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Функция тироида и множественный склероз: a two- проведение выборочного исследования по менделизации и посреднического анализа.

Множественный склероз (MS) — широко распространенное неврологическое расстройство с сложной этиологией, часто связанной с функцией щитовидной железы. Однако причинно-следственная связь между этими two По-прежнему недостаточно хорошо понимаются условия. Цель этого исследования состояла в том, чтобы выяснить причинно-следственную связь между функцией щитовидной железы и MS с использованием подхода, предусматривающего двунаправленную менделианскую случайность (MR), и изучить потенциальную посредническую роль иммунных клеток. Мы провели two- выборка результатов анализа МОР с использованием обобщен

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is a prevalent neurological disorder with a complex etiology, often associated with thyroid function. However, the c … sensitivity analyses conducted using seven additional MR methods. Furthermore, multivariable MR and mediation analysis were conducted to uncover potential mediating immune cells underlying the observed associations. The MR analysis showed that Hypothyroidism and elevated Thyroid-Stimulating Hormone (TSH) levels(normal) reduced the risk of MS (P = 0.012, OR (95%CI) : …

Mediation Analysis of Serum Fibroblast Growth Factor 20 and Poor Prognosis After Ischemic Stroke.

BACKGROUND: We aimed to examine the relationship between serum FGF20 (fibroblast growth factor 20) levels and stroke prognosis in a multicen … rds regression analysis was employed to estimate the relationship between FGF20 and study outcomes. Mediation analysis was conducted to examine the mediating effects of traditional risk factors on the association between FGF20 and stroke outcomes. A total of 1011 patients with ischemic stroke were included in the study. After adjusting for potential confounding fact …

Association between probable sarcopenia and dementia risk: a prospective cohort study with mediation analysis.

The role of alcohol consumption as a mediator in the risk between sarcopenia and dementia remains inadequately studied. There is currently l … e sarcopenia and the risk of all cause dementia (ACD), AD, and vascular dementia (VD). We conducted mediation analysis to explore the role of alcohol consumption in the association between probable sarcopenia and the risk of ACD, AD, and VD. During the median follow-up period of 13.6 years, we documented 9000 new cases of ACD (including 4061 AD and 2025 VD). Fully a …

Gut microbiota and autoimmune thyroid disease: a bidirectional Mendelian randomization study and mediation analysis.

BACKGROUND: The gut microbiota (GM) plays a pivotal role in influencing various health outcomes, including immune-mediated conditions, but its potential association with autoimmune thyroid disease (AITD) remains underexplored. We aimed to investigate the potentially pathogenic or protective causal impacts of specific GM on two types of AITD, namely Graves' disease and Hashimoto's thyroiditis, and analyzed the mediating effect of 731 immune cell phenotypes. METHODS: Leveraging pooled genome-wide association study (GWAS) data of 211 gut microbiota traits, 731 immune cell phenotypes, and two typ

Overcoming blinding confounds in psychedelic randomized controlled trials using biomarker driven causal mediation analysis.

INTRODUCTION: There is great interest in the use of psychedelic-assisted therapies to treat a range of mental health conditions and initial … nd potential confounders along with graphical illustrations is provided. It is proposed that causal mediation analysis using objectively measured mediating biomarkers could be used to identify causal pathways between treatment and outcome in psychedelic RCTs, even with de-blinding of participants and give greater confidence as to the mechanistic basis and efficacy o …

From emotional intelligence to suicidality: a mediation analysis in patients with borderline personality disorder.

BACKGROUND: Borderline personality disorder (BPD) is a serious mental illness with a high suicidality rate between 40 and 85%. However, little is known concerning psychosocial risk and protective factors associated with suicidal behaviors in this clinical group. The main focus of the present study was on examining the relationship of emotional intelligence (EI) with suicidal behaviors and its mediators (e.g., depression, self-esteem, addiction potential, and disorder severity) among patients with BPD. METHODS: In this cross-sectional study, a total of 220 participants (including 110 patients

Transdiagnostic therapy for persistent physical symptoms: A mediation analysis of the PRINCE secondary trial.

