Результаты поиска

[Concept and mechanism innovations provide a sustainable driver for echinococcosis control in China].

China is one of the countries with the highest disease burden of echinococcosis in the world. China's progress in echinococcosis control started with limited scientific research projects, followed by nationwide epidemiological surveys, and then launched a national echinococcosis control programme on the basis of a pilot intervention project. During this process, science-based control and technological innovations have been integrated into echinococcosis control in China. The concept and mechanism innovations-based echinococcosis control models and successful experiences in highly endemic foci

Osteoclast differentiation inhibitors: a patent review (2008 - 2012).

INTRODUCTION: Mononuclear macrophage/monocyte-lineage hematopoietic precursors differentiate into multinucleated osteoclasts. Abnormally increased numbers and/or overactivation of osteoclasts can lead to bone loss. Therefore, pharmaceutical inhibition of osteoclast differentiation is one therapeutic strategy for mitigating the occurrence of bone loss-associated disorders and related fractures. AREAS COVERED: This review surveys the patents and patent applications from 2008 to 2012 that are related to inventions of therapeutics and/or methods for inhibiting osteoclast differentiation. EXPERT …

Двойная инновация в деградации ЭГФР и антигенная модуляция для множественного склероза.

Недавние изобретения показали две взаимодополняющие терапевтические стратегии: циклические пептиды, которые вызывают лизосомальную деградацию рецептора эпидермального фактора роста (ЭГФР), и растворимые конструкции Пептида-МГК, которые подавляют автоматически реактивные рецепторы Т-клеток при множественном склерозе. В совокупности эти новшества высвечивают формирующиеся рамки для точного контроля за сигнализацией рецептора и адаптивным иммунитетом с использованием структурно определенных моторизаторов пептида.

Совпадение в аннотации оригинала
Recent inventions have unveiled two complementary therapeutic strategies: cyclic peptides that trigger the lysosomal degradation of the epidermal growth factor receptor (EGFR), and soluble peptide-MHC constructs that suppress autoreactive T-cell receptors in multiple sclerosis. Together, these innovations highlight emerging frameworks for precision control o…

Malaria transmission blocking compounds: a patent review.

INTRODUCTION: Despite substantial progress in the field, malaria remains a global health issue and currently available control strategies ar … host to vector, and vice versa. AREAS COVERED: This review covers innovative transmission-blocking inventions patented between 2015 and October 2021. The focus is on chemical interventions, which could be used as 'chemical vaccines' to prevent transmission (small molecules, carbohydrates, and polypeptides). EXPERT OPINION: Even though the development of no …

Excavating treasure from the amber of the prior art: why the public benefit doctrine is ill-suited to the pharmaceutical sciences.

This paper explores incongruities between patents and regulation as applied to the pharmaceutical industry in the United States. Research, d … nted by the regulatory barrier, a common line of reasoning in patent policy and jurisprudence, that inventions which are barred from patenting benefit the public, is flawed. To the contrary, the patent/regulatory system forever traps pharmaceutical inventions, once placed in the public domain. Pharmaceutical companies cannot afford to invest the resources ne …

Research on the development trend of global running protection equipment technology from the perspective of patent measurement.

This study provides a systematic examination of global development trajectories in running protective equipment by applying large-scale pate … overage, constrains commercialization potential and reduces the economic viability of many patented inventions. Core patent screening using a TOPSIS-based model demonstrates that high-quality patents are concentrated in a small number of enterprises and IPC subclasses, underscoring the uneven distribution of technological impact and market potential across t …

Integrating Industry, Innovation, and Infrastructure for Sustainable Development: A TCCM Framework Analysis of SDG 9 Implementation.

PURPOSE: Achieving Sustainable Development Goal 9 (SDG 9)-which promotes resilient infrastructure, inclusive and sustainable industrialization, and innovation-is central to global economic, social, and environmental progress. This study investigates the implementation of SDG 9 across 120 countries using an integrative Theory-Context-Characteristics-Methodology (TCCM) framework. DESIGN/METHODOLOGY/APPROACH: The TCCM framework synthesizes sustainable development theory, innovation diffusion models, infrastructure resilience concepts, and industrial ecology principles to examine interdependencie

History of urethral catheters and their balloons: drainage, anchorage, dilation, and hemostasis.

Male urethral catheterization, as practiced in early Greece, was made possible by a sound knowledge of anatomy. It has been preserved by written tradition and advanced by the development of new materials. Balloon dilation, conceived and practiced more than 160 years ago by urologists, has undergone a similar cycle. Some useful ideas, once conceived, have been forgotten and have surfaced again, decades, sometimes centuries, later as new inventions.

A Recent Trend in Diagnosis and Therapeutics for Polycystic Ovarian Syndrome (PCOS) Management: A Patent Landscape Report.

INTRODUCTION: To investigate technological advancements for the diagnosis and therapeutic management of PCOS. Another objective is to identi … n". RESULTS: A patent literature search identified 915 relevant patent applications, including 123 inventions having diagnostic potential and 777 inventions having therapeutic potential, out of which 223 patent applications are based on traditional knowledge, describing mostly the use of locally available herbs, along with 15 patent applications that descri …

Peak Fiction: XRPD and the Illusion of Novelty.

This viewpoint addresses the growing use of X-ray powder diffraction (XRPD) data to support patent claims on crystalline forms of pharmaceutical compounds. XRPD patterns are inherent material properties, not inventions. We demonstrate that different sample preparations and holders impact the XRPD peaks returned for the same commercially available sample. Thus, treating XRPD peaks as stand-alone proof of novelty weakens patentability standards across the field of medicinal chemistry and pharmaceutical intellectual property.

