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Blood donor exposome and impact of common drugs on red blood cell metabolism.

Computational models based on recent maps of the RBC proteome suggest that mature erythrocytes may harbor targets for common drugs. This prediction is relevant to RBC storage in the blood bank, in which the impact of small molecule drugs or other xenometabolites deriving from dietary, iatrogenic, or environmental exposures ("exposome") may alter erythrocyte energy and redox metabolism and, in so doing, affect red cell storage quality and posttransfusion efficacy. To test this prediction, here we provide a comprehensive characterization of the blood donor exposome, including the detection of co…

Beyond Blood and Urine: Decoding the Human Chemical Exposome across Matrices and Time.

Environmental chemicals contribute substantially to the global burden of chronic disease, yet for most compounds now detectable in human bio … o-track hazard prioritization pipeline for the largely uncharacterized molecular dark matter of the exposome. As the Global Human Exposome Project defines its operational infrastructure, these design principles offer a concrete path toward identifying chemical disease drivers before clinical manifestations.

The hepato-exposome axis: How endocrine disruptors hijack liver receptors to drive MASLD.

Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasing worldwide at a pace that cannot be fully explained by obesity, diet, or genetics alone. Emerging evidence provides mechanistic insight into how defined endocrine-disrupting chemicals (EDCs) rewire hepatic transcriptional and metabolic networks relevant to MASLD. This review focuses on the molecular interfaces through which major EDC families intersect with hepatic metabolic regulation. We propose the "hepato-exposome axis" as a receptor-centric framework that maps specific EDC classes to nuclear receptors (NRs) and …

Exposome-induced dysregulation of glycemic homeostasis: Emerging biomarkers for diabetes risk and progression.

Environmental exposures throughout life profoundly influence the development and progression of diabetes mellitus. The exposome, representing the totality of environmental exposures from conception to adulthood, interacts with genetic and metabolic pathways, leaving measurable signatures termed biomarkers. These biomarkers encompass indicators of exposure, biological effect, and susceptibility, providing mechanistic insights into glycemic regulation and disease progression. This review synthesizes current evidence on exposome-linked biomarkers in both Type 1 and Type 2 diabetes, highlighting c…

The exposome-autoimmunity axis: environmental xenobiotics, gut dysbiosis, and potential pathways to immunosenescence.

The escalating incidence of autoimmune diseases cannot be fully explained by genetics alone. It is increasingly linked to the exposome-the cumulative burden of lifelong environmental exposures. This review examines how pollutants (particulate matter, microplastics, agrochemicals, heavy metals) reshape the gut microbiota-immune axis and disrupt intestinal homeostasis. This triggers profound dysbiosis, characterized by reduced commensal diversity and expanded pathobionts. We highlight three mechanisms driving pollution-induced immune reprogramming: (i) barrier compromise facilitating metabolic e…

Exposome-driven molecular sensitization signatures in pediatric rhinitis and asthma across Spanish regions.

BACKGROUND: Allergic rhinitis and asthma in childhood arise from dynamic interactions between genetic predisposition and the exposome. However, how environmental heterogeneity shapes molecular IgE sensitization profiles during early life remains insufficiently characterized. METHODS: We conducted a prospective, observational, multicentre, cross-sectional study including 354 children (0-15 years) with allergic rhinitis and/or asthma recruited across eight Spanish cities contrasting regional climatic contexts. All patients were skin prick test-positive to at least one aeroallergen and underwent…

The occupational exposome and new-onset COPD: longitudinal analyses of two European cohorts.

OBJECTIVES: Occupational exposures may contribute to the development of COPD, a leading cause of morbidity and mortality globally. Using an exposome approach in a follow-up design, we aimed to examine the association between the occupational exposome and new-onset COPD in 2 population-based cohorts: the European Community Respiratory Health Survey (ECRHS) with 2 follow-ups (n = 4,087; observations = 6,224) and the CONSTANCES cohort with 1 follow-up (n = 8,255). METHODS: COPD was defined by respiratory symptom(s) and forced expiratory volume in the first second (FEV1)/forced vital capacity (FV…

Discovery of modifiable factors associated with Pan-Cancer Risk: An Exposome-Wide analysis.