The PRINCE secondary trial did not find any evidence that transdiagnostic cognitive behavioural therapy (TDT-CBT) plus standard medical care … and mechanisms that lead to effects of TDT-CBT plus SMC versus SMC we performed a planned secondary mediation analysis. We investigated whether TDT-CBT treatment effects on these two secondary outcomes at the end of the treatment could be explained by effects on variables that were targeted by TDT-CBT during the initial phase of treatment. We pre-specified mediator …

Association between violence and depression during pregnancy with perinatal outcomes: a moderated mediation analysis.

OBJECTIVE: To assess the direct, indirect, and total effects of violence during pregnancy on perinatal outcomes, and to evaluate the effect … pregnancy). Depressive symptoms during pregnancy were evaluated as a mediating variable. Moderated mediation analysis was performed to estimate the effects of violence and depression on perinatal outcomes. RESULTS: Three types of violence analyzed by depression had an indirect effect in BW and GA. None of the types of violence showed an association with IUGR. All …

Mediation analysis of racial disparities in triple-negative breast cancer incidence among postmenopausal women.

BACKGROUND: Triple-negative breast cancer (TNBC) is disproportionately higher in Black women relative to White women. The objective of this study was to examine to what extent the association between race/ethnicity and risk of TNBC is mediated by potentially modifiable factors. METHODS: A total of 128,623 Black and White women aged 50-79 years from the Women's Health Initiative were followed for a mean of 15.8 years. 643 incident TNBC cases (92 Black women and 551 White women) were confirmed by medical record review. Mediation analyses were conducted using an approach under a counterfactual f

Adverse childhood experiences, internalizing/externalizing symptoms, and associated prescription opioid misuse: A mediation analysis.

Adverse childhood experiences (ACEs) are associated with mental health and substance use problems, but lesser known is how they interconnect. The objective of this study was to examine how internalizing and externalizing symptoms mediate the association of ACEs with prescription opioid misuse in order to understand how ACEs interconnect with mental health and substance use problems. Adults aged 18 or older from the National Epidemiological Survey on Alcohol and Related Conditions Wave 3 (NESARC-III) conducted in 2012-2013 were included (N = 36,309). The prescription opioid misuse outcomes exam

Exploring food insecurity and obesity in Dutch disadvantaged neighborhoods: a cross-sectional mediation analysis.

BACKGROUND: Food insecurity is related to risk of adverse health outcomes such as obesity, but the explanatory factors underlying this association are still unclear. This study aimed to assess the association between food insecurity and obesity, and to explore potential mediation by sociodemographic and lifestyle factors. METHODS: This cross-sectional study was conducted among 250 participants in a deprived urban area in the Netherlands. Data on sociodemographic and lifestyle factors, food insecurity status and diet quality were collected using questionnaires. Diet quality was determined base

Kindergarten organizational climate, preschool teachers' subjective well-being, and psychological security: A latent profile analysis and mediation analysis.

To explore the relationships among different types of kindergarten organizational climate, preschool teachers' subjective well-being, and psychological security, this study surveyed 287 preschool teachers from mainland China using the Kindergarten Organizational Climate Questionnaire, the Subjective Well-Being Assessment Scale, and the Psychological Security Assessment Scale. Combined with the results of kindergarten organizational climate types derived from latent profile analysis, the study examined the statistical mediating role of psychological security between different organizational cli

Inflammatory burden index predicts arteriogenic erectile dysfunction: a mediation analysis involving the TyG index.

INTRODUCTION: Inflammation and metabolic dysregulation play important roles in the pathophysiology of erectile dysfunction. The inflammatory … ating characteristic curves were used to assess the predictive performance of inflammatory markers. Mediation analysis was conducted to explore the potential mediating role of IR using the TyG index. RESULTS: A total of 211 participants were included (109 AED; 102 controls). Patients with AED exhibited significantly higher inflammatory indices, including CRP, neutr …

Professional Values, Moral Resilience and Professional Competence in Critical Care Nursing: A Mediation Analysis.

