Different games Snacks Shopping home decor on a budget Preparing for a trip to an amusement park *In bold: …

Overview of nutritional approach in hematopoietic stem cell transplantation: COVID-19 update.

The coronavirus disease 2019 (COVID-19) is caused by the newly discovered SARS-CoV-2. Hematopoietic stem cell transplantation (HSCT) is a high-risk procedure. The novelty of COVID-19 has created more uncertainty during all phases of HSCT. It is thought that HSCT patients taking immunosuppressive agents are more likely to contract COVID-19 than healthy individuals are. Appropriate care precautions should be taken with patients undergoing HSCT to minimize the risk of COVID-19, and appropriate treatment methods must be followed in patients infected with COVID-19. Malnutrition has become a signifi

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… These patients also need to consume high-calorie snacks and increase their consumption of foods which they can tolerate better[ 43 ]. Energy and protein content of the patients’ favorite foods can be increased[ 52 ]. … In addition, snacks such as cheese, crackers, ice cream, peanut butter, fruit and yoghurt should be kept handy. As beverages create a feeling of satiety, very few drinks should be consumed with meals. Regular exercise can also lead to an increased appetite. …

Breaking the obesity-cancer link: assessing European school-based and complementary obesity-prevention strategies and their implementation obstacles

Nowadays, obesity among children and adolescents is considered an additional factor in cancer development during adulthood. These facts are supported by current epidemiological studies. To address these challenges, a wide range of obesity prevention programmes have been launched in Europe, promoting actions for personalized healthy dietary behaviors, physical exercise, and combinations of both, often using e-health platforms. Another pillar of interventions is school-based policies, such as limiting access to high-fat and high-sugar foods or providing healthy food vouchers, which represent ano

The contributions of family care-givers at end of life: A national post-bereavement census survey of cancer carers' hours of care and expenditures.

BackgroundFamily members provide vital care at end of life, enabling patients to remain at home. Such informal care contributes significantly to the economy while supporting patients' preferences and government policy. However, the value of care-givers' contributions is often underestimated or overlooked in evaluations. Without information on the activities and expenditures involved in informal care-giving, it is impossible to provide an accurate assessment of carers' contribution to end-of-life care.AimThe aim of this study was to investigate the contributions and expenditure of informal, fam

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… Prescription/non-prescription drugs | 128 (8.5) | 119 (7.9) | 107.47 (279.26) | 30.00 | 20–80 | 1376 (91.5) Household bills | 410 (27.3) | 363 (24.1) | 235.62 (395.03) | 129.00 | 80–300 | 1094 (72.7) Travel expenses | 760 (50.6) | 720 (47.9) | 208.20 (424.17) | 100.00 | 48.5–207.5 | 744 (49.5) Meals/snacks … 414 (27.5) Any time since diagnosis One-off expense | 254 (16.9) | 240 (16.0) | 8759.84 (44902.50) | 2000 | 756.25–5875 | 1250 (83.1) The most frequent expenditure was for travel expenses (47.9%) at a median cost of £100 per person over the last 3 months of life, followed by expenditure on meals and snacks …

Nutritional characteristics of patients with dry mouth and/or Sjögren disease in a Hungarian cohort.

BACKGROUND: People with any form of dry mouth may have problems with eating, swallowing, speaking, taste perception, wearing dentures, and maintaining good oral health. Subsequently, it can have a major impact on the quality of life through its effects on the qualitative and quantitative parameters of nutrition. Nevertheless, little is known about the effects of different foods and nutrients on salivation and orofacial sicca symptoms. Despite this, the literature on the relationship between xerostomia (x), hyposalivation (h), Sjögren disease (SD), and nutrition is relatively sparse. OBJECTIVE

Canadian perspectives in multiple myeloma on the use of steroids in clinical practice based on patient and healthcare provider interviews.