INTRODUCTION: Hypothesis-driven studies have identified many modifiable cancer risk factors, but research focusing on single exposures overlooks their complex interactions. OBJECTIVES: This study applied an exposome-wide approach across multiple cancer types to systematically identify modifiable exposures and evaluate their combined effects with genetic susceptibility. METHODS: We analyzed data from over 460,000 UK Biobank participants with 15 years of follow-up, assessing 93 modifiable exposures in relation to 23 site-specific cancers using Cox models. Exposomic risk scores (ERS) were const…

Dietary Adjuvanticity in the Modern Plant Exposome: Implications for Immune-Mediated Inflammatory Diseases.

Immune-mediated inflammatory diseases (IMIDs) arise from interactions among genetic susceptibility, epithelial barrier function, microbiota, … heses. Overall, plant-derived exposures are best interpreted as potential modifiers within the IMID exposome, not as primary causes of autoimmunity. Testing this model will require defined exposures, food-matrix and processing studies, biomarkers of barrier and immune activation, patient stratification, and controlled human studies.

Pesticide exposure as prenatal exposome: A biomonitoring study in pregnant women from Argentina.

Environmental exposure to pesticides may alter the prenatal exposome affecting maternal health and fetal development. This study investigated the presence of pesticides in urine samples from pregnant women residing in the center-northern region of Santa Fe, Argentina, characterized by intensive agricultural and horticultural activities. Additional analyses examined the relationship between rural and urban populations in terms of sociodemographic factors, pregnancy-related complications, and the frequency of urinary pesticides detection. A multicenter cross-sectional study was conducted, includ…

Comparing the Effects of Glyphosate and Mycotoxins in the Human Follicular Microenvironment: An Exploratory Exposome Study.

Background: Exposure to anthropogenic and/or natural (e.g., herbicides or mycotoxins) endocrine-disrupting chemicals (EDCs) has been linked to several reproductive disorders. Glyphosate (GLY), a common agricultural agent, is a potential element of the exposome that bioaccumulates and has potential endocrine and oxidative stress-related effects. However, data on its presence in the human ovarian microenvironment remain limited. Our study examined GLY levels in follicular fluid (ff) and serum and their relationships with oxidative stress markers, reproductive hormones, and stress hormones in wom…

The socio-environmental exposome and maternal cardiometabolic health in the us: a machine learning approach.

BACKGROUND: There are substantial disparities in American maternal health, with certain groups experiencing disproportionately high rates of pregnancy-related complications and adverse outcomes. Social and Environmental Determinants of Health (SEDH) may play a role in influencing maternal health in pre-pregnancy and gestational scenarios, but remain poorly understood. OBJECTIVES: We aimed to investigate the association between SEDH with pre-pregnancy and gestational conditions related to maternal cardiometabolic health throughout the US using a machine learning approach. METHODS: We conducte

Exposome-wide analysis of hypertensive disorders of pregnancy and subtypes with subsequent focus on phenols.

Hypertensive disorders of pregnancy (HDP) are major pregnancy complications, yet their environmental correlates and associated metabolic profiles remain incompletely characterized. In this prospective study of 1432 pregnant women from the Shanghai Birth Cohort, we integrated exposome-wide prioritization, mixture analyses, untargeted metabolomics, meet-in-the-middle (MITM), and exploratory mediation analyses to investigate prenatal exposures and metabolic profiles associated with HDP, gestational hypertension (GH), and preeclampsia (PE). Eighty-one exposures were ranked using ExWAS, elastic net…

Экспозитивный, окислительный стресс и воспаление у лиц с множественным склерозом: протокол исследования Exposition.