BACKGROUND: Professional values and moral resilience are recognized as essential attributes of nursing practice. In critical care settings, where nurses routinely face ethical complexity and high-stakes decisions, it is important to understand how these attributes shape professional competence. AIM: To examine the relationship between professional values and professional competence among critical care nurses, and to determine whether moral resilience mediates this relationship. STUDY DESIGN: This descriptive and correlational study was conducted among nurses working in the critical care unit

Associations Between Spiritual Sensitivity, Compassion, and Humanistic Practice Ability in Nurses: A Mediation Analysis.

AIM: This study was conducted to examine the association between nurses' spiritual sensitivity, compassion, and their humanistic practice ab … n compassion levels and humanistic practice ability (r = .373, p < .001). In the covariate-adjusted mediation analysis, spiritual sensitivity was significantly associated with humanistic practice ability (B = 0.602, SE = 0.102, t = 5.927, p < .001). The total-effect model including spiritual sensitivity and the specified covariates explained 11.4% of the variance in …

Explaining educational differences in return to work after early breast cancer: a mediation analysis.

BACKGROUND: The mechanisms behind the effect of education on the return to work (RTW) of survivors of breast cancer (BCS) are unknown. METHODS: We used data from 2461 BCS from the prospective cohort CANTO. Using inverse odds weights we studied the mediating effect of pre-existing comorbidities, clinical factors, post-treatment health related quality of life, working conditions and household composition in the association between education and non-RTW. We used education in three categories. All models were adjusted for age at diagnosis. RESULTS: Non-RTW increased at lower levels of education.

The role of declining therapy volumes in skilled nursing facility outcomes: a mediation analysis.

INTRODUCTION: Significant declines in therapy provision in skilled nursing facilities (SNFs) followed the 2019 implementation of Medicare's Patient-Driven Payment Model (PDPM) and the onset of the COVID-19 pandemic, raising concerns about effects on patient outcomes. METHODS: Using Medicare fee-for-service claims and SNF assessment data from January 2018 through September 2021, we analyzed 3.5 million post-hospital SNF stays to assess whether changes in therapy volumes mediated changes in successful community discharge and 30-day hospital readmissions. RESULTS: Average total physical, occupa

Family support, stigma, and psychological detachment in hemodialysis patients: a cross-sectional mediation analysis.

BACKGROUND: Maintenance hemodialysis (MHD) patients face profound psychological challenges that impede their quality of life and treatment o … SF), Social Impact Scale (SIS), Family APGAR Index, and the Psychological Detachment Scale for MHD. Mediation analysis was performed using the PROCESS macro (Model 6) with 5000 bootstrap samples. RESULTS: The mean score for psychological detachment was 193.10 ± 24.37. Family support was positively correlated with FoP (r = 0.16, p < 0.05) and negatively correlated wi …

Reframing Surgical Risk in Frailty: Causal Mediation Analysis of Mortality and Readmission after Pancreatectomy.

BACKGROUND: Frailty predicts poor outcomes after pancreatectomy, but whether excess mortality and readmission reflect more postoperative com … stic regression evaluated associations between frailty and 30-day mortality and readmission. Causal mediation analysis quantified total, direct, and complication-mediated indirect effects. Interaction modeling compared failure-to-rescue and nonprecedented deaths by frailty status. RESULTS: Of 71,104 patients, 15,779 (22.2%) were frail. Frailty was independently ass …

Nurse Manager Empowerment and Nurses' Engagement in Continuing Professional Development: A Parallel Mediation Analysis.

BACKGROUND: Nurse manager empowerment is integral to creating supportive work environments that may foster nurses' engagement in continuing professional development (CPD). Despite empowerment and CPD have been connected to positive professional outcome, limited research has explored the association between nurses' perceived nurse manager empowerment and CPD engagement and the mechanisms that may contribute to this association. AIM: This study examines the association between nurses' perceptions of nurse manager perceived empowerment and their CPD engagement in Saudi Arabia. It also assesses w