Genghis Khan's death (AD 1227): An unsolvable riddle or simply a pandemic disease?

The article examines Genghis Khan's death from the historico-medical perspective. Although several etiologies have been proposed over the years, most of these at a closer look appear to be later inventions by historians. A reassessment of the available evidence suggests instead bubonic plague as the most likely clinical scenario. Genghis Khan's death is also a reflection on the impact of pandemic diseases on leadership in ancient times as well as nowadays.

[Expediency of closed plastic surgery of ligaments of the knee joint].

In most patients with long-standing injuries of ligaments of the knee joint there develops a deforming arthrosis. So, the operative techniques of recovering their stability must be at most sparing. The author thinks the use of "closed" methods of plasty of the ligaments to be expedient. He has elaborated two new methods of operations which were recognized as inventions. Operations were made on 47 patients with good results observed up to 3.5 years.

Can government procurement drive corporate green technology innovation? Evidence from Chinese listed companies.

Examining the impact of public procurement mechanism government procurement systems on corporate green technology innovation from a demand-side perspective has become a critical issue for encouraging green innovation in enterprises. Using empirical data from Shanghai and Shenzhen A-share listed companies from 2015 to 2023, this study employs a dual fixed-effect model to test the effects of government purchase behavior on green technology innovation. The findings indicate that government procurement significantly promotes green technology innovation in enterprises. Mechanism analysis reveals th

Embracing a Penta helix hub framework for co-creating sustaining and potentially disruptive sterilization innovation that enables artificial intelligence and sustainability: A scoping review.

The supply of safe pipeline medical devices is of paramount importance. Opportunities exist to transform reusable medical devices for improved processing that meets diverse patient needs. There is increased interest in multi-actor hub frameworks to meet innovation challenges globally. The purpose of this scoping paper was to identify critical decontamination and sterilization needs for the medtech and pharmaceutical sectors with a focus on understanding how to effectively use the Penta helix hub framework that combines academia, industry, healthcare, policy-makers/regulators and patients/socie

Trust (in)congruence, digital technological innovation, and firms' ESG performance: A polynomial regression with response surface analysis.

We examine whether and how the different types of digital technology innovation (DTI) affect corporate ESG performance. Based on patents' information, we classify DTI into symbolic DTI and substantive DTI. Specifically, symbolic DTI is the innovation driven by firms' legitimacy strategy, while substantive DTI is the type of innovation that helps strengthen firms' competitive advantages. Using a sample of Chinese A-share-listed firms from 2009 to 2020, we use polynomial regression and response surface analysis to examine how firms balance the tension between competitiveness and legitimacy throu

Energy consumption, environmental pollution, and technological innovation efficiency: taking industrial enterprises in China as empirical analysis object.

Facing increasingly serious environmental problems, technological innovation has become the key for industrial enterprises to coordinate energy conservation and emission reduction constraints and achieve steady growth of the industrial economy. Considering the impact of energy consumption and environmental pollution on the technological innovation efficiency of industrial enterprises, this paper incorporates industrial energy consumption, pollution control, and wastewater and exhaust emissions into the technical inefficiency equation. Based on the panel data of industrial enterprises in 30 pro

Samuel Thomas Soemmerring (1755-1830): The Naming of Cranial Nerves.

Samuel Thomas Soemmerring was a Prussian polymathic doctor with remarkable achievements in anatomy, draftsmanship and inventions. His naming of 12 pairs of cranial nerves in his graduation thesis is of particular importance. He also gave original descriptions of the macula, sensory pathways and of the substantia nigra. His non-medical contributions were diverse and included criticism of the guillotine, invention of a telegraphic system, and discoveries in palaeontology.

Digital Innovations in Nursing Workforce Management: A Scoping Review of Advanced Applications and Implementation Challenges.

OBJECTIVE: Artificial intelligence (AI) is increasingly being adopted to support healthcare workforce planning and operational decision-making. However, evidence regarding its application specifically within nursing workforce management remains fragmented across diverse disciplines and publication types. This scoping review aimed to map the current evidence on AI applications in nursing workforce management, identify major application domains, synthesise reported organisational outcomes and implementation challenges and highlight priorities for future research. DESIGN: Scoping review. METHOD

A study on the impact of ESG rating on green technology innovation in enterprises: An empirical study based on informal environmental governance.

Improving corporate green technology innovation is a key link in achieving green transformation and development. Compared with formal environmental regulations that force companies to carry out green innovation passively, ESG ratings under soft environmental regulations can better stimulate the internal motivation of companies. This study uses the ESG ratings of listed companies published for the first time by SynTao Green Finance as an exogenous impact. Taking China's A-share listed companies from 2011 to 2022 as a research sample, the multi-period differences-in-differences model was used to

How to measure intra-renal pressure during flexible URS: Historical background, technological innovations and future perspectives.

INTRODUCTION: High intrarenal pressure (IRP) is a potential risk factor for infectious complications related to URS. Methods to lower IRP have been described. However, it is still not possible to assess live IRP values during URS. The objective of this study was to perform a systematic review of the literature regarding endoscopic methods to measure IRP during URS. METHODS: A systematic search and review of Medline, PubMed and Scopus was conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta Analysis (PRISMA) checklist and a narrative synthesis of the study