Разоблачение представляет собой совокупность внешних и внутренних экспозиций отдельных лиц на протяжении всей жизни и играет важнейшую роль в развитии многих хронических заболеваний, включая множественный склероз (MS). МЗ представляет собой многофакторную болезнь, на которую влияют как генетические, так и экологические факторы. Исследование " Экспозиция " (зарегистрировано на сайте www.clinicalbears.gov, NCT06325358) направлено на изучение связи между воздействием на окружающую среду (внешняя экспрессия) и биологическими маркерами окислительного стресса и воспаления (внутренняя экспр

Совпадение в аннотации оригинала
The exposome represents the totality of external and internal exposures an individual encounters throughout life and plays a critical role in developing many chronic diseases, including multiple sclerosis (MS). MS is a multifactorial disease influenced by both genetic and environmental factors. The EXPOSITION study (registered on www.clinicaltrials.gov, NCT0…

Advancements in Assays for Micro- and Nanoplastic Detection: Paving the Way for Biomonitoring and Exposomics Studies.

Although plastic pollution and exposure to plastic-related compounds have received worldwide attention, health risks associated with micro- and nanoplastics (MNPs) are largely unknown. Emerging evidence suggests MNPs are present in human biofluids and tissue, including blood, breast milk, stool, lung tissue, and placenta; however, exposure assessment is limited and the extent of human exposure to MNPs is not well known. While there is a critical need to establish robust and scalable biomonitoring strategies to assess human exposure to MNPs and plastic-related chemicals, over 10,000 chemicals h

Chemical exposomics in biobanked plasma samples and associations with breast cancer risk factors.

BACKGROUND: The chemical exposome includes exposure to numerous environmental and endogenous molecules, many of which have been linked to reproductive outcomes due to their endocrine-disrupting properties. As several breast cancer risk factors, including age and parity, are related to reproduction, it is imperative to investigate the interplay between such factors and the chemical exposome prior to conducting large scale exposome-based breast cancer studies. OBJECTIVE: This pilot study aimed to provide an overview of the chemical exposome in plasma samples from healthy women and identify asso…

External and internal exposome as triggers of biological signalling in systemic sclerosis - A narrative synthesis.

Systemic sclerosis (SSc) is an autoimmune chronic connective tissue disorder with a complex pathogenesis and a strong gene-environment interaction. Despite the low prevalence of SSc, with around 100-250 cases per million, the morbidity and mortality are high and disproportionately affecting women. In this context, we review the influence of the external and internal exposome on the "immunome" in SSc. While several studies have addressed aspects of exposure-induced autoimmunity in general, very few have focused on SSc-specific phenotypes. In epidemiological studies, targeted characterization of…

Converging Neoplasms and the Environmental Exposome: Four Distinct Encounters with Collision Tumors in Dermatology.

Collision tumors - characterized by two or more distinct cell types within a singular lesion - are uncommon yet intriguing dermatological phenomena, presenting diagnostic and therapeutic enigmas. Our case series details four diverse presentations of such tumor intersections in dermatology. Beyond the individual cases, we embark on an exploration into the potential environmental exposome's role in the emergence of these neoplastic overlaps. While the first and fourth cases underscore serendipitous discoveries during an excisional biopsy, the second revolves around diagnostic ambiguity arising f…

Integrating Intersectionality Into the Exposome Paradigm: A Novel Approach to Racial Inequities in Uterine Fibroids.

Intersectionality is a critical theoretical framework that emphasizes the influence of intersecting systems of oppression on the lived experiences of people marginalized by inequity. Although applications of intersectionality are increasing in public health, this framework is absent in environmental health, which has instead focused on the exposome, a paradigm that considers the totality of an individual's environmental exposures across the life course.Despite advancements in the biological complexity of exposome models, they continue to fall short in addressing health inequities. Therefore, w…

Health disparities in cystic fibrosis in the context of the exposome: recent developments and future directions.

INTRODUCTION: Clinical outcomes with cystic fibrosis (CF) vary substantially even among individuals with the same cystic fibrosis transmembrane conductance regulator (CFTR) genotype due to the wide spectrum of exposures that are linked to the social determinants of health. AREAS COVERED: The exposome framework offers a comprehensive lens to understand the non-genetic contributors to CF variability and the mechanisms by which sociodemographic characteristics impact upon health. It provides a structured approach to studying the effects of the natural, built, social, and policy environments on C…