Corticosteroid (steroid) medications are associated with challenging adverse effects that can negatively impact patient quality of life. However, owing to a long legacy of effective use in treatment protocols, they remain a cornerstone of multiple myeloma (MM) care. We conducted a roundtable with Canadian healthcare providers (HCPs) with diverse healthcare backgrounds and involvement in MM care as well as with patients with MM. Our goal was to develop clear guidance for steroid management aimed at improving patient quality of life, taking into account patient perspective and experiences with m

Целые пищевые рационы на основе растений являются практически осуществимыми при автоматическом воздействии на организм человека и связаны с модификацией микробиома в зависимости от дозы.

Целые пищевые рационы, основанные на кратком планете, могут представлять собой целенаправленный подход к смягчению последствий нарушения микробиома и улучшению последствий для пациентов, проходящих аутологическую трансплантацию гематопоиетических клеток (auto-HCT) в случае множественной миеломы, в которой кишечный дисбиоз связан с более низким уровнем выживаемости. Мы провели одностороннее клиническое испытание в нашем центре, в ходе которого участники прошли автоHCT (n = 22) получили свежее, заранее подготовленное, растительное питание 5 Недели, охватывающие кондиционирование, нейтрализацию и

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… Intervention From day −7 to +28 (range, −11 to +30), participants received 3 meals per day plus snacks, delivered twice weekly by Thistle, a commercial meal-delivery service. … All meals delivered to participants were completely plant-based (with no meat, eggs, or dairy) and included breakfast, lunch, dinner, and a daily snack. …

European Guidelines for Obesity Management in Adults.

Obesity is a chronic metabolic disease characterised by an increase of body fat stores. It is a gateway to ill health, and it has become one of the leading causes of disability and death, affecting not only adults but also children and adolescents worldwide. In clinical practice, the body fatness is estimated by BMI, and the accumulation of intra-abdominal fat (marker for higher metabolic and cardiovascular disease risk) can be assessed by waist circumference. Complex interactions between biological, behavioural, social and environmental factors are involved in regulation of energy balance and

Methods for nutrition monitoring in cancer patients: a cognitive perspective.

In the present medical context, the evaluation and the monitoring of factors other than mere physical symptoms are an urgent demand. In particular, the issue of quality of life (QoL) has become a relevant target in the treatment of cancer. However, the approach towards these aspects is not well standardized and the actual applications in a concrete setting are fragmented, left to personal or local initiative. If this is true for QoL in general, it is particularly relevant in the specific field of nutrition. Indeed, though the growing awareness of a correlation between chronic diseases and diet

The Impact and Molecular Mechanisms of Exercise in Cancer Therapy.

Cancer is a major global health issue, and exercise has become a key supportive treatment. It contributes to reducing cancer risk, enhancing prognosis, and aiding recovery, especially for survivors. However, the exact mechanisms, such as how exercise reduces cancer risk or enhances treatment, are still unclear. Current research often focuses on specific cancer types, ignoring the diverse needs of patients. This limits the development of personalized exercise plans. Additionally, there is insufficient comparison of exercise types-like aerobic, resistance, and high-intensity interval training-re

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… Exercise snacks, as an emerging intervention strategy, involve performing multiple brief bouts of exercise (each lasting ≤ 1 min) at intervals of 1–4 h throughout the day [ 268 ]. …

Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: children and adolescents.

The Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: Children and Adolescents was developed by dietitians, physicians, and pediatric hematologists from 10 Brazilian reference centers in hematopoietic stem cell transplantation. The aim was to emphasize the importance of nutritional status and body composition during treatment, as well as the main characteristics related to patient´s nutritional assessment. This consensus is intended to improve and standardize nutrition therapy during hematopoietic stem cell transplantation. The consensus was approved by the Brazilian

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… In the post-HSCT phase, it is common to see an increase in intake of low nutritional quality foods, such as unhealthy snacks and fried food. … p. 21-6. ( 24 ) Meal | Age (months) 6-7 | 7-8 | 8-10 | 12 Breakfast | Breast milk | Breast milk | Breast milk | Breast milk or infant formula Bread or biscuit Break | Pureed fruit | Pureed fruit | Pureed fruit | Pureed fruit Lunch | Breast milk | Food puree | Food puree | Food puree or family meal Snack …